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trophozoites
FUNDC1 alleviates doxorubicin
FC14
含 THUMP 结构域 1（THUMPD1）基因
Sphingosine
Mthfd1l
Adipocytes promote tumor progression and induce PD
Blue caprate
Ph
Conversion of trypsin to a functional threonine protease PMID 16672242
Methdilazine 1982
Adenosine antagonist
Fyn
S1PR1 agonist 3
Diopterin (Pteroyl diglutamic acid)
Ligand
CDFI
1
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors PMID 38378740
含脱棕榈酰酶的脱氢酶结构域 17A（ABHD17A）基因
Valacyclovir. New indication for genital herpes, simpler administration PMID 10424269
Ctrl
Anticonvulsant effects of bretazenil (Ro 16
Microcin C and albomycin analogues with aryl
methdilazine
An engineered cysteine sensor optimized for high
二氢嘧啶酶（DPYS）基因
Eukaryotic RNA binding protein hnRNPH1 suppresses influenza A virus replication through interaction with virus NS1 protein PMID 40052960
E3 泛素连接酶
Per2 Rat Pre
Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata PMID 25946116
Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors PMID 36951608
A novel synthetic oxazolidinone derivative BS
MMDPPO
Exploring antiviral potency of N
Discovery of Potent and Oral Bioavailable MAT2A Inhibitors for the Treatment of MTAP
Human TP
Inhibition of malonaldehyde formation in oxidized calf thymus DNA with synthetic and natural antioxidants PMID 15373421
Antifolate
Elastin structure, biosynthesis, and relation to disease states PMID 7005671
MCE
GH1
ECE2
Synthesis of 7
Improving Anticancer Activity of Doxorubicin by 4'
METTL3
SB 414240
Wasf1
MFF
CBP/P300
Discovery of a novel potent GPR40 full agonist PMID 29366647
The cGAS
Antifungal agent 110
MrgprX2 antagonist
Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines novel non
Modulation of Ca2+ oscillation following ischemia and nicotinic acetylcholine receptors in primary cortical neurons by high
Cortisol metabolism and its inhibition by glycyrrhetinic acid in the isolated perfused human placental lobule PMID 9408088
Remodelin
Fluorenone
bis (Boc
前列腺增生 (Prostatic Hyperplasia)
RPL27A Human Pre
Novel quinazoline
AGIX
Phthalamide
Bis
Bromo
Methyl
含 LIM 基序的蛋白激酶 2（Limk2）基因
Serine and glycine metabolism in cancer PMID 24657017
EGFR
MCE
[D
Caftaric acid attenuates kidney and remote organ damage induced by renal ischemia
Amatuximab 931402
Arachidoyl ethanolamide (N
Phenolic diterpenes derived from Hyptis incana induce apoptosis and G(2)/M arrest of neuroblastoma cells PMID 23155243
Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function PMID 15187130
In vivo efficacy of marimastat and chemoradiation in head and neck cancer xenografts PMID 18931526
A Phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors PMID 21638123
HMBEC
Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry PMID 29859750
Anti
TNFSF9
Dichlormate (苄胺灵)
BT
ML 400 1908414
MCE
Oil Blue N (Solvent Blue 14)
AK002, a Humanized Sialic Acid
Antifungal agent 13
Arylazolyl(azinyl)thioacetanilides. Part 16 Structure
Discovery of 2
Secoaristolenedioic acid
CRBN ligand
dUDP disodium 102814
Ropinirole
Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma PMID 28653353
Synthesis and structure
Synthesis and biological properties of novel 2
Epikatonic acid 76035
(
peralgesia
6
(R)
Allosteric Small Molecule Inhibitors of LMPTP PMID 25834896
Discovery of Potent, Selective and Efficacious Aminopyrazole Inhibitors of PLK4 PMID 41329867
Firefly luciferase
amniotic
Tamoxifen exerts anti
ARTD10
dFdG
2
Pyrazolo
Yohimbic acid ethyl ester
Diamine oxidase an overview of historical, biochemical and functional aspects PMID 8200121
Zaragozic acids D and D2 potent inhibitors of squalene synthase and of Ras farnesyl
4'
Identification of Gly
12(R)
Novel antagonists for proteinase
LysoTracker Red (solution)
Ophioglonol
CRBN ligand
Imepitoin
Songorine 509
3
NAAD
CI1007
Cardiovascular and renal effects of novel nonpeptide nociceptin opioid peptide receptor agonists PMID 34705263
EID1 Human Pre
Pinostilbene
Stereoselective Synthesis of Conformationally Restricted γ
The human neuroblastoma cell line, IMR
Kirenol attenuates pressure overload
In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (
Con B1
Cyclobendazole 31431
Ceritinib
Comparative antitumor activity of actinomycin analogs in mice bearing Ridgway osteogenic sarcoma or P388 leukemia PMID 77730
ACL
(2R,3S)
鄂报春提取物 (Primula obconica Hance)
hydrate
FAT1
Temporin B acetate
VDM11
Mannosan,95% (1,6
SR8185
furoquinoline
1,2,3
Hypoxia
Effects of µ
MCE
MCE
MLN2201
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II
The bag cells of Aplysia as a multitransmitter system identification of alpha bag cell peptide as a second neurotransmitter PMID 2870142
Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum PMID 29133056
ADIPOQ
INSL3
Rickamicin
Resorcinol 108
The industrial biocide benzisothiazolinone impairs pathogen resistance in larval zebrafish by inducing microbiota dysbiosis PMID 40749263
Gentisyl alcohol 495
AD
Bioactive sulfoximines syntheses and properties of Vioxx analogs PMID 21752640
Suberylglycine
Benzalazine 588
In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists PMID 19961936
紫穗稗提取物 (Echinochloa esculenta (A. Braun) H. Scholz)
Synthesis and properties of a highly fluorescent derivative of phosphatidylethanolamine PMID 632685
Migraine PMID 15070571
ENT01
ML
CRBN ligand
Management of allergic rhinitis with a combination antihistamine/anti
(E)
2
HIF
Study of two new non
5
6
Design, synthesis and anti
Propargyl
Azido
MCE
PSA
Sodium benzenesulfinate (苯亚磺酸钠)
urinary frequency
Discovery of chiral cyclopropyl dihydro
Novel degradation pathway of 4
Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross
Osaterone acetate 105149
CES2
Itgb3 Mouse Pre
Melicopidine 475
Receotor Affinity
YE120
Griseoluteic acid 489
Zodasiran sodium (ARO
Isoorientin Promotes Early Porcine Embryonic Development by Alleviating Oxidative Stress and Improving Lipid Metabolism PMID 39409754
Single
O
(Rac)
CRBN ligand
2
CD5L 蛋白, Mouse (HEK293, His)
Fragment hopping
N
P2X4 antagonist
S
Mannosan,95%
Cdca2
Cholesteryl acetate 604
POLA2 抗体 (YA9004)（POLA2 Antibody (YA9004)）
Identification of a Novel TAR RNA
Identification of a potent, selective non
Evaluation of single and multiple doses of a novel mGlu2 agonist, a potential antipsychotic therapy, in healthy subjects PMID 28156011
Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012 PMID 22749871
Flavokermesic acid
Synthesis and evaluation of curcumin
CRBN ligand
CRBN ligand
PHP
Gylongiposide I
TROP
Design, synthesis and biological evaluation of 3
Design, synthesis of new β
tans
H
Fmoc
2
Neuromuscular effects of morphine and naloxone PMID 4119617
Inhibition of macrophage migration by C. botulinum exoenzyme C3 PMID 22644106
Parallel solution
2,3
CRBN ligand
GSK172981
Optimal detection of the neutron capture therapy agent borocaptate sodium (BSH) a comparison between 1H and 10B NMR PMID 11243341
Primer design for RT
Glucosamine 3
Residues of spiroxamine in grapes following field application and their fate from vine to wine PMID 16366700
P2X3 antagonist 37
ATPcompetitive
Estrogen Signaling in ERα
(±)
Mas
Anti
4
Porritoxins, metabolites of Alternaria porri, as anti
Absorption of equations for non
Kemptide (amide) 70691
Poneratoxin as a key tool for investigating the relationship between sodium channel hypersensitivity and impaired nerve cell function PMID 40670556
N,N
CRBN ligand
Escin IIb 158800
CRBN ligand
CHAPSO 82473
Arylazolyl(azinyl)thioacetanilides. Part 20 Discovery of novel purinylthioacetanilides derivatives as potent HIV
RIPOR2 Human Pre
HAND2 assists MYCN enhancer invasion to regulate a noradrenergic neuroblastoma phenotype PMID 36598365
Ramucirumab A New Therapy for Advanced Gastric Cancer PMID 26413377
AlphaScreen assay
HMBS Human Pre
MCE
PEGylated denatured bovine serum albumin modified water
MSI
7
2
A landmark in drug discovery based on complex natural product synthesis PMID 31209263
Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer's disease PMID 33298440
秀丽相思提取物 (Acacia victoriae Benth.)
Serratiopeptidase An integrated View of Multifaceted Therapeutic Enzyme PMID 36291677
Five
Hyls1 Mouse Pre
CRBN ligand
THAP2 Human Pre
Cholinesterase inhibition by galanthamine and lycoramine PMID 13853036
Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy PMID 29445193
Polycystic Ovary Syndrome A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing PMID 35054768
Extracellular histone H3 induces macrophage inflammation in acute liver failure via HDAC2 activation and PKM2 subcellular relocalization PMID 40683326
CRBN ligand
LBA
Single
Azaphen dihydrochloride monohydrate 63302
Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice PMID 37842186
Evaluation of the cytotoxic effect of the monoterpene indole alkaloid echitamine in
Expansion of the S
Antihypertensive and monoamine oxidase inhibitory activity of 3
CRBN ligand
Acetaminophen
Obicetrapib 866399
Tetradifon an oligomycin
4
Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide
Novel Tetrazole
POLA2 Human Pre
Identification and Structure Elucidation of Janthitrems A and D from Penicillium janthinellum and Determination of the Tremorgenic and Anti
Structural optimization of N1
Fenprinast 75184
Banisteriopsis caapi, a unique combination of MAO inhibitory and antioxidative constituents for the activities relevant to neurodegenerative disorders and Parkinson's disease PMID 19879939
Pgam2 Rat Pre
UBE2U Human Pre
Effects of bidisomide (SC
Biosynthetic origin of carbons 3 and 4 of leucomycin aglycone PMID 6874579
Targeting NF
Ganoderma lucidum derived ganoderenic acid B reverses ABCB1
Characterization of the in vitro biotransformation of the HIV
A 5
YY
Discovery of novel harmine derivatives as potent, selective, and brain permeable GSK3β inhibitors with effective In vivo anti
Albendazole sulfone
Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes PMID 7517439
(S)
(S)
Bacterial ubiquitin ligase engineered for small molecule and protein target identification PMID 40166235
Studies on anti
Ccar1 Rat Pre
Deltorphin 2 ([D
2
C8a
6
棱枝槲寄生提取物 (Viscum angulatum B.Heyne ex DC.)
rHDL administration increases reverse cholesterol transport in mice, but is not additive on top of ezetimibe or cholestyramine treatment PMID 23725986
O
Inhibitors of arachidonoyl ethanolamide hydrolysis PMID 8083191
Markogenin 562
F13B Human Pre
Amitriptylinoxide
Characterisation of interaction between food colourant allura red AC and human serum albumin multispectroscopic analyses and docking simulations PMID 25306366
Terpecurcumins A
Effect of Vasicinone against Paraquat
Somatostatin R1/SSR1 蛋白, Human (HEK293, Fc)
Anti
Fine
MCE
CRBN ligand
2,3,5,4'
PIAS2 抗体 (YA2730)（PIAS2 Antibody (YA2730)）
Pt(II) Octaethylporphine ketone
FAP upregulates PD
PF
Distinct behavioral traits and associated brain regions in mouse models for obsessive
Bioactive constituents from the twigs of Asimina parviflora PMID 1453182
Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murine immunosuppression model PMID 7625798
MCE
Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen
Effects of a novel piperazine derivative (CGP 29030A) on nociceptive dorsal horn neurons in the rat PMID 1308469
L
Chiral Indolylarylsulfone Non
Characterization of a depolarizing dopamine response in a vertebrate neuronal somatic cell hybrid PMID 856838
Lapatinib
Anti
CRBN ligand
Hemocompatibility evaluation of poly(1,8
Mga Rat Pre
Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin
Discovery, characterization, and lead optimization of 7
An integrated chemical biology approach reveals the mechanism of action of HIV replication inhibitors PMID 28442262
enteritis
Binding Forces of Cellulose Binding Modules on Cellulosic Nanomaterials PMID 30657665
CRBN ligand
BRCA1 相关蛋白（BRAP）基因
ALK
ADORA2A Protein
Discovery of novel genipin derivatives as highly selective ferroptosis inducers for the treatment of triple
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA
AK1
Anti
CSPG4
m6A/IGF2BP3
Calcitroic acid 71204
SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming PMID 21040848
strategy
CRBN ligand
CRBN ligand
Chronic central nicotinic blockade after a single administration of the bisquaternary ganglion
Upregulation of postsynaptic cAMP/PKA/CREB signaling alleviates copper(Ⅱ)
Oxcarbazepine 28721
VT
Carboxybetaine methacrylate 24249
Discovery of JMJD7 inhibitors with the aid of virtual screening and bioactivity evaluation PMID 34048880
(±)
AL
Gentisin 437
Lifespan
SD169
Neuroprotective effects of donepezil through inhibition of GSK
Mex3a
Trpm4
Cyanine3 hydrazide dichloride
CAB39L Human Pre
IONIS PTP1BRx (ISIS 404173)
S100a8
Demexiptiline 24701
Etoricoxib N1'
Polyphosphate Kinase, Propionibacterium shermanii
BMS
WAY
Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti
WAY
β
CRBN ligand
Calcium L
Nor
Differential actions of peripheral corticotropin
PAP 蛋白, Human (His)
Stathmin 蛋白, Human (C
UPRT 蛋白, Human (His)
Signaling mechanisms mediated by G
Pharmacokinetic interactions of OBE001 and betamethasone in healthy female volunteers PMID 25899007
m
前蛋白转化酶枯草杆菌蛋白酶/kexin 6 型（PCSK6）基因
磷脂酰肌醇 4（GPC4）基因
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization PMID 38241614
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells PMID 39436996
Sodium benzenesulfinate 873
Effects of glycine receptor antagonism on spreading depression in the rat PMID 7700595
epi
CRBN ligand
Spg7 Mouse Pre
YE
Making Choices DNA Replication Fork Recovery Mechanisms PMID 33967572
Copacamphane, picrotoxane, and alloaromadendrane sesquiterpene glycosides and phenolic glycosides from Dendrobium moniliforme PMID 12932145
Efficient and scalable enantioselective synthesis of a CGRP antagonist PMID 22954228
TLP3
Cadherin
(N)
(±)
MCE
Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half
Anti
CRBN ligand
Floramanoside F
Development and residue screening of the furazolidone metabolite, 3
Sel1l Mouse Pre
CRBN ligand
CRBN ligand
Selective inhibitors of tumor progression loci
TLR4
Structure of the SARS coronavirus nucleocapsid protein RNA
VLA
Integrin modulator 1 2023788
Amitifadine 410074
DKK
E 6080 120164
成瘾行为引起的紊乱 (Behavioral Addiction)
Heraclenol 31575
CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium PMID 21912637
N
Synthesis and SAR of [1,2,4]triazolo[1,5
Temporal dynamics of neutrophil functions in multiple sclerosis PMID 39603278
Visible
(Z)
5
2& 039;
Identification and recombinant expression of anandamide hydrolyzing enzyme from Dictyostelium discoideum PMID 22730904
MCE
Evaluation of Protein Kinase Inhibitors with PLK4 Cross
CRBN ligand
TAS
GATAD2A 抗体 (YA1966)（GATAD2A Antibody (YA1966)）
Antioxidant compounds from Ebenus pinnata PMID 17067757
Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol 119700
Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV
Atypical memory B cells acquire Breg phenotypes in hepatocellular carcinoma PMID 39998891
Demethylation and desulfonation of textile industry dye, Thiazole Yellow G by Aspergillus niger LAG PMID 30997348
Atomoxetine hydrochloride 82248
Comparison of metabolic fluxes of cis
Stellettamide A TFA 129744
Cyanidin 3
An Autotaxin/Lysophosphatidic Acid/Interleukin
Anticonvulsant preclinical profile of CHF 3381 dopaminergic and glutamatergic mechanisms PMID 11566153
Discovery of novel piperidine
Synthesis and biological evaluation of C
PAX9 抗体 (YA3145)（PAX9 Antibody (YA3145)）
Plant anticancer agents XXVII Antileukemic and cytotoxic constituents of Dirca occidentalis (Thymelaeaceae) PMID 6644588
Effect of bisphenol F on reproductive function in F1 generation male mice and its potential mechanisms PMID 39710178
Factor VIII determination in patient's plasma and concentrates a novel test equally suited for both matrices PMID 12945876
WYE
Development of a triazole class of highly potent Porcn inhibitors PMID 27876319
Cassiaphenone A 2
Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase PMID 8064800
MCE
Abcb7 Rat Pre
Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease loci PMID 40667102
The effect of anagliptin on intimal hyperplasia of rat carotid artery after balloon injury PMID 28990108
Establishment of an induced pluripotent stem cell line (ZJULLi004
Antiviral agent 66
Mechanism of lipid
CRBN ligand
Maleyl
Antibiotics from basidiomycetes. XXIX Pilatin, a new antibiotically active marasmane derivative from cultures of Flagelloscypha pilatii agerer PMID 3209467
IL
IL2RB
5α
Learning and confirming with preclinical studies modeling and simulation in the discovery of GDC
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