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The involvement of branched
SNIPERs
Tetrazine
GW2580
MGAT1
Discovery of the First
Chemical genetics of Plasmodium falciparum PMID 20485428
Effects of IY
Antibacterial agent 81
organ dysfunction
Fire Acupuncture Combined with Pulse Radiofrequency Relieves Tactile Allodynia in Rats with Postherpetic Neuralgia PMID 40994884
ZLN005 Reduces Neuroinflammation and Improves Mitochondrial Function in Mice with Perioperative Neurocognitive Disorders PMID 39525311
Carbonic Anhydrase 7 蛋白, Human (His)
Activation of ventral tegmental area vesicular GABA transporter (Vgat) neurons alleviates social defeat stress
APX879 1801372
RH01617
(Lys(Me,Me)27)
CD8 beta 蛋白, Human (HEK293, Fc)
IL
Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome
WAL 2014
EN 141
3
IL
CD117/c
PRMT5
IL
TrkA 蛋白, Human (HEK293, His)
DS
Polygonatum sibiricum polysaccharides play anti
CD300LB 蛋白, Human (HEK293, hFc)
cardiomyopathy
A fibrin gel
MMP
DOPE
2
Bepotastine besilate (苯磺酸贝托司汀)
U
Fipronil sulfone
Effects of herbicide chlorimuron
Design, synthesis and evaluation of 4
Carbonic Anhydrase 9 蛋白, Canine (HEK293, hFc)
IDH1 蛋白, Human (R132H, His)
MCE
3
SP4f
Risperidone 106266
MiR
sPLA2
astrocytic glioblastoma cell
cGMP
Thioquinapiperifil dihydrochloride (KF31327)
BMS
TAF1C 抗体 (YA2139)（TAF1C Antibody (YA2139)）
ZEP
GW 590735 sodium
Alcohol
RLLFT
mce
Clionamine B
Cathepsin D 蛋白, Mouse (HEK293, His)
Biotinylated CCDC61 peptide TFA (CAPture peptide, biotin
绿麦隆
Epitinib succinate (HMPL
VISTA/B7
Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response
Sulfo
双氢速甾醇 (Standard)
Targeting the E3 ligase NEDD4 as a novel therapeutic strategy for IGF1 signal pathway
Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS
PCNA 蛋白, Human (sf9, His)
裂叶蒲葵提取物 (Livistona decipiens Becc.)
5
Amabiloside
Characterization of five novel vasopressin V2 receptor mutants causing nephrogenic diabetes insipidus reveals a role of tolvaptan for M272R
3BP
M
Melatonin Offers Dual
Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists novel analogues of 4
Red Blood Cell 2,3
Late
CD117/c
IL
FITC
A series of alpha
印度地肤提取物 (Bassia indica (Wight) A.J.Scott)
Re
KAI
Lignoceryl alcohol (Standard) (1
Eng Rat Pre
GluN2A
Ganosporeric acid A
hypoxia
COG2 Human Pre
Sp1 S
Macrocyclic compounds as anti
Pildralazine 64000
Aureothricin 574
Late
CL
hypoxia
KAI
双氢速甾醇 (Standard)
Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR PMID 32927392
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation Comparison of Bromodomain and Extra
CDA
Cytochalasin H
5
Design, synthesis, and biological evaluation of novel water
标准误
3
磷酸甘油酸变位酶 1（PGAM1）基因
Aristolochic acid
Ganodermanondiol (灵芝酮二醇)
Decanoic acid, 2
Calophyllum lanigerum Miq.提取物 (Calophyllum lanigerum Miq.)
SCTA
Overview of piperlongumine analogues and their therapeutic potential PMID 33930801
GMP IL
AUY 954 hydrochloride 820240
CADM3 蛋白, Human (HEK293, His)
BCN
Comprehensive Analyses Reveal Effects on Tumor Immune Infiltration and Immunotherapy Response of APOBEC Mutagenesis and Its Molecular Mechanisms in Esophageal Squamous Cell Carcinoma PMID 37215984
CAMK2B Human Pre
Sutezolid 168828
Paricalcitol 131918
BCMA/TNFRSF17 蛋白, Human (Biotinylated, HEK293, His
Ac
Gastric cancer cell
MGCD
CDC123 抗体 (YA2773)（CDC123 Antibody (YA2773)）
CAMK2G Human Pre
NCOA1 Human Pre
Poly(styrenyl acetal trehalose) (pSAT)
CAMK2D Human Pre
ENG Human Pre
硬脂肪酸
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation PMID 33168089
C1QB Human Pre
KRAS mutations promote the intratumoral colonization of enterotoxigenic bacteroides fragilis in colorectal cancer through the regulation of the miRNA3655/SURF6/IRF7/IFNβ axis PMID 39523457
共济失调蛋白 3（ATXN3）基因
SLN 360
C1QBP Human Pre
HR
Synthesis of functionalized new conjugates of batracylin with tuftsin/retro
Didrovaltrate 18296
NSC 354961
Tiglyl Glycine
UNC0638 hydrate
NCX4040 (Standard) (NO
Opakalim (BHV
Antroquinonol 1010081
BX795
AZD0530
Role of hypoxia
IL
Neuronal Na+ Channels Are Integral Components of Pro
8
AZD
chemical probe
PE
AQW 051
PF
VISTA/B7
1
Targeting KRAS Mutant Cancers via Combination Treatment Discovery of a 5
Flurandrenolone Acetate 2802
Antibacterial activity of components from Lomatium californicum PMID 16444670
IL
CAMK2N2 Human Pre
Sarafloxacin
6
Adapalene inhibits ovarian cancer ES
Perphenazine
超分辨率显微镜
GPR65激动剂、基因
DU145 cells
SMARCA4 loss increases RNA Polymerase II pausing and elevates R
ATP
Baicalin relieves hypoxia
cognitive
Novel 4
IL
VISTA/B7
Imepitoin 188116
BSc5371
Kielmeyera variabilis Mart. & Zucc.提取物 (Kielmeyera variabilis Mart. & Zucc.)
PDGF
digitoxigenin
4
P388
Evaluation of pentitol metabolism in mammalian tissues provides new insight into disorders of human sugar metabolism PMID 15234337
Etofenamate
Ceratotoxin 2
FGFR
7
Determination of enantiomeric purity of a novel COX
NOD/SCID
PDGF R alpha 蛋白, Human (HEK293, His
KV4.3/KChiP2
GCN2 activator
Exploring the mechanism of blindness physiopathy in Brassica oleracea var italica L. by comprehensive transcriptomics and metabolomics analysis PMID 38159550
Anti
Synthesis and biological evaluation of new substituted thioglycolurils, their analogues and derivatives PMID 28923382
皱叶酸模提取物 (Rumex crispus Linn.)
(Rac)
Sartorypyrone A (20
PET hydrolase 蛋白, Thermobifida cellulosilytica (His, Strep)
4,7
Phthalic acid bis(3,7
NC762
APRIL/TNFSF13 Trimer 蛋白, Human (HEK293, Flag
Effects of dietary gamma
Ingol 7,8,12
USP29 蛋白, Human (sf9, FLAG)
IL
Identifying the target, mechanism, and agonist of α
Cytotoxic effects of etephon and maleic hydrazide in Vero, Hep2, HepG2 cells PMID 24495230
Discovery of kinase spectrum selective macrocycle (16E)
IL
OSI
Diacerein 13739
PRNP/CD230 蛋白, Human (HEK293, Fc, solution)
CART (61
扑热息痛
Porphyra 334
Design, synthesis of novel triptolide
同位素标记维生素 (Isotope
2
P
Tyro3 upregulation is associated with muscle involvement in patients with idiopathic inflammatory myopathies PMID 40958037
Identification of lncRNA
IL
11
Anti
Protein kinase inhibitor 6 348
TrkA 蛋白, Rat (HEK293, His)
Thrombopoietin Receptor
LAMP2 抗体 (YA713)（LAMP2 Antibody (YA713)）
SQ
K 237
Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC
Coppersensor 1
IL
RWJ
Exosomal miR
3,5
2
N
Dihydropedicin (瓜馥木甲素B酮)
(Rac)
Fmoc
MT 201
Cholestenone
L
N
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer PMID 16078855
Pde3a Mouse Pre
GLP1R 蛋白, Human (HEK293, His)
IL
1
Camk2b Rat Pre
IL
IL
Pde1c Mouse Pre
C1qa Mouse Pre
3’
Camk2a Rat Pre
(S)
C1qbp Mouse Pre
PDE6C Human Pre
PDE1B Human Pre
LL
PDE1C Human Pre
PDE6H Human Pre
Camk1 Mouse Pre
Plk1 Mouse Pre
PDE4C Human Pre
p32 Inhibitor M36 (M36)
PDE4D Human Pre
PDE3A Human Pre
PDE7B Human Pre
C1qb Mouse Pre
Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague
Gba
C1qc Mouse Pre
CAMK2G Rat Pre
Pde6c Mouse Pre
LXR agonist 2
Pde4d Mouse Pre
Camk4 Mouse Pre
GBA3 Human Pre
C1RL Human Pre
Pde1b Mouse Pre
C1QL1 Human Pre
Synthesis and evaluation of 2
C1qtnf1 Rat Pre
Rivulariapeptolides 1185
Rivulariapeptolides 1121
Piperidine
DC
CDC123 抗体 (YA4650)（CDC123 Antibody (YA4650)）
L
Jujubasaponin VI
Intra
1,2
(R)
Rivulariapeptolides 1155
FR122047
TrkB 蛋白, Canine (HEK293, Fc)
PVR/CD155 蛋白, Human (HEK293, His
IL
Ro 22
Products
Gly
IL
TRAIL/TNFSF10 蛋白, Human (HEK293, Fc)
serB2 蛋白, Mycobacterium tuberculosis
Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma PMID 35801592
Tubulin/AKT1
N
RNA G
FAM83D promotes epithelial
5
Rofapitide tetraxetan acetate (FAP
Direct effect of cortistatin on GH release from cultured pituitary cells in the rat PMID 16648801
Mitochondrial Metabolism
E3 Ligase Ligand
In vitro and in silico study of the synergistic anticancer effect of alpinumisoflavone with gemcitabine on pancreatic ductal adenocarcinoma through suppression of ribonucleotide reductase subunit
VU591 hydrochloride
A non
PX5–9
Discovery of 6
Frizzled
ZEB85
Visfatin
Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2
Sele Rat Pre
Δ2,3
Locust bean gum, from Ceratonia siliqua seeds 9000
Molecular mechanism of drug inhibition of URAT1 PMID 40670375
VISTA/B7
1,3
mechanical stress
Development of novel human lactate dehydrogenase A inhibitors High
The potential role of acrolein in plant ferroptosis
Rewiring endogenous genes in CAR T cells for tumour
Fine
CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus PMID 31857346
β
28
CDK7 inhibitor THZ1 inhibits MCL1 synthesis and drives cholangiocarcinoma apoptosis in combination with BCL2/BCL
白蛋白（ALB）基因
Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist PMID 30711833
Assessment of standardization of domestic commercial black garlic extract for S
IFN
Eng Mouse Pre
Valganciclovir hydrochloride 175865
Fc 受体
Methyl benzyl
DAB tetrahydrochloride hydrate 868272
amino
DNA Alkylator/Crosslinker
TRB3 interacts with ERK and JNK and contributes to the proliferation, apoptosis, and migration of lung adenocarcinoma cells PMID 31256425
IL
癌胚抗原相关细胞粘附分子 8 (CEACAM8/NCA
VEGFR
Physapubescin, a natural withanolide as a kidney
2,6
VX689
MEK1/2 promote ROS production and deubiquitinate NLRP3 independent of ERK1/2 during NLRP3 inflammasome activation PMID 39396647
Bisphenol A an endocrine disruptor with widespread exposure and multiple effects PMID 21605673
Tat
RC
U2af2 Mouse Pre
2,6
TrkA 蛋白, Canine (HEK293, His)
In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4
Cryo
GSK1838705A 1116235
Benzo[a]pyrene diol epoxide
Purine metabolites promote ectopic new bone formation in ankylosing spondylitis PMID 36774858
Parbendazole 14255
半胱天冬酶 14（CASP14）基因
Nuclear m6A modification regulates satellite transcription and chromosome segregation PMID 40404899
USP15 inhibits hypoxia
粘附 G 蛋白偶联受体 E5（ADGRE5）基因
Safety evaluation of tirofiban PMID 20670206
CDC7 抗体 (YA1152)（CDC7 Antibody (YA1152)）
TH
Leptin aggravates house dust mite
Photon and Proton irradiation in Patient
AAV
Porcine epidemic diarrhea coronavirus infection activates caspase
AHR activation relieves deoxynivalenol
FGIN
Yes
mTOR降解剂、基因
The APPL1
Tripartite motif 25 ameliorates doxorubicin
Constructing a better binding peptide for drug delivery targeting the interleukin
NLRP12/C1qA positive feedback in tumor
estrogen
An HD
Cdx1b protects intestinal cell fate by repressing signaling networks for liver specification PMID 36460297
Long noncoding RNA MCM3AP
SZL P1
台湾哥纳香提取物 (Goniothalamus amuyon (Bl.) Merr.)
TrkB 蛋白, Rat (HEK293, His, solution)
The effect of fenugreek 4
LHC
DC
A novel lncRNA ROPM
Enhanced autophagy alleviated corneal allograft rejection via inhibiting NLRP3 inflammasome activity PMID 35092164
西利单抗
Nafimidone 64212
Chloroethene (polymer) (Standard) (Polyvinyl chloride (Standard))
(Rac)
Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile PMID 8229016
New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae PMID 23022281
PEDF/Serpin F1 蛋白, Human (HEK293, His)
FGFR
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding PMID 36947620
4
Alpha
Quercetin 3
Top Publications Citing MCE Products
DDC 蛋白, Human (Sf9, His)
Ro 67
Late
Cytotoxic and apoptosis
PC4/SUB1 蛋白, Human (His)
Lysine Deacetylase Inhibitors in Parasites Past, Present, and Future Perspectives PMID 28241112
Nitrogen recycling from the xylem in rice leaves dependence upon metabolism and associated changes in xylem hydraulics PMID 27053722
Carbamoyl phosphate synthetase an amazing biochemical odyssey from substrate to product PMID 11212301
Ampelopsin F 151487
Angiopoietin
Adipose
Top Publications Citing MCE Products
Synthesis and biological evaluation of Schizandrin derivatives as tubulin polymerization inhibitors PMID 32631552
Fas/CD95 蛋白, Cynomolgus (HEK293, Fc)
Tunicamycin induces depression
TMEM25 inhibits monomeric EGFR
Fluorobenzene
Ferulic acid promotes thrombopoiesis via TLR4/JAK2/STAT3 signaling A novel therapeutic strategy for thrombocytopenia PMID 40571222
Ephrin
BCMA/TNFRSF17 蛋白, Rhesus Macaque (HEK293, Fc)
2,2'
4
DQP
干扰素调节因子 5（IRF5）基因
FK
Protein
Synthesis and in vitro antitumor activity of asperphenamate derivatives as autophagy inducer PMID 22361137
Heclin
Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance PMID 38685067
Uvaol alleviates oxidative stress induced human umbilical vein endothelial cell injury by suppressing mitogen
氮杂丝氨酸
High throughput screens yield small molecule inhibitors of Leishmania CRK3 CYC6 cyclin
Fc gamma RIIA/CD32a 蛋白, Human (HEK293, His)
Interpretable representation learning for 3D multi
Synthesis and screening of ursolic acid
MCE
1
富亮氨酸重复激酶 2（LRRK2）基因
Synthesis and stereochemical determination of complestatin A and B (neuroprotectin A and B) PMID 21991993
N
Complement protein C3a enhances adaptive immune responses towards FVIII products PMID 36727395
IFN
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti
Glycoproteins gM and gN are indispensable factors for rhesus macaque rhadinovirus replication and spread but can be reconstituted by KSHV chimeras PMID 39998253
Sulforaphane regulates AngII
Kaurane and abietane diterpenoids from the roots of Tripterygium wilfordii and their cytotoxic evaluation PMID 27133593
碳酸铵,99.999% trace metals basis
Methyl Jasmonate Reduces Inflammation and Oxidative Stress in the Brain of Arthritic Rats PMID 31618993
Effects of some chemical reagents on sodium current inactivation in myelinated nerve fibers of the frog PMID 2430631
PHA
TARC/CCL17 蛋白, Dog (HEK293, His)
IRI
Prognostic Value of Transferrin Receptor
5β
CD34 蛋白, Rat (HEK293, Fc)
Dopamine D2 receptor binding sites for agonists. A tetrahedral model PMID 2932631
Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial
The PGC1α/NRF1
培哚普利
peroxisome
Small
ABS
Cyclamic Acid
Synthesis of a novel series of tricyclic dihydrofuran derivatives discovery of 8,9
QTX125 TFA
CYN 154806
Ganoderic acid A attenuated hepatic impairment by down
Dibenzyl
Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives PMID 29131631
Helicobacter pylori activates DOPEY1 to promote p53 degradation through the USP7/TRIP12 axis in gastric tumorigenesis PMID 39939725
acto
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