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miR
Suyin Detoxification Granule alleviates trimethylamine N
Identification and characterization of non
Decreased OGT Attenuates Endometrial Decidualization and Embryo Implantation by Affecting HIF
Design, Synthesis, and Biological Evaluation of 4
Golgi protein ACBD3 downregulation sensitizes cells to ferroptosis PMID 38953242
Biocompatible ionized air alleviates rat osteoarthritis by modulating polarization from M1 to M2 macrophages PMID 39738316
Larotaxel dihydrate 192573
弱阳离子交换层析介质 6FF (CM Agarose 6FF )
Cobaltous chloride hexahydrate, for cell culture
Acetylcysteine 616
Set
Difucosyl
Bis(acetonitrile)palladium(II) dichloride 14592
Inhibition of binding of [3H]batrachotoxinin A 20
Isolithocholic acid
Design, synthesis and biological evaluation of novel o
Urea
Design, synthesis, and antitumor activity evaluation of steroidal oximes PMID 34425478
龙舌兰提取物 (Agave americana Linn.)
Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1 PMID 34498715
Allolithocholic acid (别石胆酸)
Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis PMID 36435786
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo PMID 32031798
Sphingomyelin
Search for novel histone deacetylase inhibitors. Part II design and synthesis of novel isoferulic acid derivatives PMID 24702857
Acute stress induces visceral hypersensitivity via glucocorticoid receptor
Ekebergia senegalensis提取物 (Ekebergia senegalensis)
Discovery and structure
Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4
Inhibition of ferroptosis alleviates atherosclerosis through attenuating lipid peroxidation and endothelial dysfunction in mouse aortic endothelial cell PMID 32768568
Resibufogenin 465
A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation PMID 37167784
Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2 PMID 39815001
Synthesis of novel amide and urea derivatives of thiazol
Gatifloxacin acutely stimulates insulin secretion and chronically suppresses insulin biosynthesis PMID 17070519
Natural products in drug discovery PMID 18691670
QSAR analysis on a large and diverse set of potent phosphoinositide 3
Inhibition of CARM1
Silvestrol Inhibits Chikungunya Virus Replication PMID 30380742
Aquacobalamin Accelerates Orange II Destruction by Peroxymonosulfate via the Transient Formation of Secocorrinoid A Mechanistic Study PMID 36233209
Identification of a potent 5
Biological evaluation and structure
TRIM3 facilitates ferroptosis in non
(±)
Methylmercury induced ferroptosis by interference of iron homeostasis and glutathione metabolism in CTX cells PMID 37517642
IgA
Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)
Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response‑induced upregulation of CHAC1 expression PMID 34558645
psychomotor seizures
Autophagy blockade synergistically enhances nanosonosensitizer
Transcriptionally distinct malignant neuroblastoma populations show selective response to adavosertib treatment PMID 40118716
Amrubicin 110267
Proteasome抑制剂、基因
Exploration of interaction property between nonylphenol and G protein
Ferroptosis contributes to lead
SLC27A5 promotes sorafenib
Scopine (
Identification of N
Synthesis and biological evaluation of 2
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment PMID 18038969
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles PMID 25380299
化学探针化合物库
Silibinin ameliorates cisplatin
The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress
Berberine
A case study of an integrative genomic and experimental therapeutic approach for rare tumors identification of vulnerabilities in a pediatric poorly differentiated carcinoma PMID 27799065
HDAC6
Synthesis and investigation of novel 6
LINC02362/hsa
Dihydrotanshinone attenuates chemotherapy
Aurantiamide acetate 56121
Phentolamine 50
Resibufogenin Induces G1
Oncogenic KRAS
Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs A microdialysis study in rats PMID 34628723
Ferroptosis related genes participate in the pathogenesis of spinal cord injury via HIF
CD44 蛋白, Human (HEK293, His)
High
Parasite抑制剂、基因
Antibacterial activity of novel bacterial topoisomerase inhibitors against key veterinary pathogens PMID 37531840
The Selective SIRT3 Inhibitor 3
A disintegrin and metalloproteinase 22 activates integrin β1 through its disintegrin domain to promote the progression of pituitary adenoma PMID 37555799
Apramycin (Standard) 37321
Calcium ion cross
FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells PMID 32810509
Biological evaluation of phenolic constituents from the trunk of Berberis koreana PMID 21420296
Antiprotozoal Linear Furanosesterterpenoids from the Marine Sponge Ircinia oros PMID 28840725
Activation of the mitochondrial unfolded protein response regulates the dynamic formation of stress granules PMID 39463355
Tellimagrandin II 81571
(
Angiotensin tachyphylaxis and its reversal PMID 4288083
STAT1 increases the sensitivity of lung adenocarcinoma to carbon ion irradiation via HO
Design, synthesis and anti
ARN
Sucrose Stearate, Type II, USP
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding PMID 30291141
LncRNA SNHG1 enhances cartilage regeneration by modulating chondrogenic differentiation and angiogenesis potentials of JBMMSCs via mitochondrial function regulation PMID 38886785
Bioactive Dimeric Acylphloroglucinols from the Mexican Fern Elaphoglossum paleaceum PMID 30920216
CAP rigidification of MS
Isolation and characterization of minor analogues of silvestrol and other constituents from a large
Biocytin 576
Pafolacianine, the magic wand of intraoperative imaging of folate
Exposure to environmental black carbon exacerbates nasal epithelial inflammation via the reactive oxygen species (ROS)
Glsnf1
Estradiol hemihydrate 35380
Hypercapnia promotes microglial pyroptosis via inhibiting mitophagy in hypoxemic adult rats PMID 32666671
Silibinin ameliorates STING
Structure
Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line PMID 34398448
Targeted Metabolomics Analysis Identifies Intestinal Microbiota
LATS1 inhibitor and zinc supplement synergistically ameliorates contrast
Both carvedilol and cimetidine alleviate cisplatin
Dioxane
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress PMID 38516760
Elamipretide as a potential candidate for relieving cryodamage to human spermatozoa during cryopreservation PMID 32240641
Discovery of 2,5
The effects of S
Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors PMID 29954683
Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV
Ramelteon metabolite M
Design, synthesis and biological evaluation of carbamate derivatives incorporating multifunctional carrier scaffolds as pseudo
Targeted inhibition of the PI3K/AKT/mTOR pathway by (+)
Fostriecin sodium 87860
Synthesis and antiproliferative evaluation of 6
Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase PMID 26782976
Metal
Synthesis, antitumor, and apoptosis
Elamipretide (SS
Nicotinic acetylcholine receptors
Role of protein disulfide isomerase in mediating sulfasalazine
Artesunate induces HO
疏水层析介质 (Octyl) 6FF (Octyl Agarose 6FF )
Cytotoxic and NF
α
Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat PMID 30243158
Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN
Multimeric Anti
Effect and mechanism of the miR
NEFA Induces Ferroptosis in Transition Dairy Cattle Liver by Increasing Lipid Reactive Oxygen Species and Downregulating SLC7A11 PMID 40684388
Adiponectin Receptor
主题讲座
Vancomycin hydrochloride (盐酸万古霉素)
5
SDZ
Aminopeptidase Inhibitors
DP303c
微课堂
微课堂
多肽溶解和储存建议
Fgr抑制剂、基因
罗格列酮钠
主题讲座
Everolimus
主题讲座
xenograft model
ATM抑制剂、基因
TRRAP抑制剂、基因
Calmodulin Inhibitors
RAD001
advanced
Ruthenium(II) complexes
CALM3抑制剂、基因
Captopril hydrochloride (SQ 14225 hydrochloride)
CAM2602
Calmodulin
sickness
vasoconstriction
Z
Docetaxel Trihydrate (Standard) (RP
TRP Channel
非昔硝唑(Standard)
Ciprofloxacin monohydrochloride (Bay
Tetracycline hydrochloride (盐酸四环素)
福辛普利钠
主题讲座
罗格列酮钠盐
缓冲试剂 (Buffer Reagents)
mutant forms of ErbB
苏木素
Caspase 9抑制剂、激动剂、激活剂、调节剂、诱导剂、基因
B cell
微课堂
主题讲座
TAM Receptor
Calcein
辣椒素（标准品）
Dilevalol
Dactylocycline E
NE21650
Peptide
Transient receptor potential channels
macrophage
MCAO
Avitinib
主题讲座
Aurora A
Fenoterol
phenazine
SR
牛蒡甙元 (Standard)
Arctigenin (Standard)
Phenoterol
L
Nonenzymatic lysine D
Glycoprotein/G 蛋白, HRSV (95% Homology, HEK293, His)
白细胞介素
Tyrphostin AG
MCE 小课堂
ACSL4
Fc Receptor
antiallergic
Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors PMID 30784881
依达拉奉 (Standard)
ATP
Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae PMID 28233700
免疫系统疾病 (Immune System Disorder)
Th
Edaravone (Standard)
Surface
Zinc(II) acetate, 99.99% trace metals basis
Dual receptor specific nanoparticles targeting EGFR and PD
Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T
Carvedilol Glucuronide
SP600125 (Standard)
Etamiphyllin
FGF13
MCE 小课堂
Micafungin (FK463，米卡芬净;咪克芬净)
TSPAN8+ myofibroblastic cancer
Hematoxylin
mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor PMID 19223496
Central and peripheral alytesin cause short
Synthesis of potent taxoids for tumor
Dual Inhibitory Action of a Novel AKR1C3 Inhibitor on Both Full
Central neuromodulation of gastric acid secretion by bombesin
Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal PMID 22585572
middle cerebral artery occlusion
S
hGGPPS
Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor PMID 19066408
PRRSV utilizes MALT1
Isolation and characterization of unusual hydrazides from Streptomyces sp. impact of the cultivation support and extraction procedure PMID 23387796
Poly
Cytosolic N
Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease PMID 36325883
Docetaxel
PT
Tissue processing and hematoxylin and eosin staining PMID 25015141
BRPF3
L
Novel mixed cancer
Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF
N6
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP
TRPM2 mediates mitochondria
Fenoterol 13392
S
Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO
Development of a Time
Surface
Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC
Design and Synthesis of New α
Long non
Peroxisome Proliferator
Epimedokoreanin B 161068
LY2109761 700874
Seasonal coronavirus infections trigger NLRP3 inflammasome activation in macrophages but is therapeutically targetable PMID 37459896
(S)
Xanthorrhizol 30199
Design, synthesis, and biological evaluation of imidazolidinone derivatives as potent PPARα/δ agonists for the treatment of cholestatic liver diseases PMID 39827490
PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p
MicroRNA
A 72517
A72517
E1 activating enzyme
Combination therapy with semaglutide and rosiglitazone as a synergistic treatment for diabetic retinopathy in rodent animals PMID 33417950
Modes of action of microbially
The long history of hematoxylin PMID 16195172
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis PMID 38594496
Peripheral modulation of antidepressant targets MAO
凝血因子 III, 组织因子（F3）基因
Enhancing prognostic accuracy in head and neck squamous cell carcinoma chemotherapy via a lipid metabolism
Antibody
Targeting BARD1 suppresses a Myc
In vivo efficacy of the combination of ciprofloxacin and cefotaxime against Vibrio vulnificus sepsis PMID 24978586
Acalabrutinib (Standard)
Trehalose induces B cell autophagy to alleviate myocardial injury via the AMPK/ULK1 signalling pathway in acute viral myocarditis induced by Coxsackie virus B3 PMID 35381374
Estradiol enanthate 4956
Synthesis and anticancer activity of novel quinoline
Estradiol cypionate (Standard) (环戊丙酸雌二醇 (Standard))
Novel C2
[Cytochrome P450 enzymes in biosyntheses of some plant secondary metabolites] PMID 15635280
The myosin II ATPase inhibitor blebbistatin prevents thrombin
Management of lymph node metastasis via local chemotherapy can prevent distant metastasis and improve survival in mice PMID 33065097
HOE 239 (Standard)
3D bioprinting of multi
1
Tubulin binding, protein
疾病标志物 (Disease markers)
Exosomal circRNA Scm
SR146131 a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies PMID 10215648
BI8622 1875036
Androgen receptor splicing variant 7 (ARV7) inhibits docetaxel sensitivity by inactivating the spindle assembly checkpoint PMID 33428943
Metal
Fenamates inhibit human sodium channel Nav1.7 and Nav1.8 PMID 30528877
Deguelins, Natural Product Modulators of NF1
AF12198 185413
N
Aliskiren
Differential expression of ADRB1 causes different responses to norepinephrine in adipocytes of Duroc
NPC1
Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa PMID 28075580
Metronidazole
ADC Antibody
红豆杉科提取物 (Taxaceae)
8
H3K18 lactylation
Synthesis and cytotoxic activity of novel 10
Identification of RP
Dorzolamide 120279
Activation of the PERK/eIF2α axis is a pivotal prerequisite of taxanes to cancer cell apoptosis and renders synergism to overcome paclitaxel resistance in breast cancer cells PMID 39020371
tyrosine kinase
miR‑133b affects cell proliferation, invasion and chemosensitivity in renal cell carcinoma by inhibiting the ERK signaling pathway PMID 32377748
LP17 TFA (LQVTDSGLYRCVIYHPP TFA)
Alytesin 31078
ACSL4 a Double
Integrative genomics unveils basement membrane
lung cancer cells
FE100726 158459
Phenosafranine 81
Aliskiren 173334
SBI
BGB 290
Rosiglitazone sodium 316371
5
Hoxa5 alleviates obesity
New highly active taxoids from 9beta
AdipoRon 924416
Selective Aurora A
Ciprofloxacin monohydrochloride 93107
Tisotumab 1418628
Hepatoprotective effects of ZLY16, a dual peroxisome proliferator
BGB
Ring
溶质载体家族 34 成员 2（SLC34A2）基因
Epicaptopril 63250
Adenylyl cyclase
Regulation of adiponectin on lipid metabolism in large yellow croaker (Larimichthys crocea) PMID 32289502
Myeloid
Hydroxytriazole derivatives as potent and selective aldo
Actinonin 13434
Organoid models derived from patients with malignant phyllodes tumor of the breast PMID 37204665
Discovery of Dual TAF1
Discovery of 5
Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL
BGB290
Reactive intermediates and bioactivation pathways characterization of avitinib by LC
Arctigenin 7770
ME3221 139958
Zinc acetate, 99.99% trace metals basis
Forskolin (Standard)
Synthesis of new 2
NOTCH3 promotes docetaxel resistance of prostate cancer cells through regulating TUBB3 and MAPK signaling pathway PMID 38115797
Abrogation of ARF6 promotes RSL3
Anti
LRP6 as a biomarker of poor prognosis of breast cancer PMID 34527553
Overexpression of ULK1 Represents a Potential Diagnostic Marker for Clear Cell Renal Carcinoma and the Antitumor Effects of SBI
MiR
The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma PMID 32523091
Fabrication, optimisation and in vitro evaluation of docetaxel and curcumin Co
Autologous patient
Zankiren 138742
The hemodynamic effects of long
Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues PMID 18524425
Beneficial effects of rosiglitazone and losartan combination in diabetic rats PMID 28892640
Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain PMID 37703873
Dual structure
Fedratinib 936091
Avitinib maleate 1557268
Pamiparib maleate 2086689
Ganetespib 888216
Gosferol 37551
( )
Salpyran 2719737
Circ_0008043 promotes the metastasis of hepatocellular carcinoma by regulating the miR
(Rac)
Dihydrocapsaicin 19408
CAM2602 3056388
Tamnorzatinib 1646839
Flufenamic acid 530
海洋天然产物 (Marine natural products)
AD1058 2907782
Fexinidazole 59729
Zinc acetate 557
SP600125 129
Upifitamab 2254118
PT2399 1672662
Secologanin 19351
Tyrphostin AG1112 153150
Methyl gerfelin 700870
Deguelin 522
Fosinopril sodium 88889
Antibody
槐提取物 ( Sophora japonica (L.) Schott)
CH1055 1622250
Prazosin 19216
Go 7874
( )
Hemoglobin porcine
Cannabinoid Receptor 2
乙酰磺环己脲(Standard)
Pamiparib
非诺特罗
CCK2
EAC
antitrypanosomal
Docetaxel
Gosferol
NSCLC
lymphomas
Elimusertib
Teclistamab (JNJ
(Rac)
4
尤匹菲妥单抗
醋磺己脲(Standard)
solid
Axl
Nilotinib monohydrochloride monohydrate (AMN107 monohydrochloride monohydrate，尼洛替尼盐酸盐一水合物)
lung
LncRNA SNHG4 promotes prostate cancer cell survival and resistance to enzalutamide through a let
Plumbagin induces Ishikawa cell cycle arrest, autophagy, and apoptosis via the PI3K/Akt signaling pathway in endometrial cancer PMID 33383144
First pharmacophore
表皮生长因子受体（EGFR）基因
Docetaxel Trihydrate 148408
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity PMID 36968079
Cytarabine
Natural Black 1
Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia PMID 38752538
KIF14 mediates cabazitaxel
Damage Incorporated Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models PMID 32502336
海洋来源天然产物库
PPARγ promotes diabetes
SNAI1 promotes epithelial
Isonicotinic acid hydrazide (Standard)
Modulating versatile pathways using a cleavable PEG shell and EGFR
Design, synthesis, and biological evaluation of novel deguelin
Hypoxia
Gp78 deficiency in hepatocytes alleviates hepatic ischemia
Fenoterol a review of its pharmacological properties and therapeutic efficacy in asthma PMID 342228
Action of 3 tyrphostin derivatives on casein kinase II from rat liver PMID 10072895
GW9662 ameliorates nonalcoholic steatohepatitis by inhibiting the PPARγ/CD36 pathway and altering the gut microbiota PMID 37838102
Silicate esters of paclitaxel and docetaxel synthesis, hydrophobicity, hydrolytic stability, cytotoxicity, and prodrug potential PMID 24564494
Intraoperative fluorescence staining of malignant brain tumors using 5
Generation of prostate cancer assembloids modeling the patient
Identification of Novel PPARγ Partial Agonists Based on Virtual Screening Strategy In Silico and In Vitro Experimental Validation PMID 39459249
Aliskiren, a novel orally effective renin inhibitor, provides dose
CT
A431
TMAO Impairs Mouse Aortic Vasodilation by Inhibiting TRPV4 Channels in Endothelial Cells PMID 38980653
Penicillinase as a marker in enzyme
Time
Epsin 3 potentiates the NF‑κB signaling pathway to regulate apoptosis in breast cancer PMID 34779498
blood
Synthesis and biological evaluation of imidazol
Orexin enhances firing activities in the gigantocellular reticular nucleus through the activation of non
Effects of benzotriazoles UV
Rational design, engineer, and characterization of a novel pegylated single isomer human arginase for arginine depriving anti
Calmodulin
Tumor
Synthesis and Anticancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors PMID 32551649
Ex 451
Ischemia
c
Hck抑制剂、降解剂、基因
Blk抑制剂、基因
SRC
ATR抑制剂、激活剂、基因
ATM/ATR Inhibitors
Inactivation of microglia dampens blood
Src Inhibitors
naked antibody
Edaravone 89
Forskolin 66575
Em 496
Avitinib maleate dihydrate (Abivertinib maleate dihydrate)
AD
Etamiphyllin 314
红豆杉提取物 (Taxus chinensis (Pilger) Rehd.)
(Rac)
Hematoxylin 517
Everolimus
Alleviation of fibrosis and oxidative stress in pressure overload
HA1/Hemagglutinin 蛋白, H5N1 (ACI06178, HEK293, His)
OXPHOS
YTHDF2抑制剂、基因
Cancer 抑制剂
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