最近收录_第477页_生物活性分子
生物活性分子最近更新
GLT1D1 Human Pre
Pde11a Mouse Pre
CAMK2A Human Pre
ATP2C1 Human Pre
RO0711401
RO0711401 714971
RO5488608
Fmoc
Sulindac sulfide is a noncompetitive gamma
CD40LG Human Pre
VU6005806 (AZN
Goniotriol ((+)
VU0448088 (ML253)
New class of squalene
ETNPPL modulates hyperinsulinemia
The activation and inhibition of human nicotinic acetylcholine receptor by RJR
Thalidomide
ML00253764
chloride
Prolactin
Diatrizoic acid (Diatrizoate，泛影酸)
SLCO1C1 Human Pre
C1GALT1 Human Pre
C1galt1 Mouse Pre
Methyltetrazine
2,5
C1galt1c1 Rat Pre
Serpin E1 蛋白, Rat (HEK293, His)
Ltb4r
Liquid Paraffin 8012
IL
Protective effect of nicotinamide against poly(ADP
Anti
WWL0245
FITC
Fas Ligand 蛋白, Human (HEK293, His)
FP0429
NO328
YX0798
Design, synthesis, and biological evaluation of anti
VD4162
CDK2/CycO Recombinant Human Active Protein Kinase
7
CDK3/CycO Recombinant Human Active Protein Kinase
AG2034
N
CDK1/CycO Recombinant Human Active Protein Kinase
2
雌激素受体
Enamidonin
谷氨酸氨连接酶（GLUL）基因
Chlorpropham
P
Calcium lactobionate 5001
Top Publications Citing MCE Products
Ghrelin Induces the Production of Hypothalamic NPY Through the AMPK
(R)
Florfenicol amine 76639
Goniodiol 8
Carbonic anhydrase inhibitor 19
Design, Synthesis, and Biological Evaluation of Pierardine Derivatives as Novel Brain
Sulforaphane treatment mimics contractile activity
Tosufloxacin tosylate hydrate (A
Oleanolic acid inhibits appetite through the TGR5/cAMP signaling pathway PMID 39842616
ADR58 sodium
Serine synthesis sustains macrophage IL
screening
DOTA
Fc gamma RIIIB/CD16b 蛋白, Human (NA2, HEK293, His)
Notch Signaling Controls Oligodendrocyte Regeneration in the Injured Telencephalon of Adult Zebrafish PMID 33281119
SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression PMID 38649537
TNF RII/TNFRSF1B 蛋白, Mouse (HEK293, His
p24 蛋白, HIV
Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization PMID 40184310
Baicalin Alleviates Chronic Pancreatitis Fibrosis and Islet Dysfunction via Targeting IFNAR
Isoflupredone acetate (Standard) (醋酸异氟泼尼松 (Standard))
IFNAR1 蛋白, Human (HEK293, His
Effects of GS
Synthesis of novel 1,2,3
(+)
Eggmanone 505068
Anthraflavic acid 84
MLGFFQQPKPR
Naphthalene
Optimization of ACE
Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP (Standard)
Discovery of (2S)
n
Selection of trophoblast cell surface antigen 2
CD326
Discovery of Futibatinib The First Covalent FGFR Kinase Inhibitor in Clinical Use PMID 37077386
Discovery of XL413, a potent and selective CDC7 inhibitor PMID 22560567
TNF RII/TNFRSF1B 蛋白, Human (174a.a, HEK293, His)
trans
T7
SARS
Design, synthesis and biological evaluation of novel 1,2,4
Spectroscopic and biological investigation of nimbolide and 28
Hexythiazox (Standard) (噻螨酮 (Standard))
CDK2 抗体 (YA6227)（CDK2 Antibody (YA6227)）
Endothelin
(E)
Effect of L
Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues PMID 23927972
SCID
The impact of the nonpeptide corticotropin
PIKfyve
IL
Aloe
Cannabigerol monomethyl ether 29106
Topoisomerase 2 inhibitor etoposide promotes interleukin
Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1
Design and synthesis of diosgenin derivatives as apoptosis inducers through mitochondria
Phenolic constituents of Cassia seeds and antibacterial effect of some naphthalenes and anthraquinones on methicillin
N
Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway PMID 30243153
Protective effect of cholecystokinin octapeptide on angiotensin II
Ginsenoside Compound K Ameliorates Osteoarthritis by Inhibiting the Chondrocyte Endoplasmic Reticulum Stress
WEE1 G2 检查点激酶（WEE1）基因
ClpP
ent
Glipizide
(S)
Fatostatin inhibits SREBP2
Obacunone Alleviates Inflammatory Pain by Promoting M2 Microglial Polarization and by Activating Nrf2/HO
GDF15 activates the PI3K/AKT pathway to mediate macrophage M2 polarization to promote prostate cancer resistance to docetaxel PMID 40674958
Bofumustine 55102
Design, synthesis and biological evaluation of novel α
SUnSET, a nonradioactive method to monitor protein synthesis PMID 19305406
Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy PMID 39972068
CDK6 抗体 (YA6286)（CDK6 Antibody (YA6286)）
Meranzin
Direct Blue 108
HPRG 蛋白, Human (HEK293, His)
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin
HSN748
Prednisolone acetate 52
Stearic acid
1
Acetyl
PI5P4Ks
NCS
Tralokinumab 1044515
Truncated ADR58 sodium
Methyl 12
Alrestatin 51411
PD
ALK2
Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMGs reductase, aldose reductase and α
CaSki
One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity PMID 20561785
dehydrogenase
BChE
Clocapramine dihydrochloride hydrate (3
Perospirone hydrochloride (SM
肿瘤蛋白，翻译控制 1（TPT1）基因
tetrahydrocorticosterone
Diatrizoate meglumine 131
CGP 56999
Fluocinolone (Acetonide) 67
POP1 Facilitates Proliferation in Triple
TNF RII/TNFRSF1B 蛋白, Cynomolgus/Rhesus Macaque (HEK293, His)
Achieving a 35
SP1
Diltiazem
Kaempulchraols A
O
calcium
Pacmilimab 2145091
CEACAM21 蛋白, Human (HEK293, His)
serpin 家族成员 3（SERPINA3）基因
From Structure Modification to Drug Launch A Systematic Review of the Ongoing Development of Cyclin
Hexacosane, 2
Estrogenic and anti
Cholesterol
Pgam1 Rat Pre
Down
NGFR Protein, Human (HEK293, Fc)
The preclinical pharmacology of roflumilast
Pseudolaric Acid B (土荆皮乙酸)
CRCD2 941185
Emerging roles of ATG7 in human health and disease PMID 34725936
Inhibition of growth of Morris hepatomas 7777 and 7800 by corn oil PMID 197460
SNIPER(ER)
Melatonin derivatives combat with inflammation
(E/Z)
CFL
IL
Tr
Design and Synthesis of FR
Miriplatin (hydrate) 250159
聚氧乙烯(20)硬脂酸酯
Endogenous Metabolite
IL
Lithium Enhances Ferroptosis sensitivity in melanoma cells and promotes CD8+ T Cell infiltration and differentiation PMID 39645207
HNPCs
Oxaceprol
Carnitine esters novel inhibitors of plasma lecithin cholesterol acyltransferase in experimental animals but not in man (Homo sapiens) PMID 6822312
Spexin 1370290
Pigment Yellow 182 67906
Dehydroepiandrosterone, dehydroepiandrosterone sulfate and related steroids their role in inflammatory, allergic and immunological disorders PMID 16101547
progestin
NIBR
Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2
Pyridostigmine
HNPCs
中国沙棘提取物 (Hippophae rhamnoides subsp. sinensis Rousi)
1
Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B PMID 12709313
Synthesis of 9
AK1 蛋白, Human (His
In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246 PMID 20047911
Combination therapy with Pretarget CC49 radioimmunotherapy and gemcitabine prolongs tumor doubling time in a murine xenograft model of colon cancer more effectively than either monotherapy PMID 14506163
progestin
Endogenous Metabolite
Pyridostigmine
Formyl Peptide Receptor (FPR)
Il1rl2 Rat Pre
白鲜提取物 (Dictamnus dasycarpus Turcz.)
(Trp4)
Formyl Peptide Receptor (FPR)
FAS Human Pre
Phospho
Synthesis and bio
SARS
1H
TRAIL R2/TNFRSF10B 蛋白, Human (HEK293, His
endoplasmic
Stimulator of Interferon Genes
Antidepressant
endoplasmic
Top Publications Citing MCE Products
Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su PMID 11575946
Pseudolaric acid B suppresses NSCLC progression through the ROS/AMPK/mTOR/autophagy signalling pathway PMID 38670047
double
Salvianolic acid B alleviated myocardial ischemia
Dothiepin
Therapeutic effect of urine
Heat Shock Protein Family A Member 1A Attenuates Apoptosis and Oxidative Stress via ERK/JNK Pathway in Hyperplastic Prostate PMID 40066224
杀草强
Stimulator of Interferon Genes
含 IQ 基序的 GTPase 激活蛋白 3（IQGAP3）基因
CTD
GYY4137 alleviates sepsis
Melatonin protects HT
Ceramides branched alkyl chains in the sphingolipid siblings of diacylglycerol improve biological potency PMID 19171486
PGAM1
Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα PMID 30315845
Oral pharmacokinetics and efficacy of oral phospholipid remdesivir nucleoside prodrugs against SARS
5
Notch 1
TrxR1 is involved in the activation of Caspase
Notch 1 TFA
Exosomes derived from ADSC suppress endothelial cells ferroptosis and alleviate sepsis acute liver injury via regulation of Keap1/Nrf2/GPX4 axis an experimental study PMID 41014491
CISD3 inhibition drives cystine
Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors PMID 10888336
Medioresinol as a novel PGC
AGEs 抗体（AGEs Antibody）
Nanoplastics exposure exacerbates Aβ plaque deposition in Alzheimer's disease mice by inducing microglia pyroptosis PMID 40412250
5
Amelioration of cholesterol sulfate for lead
Prevention of lung cancer progression by bexarotene in mouse models PMID 16247446
MLN2480
SLAMF6 蛋白, Human (HEK293, Fc)
N
ACAT
inhibits platelet aggregation
The Hedgehog signaling pathway promotes chemotherapy resistance via multidrug resistance protein 1 in ovarian cancer PMID 33125122
2
(R)
MLN2480
5
WIN 62577
Inhibition Mechanisms of Indoleamine 2,3
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer PMID 33592537
AGPV TFA
Cholinesterase (ChE)化学品、基因
CD3 epsilon 抗体 (YA3691)（CD3 epsilon Antibody (YA3691)）
Janthinocin B 131086
Tetrahydrocorticosterone
IL1RL2 Human Pre
非典型趋化因子受体 4（ACKR4）基因
Perphenazine
C1q Protein (rat)
Btk
PD 168368 204066
Melatonin Synergises the Chemotherapeutic Effect of Temozolomide in Glioblastoma by Suppressing NF
Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1 PMID 16304152
2
IFN
DPPF 12150
New phenolic compounds from the seeds of Nigella glandulifera and their inhibitory activities against human cancer cells PMID 26227777
Effects of low
CDK4/6 Inhibition in Cancer Beyond Cell Cycle Arrest PMID 30061045
RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose
小苏打, meets analytical specification of Ph. Eur., BP, USP, FCC, E500
SGI
Albiducin A
黑吉豆提取物 (Vigna mungo (L.) Hepper)
PVR/CD155 蛋白, Mouse (HEK293, His)
(rac)
antidepressant
A bioenergetic shift is required for spermatogonial differentiation PMID 32864161
乳酸脱氢酶 A（LDHA）基因
(S)
Alternative splicing of HSPA12A pre
Phytosphingosine Alleviates Cigarette Smoke
Inhibition of histone deacetylase 1 suppresses pseudorabies virus infection through cGAS
Integrin alpha X beta 2 蛋白, Human (HEK293, His)
Acetylvaline 96
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid PMID 20034711
Novel 3
Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues PMID 11277538
Pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairment PMID 18827075
Integrin alpha V beta 6 蛋白, Human (HEK293, Flag
KCNJ3 Human Pre
MAN2C1 Human Pre
N
SMURF2 inhibition attenuates cardiac hypertrophy through blocking ubiquitination degradation of AXIN1 PMID 40542282
2
(Rac)
MAN1C1 Human Pre
6
Ganglioside GM3
Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells PMID 18063366
SLC1A2 Human Pre
5
Pretreatment of different biological matrices for exogenous testosterone analysis a review PMID 28679314
Scarlet 808 (Bronze Red)
Design, Synthesis, and Biological Activity of Novel Benzo[ d][1,3]dioxole
Phrixotoxin 3 880886
EDA
1,2
N
N
Breast cancer targeting peptide 18–4
TH5427
IL
GW0072
AT7519 (AT7519M)
ZH8659
EC1167
Autocrine interferon poisoning mediates ADAR1
BDP 630/650 alkyne
TH1760
SR1664
AT7519M
CQ3196
AG6033
Etomidate Attenuates the Ferroptosis in Myocardial Ischemia/Reperfusion Rat Model via Nrf2/HO
MC4171
Nemiralisib (GSK2269557 free base)
Thiamine monophosphate chloride dihydrate (Standard)
Nemiralisib (Standard)
Papain (lyophilized powder, ≥10 units/mg protein)
IL
Carcinoembryonic antigen peptide 1 (CEA peptide)
Glycochenodeoxycholic acid
RPS6KA6 Human Pre
赖氨酸脱甲基酶 6A（KDM6A）基因
The in vivo gastrointestinal activity of TD
Aberrant Expression of SLC7A11 Impairs the Antimicrobial Activities of Macrophages in Staphylococcus Aureus Osteomyelitis in Mice PMID 38725861
Synthesis and biological evaluation of new homocamptothecin analogs PMID 22647222
infarct
Propiopromazine hydrochloride
CYP11B2 蛋白, Human (His
Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway PMID 38626543
Modification of the hydroxy lactone ring of camptothecin inhibition of mammalian topoisomerase I and biological activity PMID 2537428
myeloperoxidase
Ibrexafungerp phosphate (MK 3118 phosphate)
N
VU0422288 (ML396)
ML 396
4
Synthesis and Biological Activities of Novel Pyrazole Carboxamides Containing an Aryloxypyridyl Ethylamine Module PMID 38335464
Vinca alkaloids PMID 1681845
氨普立糖
SB 271046 Hydrochloride (Standard)
Tetronasin sodium 75139
Arsenic sulfide alleviates the progression of liver cancer malignancy by inhibiting the expression of TLCD1 in mice PMID 40783540
C1QL3 Human Pre
C1qtnf3 Rat Pre
CDK12 Human Pre
C1QL2 Human Pre
Quercetin reverses 5
C1QL4 Human Pre
Anti
O
Hypocrellin B 123940
Ro 25
DNA crosslinker 2 dihydrochloride
LY
Vitamin B1 monophosphate chloride (Thiamine monophosphate chloride)
4
Top Publications Citing MCE Products
Zebrafish fkbp5 attenuates antiviral innate immunity by autophagic degradation of transcription factor irf7 PMID 40391431
PD 198306
SQ
3D
Exosome
Tabersonine attenuates lipopolysaccharide
VMAT2
Atrial Natriuretic Peptide (7
Serine Hydrolase inhibitor
Orthogonal RNA replication enables directed evolution and Darwinian adaptation in mammalian cells PMID 39753704
EHT 1610
The evolution of amidine
Ethyl 4
1,2,3
CI
Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism
LY3020371 hydrochloride
Synthesis and Structure
Dibenzo[b,f][1,4]thiazepin
武当玉兰提取物 (Yulania sprengeri (Pampanini) D. L. Fu)
Design and synthesis of new N
Human IL
Stereoselective synthesis, biological evaluation, and modeling of novel bile acid
Propamocarb (霜霉威)
Syk inhibitors with high potency in presence of blood PMID 24726806
TCRS
Prolactin
cis
Glucoregulatory effects and prolonged duration of action of davalintide a novel amylinomimetic peptide PMID 21733060
Diacetoxyscirpenol
Synthesis and biological evaluation of podophyllotoxin congeners as tubulin polymerization inhibitors PMID 25131956
Houttuynoid M, an Anti
IL2RB
Vitexin Alleviates Kainic Acid
Diacetoxyscirpenol
MCE
Synthesis and antitumor effect in vitro and in vivo of substituted 1,3
PRXS571
Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron
Nucleoprotein (118
SARD279
A promising camptothecin derivative Semisynthesis, antitumor activity and intestinal permeability PMID 24980118
PD
Mechanochemical Synthesis of Short DNA Fragments PMID 32166818
A new class of flavonol
Evaluation of the Anticancer Activity of pH
Atxn3 Mouse Pre
Tetrahydroquinolin
Bioisosteric replacements of the indole moiety for the development of a potent and selective PI3Kδ inhibitor Design, synthesis and biological evaluation PMID 34237636
Daclizumab Mechanisms of Action, Therapeutic Efficacy, Adverse Events and Its Uncovering the Potential Role of Innate Immune System Recruitment as a Treatment Strategy for Relapsing Multiple Sclerosis PMID 30862055
Evaluation of vitamin D3 A
Cynomolgus IL
CYP
Extending SAR of bile acids as FXR ligands discovery of 23
Thioredoxin reductase 9074
TRAIL R2/TNFRSF10B 蛋白, Human (127a.a, HEK293, His)
Preparation and Catalytic Properties of Carbonic Anhydrase Conjugated to Liposomes through a Bis
Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure
Thymidine 5'
RT
Synthesis, biological evaluation and modeling studies of terphenyl topoisomerase IIα inhibitors as anticancer agents PMID 25800514
The m6A
Design, synthesis and biological evaluation of small molecular polyphenols as entry inhibitors against H(5)N(1) PMID 24803363
Antitumor Effects of Glychionide
Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p
Synthesis and anti
Plasminogen, Human plasma 9001
Extending the structure
Neonatal Hypoxic
Design and synthesis of bile acid derivatives and their activity against colon cancer PMID 36439975
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches PMID 29870668
Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease PMID 25490054
Acyl derivatives of boswellic acids as inhibitors of NF
ITGA2 Mediates the Resistance of Hepatocellular Carcinoma to Lenvatinib by Activating the AKT/FOXO3A Signaling Pathway PMID 40940943
KRAS IN
An electrochemical approach for the detection of HIV
Glycophagy mediated glucose
Prenylated benzophenones and xanthones from Hypericum scabrum PMID 15568778
Design, Synthesis, and Biological Evaluation of Dimorpholine Substituted Thienopyrimidines as Potential Class I PI3K/mTOR Dual Inhibitors PMID 28409639
VZ185
Identification of an indol
Lycopersicon esculentum (Tomato) Lectin (FITC)
5
NTE
(±)
IL
Synthesis and biological assessment of novel N
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS
Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors PMID 37147730
EDA
Berry fruits modulated endothelial cell migration and angiogenesis via phosphoinositide
Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M ₁ muscarinic acetylcholine receptor PMID 24856614
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus PMID 40025004
Lysine acetyltransferase KAT2A modulates ferroptosis during colorectal cancer development PMID 38258976
The inhibitory effect of Ca2+
Z169667518
Revisiting tubercidin against kinetoplastid parasites Aromatic substitutions at position 7 improve activity and reduce toxicity PMID 30677668
Tetracyclines at subinhibitory concentrations are lethal for NADH peroxidase
PKA/PKG
Probucol recovers pathological damage in viral Myocarditis through improvement of myocardium
Administration of substances to laboratory animals routes of administration and factors to consider PMID 22330705
Nitro Blue Diformazan 16325
8β
Nylidrin HCl a beta
共663页
首页
上一页
482
481
480
479
478
477
476
475
474
473
472
下一页
尾页
生物活性分子
ICP证:
粤ICP备2021105330号-3
联系人QQ：9145908
返回首页
RSS更新