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生物活性分子最近更新
Agnuside (Standard) (Agnoside (Standard)，穗花牡荆苷 (Standard))
XEN103
GLP
Sirtuin modulator 6
Niraparib (Standard) (MK
XR9051 hydrochloride
BTI
TAT
Goserelin
11β
C20 Sphingomyelin (d18 1/20 0) (N
Rineterkib hydrochloride
PDE4
BCL6激活剂、基因
Rosnilimab (ANB030，罗斯尼利单抗)
MerTK
Conatumumab (AMG 655)
PKM2
Niraparib hydrochloride (MK
Exemestane (FCE 24304，依西美坦)
Tectorigenin (鸢尾黄素)
TGR5 Receptor Agonist (CCDC)
Glibenclamide (Glyburide，格列本脲)
FAK
BCAT
11β
Tafluprost acid (AFP
Aclimostat (ZGN
Bleomycin A5 hydrochloride (Pingyangmycin hydrochloride，盐酸平阳霉素)
CDK Ligand、基因
hCA VB
Sirtuin modulator 5
[D
Goserelin
Mixanpril
Ivuxolimab (艾沃利单抗)
Mito Red
Lumiflavin (Lumiflavine，光黃素)
SIRT1 activator 2
ASM
TNF
αvβ6抑制剂、拮抗剂、基因
CDK激活剂、基因
Z
Pilabactam (ANT3310)
[Ag(2,2′
(Rac)
Pemvidutide (ALT
Hypothemycin (寄端霉素)
HeFi
Trospium chloride (曲司氯铵)
Monosialoganglioside GM3 (bovine)
Lenbelintide
DF
PTP1B
矿物 (Minerals)
NP603
ZIKV
CD300c
Letolizumab (BMS
Lathosterol
Volociximab (M200，伏洛昔单抗)
Belantamab (GSK2857914，贝兰妥单抗)
PARP1
T025
AChE
AChE
SN
IL
cation carrier
PI3Kα
PSB
(S,R,S)
PTC
Niraparib tosylate (MK
MAP3K6/ASK2抑制剂、基因
达拉菲尼
利钠肽受体2 (Natriuretic Peptide Receptor B (NPR2))
AMG256
酞菁钴
Ferrocin A
Bretylium
FW
Exemestane
Oleoylethanolamide
PD
诺考达唑
VEGFR
Gemcitabine hydrochloride (LY 188011 hydrochloride，盐酸吉西他滨)
SCR1693
7α,27
Pulsatilla pratensis (L.) Mill.提取物 (Pulsatilla pratensis (L.) Mill.)
基于天然产物的药物开发
TEA bromide
STA 5312
SCYX7158
N
BChE
MyD88
ZP 1
PROTAC
Conodurine
Plecanatide acetate
BMAP 28 (bovine)
Coriolus Versicolor Extract
Gemtuzumab (吉妥珠单抗)
(R)
Deferoxamine mesylate (Standard) (Desferrioxamine B mesylate (Standard)，甲磺酸去铁胺 (Standard))
VEGFR
Turanose (Standard) (松二糖 (Standard))
BVT
PARP1
kCAL01
cell cycle arrest
PKCβ抑制剂、激活剂、调节剂、基因
N
Antitumor agent
丽江唐松草提取物 (Thalictrum wangii Boivin)
Osthole
BPH
Ethyl trans
Xaliproden hydrochloride (SR57746A)
外核苷酸焦磷酸酶/磷酸二酯酶2 (ENPP2)是一种分泌性糖蛋白，是产生溶血磷酸酸的关键酶。
Polatuzumab (维泊妥珠单抗)
BAY
PERK抑制剂、基因
FTO
P7C3
第一代测序技术/桑格测序
Solidagonic acid
Daumone
ACVR2A/Activin RIIA 蛋白, Mouse (HEK293, His)
Siglec
Prucalopride (普芦卡必利)
ALK
Evodiamine (Standard) ((+)
龙舌兰科提取物 (Agavaceae)
N
MR24
CD30/TNFRSF8 蛋白, Cynomolgus (HEK293, C
LRP
Eravacycline dihydrochloride (TP
NMK
类叶升麻提取物 (Actaea asiatica Hara)
LP
Salicoside
Ibuprofen sodium (Standard) (布洛芬钠盐 (Standard))
Synthesis, growth, structural, spectroscopic and optical studies of a new semiorganic nonlinear optical crystal L
liver
CT
10 kcal% Fat Diet (Matching Sucrose to HY
ABT
Kylo
CTX
LEI105
Alizarin
CAY10594
3
L
FSG67
Cystathionine β
(E/Z)
Click chemistry inspired synthesis and bioevaluation of novel triazolyl derivatives of osthol as potent cytotoxic agents PMID 25062005
MR
Glucocorticoid receptor agonist
朝鲜白头翁提取物 (Pulsatilla cernua (Thunb.) Bercht. et Opiz.)
PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA PMID 38507412
CD36/SR
岩乌头提取物 (Aconitum racemulosum Franch.)
苯溴马龙
FTY720 Modulates Microglia Toward Anti
noradrenaline
Long Non
YGT
CD27 Ligand/CD70
Butin (Standard) (紫铆亭标准品)
GSK854
HOPX 抗体 (YA846)（HOPX Antibody (YA846)）
Disulfidptosis, A Novel Cell Death Pathway Molecular Landscape and Therapeutic Implications PMID 38739940
Safe, high
Hydrogen sulfide protects against toxicant acrolein
Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins PMID 22607205
A circular RNA derived from PLXNB2 as a valuable predictor of the prognosis of patients with acute myeloid leukaemia PMID 33757550
抗类风湿性关节炎化合物库
荧光偏振光谱法
Effect of a new cholecystokinin antagonist (FK 480) on gene expression of cholecystokinin and secretin in rat intestine PMID 8061811
Rifabutin (Standard)
The ADCY1
毛喉素 (Standard)
Influence of pencillinase production by strains of Bacteroides melaninogenicus and Bacteriodes oralis on pencillin therapy of an experimental mixed anaerobic infection in mice PMID 8031
12
3
Ionizing Radiation Triggers the Antitumor Immunity by Inducing Gasdermin E
A Novel Compound 3a
Aluminum Hydroxide (Standard) (氢氧化铝 (Standard))
Tryptophan 2,3
Penicillin G potassium (Benzylpenicillin potassium，青霉素钾)
Cinchonine exerts anti
L
Structural insights into manganese
Adipose
Discovery of Novel and Highly Potent Dual PD
O
Pharmacology of L
Aurachin D
Beta
Jaceosidin
(
Characterization of a novel heterozygous frameshift variant in NDP gene that causes familial exudative vitreoretinopathy in female patients PMID 38472449
Increased CHCHD2 expression promotes liver fibrosis in nonalcoholic steatohepatitis via Notch/osteopontin signaling PMID 36477358
Ferrocenylmethyltrimethylammonium iodide
β
Interleukin 1β Mediates the Pathogenesis of Nasal Mucosal Epithelial Barrier Dysfunction in Allergic Rhinitis PMID 39588138
Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics PMID 29800827
BRD9 functions as a methylarginine reader to regulate AKT
ON 01910
Cholic acid 7
Delayed administration of rapamycin inhibits glial scar formation through upregulating matrilin
Cell Counting Kit
Inhibiting mir
Galectin
A Novel Single
Phentolamine
Dofequidar sesquifumarate (MS
BAY
METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6
SM
Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth in vitro PMID 33403016
Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability PMID 26001785
Antiferroptosis therapy alleviated the development of atherosclerosis PMID 38576455
(S)
Oxazolo[3,2
ALCAT1
A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution PMID 28746882
Glypican
Design, synthesis, and biological evaluation of 1, 3
MHES0488A (DHES0815A antibody)
Multidrug tolerance conferred by loss
1
Hydroxamic Acid Derivatives of β
Microcystin
Lonicerin alleviates intestinal myenteric neuron injury induced by hypoxia/reoxygenation treated macrophages by downregulating EZH2 PMID 39163614
SARS coronavirus
HA/Hemagglutinin 蛋白, H3N2 (EPI541659, sf9)
多被银莲花提取物 (Anemone raddeana Regel)
The Antitumor and Sorafenib
Synthesis and evaluation of daunorubicin
Adinazolam mesylate (U 41123F mesylate)
Betulinic Acid Alleviates Acute Pancreatitis by Promoting SIRT1
血管内皮生长因子受体 2 (FLK
Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin
Jaceosidin (Standard)
Computational drug discovery for castration
ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation
CDK2抑制剂、基因
Sirtuin
Tumor cell
Berberine triggers apoptosis through the PI3K/Akt pathways and Nrf2 by inducing ROS in papillary thyroid cancer PMID 40436359
3
9
Dyngo
Celastrol induces DNA damage and cell death in BCR
Carbonate dehydratase
Polyethylene glycol 300
Automated FRET Two
Reserpine alleviates cisplatin
Bone Marrow Mesenchymal Stem Cell
VHL regulates NEK1 via both HIF
Bax/Bak double
Dipeptidyl Peptidase
Structure
HA/Hemagglutinin 蛋白, H11N2 (ADD21478, sf9, His)
DBI 蛋白, Human (103a.a, His)
Oxaliplatin (Standard)
BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS PMID 31453322
Dendritic cell activation by recombinant hemagglutinin proteins of H1N1 and H5N1 influenza A viruses PMID 20844030
Diptoindonesin G antagonizes AR signaling and enhances the efficacy of antiandrogen therapy in prostate cancer PMID 35322879
tuberculostatic
The NEDD4
相对荧光单位
tri
8
New 8
L
其他类化合物 (Other Antibiotics)
Kynurenic acid
Potent Protein Delivery into Mammalian Cells via a Supercharged Polypeptide PMID 30398334
myosin
Paris saponin VII (Chonglou Saponin VII，重楼皂苷 VII)
人肠道微生物代谢物 (Human Gut Microbiota Metabolites)
Inhibition of TREM
Ly93
Tacrolimus, a rapamycin target protein inhibitor, exerts anti
MAP4K1/HPK1抑制剂、基因
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia
PAK2抑制剂、基因
Kisspeptin
TAK1/MAP4K2 inhibitor 1
Ai
Catalpolaglycone disrupts mitochondrial thermogenesis by specifically binding to a conserved lysine residue of UCP2 on the proton leak tunnel PMID 38241920
Methylprednisolone acetate
Targeting lncRNA DDIT4
兰科提取物 (Orchidaceae)
Identification of a Nonelectrophilic and Selective TRPA1 Agonist for Alleviation of Inflammatory Pain through Channel Desensitization PMID 40846466
Stemness and anti
HCoV229E
Bacteriophage defends murine gut from Escherichia coli invasion via mucosal adherence PMID 38834561
糖生物学酶 (Glycobiology Enzymes)
Kiss2 peptide
(±)5
O
Ferrostatin
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A
Iguratimod inhibits protein citrullination and inflammation by downregulating NBCe2 in patients with rheumatoid arthritis PMID 38636399
Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin PMID 35363257
Endotoxin inhibitor
Protein kinase A is a dependent factor and therapeutic target in mouse models of fibrous dysplasia PMID 40593719
W
A method to improve the efficacy of topical eflornithine hydrochloride cream PMID 25182303
Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer PMID 29308895
Carbocisteine
Development of a Competitive Nutrient
Chrysanthemum × morifolium (Ramat.) Hemsl.提取物 (Chrysanthemum × morifolium (Ramat.) Hemsl.)
o8G
Neddylation of PTEN regulates its nuclear import and promotes tumor development PMID 33299139
Liver X Receptor Activation Alleviates Hepatic Ischemia
Microcystin
Preclinical Efficacy of the Auristatin
Atenolol
3
Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L PMID 11141092
Lycopene Alleviates Chronic Stress
Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes PMID 39245708
PLLA4000
HA1/Hemagglutinin 蛋白, H1N1 (ABD77675, HEK293, His)
MicroRNA
Design, synthesis, and biological evaluation of novel constrained meta
Modeling drug mechanism of action with large scale gene
B10 cells regulate macrophage polarization to alleviate inflammation and bone loss in periodontitis PMID 39210600
Leonurine alleviates ferroptosis in cisplatin
白细胞介素
Cardioexcitatory peptide 1
Obatoclax inhibits SARS
Rapamycin reduces DNA damage of in vitro matured oocytes by promoting Rad51
Effects of N
miR
Doxycycline
Establishment and characterization of preclinical model of primary ovarian squamous cell carcinoma PMID 40624380
Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice PMID 27533252
Vpu virus ion channel
Longitudinal Fragment Profiles Based on Multi
BAY 632521 (Standard)
L
CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction PMID 39261742
MP
Antidiarrheal effect of the ethanol extract from Scutellaria barbata and its effect on the contraction of jejunum smooth muscles PMID 35642414
Hepatoprotective Effect of Citral on Acetaminophen
HOLO 人白介素
RA and ω
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1 PMID 33159421
Drug Delivery
Phenyl sulfate (Standard)
ATP
Lower dose of metformin combined with artesunate induced autophagy
Inhibition of the Extracellular Signal
LncRNA CCRR maintains Ca2+ homeostasis against myocardial infarction through the FTO
OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR PMID 35233061
S1PR3
SIRT4 promotes neuronal apoptosis in models of Alzheimer's disease via the STAT2
Sphingolipids and glycerolipids. I. Chemical structures and ionophoretic activities of soya
Cardioprotective effect of MLN4924 on ameliorating autophagic flux impairment in myocardial ischemia
Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14
Ferric citrate hydrate (一水柠檬酸铁)
Nesfatin
Repurposing MDM2 inhibitor RG7388 for TP53
FG
Polyphyllin Ⅲ
CD44v6
Regulation of pancreatic cancer cells by suppressing KIN17 through the PI3K/AKT/mTOR signaling pathway PMID 39791213
Insights into the role of FoxL2 in tebuconazole
Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML PMID 37736724
Evasion of Innate Immunity Contributes to Small Cell Lung Cancer Progression and Metastasis PMID 33495232
Overcoming the Tumor Collagen Barriers A Multistage Drug Delivery Strategy for DDR1
Inhibition of acetaminophen
CD297/ART4
Patient
Natural Black1
gastric cancer
Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer PMID 37772772
ATTO 465 amine
Co
HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism PMID 26707879
Low BCL
Identification of AaAtg8 as a marker of autophagy and a functional autophagy
Reversing microtubule
Branched
LG308
A subpopulation of luminal progenitors secretes pleiotrophin to promote angiogenesis and metastasis in inflammatory breast cancer PMID 38507720
NSC
Targeting SIX2 as a novel sensitization strategy of sorafenib treatment on advanced hepatocellular carcinoma through modulating METTL9
α1
Ubiquitin
Determination of alpha
Cardamonin induces G2/M phase arrest and apoptosis through inhibition of NF
缺血再灌注损伤
Synthesis of a 11C
Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation PMID 31301771
Bioactive compounds from the scale insect pathogenic fungus Conoideocrella tenuis BCC 18627 PMID 21473608
FTO 蛋白, Human (His)
Fucoidan from Ascophyllum nodosum Suppresses Postprandial Hyperglycemia by Inhibiting Na+/Glucose Cotransporter 1 Activity PMID 32971911
Anti
Berberine inhibits IL
TRIM65 regulates glucose metabolic reprogramming to promote glioma cell proliferation via ubiquitination and degradation of AMPK PMID 40473847
Artesunate induces ferroptosis in osteosarcoma through NCOA4
Medicarpin
KAT2A
Electroacupuncture modulates the gut
Inhibiting Caveolin
Sensitivity of triple negative breast cancer cells to ATM
Quercetin Inhibits Neuronal Pyroptosis and Ferroptosis by Modulating Microglial M1/M2 Polarization in Atherosclerosis PMID 38755521
Design, Synthesis, and Preclinical Evaluation of Fused Pyrimidine
Drug repositioning for pan
Bortezomib 179324
LAMP1/CD107a 蛋白, Human (HEK293, His)
The BASHY Platform Enables the Assembly of a Fluorescent Bortezomib
YTHDC1 Overexpression Inhibits Inflammation and Promotes Autophagy to Ameliorate Ulcerative Colitis Through the XBP1/AMPK/mTOR Pathway PMID 40772592
MST4 negatively regulates the EMT, invasion and metastasis of HCC cells by inactivating PI3K/AKT/Snail1 axis PMID 34149910
colorectal cancer
Glaucocalyxin A induces apoptosis and autophagy in tongue squamous cell carcinoma cells by regulating ROS PMID 33904969
BET inhibitors induce NF
Silencing NRF2 enhances arsenic trioxide
MCE 小课堂
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome PMID 30228310
肝细胞癌
CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial
Inhibition of PI3K
Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension PMID 24582812
Connexin 43 contributes to the sensitization of colorectal cancer cells to photodynamic therapy through Akt inhibition PMID 35907621
Lactate Dehydrogenase (LDH), Bovine Heart (LAD, LD, L
Granisetron 109889
Nectin
Next generation of immune checkpoint therapy in cancer new developments and challenges PMID 29544515
USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression PMID 39406703
Wnt pathway inhibitor 5
Episilvestrol
Synthesis and antiproliferative evaluation of certain iminonaphtho[2,3
Cohesin mutations are synthetic lethal with stimulation of WNT signaling PMID 33284104
Tartrolon D, a cytotoxic macrodiolide from the marine
Autophagy inhibitors as a potential antiamoebic treatment for Acanthamoeba keratitis PMID 25896709
Biliverdin alleviates cerebral ischemia
氯化乙酰胆碱
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors PMID 29890135
Abemaciclib methanesulfonate (LY2835219 methanesulfonate)
Simedeutirom
AChE
Annexin A2/ANXA2 蛋白, Mouse (His)
Cats
clasto
Gramicidin
RJF02215
PRS343
NSC756093 (SU093)
CD72
阿利克仑半富马酸盐
Halocyamine B
博来霉素
HK
KBR 2822
Idelalisib
HIV
Starch (from corn) (Edible corn starch (from corn))
Acetylcysteine
Nuezhenoside
cervical carcinoma
PARP2抑制剂、基因
ANT2681
PD
Fusaric acid (萎蔫酸)
VEGFR
异丙美沙嗪 (标准品)
BChE/hCA II
Angiotensin II (1
3
DR2313
β
Flocoumafen (WL 108366)
Tryptophan
NOS2 Rat Pre
β
亚麻科提取物 (Linaceae)
L
BAR
Glicoricone
萘醌类化合物 (Naphthalene Quinones)
Gypsogenin (Standard)
GnRH Receptor
Fluoxetine hydrochloride (LY 110140，盐酸氟西汀)
Minocycline
GOPC Human Pre
PRT062607 Hydrochloride (P505
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