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(S)
Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis PMID 35581193
(S)
Farnesyl pyrophosphate ammonium 116057
dehydroaripiprazole
MCE
NDRG2 suppresses proliferation, migration, invasion and epithelial
克瑞沙硼(Standard)
Highly improved antiparasitic activity after introduction of an N
Heat Shock Protein 60 Is Involved in Viral Replication Complex Formation and Facilitates Foot and Mouth Virus Replication by Stabilizing Viral Nonstructural Proteins 3A and 2C PMID 36106732
PIAS1/2 抗体 (YA2475)（PIAS1/2 Antibody (YA2475)）
The Significance Application of Indigenous Phytohemagglutinin (PHA) Mitogen on Metaphase and Cell Culture Procedure PMID 24250428
Epithelial
Optical control of adenosine A3 receptor function in psoriasis PMID 34157422
N
NBI
Enniatin complex 11113
N
Anti
GSK189254A (GSK189254 free base)
Chelation of the Optimal Antifungal Pogostone Analogue with Copper(II) to Explore the Dual Antifungal and Antibacterial Agent PMID 38366986
Semisynthetic Phenol Derivatives Obtained from Natural Phenols Antimicrobial Activity and Molecular Properties PMID 29286652
Ctrb1
PKI (14
allergic rhinitis
Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP PMID 33636388
p
Elevated lactate production exacerbates PM2.5
Forsythoside B 81525
Adamantane 281
Gypenoside XVII inhibits ox
Interferences associated with the factor XIa inhibitors asundexian and milvexian in routine and specialized coagulation assays and their removal by activated charcoal
A RIPK3
Cyclovirobuxine D 860
SOX9 modulates Müller cell gliosis in diabetic retinopathy through upregulating TXNIP transcription PMID 36642539
GMP IFN
Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes PMID 26824742
Shexiang baoxin pill ameliorates cardiac fibrosis by inhibiting fibroblast to myofibroblast transition through STAT3 phosphorylation suppression PMID 40975042
ACE2 蛋白, Human (HEK293, His, solution)
CHMFL
14S(15R)
A chemical switch for inhibitor
IL
奥托普林（OTOR）基因
CARM1 phosphorylation at S595 by p38γ MAPK drives ROS
组蛋白脱乙酰酶 7（Hdac7）基因
Citreamicin alpha
XMT
MCE
Clinical and Molecular Spectrum of Glucose
Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis PMID 40481499
ICOS 蛋白, Rat (C137S, C138S, HEK293, His)
Overcoming resistance to EGFR monotherapy in HNSCC by identification and inhibition of individualized cancer processes PMID 35154483
D
Discovery of 2
HSPA12A unstabilizes CD147 to inhibit lactate export and migration in human renal cell carcinoma PMID 32754264
Inhibition of CD38 enzymatic activity enhances CAR
IL
RNA granule
Oclacitinib 1208319
The vanadyl ribonucleoside complex inhibits ribosomal subunit formation in Staphylococcus aureus PMID 22643191
Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis PMID 36138009
Locacorten
FGFR
SSTC3 1242422
Cblb
Cblb
CLEC5A/MDL
Antitumor effect of 2
BET Bromodomain Inhibitors with One
(3S,8R,9R)
Evaluation of Targeted Delivery to the Brain Using Magnetic Immunoliposomes and Magnetic Force PMID 31683542
Carbocisteine as a Modulator of Nrf2/HO
m6A mRNA methylation initiated by METTL14 promotes STK11 translation and increases STK11 activity to induce anti
Discovery and Structure
Diatrizoic acid 117
TSHR Protein
IFN
Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells PMID 35244876
Ritrosulfan 4148
A phase III, randomized, double
Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists PMID 30743097
All
Apoa5
m
QS 7 208933
Mono
四肽重复结构域 21B（TTC21B）基因
ALK5
mutagenic
Neurochemical effects of the synthetic ACTH4
Top Publications Citing MCE Products
A peripherally acting, selective T
PEDF promotes the repair of bone marrow endothelial cell injury and accelerates hematopoietic reconstruction after bone marrow transplantation PMID 32873283
Chinese herbal compound Huangqin Qingrechubi capsule reduces lipid metabolism disorder and inflammatory response in gouty arthritis via the LncRNA H19/APN/PI3K/AKT cascade PMID 36994890
NRG1
CID
Design, synthesis and biological evaluation of 2
Fasudil inhibits α
Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41 PMID 26513643
S
IL
PN
Discovery of SY
KB
Ephrin
N6
Pharmacokinetics, metabolism, and excretion of the antidiabetic agent ertugliflozin (PF
Concentrations of 3 alpha
Photoaffinity labelling of cyclic GMP
SlIAA23
Ro
CGRP(2) receptor in the internal anal sphincter of the rat implications for CGRP receptor classification PMID 10807687
PVR/CD155 蛋白, Human (HEK293, mFc)
CP
A natural product inspired hybrid approach towards the synthesis of novel pentamidine based scaffolds as potential anti
ADAM8 as a drug target in pancreatic cancer PMID 25629724
Sinomenine attenuates lipopolysaccharide
Development of TsDPEN based imine
Germacrone mitigates cardiac remodeling by regulating PI3K/AKT
SOS1
Malic acid 6915
Nonhomologous end joining and homologous recombination involved in luteolin
RO
Catumaxomab 509077
Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress PMID 30790702
B
Jaceosidin induces apoptosis and inhibits migration in AGS gastric cancer cells by regulating ROS
ATP1A2 抗体 (YA2934)（ATP1A2 Antibody (YA2934)）
Isoliquiritigenin prevents Doxorubicin
Multi
YOK
Signal transduction pathways involved in dopamine D2 receptor
c
Cell surface GRP78
Properties of poly(3
COX
USP7 alleviates neuronal inflammation and apoptosis in spinal cord injury via deubiquitinating NRF1/KLF7 axis PMID 39007840
[Lys8, Lys9]
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP
The neural stem
PDE4
SILA
Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions a correlation? PMID 22503361
TBXAS1 deficiency causes autoinflammation responsive to IL
Netrin
FCGRT
EphB6 Regulates TFEB
Pomalidomide promotes macrophage control of Mycobacterium tuberculosis via enhancing HDAC6
Molecular basis of human taurine transporter uptake and inhibition PMID 40789850
RANK/TNFRSF11A 蛋白, Rat (HEK293, His)
Research progress in the biological activities of 3,4,5
BMS
丝裂原活化蛋白激酶 9（MAPK9）基因
Isolation of virus
Comparative activity of cisplatin, ifosfamide, doxorubicin, carboplatin, and etoposide in heterotransplanted hepatoblastoma PMID 9840541
2
DNA 连接酶
依帕司他(Standard)
Triclopyr 55335
Effects of soy protein and isoflavone on hepatic fatty acid synthesis and oxidation and mRNA expression of uncoupling proteins and peroxisome proliferator
Exogenous stromal cell
Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β
Identification of an autoinhibitory, mitophagy
Mrgx2 antagonist
Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase PMID 26262613
Augmentation of PRDX1
NH2
Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy PMID 31597089
Bone marrow mesenchymal stem cells
PFKFB3 downregulation aggravates Angiotensin II
IL
Ms4a7 Rat Pre
ST6 Gal Sialyltransferase 2 (EC 2.4.3.1)
Integrin beta
Emapunil 226954
白细胞介素 10（Il10）基因
Synthesis of Plasmalogen Derivatives with Unnatural Fatty Acids as Substrates for Ferroptosis Induction PMID 39116319
Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL
HSPD1 Human Pre
杀伤细胞凝集素样受体 C1（KLRC1）基因
The association between 4
Nitrovin hydrochloride 2315
盐酸硫利达嗪
HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis PMID 38219869
Maltitol 585
IFN
A Clinical Study to Assess the Efficacy and Safety of MP
High
Meclizine is neuroprotective in models of Huntington's disease PMID 20977989
Temporin L
F15845 470454
Caspase
Gut restricted
MAT1A 蛋白, Human (His)
CD24 is a promising immunotherapeutic target for enhancing efficacy of third
Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma PMID 35593307
Betazole dihydrochloride (Ametazole dihydrochloride)
AP
Discovery of First
dose
(Rac)
Novel class of benzimidazole
Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice PMID 18448867
MMP
A Novel Pharmacodynamic Biomarker and Mechanistic Modeling Facilitate the Development of Tovetumab, a Monoclonal Antibody Directed Against Platelet
Arformoterol tartrate in the treatment of COPD PMID 20406080
Magnesium silicate 1343
Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway PMID 34296312
Discovery of Oral Degraders of the ROS1 Fusion Protein with Potent Activity against Secondary Resistance Mutations PMID 39361251
Runx2 (Runt
The impact of wastewater treatment plants on the composition and toxicity of pollutants in urban rivers in Nanjing, China PMID 39306123
N6
Non
Targeted degradation of DDR1 by proteolytic targeting chimera reverses immune exclusion for tumor immunotherapy PMID 40382838
Metformin prevents against oxidative stress
4
TBL1X 抗体 (YA1065)（TBL1X Antibody (YA1065)）
Formaldehyde
variability
A2793
Trombodipine 113658
Elesclomol
3
PDK1/Akt/Flt dual pathway inhibitor 331253
ACSS2
Visugromab 2556646
Functional lipid nanoparticles for safe delivery of macromolecular antibiotics to gram
Antithrombin III, human plasma 90170
Transplacental transfer of oseltamivir phosphate and its metabolite oseltamivir carboxylate using the ex vivo human placenta perfusion model in Chinese Hans population PMID 27426925
CaMKII Exacerbates Doxorubicin
2& 039;
Adoxosidic acid
2
Antibiotic efficacy against Vibrio vulnificus in the mouse superiority of tetracycline PMID 6864521
co
硫酸双生霉素
A
7
GFRA1/GDNFR
SMARCA2 ligand
ZM
外周髓鞘蛋白 22（PMP22）基因
Furafylline 80288
The V2 domain of HIV gp120 mimics an interaction between CD4 and integrin ⍺4β7 PMID 38064524
Methyltransferase ZC3H13 regulates ferroptosis of alveolar macrophages in sepsis
WS
Rimtuzalcap 2167246
Steroid
Ptpn1
TRIM21
AZD 9574
Contribution of membrane cholesterol to outer hair cell lateral wall stiffness PMID 9674509
6
Isodispar B 98192
Canocapavir Is a Novel Capsid Assembly Modulator Inducing a Conformational Change of the Linker Region of HBV Core Protein PMID 37243280
Endothelin
Pictilisib dimethanesulfonate (Standard)
Serotonin Receptor
Pgp Mouse Pre
Inhibitors of glutamate release from breast cancer cells; new targets for cancer
Analogues of the Inhoffen
Nectin
Licochalcone A promotes autophagy to ameliorate NAFLD by inhibiting the mTOR and regulating ULK1/Beclin1/VPS34 pathway PMID 40744422
Wy 41747
RNF126
Mrtfa
1
Chemotherapy of leishmaniasis. Part IX synthesis and bioevaluation of aryl substituted ketene dithioacetals as antileishmanial agents PMID 23031588
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide
Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A PMID 22763704
Novel dual
SLN124, a GalNac
Porphyrias in the Age of Targeted Therapies PMID 34679493
中心体蛋白 350（CEP350）基因
Dehydrohautriwaic acid 51905
Icariside B1 109062
Fkbp7
Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action PMID 34676755
The role of glutathione reductase and related enzymes on cellular redox homoeostasis network PMID 26923386
Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR
CD137/4
Determination of Menthol in Plasma and Urine by Gas Chromatography/Mass Spectrometry (GC/MS) PMID 26660189
Aerobactin (Standard)
Validamycin A 37248
Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3
Variations in the levels of 3
Ac
vitamin B3
Dihydroartemisinin inhibits follicular helper T and B cells implications for systemic lupus erythematosus treatment PMID 38977652
Methyl pyrimidine
Design of the First
Prkg1 Mouse Pre
Protective effects of folic acid on PM2.5
Rutin as a Natural Therapy for Alzheimer's Disease Insights into its Mechanisms of Action PMID 26898570
Human Immunoglobulin G1 (Human IgG1，人免疫球蛋白G1)
Therapeutic efficacy of monoclonal antibodies and antivirals against SARS
Carbocisteine inhibits the expression of Muc5b in COPD mouse model PMID 31571828
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production PMID 25778803
ROS
N
Sotrovimab 2423014
PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity PMID 38272236
Cyanine 523
gluconeogenesis
Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile The LAURA study PMID 17073834
Wedelolactone 524
Curcumin induces high levels of topoisomerase I
Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release PMID 6184259
Hepatic Krüppel
EphA
Effects of monatepil maleate, a new Ca2+ channel antagonist with alpha1
11
Tiopronin
Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R in Candida albicans PMID 39139375
Human B cell
Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline PMID 21106374
Lactate promotes myogenesis via activating H3K9 lactylation
IQ 1
Integrative genomic identification of therapeutic targets for pancreatic cancer PMID 40848256
SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape PMID 34534457
MYC amplification sensitizes TNBC to CHK1 inhibitors PMID 40037423
Benzo[k]fluoranthene (Standard) 207
Brivanib 649735
Progesterone carboxylic acid 302
Flow cytometric analysis of RNA content in different cell populations using pyronin Y and methyl green PMID 6180873
Galanthamine hydrobromide 1953
Ajmalicine induces the pyroptosis of hepatoma cells to exert the antitumor effect PMID 38064316
Gut microbe
Vitamin D and Its Analogues Decrease Amyloid
M6A demethylase FTO
Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID
In vitro studies on the effect of certain natural products against hepatitis B virus PMID 2370093
5’
Spinetoram J 187166
BIM
Cytoskeletal orchestration of glucose uptake in Sertoli cell to support efferocytosis of apoptotic germ cells PMID 36716822
DNDI
Tazemetostat 1403254
Gemfibrozil, a lipid
Discovery and pharmacological characterization of 1,2,3,4
Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB
In vitro evaluation of the therapeutic potential of nevirapine in treatment of human thyroid anaplastic carcinoma PMID 23462194
The cyclophilin inhibitor alisporivir prevents hepatitis C virus
TNIK A redox sensor in endothelial cell permeability PMID 39705357
Rat Serum Albumin (大鼠血清白蛋白)
4
NFATc1
PRRSV GP5 inhibits the antivirus effects of chaperone
加卡奈珠单抗
GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin PMID 15910002
DOCK2 Human Pre
Potential Anticancer Agents against Melanoma Cells Based on an As
GTL
HY
L
13
Phosphorylase a, rabbit muscle 9032
N6
Cimbuterol
Galectin
Characterization of the Fluorescent Spectra and Intensity of Dabigatran and Dabigatran Etexilate Application to HPLC Analysis with Fluorescent Detection† PMID 27473419
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose PMID 33773470
AZ
Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection a proof
Synthesis, X
Reactivation of MAPK
Potential antiviral effects of the marine probiotic Paraliobacillus zengyii on the respiratory syncytial virus PMID 40600055
Eef1b2
Integration of cell
3
NS
樟脑(Standard)
DiSC18(3) 53533
Identification of new potent anticancer derivatives through simplifying the core structure and modification on their 14
Caulophylline B 1359978
Cytotoxic triterpenoid saponins acylated with monoterpenic acid from Pithecellobium lucidum PMID 18095653
N
Molibresib (I
SNIPER(ABL)
Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation PMID 40774947
CD5L Human Pre
N
4& 039;
Microglial
5
NOB1 Human Pre
Novel 8
LIM 域只有 4（LMO4）基因
ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway PMID 40253517
((3
AGER 蛋白, Human (HEK293, His)
The tricyclic antidepressant imipramine induces autophagic cell death in U
Etherolenic acid 169217
Targeted immunomodulation therapy for cardiac repair by platelet membrane engineering extracellular vesicles via hitching peripheral monocytes PMID 35447403
二氢嘧啶脱氢酶
A549
Dihydroartemisinin
Quantitative and site
Abiraterone sulfate N
PD
Hijacking antibody
Piperlongumine Induces Reactive Oxygen Species (ROS)
4,5
F
(
Protective Effect of Sirtuin 3 on CLP
Alisol A 24
Meclizine dihydrochloride monohydrate 31884
Inhibition of ATF4
Naquotinib exerts antitumor activity in activated B
L
Inhibitory effect of monatepil maleate on acyl
The indoleamine 2,3
PS
EM20
Xanthopterin in the Oriental hornet (Vespa orientalis) light absorbance is increased with maturation of yellow pigment granules PMID 19222794
The synthesis of novel water
Fst
Design and synthesis of 1
Doxapram hydrochloride hydrate (Standard) (多沙普仑盐酸一水合物(Standard))
Cimetidine promotes STUB1
MCE
Two new sulfated sesquiterpenoids from Petasites tricholobus PMID 25577874
Influence of Teriparatide and Ibandronate on Cortical Bone in New Zealand White Rabbits A HR
Puerarin improves busulfan
Dietary guanidino acetic acid is an efficacious replacement for arginine for young chicks PMID 23243244
Synthesis and biological evaluation of santacruzamate A analogues for anti
Gut symbiont
Calcipotriol monohydrate 147657
AMP
GPR39 Agonist TC
2
CAD 抗体 (YA2523)（CAD Antibody (YA2523)）
allergic rhinitis
Diaphanous
T
Identification of cellular pathways affected by Sortin2, a synthetic compound that affects protein targeting to the vacuole in Saccharomyces cerevisiae PMID 18179719
Tiopronin 1953
Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary PMID 26986199
Temporin SHF
Chemotherapy of leishmaniasis part X synthesis and bioevaluation of novel terpenyl heterocycles PMID 23177254
In vitro and in vivo antileishmanial and trypanocidal studies of new N
Role of nuclear factor of activated T Cells
Ferulic acid 4
HGF 蛋白, Mouse (HEK293)
The Targeted Degradation of BRAF V600E Reveals the Mechanisms of Resistance to BRAF
Ror
Histamine release and pain production by xanthosine and related compounds PMID 13460246
Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion PMID 41162642
Cochlear
阿苯达唑亚砜
Gingerol ameliorates neuronal damage induced by hypoxia
SB
3’
(±) Anabasine 13078
激活素 A 受体样 1（Acvrl1）基因
Dispase, a neutral protease from Bacillus polymyxa, is a powerful fibronectinase and type IV collagenase PMID 2546994
GNF2133
Dysferlin 抗体 (YA3036)（Dysferlin Antibody (YA3036)）
Autophagic degradation of claudin
Potassium ion efflux induces exaggerated mitochondrial damage and non
Elastase, Human leukocytes 9004
FEV
VNN1/Vanin
25
Trimetazidine dihydrochloride (Standard)
ATF4 Human Pre
Repurposing Cytarabine for Treating Primary Effusion Lymphoma by Targeting Kaposi's Sarcoma
LncRNA MNX1
Targeting STING to disrupt macrophage
Decaprenyl
USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ
Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation
Dehydroacetic acid 520
Animal
Melatonin mitigates PGF
MerTK
Aminothiazoles Hit to lead development to identify antileishmanial agents PMID 26318065
In vitro and in vivo effects of UP 269
Azole
JTP
PROTAC EGFR degrader
Z
Design, synthesis, and biological evaluation of novel discoidin domain receptor inhibitors for the treatment of lung adenocarcinoma and pulmonary fibrosis PMID 38171149
Selenium
MHC I 类多肽相关序列 A（MICA）基因
KB0742
HuoXueTongFu formula induces M2c macrophages via the MerTK/PI3K/AKT pathway to eliminate NETs in intraperitoneal adhesion in mice PMID 38703872
A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC PMID 36300799
Sortin2 372972
Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency PMID 32178712
Augmenting chemotherapy with low
5'
The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL
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