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Synthesis and structure
β
Broad Anti
Yellow Wine Polyphenolic Compound Protects Against Doxorubicin
Transcription control by the ENL YEATS domain in acute leukaemia PMID 28241139
PROTAC Hsp90α degrader 1
Discovery of Imidazoquinolines with Toll
FTO inhibition represses B
A compact, versatile drug
C3a receptor agonist 1
Halofuginone enhances the chemo
2
Hexacosanoic acid (Standard) (蜡酸 (Standard))
AN100226
Design, synthesis and biological evaluation of 2
Methylzedoarondiol 108944
Tiracizine hydrochloride 78816
Ganglioside GM1 (bovine) ammonium
N
Anti
(
Anti
β
Aristolochic acid D (Standard) (Aristolochic acid
Guinea pig Immunoglobulin G (豚鼠免疫球蛋白G)
TMTHSI succinimide NHS ester
clearance
Bis(2
Bis(2
Anti
GSK894490A 1012035
11(Z),14(Z),17(Z)
Eclutatug 2922054
Esaxerenone 1632006
Abazistobart 3002062
Izeltabart 2642078
5′
Lyso
NSC707545
Pharmacology of novel small
ATTECs
The membrane
SR
Trypsin
SID
NS1 蛋白, Dengue virus 1 (HEK293, His)
Animal
Benzamidine hydrochloride (苄脒盐酸盐)
1
Fipronil sulfone (Standard)
Cytotoxic effects of targeted agent alone or with chemotherapy in the treatment of adenoid cystic carcinoma a preclinical study PMID 35705678
D
Impaired AT2 to AT1 cell transition in PM2.5
Male Swiss Webster mice
Inhibitory effect of the human liver
Exploring the Therapeutic Mechanism of Desmodium styracifolium on Oxalate Crystal
PRL
Z55660043 865271
YF135 2913177
Stamulumab (MYO
(R)
DNAM
MALT1 small molecule inhibitors specifically suppress ABC
ASR
KRP
Monitoring T
Temperature
Trimethyllysine
Q94 hydrochloride 1052076
GLP
Rezvilutamide 1572045
ALG
Ruxoprubart 2842046
E3 Ligase Ligand
DNAM
Platycodin D reduces PD
HEMADO 403842
Mono
The cytotoxicity of karanjin toward breast cancer cells is involved in the PI3K/Akt signaling pathway PMID 36065628
Heteroclitin D
Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors PMID 18942827
BW
Dual action Smac mimetics
QL 47
CC 基序趋化因子配体 20（CCL20）基因
Kdm6a Mouse Pre
Biotin
JAK2
Targeted temperature management alleviates post
Sanguisorba officinalis L. and Sophora japonica L. Inhibit Angiogenesis in Ulcerative Colitis PMID 40518692
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity PMID 38016475
Ophthalmic adverse effects of nasal decongestants on an experimental rat model PMID 29538595
Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain PMID 24518550
BMS
Excellent effects and possible mechanisms of action of a new antibody
Post
Belantamab mafodotin
CD3E
RIP1
KW
1
1
Hepatitis b virus pre
FCGRT
cis
PF
Methyltetrazine
Carbonic anhydrase inhibitor 10
Isobiflorin 152041
Sontuzumab 372075
Octacosamicin A 122005
SPINK2 蛋白, Human (HEK293, Fc)
Assessment of the cytotoxicity and genotoxicity of homosalate in MCF
SW157765 332063
10
Lactobacillus amylovorus extracellular vesicles mitigate mammary gland ferroptosis via the gut
2,6
MRS1334 192053
Ramosetron 132036
Bicyclopyrone 352010
Hydroxyakalone 182056
Identification of broad anti
Atesidorsen 872063
Saredutant 142001
2
KISS1
Bile acids
Betaprone
Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis PMID 33675785
Petromyzonol (5α
Cyclobutyrol sodium (BRN
Betazole (Standard) (Ametazole (Standard))
CAY10580
Fexarene
Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging PMID 40593722
Cyclobutyrol (BRN
Glycolithocholic acid (Lithocholylglycine)
Cholic acid 3
Framycetin sulfate (Standard) (Neomycin B sulfate (Standard)，新霉素B硫酸盐 (Standard))
Betazole (Ametazole)
Diphenyl phthalate (Standard)
meso
Pefloxacin mesylate (Standard) (Pefloxacinium mesylate (Standard)，甲磺酸培氟沙星 (Standard))
7
Potassium hydrogen phthalate
Progesterone carboxylic acid (Etienic acid)
7
Iloperidone carboxylic acid (P95
Nordeoxycholic acid (Standard) (3α,12α
ALizarin complexone dihydrate (茜素氨羧络合剂二水合物)
Y
(±)
Proteinase, Aspergillus oryzae (蛋白酶)
Desmethyl Erlotinib (Standard) (OSI
Dehydroacetic acid (Standard) (Biocide 470F (Standard)，脱氢乙酸 (Standard))
Benzoxonium chloride (Standard)
Alizarin complexone (Standard)
Hydrocinnamic acid (Standard) (3
Salmeterol xinafoate (Standard) (GR 33343X xinafoate (Standard)，沙美特罗昔萘酸酯 (Standard))
KDM6A Human Pre
Tiopronin (硫普罗宁)
Prenylamine lactate (Standard)
Cdk12 Rat Pre
Mebhydrolin napadisylate (Mebhydroline 1,5
Bacterial toxins induce non
The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression PMID 15820413
2,4,6
Cancer immunotherapy
BI
Fenmetozole hydrochloride
Trypsin inhibitor DE
Proteinase 3 (PR3), Human Neutrophil (蛋白酶3（PR3），人中性粒细胞)
(8R,9S)
FK706
N
NKG2A
4,5
2,6
D
Umeclidinium bromide (Standard) (GSK573719A (Standard)，芜地溴铵(Standard))
Tolterodine tartrate (Standard) (Kabi
Acute Administration of Lactate Exerts Antidepressant
Clocapramine dihydrochloride hydrate 60789
Procyanidin B1 20315
GAT229
Zilvetrigine 3002072
Crebinostat 1092061
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway PMID 31678170
Deficiency of Rab26 causes behavioral defects in mice through impaired trafficking of serotonin (5
UBE4B promotes gastric cancer proliferation and metastasis by mediating FAT4 ubiquitination and degradation PMID 40701960
Isariin B 80111
Suc
DA
Aberrant acetylation caused by a CDYL splicing mutation contributes to thin mid
D
4
6
Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma PMID 34315493
Glucagon (1
Futoenone
CRM1 degrader 1 2986647
NSUN5/TET2
Membrane Cofactor Protein/CD46
Analysis of Lysosomal pH by Flow Cytometry Using FITC
Drp
AS601245 TFA
p53
Pore
MAP2K6 抗体 (YA4968)（MAP2K6 Antibody (YA4968)）
Tur1A
Protective effects of glycycoumarin and procyanidin B1, active components of traditional Japanese medicine yokukansan, on amyloid β oligomer
Sucrose phosphorylase (SP，蔗糖转葡糖基酶)
3,3'
PLH1215 1332084
Abeta
Growth Hormone Signaling Pathway Leading to the Induction of DNA Synthesis and Proliferation in Primary Cultured Hepatocytes of Adult Rats PMID 33434118
IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting Netrin
Cytotoxic and antimalarial beta
NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization PMID 40883305
High expression of RUNX1 in colorectal cancer subtype accelerates malignancy by inhibiting HMGCR PMID 38971271
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway PMID 35906830
2
decapeptide hormone
STAT2 抗体 (YA5874)（STAT2 Antibody (YA5874)）
FAZ
Novel derivatives of deoxycholic acid bearing aliphatic or cyclic diamine moieties at the C
In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones PMID 14737001
Robigenin
Highly Oxidized Guaianolide Sesquiterpenoids with Potential Anti
Gamma
CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability PMID 37340423
11
Discovery of an Orally Bioavailable Reversible Covalent SARS
Nanobubble
Drp
Top Publications Citing MCE Products
Robigenin
Tissue stiffness controls neuroblast migratory behavior and reprogramming during myelin repair PMID 40837231
decapeptide hormone
Abeta
Mecasermin 68562
Influenza A virus (H1N1) triggers a hypoxic response by stabilizing hypoxia
Swertiajaponin 6980
A non
Ac
MDX
Necrosulfonamide 1360614
6
Arctigenin inhibits proliferation of ER
Investigation of substance P transport across the blood
Highly purified Type V collagen, from human amnion (Human Amnion Type V collagen, immunization grade)
6
ARL67156 160928
MDX
drug resistant
5
Microwave
Pterosin B 34175
Trimetrexate 52128
VEGFR
Kevetrin induces apoptosis in TP53 wild‑type and mutant acute myeloid leukemia cells PMID 32945487
Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita PMID 30010341
1
IL
v
Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti
3,4
MLS000532223 16616
Luteolin 491
marine toxin
Anti
Mitochondria
MCE
Tubulin inhibitor 12
PDGF R beta 蛋白, Canine (HEK293, His)
Tetrahydrorhombifoline 3382
Enantioselective syntheses of potent retinoid X receptor ligands differential biological activities of individual antipodes PMID 11428923
胆囊收缩素 A 受体（CCKAR）基因
A transition state analogue for an RNA
type 2 diabetes mellitus
Glychionide A
Wf
marine toxin
Characteristics of substance P transport across the blood
SC 4642
Anti
(S)
Tubeimoside
CCL17 drives fibroblast activation in the progression of pulmonary fibrosis by enhancing the TGF
Thioaryl naphthylmethanone oxime ether analogs as novel anticancer agents PMID 25198997
EC23 104561
IL17RA Human Pre
A UPLC/MS
Anti
4
YM
3
Discovery of DCAF16 Binders for Targeted Protein Degradation PMID 39882752
Mechanism of mitofusin 2, mitochondria
Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus PMID 2153254
TNF
Anti
GSK2239633A
XmAb
QSSP
FasL/CD178
Valerylcarnitine
i
NOTCH1 蛋白, Human (HEK293, His
4
Glychionide A
type 2 diabetes mellitus
3
Valerylcarnitine
3
SC 4642
RSV
Nobiletin Triggers Reactive Oxygen Species
Interleukin
去氢胆酸钠
4
i
ent
Gold(III) chloride trihydrate (Chloroauric acid trihydrate，四氯金酸三水合物)
3
R
Valerylcarnitine
CpG
Tubulin Inhibitor
Antithrombin III, human plasma (抗凝血酶III, 来源于人类血浆)
4
JNJ
Patulin Induces Acute Kidney Injury in Mice through Autophagy
Synthesis and evaluation of novel thiosemicarbazone and semicarbazone analogs with both anti
i
去氢胆酸钠
The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists PMID 24204944
鼠尾蚤草提取物 (Pulicaria salviifolia Bunge)
IL
LYA914
Steroidal constituents from the leaves of Hosta longipes and their inhibitory effects on nitric oxide production PMID 23411079
2
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF
Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta
Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti
Ins(1,2,6)
High
Design, synthesis, and evaluation of tricyclic compounds containing phenyl
MicroRNA
Tetrahydrocorticosterone 68
GD3 ganglioside directly targets mitochondria in a bcl
DYRK1
Idarubicin combats abiraterone and enzalutamide resistance in prostate cells via targeting XPA protein PMID 36509750
Acox1 Rat Pre
KGP591
Novel Pyrazole
Mucin化学品、基因
APETx2
Mt3 Rat Pre
Nitric Oxide Inhibitory Activity and Absolute Configurations of Arylalkenyl α,β
Amide derivatives of Gallic acid Design, synthesis and evaluation of inhibitory activities against in vitro α
The host protein CALCOCO2 interacts with bovine viral diarrhoea virus Npro, inhibiting type I interferon production and thereby promoting viral replication PMID 38047736
Approaches for the preparation of non
Nucleus
New SIRT2 inhibitors Histidine
ApoA
酪氨酸 3
Fluorescent Substrate for Glu
CTLA
CTPI
Multi
Palmitic acid
(5S)
Pharmacokinetics and metabolism of H3B
Valepotriates, a new class of cytotoxic and antitumor agents PMID 7232547
Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T
Sibiromycin 12684
Amino Acid Derivatives
Anti
帕唑帕尼盐酸盐
Endosidin 2 accelerates PIN2 endocytosis and disturbs intracellular trafficking of PIN2, PIN3, and PIN4 but not of SYT1 PMID 32790800
Neolignans from Piper kadsura and their anti
Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2
IL
Fipronil sulfone
Il17ra Rat Pre
The function role of ubiquitin proteasome pathway in the ER stress
SPINK1 蛋白, Mouse (P.pastoris, His)
P
aPKC
Propargyl
Scaffold hopping approach towards various AFQ
NOTCH1 蛋白, Human (Biotinylated, HEK293, His
Flavonoid glycosides from the leaves of Allium victorialis var. platyphyllum and their anti
Identification of FDA
Quinolinic acid
Decanoyl
The activity of grepafloxacin in two murine models of Mycobacterium avium infection PMID 15290460
S
Natural product sennoside B disrupts liquid
Pictilisib (Standard)
Robigenin
Synthesis and evaluation of potent novel inhibitors of human sulfide quinone oxidoreductase PMID 34763081
Macrocyclization of Quinazoline
Hexacosanoic acid
Proglumide hemicalcium 85068
(S)
碳酸酐酶 7 (Carbonic Anhydrase 7 (CA
Amodiaquine
A novel partial agonist of the A(1)
D
续断菊提取物 (Sonchus asper (L.) Hill)
Ethoxzolamide 452
Novel protein kinase C phosphorylated kinase inhibitor
Anti
EP2 receptor antagonist
(Val3,Pro8)
The mechanisms of mitochondrial dysfunction and glucose intake decrease induced by Microcystin
Mesoxalate sodium (monohydrate) 31635
JOE
Undecan
6,7
Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple
(R,R)
Aerobactin
1
Sphingomyelinase activity associated with human plasma low density lipoprotein PMID 10828058
House dust mite extract, from D.pteronyssinus (biotinylated)
Tiagabine
Synthesis, structure, and cytotoxicity studies of some fungal isochromanes PMID 24033077
IRF5
Fenbendazole sulfone (Oxfendazole sulfone)
Benzamidine
MCE
Two polymorphic forms of the oxathiin systemic fungicide active carboxine PMID 30574366
Synthesis and structure
Ferroptosis sensitization in glioma exploring the regulatory mechanism of SOAT1 and its therapeutic implications PMID 37980334
METTL3
Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1 PMID 37156267
The histone methyltransferase G9a a new therapeutic target in biliary tract cancer PMID 29133140
LGD
Dibenzocyclooctadiene lignans from Schisandra lancifolia and their anti
Generation of allo
HGFR 蛋白, Human (HEK293, His)
Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation PMID 25934288
Ras
Microbiome metabolism of dietary phytochemicals controls the anticancer activity of PI3K inhibitors PMID 40393457
mmu
RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation PMID 32908202
CTLA
Discovery of 2,4
KYP
Antioxidant activities and lipid lowering effects of isoflavone in male rabbits PMID 15234080
Angiopoietin
Apelin
Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model PMID 27275096
4,7
非小细胞肺癌
Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway PMID 34643248
Acetyltrypsin, Bovine pancreas (乙酰化胰蛋白酶，来源于牛胰腺)
Development of Small Molecule MEIS Inhibitors that modulate HSC activity PMID 32409701
Anti
2,3,4,5
Chlorogenic Acid Alleviates Hyperglycemia
Structure and permeation mechanism of a mammalian urea transporter PMID 22733730
Sirtratumab vedotin (AGS15E)
Sunobinop 1126793
Identification of aurintricarboxylic acid as a potent allosteric antagonist of P2X1 and P2X3 receptors PMID 31461640
Discovery of 3,5
BKN
MCE
Discovery and characterization of a novel non
Aging
神经调节蛋白 4（NRG4）基因
Pyrvinium embonate
Enantiospecific synthesis of genetically encodable fluorescent unnatural amino acid L
Activation of aryl hydrocarbon receptor ameliorates rosacea
Highly purified Type IX collagen, from chick articular cartilage (Chick Type IX collagen, immunization grade)
pVHL promotes lysosomal degradation of YAP in lung adenocarcinoma PMID 33823241
VY
Anti
Trimetazidine enhances myocardial angiogenesis in pressure overload
Prnp
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis PMID 39079536
HDAC2
Torkinib (Standard) (PP 242 (Standard))
Probing the ligand binding sites of fatty acid and sterol carrier proteins effects of ethanol PMID 7547928
Chlorpromazine affects autophagy in association with altered Rag GTPase
HBx regulates fatty acid oxidation to promote hepatocellular carcinoma survival during metabolic stress PMID 26744319
IAJD93 3076338
细胞周期蛋白依赖性激酶 16（Cdk16）基因
MIIP inhibits the growth of prostate cancer via interaction with PP1α and negative modulation of AKT signaling PMID 31092266
Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test PMID 18676086
Targeting Intratumoral Copper Inhibits Tumor Progression via p62
Capivasertib 1143532
ISP1
Az
Erythropoietin/EPO 蛋白, Pig (P.pastoris, His)
Cycloposine 23185
INSCoV
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