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GCN2
Decamethoxine 38146
Biased Ligands of G Protein
Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA
GLI2/Parkin
Discovery of (5
ATTO 550 NHS ester 1005770
Inhibitory activity of eudesmane sesquiterpenes from Alpinia oxyphylla on production of nitric oxide PMID 22277277
Triterpenes and lignans from Artemisia caruifolia and their cytotoxic effects on meth
Design and structural basis of selective 1,4
The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke
Involvement of p38 MAPK/cPLA2 and arachidonic acid metabolic pathway in Shengmai injection
3,5
Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes possible involvement of CYP2D and CYP3A PMID 10950860
Discovery of the first
HPK1
ACP196
CD38 inhibits ferroptosis to promote radiotherapy resistance in nasopharyngeal carcinoma by competitively binding to TRIM21 to stabilize SLC7A11 protein PMID 40449774
2'
Umeclidinium bromide 869113
An inhibitor of oxidative phosphorylation exploits cancer vulnerability PMID 29892070
损伤特异性 DNA 结合蛋白 1（DDB1）基因
Propyl red 2641
Etoperidone 52942
Rhoj Mouse Pre
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders PMID 31330105
Quercetin inhibits NTHi
Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure
Sarracine 2492
钾内向整流通道亚家族 J 成员 3（KCNJ3）基因
Melatonin attenuates palmitic acid
XP13512 [(+/
BRAFV600E
Peptidomimetic Analogues Act as Effective Inhibitors against SARS
In vitro synergistic effect of AXL, FAK and ErbB receptors inhibitors for head and neck cancer PMID 40605022
Plozasiran (ARO
Devimistat 95809
C225
Profiling Cysteine Proteases Activities in Neuroinflammatory Cells PMID 39475209
Acibenzolar
Pachymic acid inhibits growth and metastatic potential in liver cancer HepG2 and Huh7 cells PMID 36273899
(R)
Trim38
ATF4
Lmo2 Mouse Pre
Adamantaniline Derivatives Target ATP5B to Inhibit Translation of Hypoxia Inducible Factor
3,5,7,8,3′,4′
A polymeric paste
MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression PMID 37905571
JGB1741 (ILS
2
1,7
Avenciguat 1579514
TRAF6 Suppresses the Development of Pulmonary Fibrosis by Attenuating the Activation of Fibroblasts PMID 35668944
LPC
Immunology of lymphatic filariasis PMID 24134686
Anti
Glucose inhibits the inflammatory response in goose fatty liver by increasing the ubiquitination level of PKA PMID 39158360
Anti
EGFR
RTI
8
Ferulic acid 1135
Death associated protein like 1 acts as a novel tumor suppressor in melanoma by increasing the stability of P21 protein PMID 38980592
Discovery of N
S
TLQP
MCE
LpxC
CD163 蛋白, Mouse (HEK293, His)
Upregulation of phosphoinositide 3
策划者样转录共激活因子 1（MAML1）基因
JGB1741 1256375
Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells PMID 20813094
HCGRP
A conserved H3K14ub
Dehydrohautriwaic acid
Osmr Rat Pre
Novel self
A Dendrimer Peptide (KK2DP7) Delivery System with Dual Functions of Lymph Node Targeting and Immune Adjuvants as a General Strategy for Cancer Immunotherapy PMID 36950751
Asperanstinoids A
Kidney toxicity and transcriptome analyses of male ICR mice acutely exposed to the mushroom toxin α
Meloxicam 71125
Concentration of 2'C
Improvement in glucose metabolism in adult male offspring of maternal mice fed diets supplemented with inulin via regulation of the hepatic long noncoding RNA profile PMID 34706105
GDF
kelch 样 ECH 相关蛋白 1（KEAP1）基因
pharmaceutical auxiliarie
QSAR Modeling of SARS
USP6 蛋白, Human (sf9, GST)
Alteration of the membrane lipid environment by L
Identification of dihydroorotate dehydrogenase inhibitor, vidofludimus, as a potent and novel inhibitor for influenza virus PMID 38235544
β
胆汁酸辅酶 A 氨基酸 N
α
Inhibition of mitochondrial OMA1 ameliorates osteosarcoma tumorigenesis PMID 39487118
PI
G 蛋白偶联受体激酶 6（GRK6）基因
Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia
1
KYP
Bik BH3 505070
CDK4 inactivation inhibits apoptosis via mitochondria
Formycin triphosphate 16409
Vitamin B1 monophosphate chloride 532
Kinome
Effects of Triclosan on Neural Stem Cell Viability and Survival PMID 26759708
Butyl tetradecanoate 110
HuR promotes castration
8
JNJ
Top Publications Citing MCE Products
Muscone Ameliorates Synaptic Dysfunction and Cognitive Deficits in APP/PS1 Mice PMID 32538849
6
Effects of Shikonin on HIF
Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH
FCGRT
SHANK1 facilitates non
PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti
L
In vitro biological evaluation of new antimycobacterial salicylanilide
Tubacin 537049
Dibenzylfluorescein (DBF)
Identification and characterization of Sofosbuvir
Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy PMID 34676759
Selenomethionine Inhibits NF
Somatostatin 抗体 (YA4120)（Somatostatin Antibody (YA4120)）
The Tobacco β
Pseudolaric acid D 115028
LIM 域绑定 1（LDB1）基因
Age
POT
Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4
DC
(E,E,Z)
Profiling the chemical nature of anti
MT
BCMA72
Ivacaftor benzenesulfonate 1134822
Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus
Dose
Kaempferol
4
Vitamin D receptor agonists inhibit liver fibrosis by disrupting the interaction between hepatic stellate cells and neutrophil extracellular traps PMID 40571206
L
MEPicides α,β
MCE
Fingolimod as a potent anti
Sulfasalazine maintains blood
Meturedepa 1661
Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons PMID 40502172
In vivo self
The L
NBD
IL
Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues PMID 19243176
Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms PMID 25681130
Targeting MCL1 with Sanggenon C overcomes MCL1
RIP3 facilitates necroptosis through CaMKII and AIF after intracerebral hemorrhage in mice PMID 33540056
白细胞介素 12B（IL12B）基因
Red
2
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development PMID 33275901
2
Distinct Responses of Cystic Fibrosis Epithelial Cells to SARS
Antileukemic effect of caffeic acid 3,4
Triacetonamine
Gambogic acid induces apoptotic cell death in T98G glioma cells PMID 26631318
Long non
Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin PMID 10411944
Growth inhibition of pancreatic cancer by targeted delivery of gemcitabine via fucoidan
Acetaldehyde Induces Cytotoxicity via Triggering Mitochondrial Dysfunction and Overactive Mitophagy PMID 35438433
C14
Triacetonamine
Anti
Integrating analytical quality by design into bioanalytical method development an HPLC
Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation PMID 40240608
Extracellular vesicles from organoid
VDAC调节剂、基因
SIRT3 confers protection against acute pulmonary embolism by anti
Glutamate 1
Mixed bifunctionality. 4. Antitumor activity of alkylating derivatives of polycyclic aromatic hydrocarbons as a function of structure and of vehicle PMID 5007096
The systemic lupus erythematosus
Placental transfer of Letermovir & Maribavir in the ex vivo human cotyledon perfusion model. New perspectives for in utero treatment of congenital cytomegalovirus infection PMID 32353010
Anti
PF
Tetradecanoylcarnitine
Thalidomide
CNR1 Human Pre
Design, synthesis and pharmacological evaluation of novel substituted quinoline
Stachybotramide 149598
(20S)
Suppression of PFKFB3
trans
CKIP
Tetradecanoylcarnitine
STAT3 抗体 (YA666)（STAT3 Antibody (YA666)）
β
A modular mRNA platform for programmable induction of tumour
PRMT5
Alexa Fluor 430 NHS ester
The role of catecholamines, 5
Photodynamic therapy
Tetradecanoylcarnitine
Furazolidone 67
Maropitant 147116
Activation of BDNF by transcription factor Nrf2 contributes to antidepressant
Cloxyfonac 6386
Cholesterol Depletion by TASIN
The nicotinic agonist RJR
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition PMID 38492180
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity PMID 32724478
Combination of Vitamin C and Lenvatinib potentiates antitumor effects in hepatocellular carcinoma cells in vitro PMID 36718449
2,3
ATX
NBTGR 13153
mAChR
Glycocholic acid
Aprotinin, the first competitive protein inhibitor of NOS activity PMID 9705869
DR region of NKAα1 is a target to ameliorate hepatic lipid metabolism disturbance in obese mice PMID 37127227
P
Notch
Pharmacokinetics of low
The effects of increasing doses of MK
Aberrant JmjC domain
The Role of Interferon
Jian
Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells PMID 30217950
Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid
Rhoj Rat Pre
4
High
Activated MET is a molecular prognosticator and potential therapeutic target for malignant peripheral nerve sheath tumors PMID 21540237
Novel Insights from Comprehensive Bioinformatics Analysis Utilizing Large
Galactose
MG
Nervonyl methane sulfonate 51040
GSK3004774
ND
TCN1 Human Pre
DNA 甲基化
CNOT6/6L
Azetidine
Targeting Super
Sorafenib
FGFR
IL
Alphadolone 14107
HSP90/CDC37 inactivation promotes degradation of LKB1 protein to suppress AMPK signaling in bronchial epithelial cells exposed to sulfur mustard analog, 2
Integrated multi
Halogenation
Discovery of Soft
Lyso
CXCL13 promotes intestinal tumorigenesis through the activation of epithelial AKT signaling PMID 33894331
In vitro activity of cefepime/zidebactam and cefepime/taniborbactam against aztreonam/avibactam
TLQP
多巴胺
Development of a Second
Prostaglandins antinociceptive effect of prostaglandin E1 in the rat PMID 891040
VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival PMID 36971758
Ferroptosis and Lipid Peroxidation Participate in Valproic Acid
ECGS,Bovine
Design, synthesis and activity study of a novel PI3K degradation by hijacking VHL E3 ubiquitin ligase PMID 35344835
CPNE7 Regulates Amyloidogenesis Through CAP1
2
Chemical Space Expansion of Flavonoids Induction of Mitotic Inhibition by Replacing Ring B with a 10π
Echinatin alleviates sepsis severity through modulation of the NF
脱氨反应
PROTAC based STING degrader attenuates acute colitis by inhibiting macrophage M1 polarization and intestinal epithelial cells pyroptosis mediated by STING
Indicine 480
G3BP 抗体 (YA2432)（G3BP Antibody (YA2432)）
Anisodamine hydrochloride 131674
Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain PMID 24387280
1
Avasimibe A novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles PMID 29074218
Agmatine activation of nitric oxide synthase in endothelial cells PMID 9010916
Abnormal downregulation of 10
Integrative multi
FASN
Vistusertib 1009298
Nitric oxide regulates spindle dynamics to modulate the maturation of goat oocytes PMID 40460471
Falcarindiol 3
Gypenoside XVII Prevents Atherosclerosis by Attenuating Endothelial Apoptosis and Oxidative Stress Insight into the ERα
Fusaramin 2374906
Rhodomycin A, a novel Src
Osmotic Pressure Enables High
Ivabradine impurity 7
去乙酰化酶活性测定
Organelle
A novel cyclic GMP
Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca2+ Homeostasis PMID 39082833
Targeting the human parasite Leishmania donovani discovery of a new promising anti
Integrating 16S rDNA sequencing analysis and targeted metabolomics to explore the mechanism of Xiexin Tang in treating atherosclerosis mice induced by high
Calcium ionophore I 58801
MCE
LONP1 alleviates ageing
HSYA ameliorates venous thromboembolism by depleting the formation of TLR4/NF
Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers PMID 37452026
Mark2
Econazole
Induction of hepatic nodules in the rat by aristolochic acid PMID 8364902
Arachidonic acid enhances hepatocyte bile acid uptake and alleviates cholestatic liver disease by upregulating OATP1 expression PMID 39258405
Structural insights into the binding of nanobodies to the Staphylococcal enterotoxin B PMID 39029852
Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors PMID 35439688
Mechanism of Mettl14 regulating AIM2 inflammasome activation and neuronal apoptosis and pyroptosis in spinal cord injury by mediating PPARγ m6A methylation PMID 39400644
蛋白激酶 AMP 激活的非催化亚基 β 2（PRKAB2）基因
CAY 10462 dihydrochloride
Autotaxin Inhibition with PF
Integrin alpha 6 beta 4 蛋白, Human (HEK293, Flag
PRRSV promotes bacterial infection by remodeling actin cytoskeleton and cell membrane proteins PMID 40937850
Cefetamet hydrochloride 724438
YOD1 mediates isoproterenol
Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague PMID 28220110
Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility PMID 16254824
Blocking VEGF signaling augments interleukin
Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on D
Ionizable lipid1
Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells PMID 30765842
Profilin 2 and Endothelial Exosomal Profilin 2 Promote Angiogenesis and Myocardial Infarction Repair in Mice PMID 35479278
Epstein
Kir2.1
D
Pharmacodynamic study of the 7,8
Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane PMID 2632076
Cdc6 Mouse Pre
Array
Design, synthesis and anti
Rifamycin action on RNA polymerase in antibiotic
Discovery of a novel BCL
Propofol β
Pde12 Rat Pre
Lin28b
Diatrizoic acid (Standard) (Diatrizoate (Standard)，泛影酸 (标准品))
红景天甙
Nutrient availability regulates the secretion and function of immune cell
Synthesis of N
Translational findings for odronextamab From preclinical research to a first
Disruption of the FOXM1 Regulatory Region Inhibits Tumor Progression in Ovarian Cancer by CRISPR
Oxidized DNA fragments exit mitochondria via mPTP
The angiopoietin
Thalidomide
Discovery of Thieno[2,3
Ricasetron 117086
5
Heptaplatin 146665
Oncogenic fusions converge on shared mechanisms in initiating astroblastoma PMID 40369078
Decoding ligand recognition and constitutive activation of histamine H3 and H4 receptors PMID 40877594
The Effect of JAK Inhibitor Tofacitinib on Chondrocyte Autophagy PMID 37310645
蛋白激酶 cGMP 依赖性 1（PRKG1）基因
基质金属肽酶 13（Mmp13）基因
Epstein
Classification and pharmacology of progestins PMID 19434889
Synthesis and structure
In vitro and in vivo comparative toxicological study of a new preservative
NEB Human Pre
Amylin Receptor
Castor oil, hydrogenated, polyethoxylated
Tudor
Binary Colloidal Crystals Promote Cardiac Differentiation of Human Pluripotent Stem Cells via Nuclear Accumulation of SETDB1 PMID 36655945
cell repair
Generation and characterization of a stable cell line persistently replicating and secreting the human hepatitis delta virus PMID 31292511
Cnr1 Rat Pre
BIBF
白介素 1 β（IL1B）基因
Chicken interferon
Synthesis and biological studies of new piperidino
NH2
Toosendanin, a novel potent vacuolar
MAP2K7
Betulinaldehyde exhibits effective anti
Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway PMID 32199935
Integrative bulk RNA analysis unveils immune evasion mechanisms and predictive biomarkers of osimertinib resistance in non
HCC827 cells
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C PMID 1874734
Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa PMID 35320716
PAR
Improved Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents Targeting 3C and 3CL Proteases Including SARS
SARS
Design and development of a stable polyherbal formulation based on the results of compatibility studies PMID 21772756
Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3
Pde4dip
β
Schisandrin A Alleviates Inflammation and Oxidative Stress in Aβ25
nNOS
Lercanidipine hydrochloride 132866
Naftalofos 1491
Fosmidomycin sodium salt 66508
Inhibition of methotrexate
Isomer
ISIS 626112 2091995
CCL21
Secondary Metabolites from the Leaves of Digitalis viridiflora PMID 30549826
SK&F 86002 a structurally novel anti
SC 51089 free base
(S,R,S)
GSK
NLRP3 蛋白, Human (GST)
Neb Mouse Pre
CDK7
SPNS2 promotes the malignancy of colorectal cancer cells via regulating Akt and ERK pathway PMID 31206801
BEPP hydrochloride 455311
DNSAH
5
Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue PMID 16279790
Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines PMID 10501630
Involvement of M2 macrophages polarization in PM2.5
Inhibition of Ephrin B2 Reverse Signaling Suppresses Multiple Myeloma Pathogenesis PMID 38231476
普罗雌醚(Standard)
Dimethyl sulfoxide vitrification agent
Epigenetic Regulation of DAPK1 and Netrin
4
Zarzissine, a new cytotoxic guanidine alkaloid from the Mediterranean sponge Anchinoe paupertas PMID 7807130
Methyl ((benzyloxy)carbonyl)
Sulfanitran
Desethyl Amiodarone
Deciphering the Metabolic Basis and Molecular Circuitry of the Warburg Paradox in Lymphoma PMID 39518046
Attenuation of virulence in pathogenic bacteria using synthetic quorum
P
4& 039;
Enhancing CRISPR deletion via pharmacological delay of DNA
Lonafarnib 193275
CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer Determinants of Response and Synergy with EGFR Inhibition PMID 32155786
肌动蛋白相关蛋白 1B（ACTR1B）基因
Nicotinamide improves in vitro lens regeneration in a mouse capsular bag model PMID 35550648
A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats PMID 20159859
Expression of miRNA
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation PMID 38147543
(2E,7Z,10Z)
Synthesis and biological evaluation of 1
Amyloid
ODN 24991
Microbial metabolite indole
Cuminaldehyde
Sulfo Cy5.5
Prdx2 Rat Pre
Sodium Acetate
Cross
Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells PMID 28003763
Alpha
Discovery of Novel Ortho
Oxaceprol (N
Reprogrammed IDO
SIGIRR 蛋白, Human (HEK293, His)
Thiazolidinedione Magic Bullets Simultaneously Targeting PPARγ and HDACs Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects PMID 34006099
溶酶体相关膜蛋白家族成员 5（LAMP5）基因
Central cholinergic antinociception induced by 5HT4 agonists BIMU 1 and BIMU 8 PMID 8649219
ent
calcium channel inhibitor
Ertugliflozin attenuates atherosclerosis in nondiabetic ApoE
Azetidine
Probucol as a potent inhibitor of oxygen radical
水黄皮提取物 (Derris indica)
The single
SR
CXCL4 and CXCL4L1 in cancer PMID 29903575
SH3GLB1 Human Pre
咔唑生物碱类化合物 (Carbazole Alkaloids)
SOS1
Detection of matrix metalloproteinase active forms in complex proteomes evaluation of affinity versus photoaffinity capture PMID 19271733
3′,6
Possible Clinical Effects of Ketoconazole on Sorafenib
Epigenetic Remodeling Hydrogel Patches for Multidrug
A skin organoid
UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer PMID 35551175
Melatonin
Racetrack FAIMS for High
Aplyronine C 151923
S
PROTAC
Gut Microbiota
Crucial Role of 3
Optimization of cellular activity of G9a inhibitors 7
A Prion
N6
PSMD6 Human Pre
Tocainide 41708
细胞周期蛋白依赖性激酶 15（CDK15）基因
Association between KRAS and PIK3CA Mutations and Progesterone Resistance in Endometriotic Epithelial Cell Line PMID 38666954
Cyclo(L
Cell
Discovery of precision targeting EZH2 degraders for triple
Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir PMID 12878501
2
Ac
CDKN2A Human Pre
Formulation of simvastatin within high density lipoprotein enables potent tumour radiosensitisation PMID 35447296
Palmitoleic acid induces the cardiac mitochondrial membrane permeability transition despite the presence of L
TRITC (5(6)
Tanshinone IIA 568
Reactive oxygen species induced
Identification of CKD
Dmac1 Rat Pre
Shz 1
Orsellinic acid (Standard) (苔色酸 (Standard))
complement C3
Graphdiyne oxide nanosheets display selective anti
Hpse Rat Pre
Discovery and validation of a new class of small molecule Toll
GDC
UK
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