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(S)
Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP
Fenmetozole
The influence of adrenoceptor activity on cell proliferation in colonic crypt ipithelium and in colonic adenocarcinomata PMID 407708
短开放阅读框
Zafirlukast
2
N
Synthesis of (aryloxyacetylamino)
sweetener
雾水葛提取物 (Pouzolzia zeylanica (L.) Benn.)
Reversal of P
VEGF
(6,11
钠
趋化因子 CCL9/CCL10 (MIP
Agouti
UDP
Resveratrol 3
Azido
Discovery and optimization of novel 4
干扰素基因刺激因子
Rockout
Irsogladine maleate (Dicloguamine maleate，马来酸伊索拉定)
1,7
The cytotoxic properties and preferential toxicity to tumour cells displayed by some 2,4
A small
Cimetropium Bromide 51598
anti
TBC 1269
APRIL/TNFSF13 蛋白, Mouse
CDK5(N
Ncoa1 Rat Pre
17β
[Melatonin promotes osteogenesis of bone marrow mesenchymal stem cells by improving the inflammatory state in ovariectomized rats] PMID 37586803
Tiamulin
Ethambutol 74
Sodium carbenicillin
Genome
单核苷酸多态性 (SNP)
Acrylamide Functional Group Incorporation Improves Drug
Imidocarb
N
Novel indazole skeleton derivatives containing 1,2,3
MHJ
Lagociclovir (MIV
Regulatory role of human fibrocartilage stem cells in condyle osteochondroma PMID 36162830
SN50
VEC6 3431
鞘脂
CDK1 抗体 (YA6096)（CDK1 Antibody (YA6096)）
One
Sodium diatrizoate (Diatrizoic acid sodium salt，泛影酸钠)
Modulating Androgen Receptor
Xanthopterin
Synthesis, antiproliferative and anti
Ursonic acid (Standard) (3
Larazotide
Oxadiazon affects the expression and activity of aldehyde dehydrogenase and acylphosphatase in human striatal precursor cells A possible role in neurotoxicity PMID 30391265
Histone deacetylases
固态核磁共振
H3 成簇组蛋白 1（H3C1）基因
diabetes mellitus model
N
Diloxanide furoate 3736
Ethyl undecanoate 627
SQ
Petasitenine 60102
IL
The fission yeast bromodomain protein Bdf2 is required for the growth of cells with circular chromosomes PMID 34918022
Competence
Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections PMID 24900715
FKBP51 promotes invasion and migration by increasing the autophagic degradation of TIMP3 in clear cell renal cell carcinoma PMID 34599146
NOTCH1 蛋白, Mouse (HEK293, His)
HDAC1 and 2 regulate endothelial VCAM
Altered expression of fucosylation pathway genes is associated with poor prognosis and tumor metastasis in non‑small cell lung cancer PMID 31894325
Phytoene
Comparison of Bioactive Compounds and Antioxidant Activities of Maclura tricuspidata Fruit Extracts at Different Maturity Stages PMID 30720740
睡眠呼吸障碍
Monensin sodium 22373
2'
Beta Tubulin 抗体 (YA839)（Beta Tubulin Antibody (YA839)）
Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A PMID 34200371
EphA4/ephrinA3 reverse signaling mediated downregulation of glutamate transporter GLAST in Müller cells in an experimental glaucoma model PMID 36416239
In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy PMID 39271933
流式细胞术
Cathepsin L1 蛋白, Human (HEK293, His, solution)
Cell Death
The Covalent CDK7 Inhibitor THZ1 Potently Induces Apoptosis in Multiple Myeloma Cells In Vitro and In Vivo PMID 31358538
AZD
Cytotoxic alpha
5
VEGF Receptor 1 抗体 (YA6239)（VEGF Receptor 1 Antibody (YA6239)）
Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction experimental data and clinical results from a phase 2a trial PMID 32558989
Oxalic acid dihydrate
Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)
Ketotifen
Diltiazem
Salvianolic acid B inhibits hepatic stellate cell activation and liver fibrosis by targeting PDGFRβ PMID 37451016
Prps2
IL
Cytotoxic activities of hypocretenolides from Leontodon hispidus PMID 10425121
Aflavarin
Amino
CADM3 蛋白, Rat (HEK293, Fc)
melanoma
The Bacillus cereus toxin alveolysin disrupts the intestinal epithelial barrier by inducing microtubule disorganization through CFAP100 PMID 37192300
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2
Goniopypyrone ((+)
SU3327
In vitro antibacterial properties of cefetamet and in vivo activity of its orally absorbable ester derivative, cefetamet pivoxil PMID 2504597
H
The muscarinic antagonists scopolamine and atropine are competitive antagonists at 5
Natural product
Discovery of N
Anti
M617 TFA
Hyperibone J exerts antidepressant effects by targeting ADK to inhibit microglial P2X7R/TLR4
IL
RS 2135
CG alpha 蛋白, Human (HEK293)
AC220
CGA
O
MMP
Duoperone 62030
Plant sterol ester of α
Discovery of N
Top Publications Citing MCE Products
Potential and promising anticancer drugs from adenosine and its analogs PMID 33639248
Deprodone 20423
Improved isolation and characterization procedure of sialylglycopeptide from egg yolk powder PMID 29096185
Oxytetracycline 79
D
ML 193
Rovazolac (ALX
Hopeyhopin
CERB signaling
Efficient targeted oncogenic KRASG12C degradation via first reversible
Baloxavir (Baloxavir acid)
In Vitro Characterization of Multidrug
E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo PMID 11677118
8
NR2B
Nitroxynil (Standard)
LY450108
IL
Coptisine chloride (盐酸黄连碱)
monocarboxylic acid amide
Small
Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)
Critical roles of tyrosyl
Azelastine
Autophagy inducer 3 2691054
Noscapine ((S,R)
Elephantopus scaber attenuates MC903
Lasalocid inhibits melanoma by down
VISTA/B7
Tolrestat (Standard) (AY
Synthesis, structure
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8
CCPA (Standard) (2
SCM
3,5
1
tert
ALK L1196M Recombinant Human Active Protein Kinase
MET D1228N Recombinant Human Active Protein Kinase
Bilirubin oxidase, Bacillus pumilus (BOD, Bacillus pumilus)
MET L1195V Recombinant Human Active Protein Kinase
Butane
ONO 3708
Quercetin prevents isoprenaline
STM2457 decreases m6A methylation to reduce cisplatin
Tartaric acid sodium hydrate (L
Benzoin (Standard) (DL
Cefuzonam sodium
Cerberin 25633
Top Publications Citing MCE Products
Protein Kinase C γ Peptide
Ferric glycinate
ONO
Dasabuvir sodium (ABT
CDK7 Inhibition Suppresses Castration
Beta
N
SQ22536 (Standard)
rac 1,2
PC9/gef
Exploration for the effect of renal function and renal replacement therapy on pharmacokinetics of remdesivir and GS
IAJD249
Myosin light chain kinase fragment 11
Triheptanoin (Standard) (UX007 (Standard)，三庚酸甘油酯(Standard))
Allyl heptanoate (Prop
Calcium lactobionate (Lactobionic acid hemicalcium)
Sodium diacetate (Sodium hydrogen diacetate，双乙酸钠)
USP4 Human Pre
ALKBH5
Methyl melissate (Triacontanoic acid methyl ester)
Alkyne maleimide
Leumorphin, human
(Rac)
CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival PMID 31395606
Buffer Reagents
4
突触
GLUT4
Design, synthesis, biological evaluation and preliminary mechanism study of novel benzothiazole derivatives bearing indole
Tridecanoic acid
Triparanol 78
Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K/AKT/mTOR
池化双杂交法
5
Parasite
1,1
Phospho
Prototyping kinase inhibitor
RS
Behavioral effects of AMI
Adenosine Alleviates Necrotizing Enterocolitis by Enhancing the Immunosuppressive Function of Myeloid
OTSSP167 (OTS167)
IBMX 28822
Prednisolone acetate (Standard) (Prednisolone 21
Design, synthesis and bio
Semagacestat (Standard) (LY450139 (Standard)，司马西特 (Standard))
Olmutinib (HM61713，奥莫替尼)
Hepatocyte Growth Factor
Menbutone (Genabilic acid，孟布酮)
CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K
[pGlu4]
1
Hexacosanoic acid (蜡酸)
UK
Alrestatin sodium (AY
H
1,2
Small molecule activators of TAK1 promotes its activity
Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation PMID 26989084
20
4'
human endometrial stem cells
Catalpol inhibits Hedgehog signaling pathway to suppress proliferation and promote lipid accumulation in rat meibomian gland epithelial cells PMID 40406032
Small Molecule Inhibition of MicroRNA miR
Animal
Ganoboninketals A
Harmane 486
BAG3 promotes autophagy and suppresses NLRP3 inflammasome activation in Parkinson's disease PMID 36544667
JNK
醋酸蒲公英酯 (Standard)
CDK5 抗体 (YA5385)（CDK5 Antibody (YA5385)）
Pleurospiroketals A
Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors PMID 27987485
A novel 7
IL
脑室下区
(S)
A novel therapy for hepatic cholestasis treatment
AP2S1 regulates APP degradation through late endosome
FAK inhibitor 6
An open
Design and Synthesis of a Trifunctional Molecular System Programmed to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages PMID 37748566
A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage PMID 32039405
GPR34 Stabilized by Deubiquitinase USP8 Suppresses Ferroptosis of ATC PMID 40862294
Osm
N
单核苷酸多态性
Wnt
Taltobulin intermediate
Ethyl linoleate 544
BAY X1005, a new inhibitor of leukotriene synthesis in vivo inflammation pharmacology and pharmacokinetics PMID 8229782
Bis(2,3
The lncRNA EPIC1 suppresses dsRNA
Cetirizine dihydrochloride 83881
Synthesis and biological evaluation of novel 3,9
Aminochalcone 4AAF 38239
FGFR
Otophylloside T 1642306
FK506 Targets MoFpr1 to Modulate Autophagy and Ubiquitination, Inhibiting the Pathogenicity of Magnaporthe oryzae PMID 40490869
Fibrous polyisocyanide hydrogels for 3D cell culture applications PMID 40447888
Anti
C1orf112 Human Pre
The common YAP activation mediates corneal epithelial regeneration and repair with different
PDGF R alpha 蛋白, Human (HEK293, Fc)
Overexpression of heat shock protein 70 inhibits epithelial
17β
Chloroethene (polymer) 9002
N
Ezetimibe ketone (EZM
Ezetimibe ketone (Standard)
Synthesis and biological evaluation of all possible inosine
glycosphingolipid
Bufalin Inhibits Tumorigenesis, Stemness, and Epithelial
BDP R6G NHS ester
Dihydroxyacetone phosphate hemimagnesium hydrate
Fas
INHBB 蛋白, Human (HEK293, His)
LUF6000
刺儿菜提取物 (Cirsium arvense var. integrifolium Wimm. & Grab.)
Inhibition of Plasmodium falciparum Hsp90 Contributes to the Antimalarial Activities of Aminoalcohol
Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells PMID 30344755
Design, synthesis, and evaluation of indeno[2,1
Silencing of PODXL2 Modulates Cell Viability and Tumor Immune Microenvironment of Prostate Cancer and Involves PI3K/AKT Pathway Inactivation PMID 40152216
Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs synthesis and activity against human cytomegalovirus PMID 7752205
Pancratistatin 96203
PD
Synthesis, computational study and cytotoxic activity of new 4
7,8
前血小板碱性蛋白（PPBP）基因
Metal binding 6
YH
IL
AITRL/TNFSF18 Trimer 蛋白, Human (HEK293, His
PDGF R alpha 蛋白, Rat (HEK293, His)
2
Serpin E1 蛋白, Human (HEK293, His)
Clomiphene
MCE
MMP
Kcnj3 Mouse Pre
CAMK4 Human Pre
C1QC Human Pre
C1QA Human Pre
Acetyl
A simple practice guide for dose conversion between animals and human PMID 27057123
Thymidine 5'
CDK3 Human Pre
mTOR Substrate、基因
OPRK1 Human Pre
Oncogenic dependency plays a dominant role in the immune response to cancer PMID 37782788
Chemical constituents from the aerial parts of Artemisia minor PMID 19476336
DC
Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase
L 152804
IL
Design, synthesis, and structure
Cortistatin a member of the somatostatin neuropeptide family with distinct physiological functions PMID 11011067
Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease PMID 26526742
Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma PMID 38287168
Serpin A6 蛋白, Human (HEK293, His)
IL2RB
GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis PMID 33850109
cofilin
Low level of tumor necrosis factor α in tumor microenvironment maintains self
CDK12 R722C/CycK Recombinant Human Active Protein Kinase
C1orf167 Human Pre
C1orf127 Human Pre
C1orf109 Human Pre
JNJ
C1orf159 Human Pre
1
Milvexian (BMS
Structure
Design, synthesis of DNA
CD22 抗体 (YA4667)（CD22 Antibody (YA4667)）
TrkA 蛋白, Canine (HEK293, Fc)
CWHM
Therapeutic potential of targeting MKK3
UVA influenced the SIRT1
Dexfadrostat 102676
CD8 beta 蛋白, Human (HEK293, His)
BAY 73
Cularine
E3 Ligase Ligand
ALK G1202R Recombinant Human Active Protein Kinase
ALK C1156Y Recombinant Human Active Protein Kinase
SYTM Green
Altering APP proteolysis increasing sAPPalpha production by targeting dimerization of the APP ectodomain PMID 22768208
Sulfiram (Standard)
EML4 ALK F1174L Recombinant Human Active Protein Kinase
AZD7648
neuroprotective
Mechanism of Interaction between hsa_circ_0002854 and MAPK1 Protein in PM2.5
Glabrescione B
PIEZO2 Human Pre
CCPA hemihydrate (2
1,2
Cdk17 Mouse Pre
Cdk12 Mouse Pre
C1ql3 Mouse Pre
Cdk13 Mouse Pre
中心体蛋白 89（CEP89）基因
Aquaporin 4 抗体 (YA5349)（Aquaporin 4 Antibody (YA5349)）
FaX
5
GSK0660 (Standard)
Asterriquinone SU5504
AZD 8871
Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron Design, synthesis and biological evaluation of dual
TCIP 1 ligand
Nuclear factor
N
Coptisine
Tilting the Scales toward EGFR Mutant Selectivity Expanding the Scope of Bivalent Type V Kinase Inhibitors PMID 39626019
K00135
The kinetic aspects of intracellular fluorescence labeling with TMA
BTB
MCE
IFNAR2 蛋白, Cynomolgus (HEK293, His)
Z
3,5,6
Small molecule modulation of Smoothened activity PMID 12391318
Halobetasol propionate
CDK4 抗体 (YA6163)（CDK4 Antibody (YA6163)）
CG alpha 蛋白, Human (HEK293, His)
碳酸酐酶 10 (Carbonic Anhydrase 10)
264W94
Fmoc
lipophilic
Structure of 4'
番茄碱
Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine PMID 39627234
Skeletal muscle hypertrophy rewires glucose metabolism An experimental investigation and systematic review PMID 38742477
A Stapled Peptide Inhibitor Targeting the Binding Interface of N6
LILRB1/CD85j/ILT2 蛋白, Rhesus macaque (474a.a, HEK293, His)
Targeting miR
Phrixotoxin 3
ATR/Chk1 signaling induces autophagy through sumoylated RhoB
Design, synthesis, and evaluation of indolinones as inhibitors of the transforming growth factor β receptor I (TGFβRI) PMID 20919678
REG
Exploring the effect of chirality on the therapeutic potential of N
Structure
DNA microarray reveals different pathways responding to paclitaxel and docetaxel in non
Osocimab (BAY 1213790，奥索西单抗)
Inhibition of thioredoxin reductase by a novel series of bis
HDAC8 抗体 (YA2994)（HDAC8 Antibody (YA2994)）
TNFRSF12A 蛋白, Human (HEK293, Fc)
Synergistic Combination of the Total Steroidal Saponins from the Berries of Black Nightshade and Adriamycin to Overcome Leukemia Multidrug Resistance PMID 36752041
The production of propionic acid by decarboxylation of succinic acid in a bacterial fermentation PMID 18934530
The conversion of oridonin to spirolactone
Synthesis of novel galeterone derivatives and evaluation of their in vitro activity against prostate cancer cell lines PMID 31271960
development
Retinoic acid 302
Frizzled
Akt
Downregulation of LINC00665 suppresses the progression of lung adenocarcinoma via regulating miR
白介素 1 受体样 2（IL1RL2）基因
Structural development of 1H
AZD 3043 (THRX 918661)
(R)
Halobetasol propionate (Standard) (BMY
VISTA/B7
白介素
DOPE
非洲藤黄提取物 (Garcinia livingstonei T.Anderson)
IL
Leishmanicidal and cytotoxic activity of hederagenin
哈进酸
IL
IL
Anti
N
MIF 蛋白, Human (His, solution)
CaV3
PPC
The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF
7
ACT 389949
D
Discovery of a selective small
Eupatorium glehni F. Schmidt ex Trautv.提取物 (Eupatorium glehni F. Schmidt ex Trautv.)
Mebhydrolin
达格列酮钠盐
P2RX7
Hederagenin as a triterpene template for the development of new antitumor compounds PMID 26476750
THP
IL
7
Fas 细胞表面死亡受体（FAS）基因
GS
Artemisinin protects PC12 cells against β
Influence of fatty acid synthase inhibitor orlistat on the DNA repair enzyme O6
Melatonin protects against PM2.5
GW2580 (Standard)
ABT1 Human Pre
Discovery of 8,9
卡氏乳香树提取物 (Boswellia carterii)
2
CDK4 抗体 (YA5223)（CDK4 Antibody (YA5223)）
EP4 inhibition attenuates the development of diabetic and non
The effect of zolimidine, imidazopyridine
1,2
CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer PMID 35945614
MB710
Serpin G1 蛋白, Human (HEK293, His)
NAMPT
2
Comprehensive analysis reveals the tumor suppressor role of macrophage signature gene FCER1G in hepatocellular carcinoma PMID 39893200
PF
Nitric Oxide
M
Natural pseurotins and analogs thereof inhibit activation of B
IL
FGFR
Direct conversion of human fibroblasts into dopaminergic neuron
Pristane, a non
LGD
NCT
Madecassic acid 18449
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