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TAT
Electrolyte Additive
SB
Eugenol Suppresses Platelet Activation and Mitigates Pulmonary Thromboembolism in Humans and Murine Models PMID 38396774
co
Regulation of PHD2 by HIF
Pyraflufen 129630
A Unique Recombinant Fluoroprobe Targeting Activated Platelets Allows In Vivo Detection of Arterial Thrombosis and Pulmonary Embolism Using a Novel Three
A minor, sweet cucurbitane glycoside from Siraitia grosvenorii PMID 19634319
BT
PERK
Cocculin
HDAC6/HSP90
Repurposing dyphylline as a pan
Downregulation of miRNA
Pyroptotic macrophages promote proliferation and chemotherapy resistance of peripheral T
Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP
Synthesis of new triazole fused imidazo[2,1
1
Improving potency and metabolic stability by introducing an alkenyl linker to pyridine
Activation of alpha7 nicotinic acetylcholine receptor protects bovine endometrial tissue against LPS
Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4
E
Triterpenoid glycosides from Bacopa monnieri PMID 16293276
Talaromyketides A
Sodium oleate 143
Inhibition of TREM
Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by Aβ1
intestinal
Structure
Naringin regulates mitochondrial dynamics to protect against acetaminophen
Revealing GRP75
PD
nh2
Apelin
Naturally Derived Membrane Lipids Impact Nanoparticle
nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice PMID 39737550
3α
intestinal
Galectin
Total barley maiya alkaloids inhibit prolactin secretion by acting on dopamine D2 receptor and protein kinase A targets PMID 33711439
SUMOylated IL
Ro 11
Discovery of an ApoE4
Cd27 Rat Pre
(S)
5
LMO4 Human Pre
Bergamottin and PAP
Ro 11
Dapoxetine hydrochloride 129938
Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII PMID 16189524
G 蛋白信号调节器 2（RGS2）基因
In silico identification of new ligands for GPR17 a promising therapeutic target for neurodegenerative diseases PMID 21744154
Mosunetuzumab 1905409
In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi PMID 11282265
ATP6AP1 promotes cell proliferation and tamoxifen resistance in luminal breast cancer by inducing autophagy PMID 40133274
mmu
4
Bioactivity
Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'
Boc
Studies on L
Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway PMID 39450556
Cinnamyl
autoimmune disorders
Design, synthesis and biological evaluation of 4
Synthesis and kinase inhibitory activity of novel substituted indigoids PMID 19665384
Acetyl coenzyme A
Effects of kisspeptin
Cdh2 Mouse Pre
N
Divergent Synthesis of Natural Benzyl Salicylate and Benzyl Gentisate Glucosides PMID 33008263
miRNA
黑腺珍珠菜提取物 (Lysimachia heterogenea Klatt)
Harmine hydrochloride 343
Lactiplantibacillus plantarum
TM2D1 contributes the epithelial
Influence of Cirrhosis on 68Ga
Cellular fate of intersex differentiation PMID 33846307
autoimmune disorders
Betrixaban 330942
Acetyl coenzyme A
Polyamines protect boar sperm from oxidative stress in vitro PMID 35247050
Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ
CFHR1 蛋白, Human (HEK293, His)
ADAMTS13 regulates angiogenic markers via Ephrin/Eph signaling in human mesenchymal stem cells under serum
Potent bacterial neuraminidase inhibitors, anthraquinone glucosides from Polygonum cuspidatum and their inhibitory mechanism PMID 27553976
ZAK
citrate
Battle tactics against MMP
Novel oxazolo[4,5
Measurement of anti
Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain PMID 16835065
DOCK2 Promotes Pleural Fibrosis by Modulating Mesothelial to Mesenchymal Transition PMID 34710342
NOX4 promotes Kupffer cell inflammatory response via ROS
4
Suyin Detoxification Prescription Regulates the Klotho and ERK/NF
Mailuoning oral liquid ameliorates vasculitis in thromboangiitis obliterans rats via inactivating cGAS
Actinopolysporins A
The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations PMID 21558396
BRD9 degraders as chemosensitizers in acute leukemia and multiple myeloma PMID 35853853
Naftifine a review PMID 18346400
A novel, broad
CPD
CD367/CLEC4A 蛋白, Rat (HEK293, His)
Long chain lipid hydroperoxides increase the glutathione redox potential through glutathione peroxidase 4 PMID 30844486
Anti
Inhibition of soluble epoxide hydrolase enhances the dentin
Improvement of cerebral ischemia
FSLLRY
BIX02189 1265916
Contribution of tissue transglutaminase to the severity of hepatic fibrosis resulting from Schistosoma japonicum infection through the regulation of IL
WD6305 TFA
Lipophagy mediated glucose
2
LH responses to chicken luteinizing hormone
Rational design and synthesis of novel phenylsulfonyl
In silico identification of two peptides with antibacterial activity against multidrug
The discovery of 2
TQ05310 2071196
Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold Cell cycle analysis PMID 33142413
Key fragments for identification of positional isomer pair in glucuronides from the hydroxylated metabolites of RT
Discovery of the cancer cell selective dual acting anti
Jun
F2R 样凝血酶或胰蛋白酶受体 3（F2RL3）基因
CB1 enhanced the osteo/dentinogenic differentiation ability of periodontal ligament stem cells via p38 MAPK and JNK in an inflammatory environment PMID 31599069
Effects of spray cryotherapy on cough receptors and airway microenvironment in a canine model of chronic bronchitis PMID 37597598
The USP11/Nrf2 positive feedback loop promotes colorectal cancer progression by inhibiting mitochondrial apoptosis PMID 39617751
Discovery of Novel N
Olive oil 8001
AT7519 Hydrochloride 902135
The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice PMID 38769396
Design, synthesis and antimicrobial evaluation of propylene
Effects of synthetic and natural in vivo inhibitors of β
Ggt1
vomit
Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2
TPPS
Bromopropylate 18181
The untold story of IFN
VER
Molecular mechanisms of subtype
Unveiling the common mechanisms and therapeutic targets of medicinal herbs in acute pancreatitis a network pharmacology and experimental validation approach PMID 40736877
Effects of CKS
PLCε regulates metabolism and metastasis signaling via HIF
MAO
白细胞介素 24（IL24）基因
Effects of autotaxin and lysophosphatidic acid deficiencies on depression
Camptothecin induced DDX5 degradation increased the camptothecin resistance of osteosarcoma PMID 32585151
The mitochondrial
Quinelorane dihydrochloride (LY163502)
Systems Biology Approach Identifies Prognostic Signatures of Poor Overall Survival and Guides the Prioritization of Novel BET
Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N
Varenicline promotes endothelial cell migration by lowering vascular endothelial
2,4
Roles of centrioles in neural attraction of dental pulp stem cells PMID 38155028
Mechanosensitive Piezo1 channels mediate renal fibrosis PMID 35230979
TFRC 蛋白, Mouse (HEK293, Fc)
Methylene Blue 61
NCS
Fluticasone dimer impurity 220589
Isorugulosuvine 6521
Prolonged sleep deprivation induces a cytokine
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules PMID 32044386
Cefixime 79350
Discovery of Novel 2
KP
Flumioxazin soil persistence and mineralization in laboratory experiments PMID 14705902
Development of selective agonists and antagonists of P2Y receptors PMID 18600475
IFNA2 The prototypic human alpha interferon PMID 25982860
Aβ/tau aggregation
GSK481 1622849
Transfer of nitroimidazoles from contaminated beeswax to honey PMID 27838954
(E,E,E,)
Constituents from Scutellaria barbata Inhibiting Nitric Oxide Production in LPS
4'
Polatuzumab vedotin an investigational anti
Erianin inhibits indoleamine 2, 3
Do Bioflavonoids in Juniperus virginiana Heartwood Stimulate Oviposition in the Ladybird Coleomegilla maculata? PMID 29531477
GRP75 triggers white adipose tissue browning to promote cancer
Cost Effectiveness of Paricalcitol versus a non
Neuropeptide PEN and Its Receptor GPR83 Distribution, Signaling, and Regulation PMID 30726666
Comprehensive landscape of epigenetic
An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis PMID 11908949
MMP
Development of Fluorescent Assay for Monitoring of Dehalogenase Activity PMID 30052322
Neuroprotective effect of microglia against impairments of auditory steady
Theacrine ameliorates experimental liver fibrosis in rats by lowering cholesterol storage via activation of the Sirtuin 3
Characterization of the sulfhydryl
5
2
17β
Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis PMID 28865368
Bis
Discovery of Novel Inhibitors Targeting Fungal Chitin Deacetylase via Virtual Screening for Plant Disease Control PMID 40173383
The soluble guanylyl cyclase activator BAY 60
IL
METTL3
N1,N11
Inhibition profiling of human carbonic anhydrase II by high
Protein kinase D inhibitor1
4
A comprehensive review on the colorless carotenoids phytoene and phytofluene PMID 25615528
TMF 抗体 (YA6803)（TMF Antibody (YA6803)）
Design, Synthesis, and Biological Evaluation of Selective STING Synergists That Enhance cGAMP
Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure PMID 29545848
IMM
Contribution of phenoloxidase activation mechanism to Bt insecticidal protein resistance in Asian corn borer PMID 32135253
Neuropeptide EI, rat 125934
Lubiprostone
C.I. Vat Blue 16 (Navy Blue G)
Structural requirements of the N
Bunazosin, a selective alpha1
盐酸吡甲胺
Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25
Epsom salts
4
β
MCMB
Dihydroartemisinin inhibits NSCLC by targeting MDM2/c
Antithrombotic activities of pellitorine in vitro and in vivo PMID 23973654
Gold Nanoparticles Treatment Reverses Brain Damage in Alzheimer's Disease Model PMID 31612296
TUG
Polfurmetinib hydrate 2845153
KLF15 suppresses stemness of pancreatic cancer by decreasing USP21
MRK
2,2',3,4',5,5',6
Top Publications Citing MCE Products
Tubastatin A
Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein
Cinoxate
Ethybenztropine
Design, synthesis and structure activity relationship of potent pan
Nigericin decreases the viability of multidrug
3'',4''
丝裂原活化蛋白激酶激酶激酶 5（Map3k5）基因
GR 113808 144625
Ploidy
RUNX1
Bromperidol decanoate (depot) for schizophrenia PMID 23152208
Fmoc
Gefitinib inhibits M2
hnNOS
VH032 1448188
细丝蛋白结合 LIM 蛋白 1（FBLIM1）基因
DNA
ortho
Ciclotizolam 58765
Safranin 477
Ursodeoxycholic acid alleviates fat embolism syndrome
3,5,7,8,3′,4′
Ctrb1 Mouse Pre
GZMK
(rel)
Ubiquinone
A tyrosine catabolic intermediate 4
RB
Synergistic efficacy of telomerase
(S)
Abemaciclib metabolite M18 2704316
PAK1 modulates a PPARγ/NF
Sustained
Vortioxetine
Elinogrel pharmacological principles, preclinical and early phase clinical testing PMID 20608816
Levo
AM281
Discovery of a Novel and Potent LCK Inhibitor for Leukemia Treatment via Deep Learning and Molecular Docking PMID 38847742
Circ_0074158 and QKI6 A regulatory axis for PD
Carbon dioxide expanded liquid an effective solvent for the extraction of quercetin from South African medicinal plants PMID 35739596
Characterization of two genes for the biosynthesis of the labdane diterpene Z
Dacarbazine PMID 26940170
Simultaneous determination of choline, L
Oxypyrrolnitrin 15345
Hybrid molecule from O2
Synthesis, Structure
Baohuoside VII 119730
EBV(LMP1)
Curcumin Monoglucoside Shows Improved Bioavailability and Mitigates Rotenone Induced Neurotoxicity in Cell and Drosophila Models of Parkinson's Disease PMID 27535828
Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases PMID 26789933
Hydrostatin
Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient
β,β
PAC1R agonist maxadilan enhances hADSC viability and neural differentiation potential PMID 26798992
Em 381
Clinical development of neridronate potential for new applications PMID 23589692
Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques PMID 11742876
The beta
Discovery of Potent and Orally Bioavailable Pyridine N
Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells PMID 19118003
Isoborneol 124
An efficient antimicrobial depot for infectious site
Evolutionary fingerprints of epithelial
Terpene alkaloids from Tripterygium wilfordii PMID 16176909
Lmx1b Mouse Pre
Utilization of Quercetin as an Oviposition Stimulant by Lab
FLLRN (TRAP
P
Crystal structures of human ENPP1 in apo and bound forms PMID 32876064
ALDH1A2 蛋白, Human (His)
LMX1B Human Pre
PF429242 dihydrochloride
NDUFA2 Human Pre
Identification of novel human immunodeficiency virus type 1
Bioinformatic analysis reveals novel hub genes and pathways associated with hypertensive nephropathy PMID 30298691
Sphondin 483
TSHZ2 is an EGF
Carvedilol
LT175 is a novel PPARα/γ ligand with potent insulin
Proteasome inhibitor MG
Phosphatase PHLPP1 is an alveolar
RABV抑制剂、基因
The MARCH6
Treatment of hypertension by increasing impaired endothelial TRPV4
Simultaneous and rapid determination of gefitinib, erlotinib and afatinib plasma levels using liquid chromatography/tandem mass spectrometry in patients with non
3
单加氧酶 DBH 样 1（MOXD1）基因
α
Cyclosporin 79217
Methoxy adrenaline hydrochloride 74571
L
PK 130
(R)
Laboratory Evaluation of Interferences Associated with Factor XIa Inhibitors Asundexian and Milvexian in Routine Coagulation Assays PMID 39272775
Design, synthesis and pharmacological evaluation of 4,5
JNJ
Liraglutide
Protective effect of Indole
(R)
Effective treatment of a murine model of adult T
IGF1R
剪接因子 3b 亚基 4（SF3B4）基因
Blood SSR1 A Possible Biomarker for Early Prediction of Parkinson's Disease PMID 35310885
27
Comparative studies on the constituents of ophiopogonis tuber and its congeners. VIII. Studies on the glycosides of the subterranean part of Ophiopogon japonicus Ker
The comparative disposition and metabolism of dolutegravir, a potent HIV
S
Oblimersen Bcl
CDH2 Human Pre
HZX
Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B
Single
Development of 3
Cuproptosis
GB83
Hyperosmolarity
KN
NAPIE 2748289
mmu
MCE
The SETDB1
7
PSME2 promotes malignant progression through autophagy modulation via IL
Erectile properties of the Rho
ZYZ
Dpp7
S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome PMID 40346703
Synthesis and biological evaluation of selenogefitinib for reducing bleomycin
EBC46
Telomerase
Somatostatin blocks the potentiation of TRH
autophosphorylation
Discovery of 5
Fmoc
Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole
Boc
Vatanidipine hydrochloride 133743
m6A‑modified HOXC10 promotes HNSCC progression via co‑activation of ADAM17/EGFR and Wnt/β‑catenin signaling PMID 38063205
有丝分裂原活化蛋白激酶激酶 7（MAP2K7）基因
Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice PMID 11405556
Chronic activation of FXR
Repurposing disulfiram to induce OSCC cell death by cristae dysfunction promoted autophagy PMID 32989819
Design, Synthesis, and Activity Evaluation of BRD4 PROTAC Based on Alkenyl Oxindole
c
Ethyl 5
ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21
Phenylbutazone
MCE
Cathepsin L in COVID
CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma PMID 35615982
含卷曲螺旋结构域 88B（CCDC88B）基因
Integrin alpha V beta 8 蛋白, Human (HEK293, His
R 50 595, a selective non
hsa
Application of metabolic engineering for the biotechnological production of L
BmP 02
DBCO
TAT
Opioid receptor binding properties of analgesic analogues of cholecystokinin octapeptide PMID 1663041
Cyprosulfamide 221667
EphA1 蛋白, Mouse (HEK293, His)
Targeting m6A mRNA demethylase FTO alleviates manganese
TRAP
P2X7R
Eleclazine 1443211
Ferric citrate 3522
(
The small molecule AUTEN
Metabolite Profiling and Anti
CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPARγ pathway PMID 27145370
NSC
hsa
Rehmapicrogenin attenuates lipopolysaccharide
Indole
Gut microbiota dysbiosis
L
PS315 1221964
Dual Inhibition of Ornithine Decarboxylase and A1 Adenosine Receptor Efficiently Suppresses Breast Tumor Cells PMID 33777791
G10 is a direct activator of human STING PMID 32911484
(S,R,S)
Comprehensive analysis of mesenchymal cells reveals a dysregulated TGF
ETC
Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease PMID 32134269
MEK
Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis PMID 28218840
Pdgfb
2’,3’,5’
Reduced Contractility and Motility of Prostatic Cancer
Tulrampator 1038984
Reln
BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly PMID 38498560
BIM
Fucosyltransferase 8 (EC 2.4.1.68，岩藻糖基转移酶8)
4
CAPON
S961 TFA
ERK2 IN
S
A novel protein encoded by circCOPA inhibits the malignant phenotype of glioblastoma cells and increases their sensitivity to temozolomide by disrupting the NONO
Cd27 Mouse Pre
Alda
ARN19702 1971937
Synthesis and biological profile of the pan
Annual review of LSD1/KDM1A inhibitors in 2020 PMID 33581557
Differential regulation of mTORC1 and mTORC2 is critical for 8
Glucomannan from Aloe vera gel maintains intestinal barrier integrity via mitigating anoikis mediated by Nrf2
Targeting HSP90 dimerization via the C terminus is effective in imatinib
(±)9(10)
Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors Candidate Structure
Hydroxy levamisole and its phase II conjugates as potential indicators of levamisole doping in thoroughbred horses PMID 36382989
LDL
Microglia increases the proliferation of retinal precursor cells during postnatal development PMID 30090016
Remdesivir O
Valproic acid
Deciphering the molecular mechanism of tetrandrine in inhibiting hepatocellular carcinoma and increasing sorafenib sensitivity by combining network pharmacology and experimental evaluation PMID 34962429
Chronic Sleep Deprivation Impairs Visual Functions via Oxidative Damage in Mice PMID 38245252
ART4/CD297 蛋白, Cynomolgus (HEK293, Fc)
Discovery of novel and potent P2Y14R antagonists via structure
Targeted Fluorescent Polysaccharide Platform for Solute Carrier Protein PCNA Detection and Cervical Squamous Cell Carcinoma Inhibition PMID 40512372
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy PMID 34388391
A tri
Tesimide 35423
Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1 PMID 36759571
AS1069562, the (+)
PRMT6 promotes colorectal cancer progress via activating MYC signaling PMID 39819457
Ozone
组蛋白脱乙酰酶 5（Hdac5）基因
Design and Synthesis of Dual EZH2/BRD4 Inhibitors to Target Solid Tumors PMID 35500243
MARCO expression on myeloid
Design, synthesis, and anti
Mechanistic insights into the role of FAT10 in modulating NCOA4
Fast
Yki stability and activity are regulated by Ca2+
Maltotriose
Naphthol AS
Development of new methodologies for the chromogenic estimation of betrixaban concentrations in plasma PMID 30604921
Cerivastatin
Deapi
N
MUC16 抗体 (YA890)（MUC16 Antibody (YA890)）
Determination of gacyclidine enantiomers in human plasma by gas chromatography
SC
IQ 1 331001
Gidazepam
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis PMID 39848351
Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock
action
GORASP2 promotes phagophore closure and autophagosome maturation into autolysosomes PMID 39056394
CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B
PDE4
Schizandrin A enhances the efficacy of gefitinib by suppressing IKKβ/NF
Cdh2 Rat Pre
Pigment Red 245 68016
Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies PMID 16140171
(E,E,Z)
A potassium
Lycopene abolishes typical polyhalogenated carbazoles (PHCZs)
Dynamic control of mTORC1 facilitates bone healing in mice PMID 39426581
Thiamethoxam 153719
Synthesis and evaluation of AZT
Zwitterionic Brush
Inhalable Anti
Antibacterial agent 123 2615254
Development of a chimeric anti
Protective Effect of Gentianine, a compound from Du Huo Ji Sheng Tang, against Freund's Complete Adjuvant
Melatonin suppresses TLR4
In vitro and initial in vivo evaluation of (68)Ga
Integrin alpha V beta 8 蛋白, Rhesus Macaque (HEK293, His)
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