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Co
3
A novel dual MEK/PDK1 inhibitor 9za retards the cell cycle at G0/G1 phase and induces mitochondrial apoptosis in non
Chidamide and cytarabine synergistically treat acute myeloid leukemia inhibiting ribosome biogenesis via the MYC
Fatty Acid Desaturase 1 Knockdown Promotes Wound Healing and Functional Recovery of the Corneal Epithelium in Diabetes PMID 40459498
METTL3, m6A modification, and EGR1 interplay affecting myocardial I/R injury outcomes PMID 39707117
Eugenol derived immunomodulatory molecules against visceral leishmaniasis PMID 28826085
3
Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia PMID 38361240
RAD51
Cdk19 Mouse Pre
Technical Support
Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway PMID 32903813
Acid Yellow
Urine glycyl
Synthesis and biological evaluation of 2,3
LacCer (d18 1/16 0) 4201
HIV Protease Substrate I 124077
Meclocycline Sulfosalicylate Salt 73816
Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity PMID 22380770
Chronic and acute effects of thiazolidinediones BM13.1258 and BM15.2054 on rat skeletal muscle glucose metabolism PMID 10578125
Anti
Phosphorylated upstream frameshift 1
A Simple but Accurate Method for Evaluating Drug
NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β
The oxindole Syk inhibitor OXSI
IL
A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels PMID 25692452
Notoginsenoside Ft1 155683
Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID
Pronethalol
GC
Rezetamig 2795115
Characterisation using microphysiometry of CRF receptor pharmacology PMID 10497910
Novel pleconaril derivatives Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses PMID 31881489
mGluR8激动剂、基因
YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression PMID 39731187
Design and synthesis of HIV
PF
3,4
A positive feedback loop between PFKP and c
Ganciclovir 82410
RP182
Development of an LC
Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide PMID 11162661
Hexadecanal 629
Synthesis and pharmacological characterization of 2
Pregnenolone
TFR
Effects of NAAG peptidase inhibitor 2
Mitochondria
Effect of 5'
Ex 571
Functional 2D Iron
Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates PMID 10449539
Piromelatine 946846
PXS
Mas
Antitumor activity of the polyamine analog N(1), N(11)
Curcumol simultaneously induces both apoptosis and autophagy in human nasopharyngeal carcinoma cells PMID 34750896
CCG
Polybenzyls from Gastrodia elata, their agonistic effects on melatonin receptors and structure
Receptor
Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune
Glycitin 40246
N
(Rac)
Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil Characterization in Rodent Seizure and Epilepsy Models PMID 31619464
Melatonin protects embryonic development and maintains sleep/wake behaviors from the deleterious effects of fluorene
Monamycin H2 31556
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CLpro Inhibitors as anti
Blocking the isoflavone chemoreceptor in Phytophthora sojae to prevent disease PMID 39772695
Experiments on the pharmacology of hydroxydione sodium succinate PMID 13761053
Mal
TA6366
Disruption of PPARG Activity and CPT1A Regulation by Bisphenol A Implications for Hepatic Lipid Metabolism PMID 40346756
NCI
Atorvastatin exerts dual effects of lesion regression and ovarian protection in the prevention and treatment of endometriosis PMID 38141938
Kynurenine causes vasodilation and hypotension induced by activation of KCNQ
Synthesis and evaluation of novel triazolyl quinoline derivatives as potential antileishmanial agents PMID 29793211
The tissue protective functions of interleukin
Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy PMID 32736231
Lubeluzole Repositioning as Chemosensitizing Agent on Multidrug
Design, synthesis and biological evaluation of biaryl amide derivatives against SARS
Arachidonic Acid Metabolism and Kidney Inflammation PMID 31357612
Inhibition of the P2X7/NLRP3 Inflammasome Signaling Pathway by Deacetylgedunin from Toona sinensis PMID 35427124
Citric acid triammonium
Ethyl linoleate
Mc
A novel process for transcellular hemoglobin transport from macrophages to cancer cells PMID 39605056
Preclinical efficacy of tasquinimod
GFRA1/GDNFR
Machine Learning
Antitumor activity of mitoxantrone against murine experimental tumors comparative analysis against various antitumor antibiotics PMID 7105379
Heliosupine N
Antiproliferative agent
Inhibition of JAK1/STAT3 pathway by 2
CMF019
HOOCCH2O
Slc1a5
Atf4 Rat Pre
Mevalonate metabolites boost aged oocyte quality through prenylation of small GTPases PMID 40858817
PRMT5
Synthesis and biological evaluation of new long
Arsenic trioxide preconditioning attenuates hepatic ischemia
Intraocular VEGF deprivation induces degeneration and fibrogenic response in retina PMID 31648566
Kcnj3 Rat Pre
4
Thrombopoietin/THPO 抗体 (YA7089)（Thrombopoietin/THPO Antibody (YA7089)）
ALK
Aurora
Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK
Anti
PML Suppresses Influenza Virus Replication by Promoting FBXW7 Expression PMID 34046815
Possible involvement of tachykinin NK(1) and NMDA receptors in histamine
Single
A bovine milk
SRC and PIM1 as potential co
UM
IL
The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma PMID 25351247
TRMT10C
Phthalein Purple
Dimethyl (2
Trimetazidine dihydrochloride 13171
Synthesis and antiprotozoal activity of original porphyrin precursors and derivatives PMID 23851117
[Metapramine antidepressant and psycho
DNA 双链断裂
CXCR2, as a key regulatory gene of HDP
Br
Wnt2b 抗体 (YA2424)（Wnt2b Antibody (YA2424)）
Beta
CC
Cross
Cholinesterase (ChE)
1,3
CD38 抗原（Cd38）基因
THP
Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice PMID 25016295
Cd5l Rat Pre
Proteinase, Aspergillus oryzae 9001
Licoagrochalcone B
含三方基序 21（TRIM21）基因
Melatonin mitigates traumatic brain injury
Ziprasidone (CP
Oxytocin and vasopressin linking pituitary neuropeptides and their receptors to social neurocircuits PMID 26441508
D
hCA/Wnt/β
Myeloma extracellular vesicle
A novel polypeptide inhibitor of MMP
Saterinone hydrochloride (BDF 8634 hydrochloride)
Novel analogues of Istaroxime, a potent inhibitor of Na(+),K(+)
UNC2025, a MERTK Small
Salidroside Promotes the Pathological α
Peptide T 106362
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib PMID 27432558
Effect of peiminine on DNCB
TAMRA alkyne,5
An RNA replicon system to investigate promising inhibitors of feline coronavirus PMID 38236006
Targeting serum response factor (SRF) deactivates ΔFosB and mitigates Levodopa
Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5 PMID 34648292
Exogenous hydrogen sulphide sensitizes carbapenemase
LG 83
Ginsenoside
Seneca Valley virus 3C protease cleaves HDAC4 to antagonize type I interferon signaling PMID 39927774
Immunoregulation by IL
Effect of 1,2,3
Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c
Asenapine reduces anxiety
NPEC
spliced
N,N
Daidzoside
Methyltransferase
Ritlecitinib an investigational drug for the treatment of moderate to severe alopecia areata PMID 34826225
Establishment of a High Content Image Platform to Measure NF
Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan
N6
AF647
GNF179
The role of the N
白细胞介素
Dual
Acetylamino
Vagus nerve stimulation enhances the cholinergic anti
Formulation and development of pH
Cadpr
Fenbendazole sulfone (Standard) (Oxfendazole sulfone (Standard)，芬苯达唑砜 (Standard))
OBI
High
5
Protective Effects of Peanut Sprouts from a Smart Farming System on the Barrier Function of Human Epithelial Cells PMID 39759809
Synthesis of New Derivatives of Benzylidinemalononitrile and Ethyl 2
Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors PMID 35764642
Avanafil, a potent and highly selective phosphodiesterase
NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway PMID 36738427
4
emulsifiers
The Collagen Suprafamily From Biosynthesis to Advanced Biomaterial Development PMID 30126066
Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway PMID 34089839
4,4'
Incorporation of nitric oxide donor into 1,3
BI 847325
AZ5385 848439
(R)
Uridine
组蛋白 3（HTN3）基因
3,5,6
25
Binding kinetics differentiates functional antagonism of orexin
Roquefortine E
Raxlaprazine etomoxil 3034857
Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity PMID 40536345
Thalidomide
Circadian light/dark cycle reversal exacerbates the progression of chronic kidney disease in mice PMID 38803014
Flurochloridone (R
Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro and in Vivo Antitumor Activities PMID 26331334
Spectroscopic view on the interaction between the psoralen derivative amotosalen and DNA PMID 38457118
A miniature CRISPR
Autophagy inducer 5
Quinoclamine (灭藻醌)
Cancer Cell enters reversible quiescence through Intracellular Acidification to resist Paclitaxel Cytotoxicity PMID 32669967
PD173952 305820
苄环庚烷 (标准品)
N
α
Inhibition of CDK9 exhibits anticancer activity in hepatocellular carcinoma cells via targeting ribonucleotide reductase PMID 37245555
Invertase, candida sp. (β
Pharmacologic treatment of obstructive sleep apnea PMID 7602229
Sudubrilimab 2387417
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation PMID 34779126
Clomipramine
Non
DPP4 as a Potential Candidate in Cardiovascular Disease PMID 36147690
HBA(111–142)
Acod1
Identification of novel broad
Design, synthesis and biological evaluation of bisthiazole
(1aR,5aR)1a,3,5,5a
KYA1797K
A comparison of brain and serum pharmacokinetics of R
TNF
PAD4
Kaempferitrin 482
Coretinphencone 1631711
PRKAA1 induces aberrant mitophagy in a PINK1/Parkin
N2
Latanoprost promotes neurite outgrowth in differentiated RGC
主题讲座
ADAM17
Il18r1
红花羊蹄甲提取物 (Bauhinia × blakeana Dunn)
Adipocyte
A non
Bepotastine ethyl ester
Ornidazole 16773
Antifungal agent 28
Anti
Development of a chimeric c
Hsp70 Inhibits the Replication of Fowl Adenovirus Serotype 4 by Suppressing Viral Hexon with the Assistance of DnaJC7 PMID 35852354
2& 039;
The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide
OASL activates MAPK to drive psoriatic pathogenesis Astilbin targeting this axis improves metabolic
Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names PMID 36109838
Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity PMID 8595067
A Self
Antifolate agent 1 518063
Capsaicin functions as a selective degrader of STAT3 to enhance host resistance to viral infection PMID 37311796
Discovery of 2
N
DNA 测序
Cholesterol overload in macrophages drives metabolic dysfunction
A deubiquitination module essential for Treg fitness in the tumor microenvironment PMID 36427305
Discovery of Novel 5
Microglia
PMAP
Lipofectamine 2000™ at transfection dose promotes EphA2 transcription in an HDAC4
Ethyl (E)
HY
Cytokine
LILRB2/CD85d/ILT
负霉素
N
Identification of a sequence of human activated protein C (residues 390
Pranazepide 150408
Hemopressin (human, mouse)
A Simple Protocol for the Isolation and Culture of Hepatocytes from MASLD Mice PMID 40758599
HY
Cambinol 14513
LIMA1 links the E3 ubiquitin ligase RNF40 to lipid metabolism PMID 38909032
Aging and amyloid β oligomers enhance TLR4 expression, LPS
GSS Human Pre
TAM
Retrieval
Exploiting an evolutionary constraint Targeting TatD nuclease with chrysosplenol D disrupts Mycoplasma gallisepticum infection PMID 40744178
Natural antioxidant
ISIS678354
Antileishmanial pharmacomodulation in 8
Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP
Characterization of a novel D
Tumor necrosis factor
MMP28 recruits M2
A 3
TC
Microcolin B 141205
二氢山奈酚
Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis preclinical characterization of INCB028050 PMID 20363976
ApoE2 affects insulin signaling in the hippocampus and spatial cognition of aged mice in a sex
N
FAP Human Pre
Insights into ALK
Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3
Btf3 Rat Pre
Perillaldehyde Protects Against Aspergillus fumigatus Keratitis by Reducing Fungal Load and Inhibiting Inflammatory Cytokines and LOX
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers PMID 28653662
γ
Structure
4μ8C 14003
C21 steroidal glycosides with cytotoxic activities from Cynanchum otophyllum PMID 29625825
Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells PMID 29749473
CB2R agonist GW405833 alleviates acute liver failure in mice via inhibiting HIF
Effects of carbocisteine on altered activities of glycosidase and glycosyltransferase and expression of Muc5ac in SO2
S 9788
The messenger RNA decapping and recapping pathway in Trypanosoma PMID 26038549
JAK
Evidence that c
Propofol β
RDS03
DOPE
CaMKI(299
Biotin
HY
Baricitinib 1187594
The Emission of Internal Conversion Electrons Rather Than Auger Electrons Increased the Nucleus
Dexmedetomidine activates mitophagy and protects against pyroptosis in oxygen
Synthesis of alkyl chain
Trypanothione reductase inhibition and anti
3
Calycosin improves insulin resistance by regulating the hsa
The apoptotic effect of oral administration of microcystin
Cyclin
Trim44
L
Comparative study on the anti
The effects of pigment epithelium
2,4,6
Taligantinib 2243235
Antitumor activity of an anti
Diosmetin Protects Against Obesity and Metabolic Dysfunctions Through Activation of Adipose Estrogen Receptors in Mice PMID 34223710
Firmonertinib mesylate 2130958
Inhibition by nitric oxide
Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide
RVG29
cis
Scutellarin combined with lidocaine exerts antineoplastic effect in human glioma associated with repression of epidermal growth factor receptor signaling PMID 39888904
hMAO
Kanzonol D
Methoxyamine hydrochloride 593
Structural insights into preinitiation complex assembly on core promoters PMID 33795473
IRE1抑制剂、基因
TYRA
STAT3
柠檬酸合酶（CS）基因
Pan
The protective role of GPX4 in naïve ESCs is highlighted by induced ferroptosis resistance through GPX4 expression PMID 40010136
Artifact
MCE
Moracin N
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection PMID 20643340
AITRL/TNFSF18 蛋白, Human (HEK293, Fc)
Tolindate 27877
Moniliformin sodium salt
Design and development of ((4
CCNB2 Human Pre
1,2
Changes in Honey Bee Head Proteome in Response to Dietary 24
Gliclazide (S1702，格列齐特)
Ac
钙粘素 2（CDH2）基因
2,6
Synthesis of structural analogues of hexadecylphosphocholine and their antineoplastic, antimicrobial and amoebicidal activity PMID 25698517
6
gliclazide
Autophagy Participates in Lysosomal Vacuolation
ATR phosphorylates DHX9 at serine 321 to suppress R
In vivo metabolism study of polygalic acid in rat using HPLC
Top Publications Citing MCE Products
Effects of amiodarone and posaconazole on the growth and ultrastructure of Trypanosoma cruzi PMID 22591838
Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar
Neuroinflammatory
O
Context
3
Phospho
Is agmatine a novel neurotransmitter in brain? PMID 10785653
Discovery of Cysteine
Oxyphenisatin acetate (Standard) (双醋酚丁 (Standard))
Novel dual LSD1/HDAC6 inhibitors for the treatment of multiple myeloma PMID 33359604
3
cysteine residue
Glycogen synthase kinase
Top Publications Citing MCE Products
trans
VEGFA Human Pre
细胞分裂周期相关 5（CDCA5）基因
Cu(II)
Review of emerging contaminant tris(1,3
Motavizumab 677010
Top Publications Citing MCE Products
Total synthesis of the antiallergic naphtho
Novel propeptin analog, propeptin
N
(+)
Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice PMID 39779967
NUC
An ALOX12
Regioselective synthesis of water
Sporogen AO
Enterolactone has stronger effects than enterodiol on ovarian cancer PMID 28738876
CD8 alpha 蛋白, Human (HEK293, His)
IT
Glycyrrhizin
Effect of sulfation on the gastrointestinal actions of caerulein PMID 4904949
In vitro activity of nemonoxacin, a novel nonfluorinated quinolone antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae PMID 24366753
Abeta(1
Himalomycin A 701915
Minretumomab 195189
Aspirin
S
Complete microtubule
Triazolopyridyl ketones as a novel class of antileishmanial agents. DNA binding and BSA interaction PMID 24953952
BEC2 1429614
Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding PMID 23358418
Highly selective off
Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at its use in combination with pseudoephedrine PMID 8319163
Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis PMID 27986123
Furametpyr
Silandrone 5055
DAR
YLF
E3 Ligase Ligand
PRKG1 Human Pre
Oxaceprol (Standard) (N
The influence of GDF11 on brain fate and function PMID 30729414
Enhancing HIV
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA
Fosfomycin PMID 26960938
Synthesis and activity of nucleoside
Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC
Cis
PIM2
SF 11 443292
Application of an Integrated Single
Inhibition of cyclic GMP phosphodiesterase by xanthine derivatives relaxes guinea
Carbonic anhydrase IV
Decarestrictine D 127393
O
Oxindole 59
Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells PMID 30890462
The impact of liver resection on the dihydrouracil uracil plasma ratio in patients with colorectal liver metastases PMID 29430582
Strychnan and secoangustilobine A type alkaloids from Alstonia spatulata. Revision of the C
16,16
Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice PMID 28592614
MU
APETx2 TFA
2
TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway PMID 36896765
Combinatorial Inhibition of Complement Factor D and BCL2 for Early
NSC73306 79560
Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti
Interleukin
Design, synthesis, and biological evaluation of novel pyrazolo [3,4
Sutimlimab in Cold Agglutinin Disease PMID 33826820
PAD4
Assessment of Azeliragon QTc Liability Through Integrated, Model
(S)
CD5 蛋白, Human (HEK293, Fc
CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist PMID 20728351
Synthesis and evaluation as potential anticancer agents of novel tetracyclic indenoquinoline derivatives PMID 23357037
Concise synthesis of carbazole
Bid BH3 peptide
Gel filtration of protected peptides on sephadex G
The effect of radiation exposure on multidrug resistance in vitro and in vivo studies using non
Metabolic profiling unravels the effects of enhanced output and harvesting time on royal jelly quality PMID 33509520
Antituberculosis agent
Study of marine natural products including resorcyclic acid lactones from Humicola fuscoatra that reactivate latent HIV
Yes 相关蛋白
D
Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation PMID 36228585
CDCP1 蛋白, Rhesus Macaque (HEK293, His)
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2 PMID 20371709
Synthesis, biological activity, and mechanism of action of new 2
Macroporous chitosan/methoxypoly(ethylene glycol) based cryosponges with unique morphology for tissue engineering applications PMID 33542336
Pharmacological inhibition of G protein
Semaphorin 4C promotes motility and immunosuppressive activity of cancer cells via CRMP3 and PD
mmu
HDAC6 Facilitates PRV and VSV Infection by Inhibiting Type I Interferon Production PMID 39861880
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