最近收录_第482页_生物活性分子
生物活性分子最近更新
JNJ
Withaferin A suppresses skin tumor promotion by inhibiting proteasome
Natural and non
IL
The TPO mutation screening and genotype
Benzophenone
Thalidomide
BAALC
Hydrostatin
The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides PMID 15207463
AMPK抑制剂、基因
Zoledronic acid enhances the efficacy of the MEK inhibitor trametinib in KRAS mutant cancers PMID 30429107
Protein engineering enables a soakable crystal form of human CDK7 primed for high
KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1 PMID 40216969
维生素D及其受体
Anti
USP8 protects rat
SARS
Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri PMID 16394535
Tim
3
TAM558 intermediate
TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus PMID 39312069
Identification of new benzimidazole
In Vitro and In Vivo Analysis of the Gram
Activin RIA 蛋白, Human (HEK293, His)
Non
TrkC 蛋白, Human (HEK293, Fc)
Multiple stimulus
Design and synthesis of novel Gefitinib analogues with improved anti
Aldh7a1 Rat Pre
New antioxidant and antimicrobial ellagic acid derivatives from Pteleopsis hylodendron PMID 11458450
Dextran sodium sulfate potentiates NLRP3 inflammasome activation by modulating the KCa3.1 potassium channel in a mouse model of colitis PMID 35799057
Retinal ganglion cell protection with geranylgeranylacetone, a heat shock protein inducer, in a rat glaucoma model PMID 14971562
H
An Eighteen
Ldha
CypA inhibits respiratory syncytial virus (RSV) replication by suppressing glycolysis through the downregulation of PKM2 expression PMID 40552816
Tirbanibulin Mesylate (Standard) (KX2
PROTAC SMARCA2/4
Wighteone 51225
Identification of Phialomustin‑B (PHL
PSMD14/E2F1 Axis
Ropivacaine inhibits pressure
Scaffold Hopping of Natural Product Evodiamine Discovery of a Novel Antitumor Scaffold with Excellent Potency against Colon Cancer PMID 31880942
Herbicidal agent 2 3024668
Erdafitinib inhibits the tumorigenicity of MDA
Isolation of gelsedine
Histone Methyltransferase
PROTAC BRD4 Degrader
Amphiregulin blockade decreases the levodopa
Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53
Macrophage migration inhibitory factor (MIF)
Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders PMID 40532131
Benzoin
Non
The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses PMID 29789637
SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway PMID 37316499
Tricosanoyl ethanolamide
AGR2 expression as a predictive biomarker for therapy response in esophageal squamous cell carcinoma PMID 36327302
Development of novel N
2
Activation of TGR5 with INT
LPS Disrupts Endometrial Receptivity by Inhibiting STAT1 Phosphorylation in Sheep PMID 39769435
Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ PMID 28621933
Commentary on the study impact of depressive symptoms on future alcohol use in patients with co
4
S
Neb Rat Pre
13
BCKDH kinase promotes hepatic gluconeogenesis independent of BCKDHA PMID 39389936
Erythrocytic α
STING inhibits the progression of esophageal squamous cell carcinoma by suppressing CPT1A
AGPV
Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression Exploring the potential mechanisms of arrhythmia PMID 40653133
15
Chronic Unpredictable Mild Stress Promotes Atherosclerosis via HMGB1/TLR4
FLT3 Inhibitors in Acute Myeloid Leukemia Challenges and Recent Developments in Overcoming Resistance PMID 33719439
KB02
Sulforaphane activates anti
The NLRP3 inflammasome regulates corneal allograft rejection through enhanced phosphorylation of STAT3 PMID 32583615
Rho GTP 酶激活蛋白 4（ARHGAP4）基因
Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE
TBK1 Suppresses RIPK1
Mechanotransduction by integrin is essential for IL
HGFR 蛋白, Rat (HEK293, Fc)
Fingolimod (FTY720) a recently approved multiple sclerosis drug based on a fungal secondary metabolite PMID 21456524
Lobuprofen
Havcr1 Rat Pre
Meliasendanin D 1820034
Short
Cytotoxic potentiation of vinblastine and paclitaxel by L
Tumor
ELOA promotes tumor growth and metastasis by activating RBP1 in gastric cancer PMID 37694492
Lmo2 Rat Pre
The effects of topical mafenide acetate application on skin graft survival in bacterial contaminated wounds PMID 37985270
SOX4 silencing alleviates renal injury in rats with acute renal failure by inhibiting the NF
Flow
VKORC1 Human Pre
Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists PMID 7682138
Chemometric
卡奇霉素
HSR6071 111374
miR
PNU
The pseudogene GBP1P1 suppresses influenza A virus replication by acting as a protein decoy for DHX9 PMID 38940585
Diatrizoic acid
Lenvatinib inhibits the growth of gastric cancer patient
Csf3r
Isothiocyanates attenuate immune checkpoint blockage therapy in gastric cancer via induction of PD
Selective, covalent modification of beta
Furazolidone reduces the pathogenesis of Trueperella pyogenes and Pseudomonas aeruginosa co
2
Binding and Activation of Estrogen
TiO2 Nanotube Implants Modified with Silk Fibroin and Mesoporous Silica Nanocomposite Coatings Enable Efficient Drug Release to Promote Osteogenesis PMID 40289330
O
Drugging the NLRP3 inflammasome from signalling mechanisms to therapeutic targets PMID 38030687
Benzylacyclouridine 82857
GLPG4471 2499855
Gliotoxin analogues from a marine
Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway PMID 29286125
EGF 蛋白, Human (HEK293, mFc)
Eriodictyol inhibits glioblastoma migration and invasion by reversing EMT via downregulation of the P38 MAPK/GSK
High
Safflower oil (from Carthamus tinctorius seed) 8001
Phase I study of liposomal annamycin PMID 11127949
The potent anti
Reproterol hydrochloride 13055
JS
Mechanism of CYP2C9 inhibition by flavones and flavonols PMID 19074529
Hepatocellular carcinoma cells downregulate PGAM2 via SIRT2
Discovery of a potent SCAP degrader that ameliorates HFD
Synthesis and antitumor activity of biotinylated camptothecin derivatives as potent cytotoxic agents PMID 30509782
Bestatin hydrochloride 65391
Dimethyl phthalate (Ring
YAP nuclear translocation induced by HIF
CCL27
8beta
Anti
Autophagy Promotes α
AVL
β
Effect of dihydrotestosterone on melatonin secretion and the expression of melatonin receptors and apoptosis
Pyridobenzothiazolones Exert Potent Anti
Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer PMID 19011599
Alfacalcidol 41294
Extravillous trophoblast cell derived exosomes induce vascular smooth muscle cell apoptosis via a mechanism associated with miR
FAM110A promotes mitotic spindle formation by linking microtubules with actin cytoskeleton PMID 38995965
Single
Biological and mutational analyses of CXCR4
ZSTK474
Neutralization Mechanisms of Two Highly Potent Antibodies against Human Enterovirus 71 PMID 29970466
DU
激活转录因子 4（ATF4）基因
The potential of swine pseudorabies virus attenuated vaccine for oncolytic therapy against malignant tumors PMID 37891570
Compositional inhomogeneity of drug delivery liposomes quantified at the single liposome level PMID 33065286
N
YAP silencing by RB1 mutation is essential for small
Anti
RNase A activity analysis and imaging using label
Orziloben 1555822
BCR
Chemogenetic control of gene expression and cell signaling with antiviral drugs PMID 29967495
Permethrin 52645
Harmol induces apoptosis by caspase
The effect of modulation Piezo2 by IGF
Branched
Expression and properties of recombinant alpha 1 beta 2 gamma 2 and alpha 5 beta 2 gamma 2 forms of the rat GABAA receptor PMID 8223951
Enzyme activity assay
Interferon inhibitors increase rAAV production in HEK293 cells PMID 39824361
GABA transporter heterogeneity pharmacology and cellular localization PMID 8939442
21
3
Age
leukemia
In vivo multiplex imaging of dynamic neurochemical networks with designed far
11
Structure
Rare Thioglycosides from the Roots of Wasabia japonica PMID 30232882
小扁豆提取物 (Polygala tatarinowii Regel)
The multiple faces of CCL13 in immunity and inflammation PMID 23846739
TNIK inhibition abrogates colorectal cancer stemness PMID 27562646
5'
Bortezomib potentiates antitumor activity of mitoxantrone through dampening Wnt/β
AKT1 抗体 (YA834)（AKT1 Antibody (YA834)）
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia
Chlorantholide B (氯虫胺 B)
GRAMD4 regulates PEDV
Temperature
CD27
Enhancer architecture
Bptf
JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma PMID 31346162
NF
Elucidating a Potential Mechanism of Permeability Enhancer Sodium N
Activated PKB/GSK
RNF31 represses cell progression and immune evasion via YAP/PD
CD81 Protein
成纤维细胞生长因子 4（FGF4）基因
Zearalenone Induces MLKL
The effects of cyclooxygenase (COX)
miR
Ruthenium drug BOLD
PLCγ1 inhibition combined with inhibition of apoptosis and necroptosis increases cartilage matrix synthesis in IL
SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel
CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease PMID 35732922
Bendamustine 16506
Metabolic Mechanisms and a Rational Combinational Application of Carboxyamidotriazole in Fighting Pancreatic Cancer Progression after Chemotherapy PMID 30002095
Targeting USP11 regulation by a novel lithium
ALKBH1
The addition of 5
MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization PMID 40640787
Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism PMID 34172534
Ubiquitination status does not affect Vps34 degradation PMID 32884994
Salidroside Attenuates Doxorubicin
Pembrolizumab promotes degradation of cyclin dependent kinase 6 and suppresses ovarian cancer progression in vitro PMID 40652113
Discovering the anti
High Intensity Focused Ultrasound
中心体蛋白 70（CEP70）基因
PHB2 (prohibitin 2) promotes PINK1
MCE
IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2
(20S)
PET117 assembly factor stabilizes translation activator TACO1 thereby upregulates mitochondria
FGFR
The ROS/NF
COMP 蛋白, Human (HEK293, His)
Necrostatin
Chicoric acid exerts therapeutic effects in DSS
Gelsevirine improves age
GPER
PSA controls hepatic lipid metabolism by regulating the NRF2 signaling pathway PMID 34048566
Trimethylamine
Idelalisib 870281
12
Novel PI3Kδ inhibitor exerts antitumor activity in Burkitt lymphoma by inducing ROS
INCB13739
Identification of a receptor tyrosine kinase inhibitor CP
DL5055
SHC4 promotes tumor proliferation and metastasis by activating STAT3 signaling in hepatocellular carcinoma PMID 35033067
Microglial Melatonin Receptor 1 Degrades Pathological Alpha
(S)
In vivo structure
Osmr Mouse Pre
Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer PMID 34506134
1
BACH1 regulates the differentiation of vascular smooth muscle cells from human embryonic stem cells via CARM1
NOX2 deficiency promotes GSDME
LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages PMID 37782452
CircRNA_103765 acts as a proinflammatory factor via sponging miR
BI
TFAP2C/FLT3 axis reduces ferroptosis in breast cancer cells by inhibiting mitochondrial autophagy PMID 39536858
PDE4B Modulates Phosphorylation of p65 (Ser468) via cAMP/PKA in Acute Lung Injury PMID 39956855
nordeprenyl
In search of uracil derivatives as bioactive agents. Uracils and fused uracils Synthesis, biological activity and applications PMID 25306174
Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell
miR
Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation PMID 36089914
Hypoxia destroys the microstructure of microtubules and causes dysfunction of endothelial cells via the PI3K/Stathmin1 pathway PMID 30820314
lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription PMID 34326237
A study of the effects of lamotrigine on mice using two convulsive tests PMID 21797108
ZYH005, a novel DNA intercalator, overcomes all
Bioactive diterpenes from Callicarpa longissima PMID 22429052
SGC8158
The role of the PI3K/AKT/mTOR pathway in mediating PD
ErbB1
MFAP4 蛋白, Human (HEK293, His
Oral intake of Lactobacillus plantarum L
LY2811376 1194044
Cancer
DOTA Zoledronate
Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP
Protease
Inhibition of NF
Large
Plasmon
type II diabetes
The Combination of Quantitative Proteomics and Systems Genetics Analysis Reveals that PTN Is Associated with Sleep
Histamine H1 receptors mediate vasodilation in guinea
rhinovirus
An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia
An ethanolic extract of Arctium lappa L. leaves ameliorates experimental atherosclerosis by modulating lipid metabolism and inflammatory responses through PI3K/Akt and NF
Discovery of PZ671, a highly potent and in vivo active CRBN
Effects of R
Sequential Labeling
SR
Caveolin 2 抗体 (YA2387)（Caveolin 2 Antibody (YA2387)）
Crmp1
甲基转移酶活性测定
The effect of DDD on barbiturate and steroid
Curcumin alleviated dextran sulfate sodium
FAM3D inhibits gluconeogenesis in high glucose environment via DUSP1/ZFP36/SIK1 axis PMID 36524461
SGN
Tanshinone IIA sulfonate sodium (Sodium Tanshinone IIA sulfonate，丹参酮IIA磺酸盐)
EPM2A 相互作用蛋白 1（EPM2AIP1）基因
Osimertinib 1421373
USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation PMID 40619097
Respiratory syncytial virus co
Toward selective drug development for the human 5
异烟棒曲霉素
Nafadotride 149649
Cell
The absolute configuration of belactin A, a beta
Tektin4 loss promotes triple
(4
Trim65 attenuates isoproterenol
Chloroquine
Double
Flutamide, an androgen receptor antagonist, improves heatstroke outcomes in mice PMID 22609231
GABAA receptor subtype
Donepezil
Antitrypanosomal agent 23
A778317 808756
The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver PMID 39279523
Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells PMID 34335955
OSMR Human Pre
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms PMID 40462136
Demethoxycurcumin 22608
EGF
BI
Antitumor activity of 2
Design, synthesis, molecular docking and anticancer evaluations of 5
De
An integrated PKD1
interbioscreen
Bioassay
FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma PMID 38839752
NOBA 55894
Supramolecular Engineering of Molecular Inhibitors in an Adaptive Cytotoxic Nanoparticle for Synergistic Cancer Therapy PMID 31816241
The Effective Duration of Antimicrobial Activity of Mafenide Acetate After Reconstitution PMID 29931082
E2
Lanicemine a low
Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model PMID 39298444
E
Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil
Phenolic acid amides a new type of DNA strand scission agent from Piper caninum PMID 15210155
SCH 563705 473728
Inhibition of osteoclastogenesis by histone deacetylase inhibitor Quisinostat protects mice against titanium particle
Gentianine 439
CD47
The Lck inhibitor, AMG
CR
RHOJ Human Pre
Ttn Mouse Pre
CDK2
Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L
PRKDC Human Pre
α
CaMK
4
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1
SP 2509
Protective effect of schisandrin B against cyclosporine A
A Dual
HLA
The nucleoside analog clitocine is a potent and efficacious readthrough agent PMID 28096517
Elritercept, a modified activin receptor IIA ligand trap, increased erythropoiesis and thrombopoiesis in a phase 1 trial PMID 39437803
MEK1 抗体 (YA6162)（MEK1 Antibody (YA6162)）
BBO
Apigenin
Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells PMID 20878096
Artemisic acid (Standard) (Qing Hao acid (Standard)，青蒿酸 (Standard))
Blue light promotes vitamin C
BAY
5,6
Immunofluorescence
ADAM9 蛋白, Human (HEK293, His, solution)
Development of streptavidin
CpG
5
D
Hinokiflavone exerts dual regulation on apoptosis and pyroptosis via the SIX4/Stat3/Akt pathway to alleviate APAP
泛素结合酶 E2 J2（UBE2J2）基因
Polyfunctional IL
Benzamidine hydrochloride 1670
Inecalcitol, an analog of 1α,25(OH)(2) D(3) , induces growth arrest of androgen
Tanespimycin 75747
Transcriptional Regulation of Siglec
Ochratoxin B 4825
High
organ
New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir PMID 29914965
Sitagliptin phosphate 654671
GD2 Sphingosine (d18 1) 497863
Genolimzumab
紫草酸
HOXD9/miR
Topoisomerase
GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non
JNK knockdown enhances CAR
Parkin modulates the hepatocellular carcinoma microenvironment by regulating PD
PRDX6
Safety and efficacy of alteplase in the treatment of acute ischemic stroke PMID 19475777
AMD 3465 185991
PRODH2
Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFRL858R/T790M/C797S PMID 31223440
ABBV
The MYEOV
Bisindolylmaleimide IX
Moxifloxacin rescues SMA phenotypes in patient
Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma PMID 37043698
PRR11 promotes ccRCC tumorigenesis by regulating E2F1 stability PMID 34499617
PARP1
Paclitaxel
SAP 1
Repositioning VU
Drofenine hydrochloride 548
Efficacy of afoxolaner against Ixodes scapularis ticks in dogs PMID 24685321
16 0 Coenzyme A triammonium 799812
[Actilyse (a recombinant tissue
Design, Synthesis, and Biological Evaluation of Quinazolin
Top Publications Citing MCE Products
Targeting both wild
4alpha,8beta
Avanafil
[Norfloxacin more than 20 years of clinical use, the results and place among fluoroquinolones in modern chemotherapy for infections] PMID 15002177
Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model PMID 39994247
LMO2 Human Pre
Isomaltotriose 3371
Phosphoenolpyruvic acid, an intermediary metabolite of glycolysis, as a potential cytoprotectant and anti
Loratadine a non
T
Synthesis and biological evaluation of 2
Identification and inhibition of the ICE/CED
IL
ODN D
A crotonyl
A Chemical
Saikosaponin
TRIM21 promotes inflammation by ubiquitylating NF
Ularitide 118812
UBCS039
NAcM
Glucocorticoid receptor triggers a reversible drug
Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1 PMID 37144221
Effects of substituent pattern on the intracellular target of antiproliferative benzo[b]thiophenyl chromone derivatives PMID 34171512
Oroxylin A
MGMT
Concurrent intratumoural Treg cell depletion and CD8+ T cell expansion via a cleavable anti
Activated ALK signals through the ERK
Roles for PDGF
3
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy PMID 35429439
Benzamidine 618
Actinobacillus pleuropneumoniae infection activates IL
SKF 77434 hydrobromide 300561
Dengue virus Capsid 蛋白 (His)
Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF
Concentrated Phosphatidic Acid in Cereal Brans as Potential Protective Agents against Indomethacin
Pharmacological inhibition of SUMOylation with TAK
AZD
Iscartrelvir 2921711
Thiacloprid
Palbociclib
Squalene
Matrix metalloproteinase interactions with collagen and elastin PMID 25599938
Real
Phosphorus
DOTA
CD204/MSR1 蛋白, Human (HEK293, His)
4
The FTO m6A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m6A levels PMID 33571513
12a
(R)
Ammonium benzoate 1863
Multi
α
Mim
Desloratadine ameliorates paclitaxel
The full
Start Selective and Rigidify The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors PMID 31689114
Novel N
Caspase
Me3
CFM
Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase PMID 18645010
(S)
Fos
ZL
Relating structure to mechanism in creatine kinase PMID 15804623
Malonyl
Functionalized congeners of 1,3
T638 2770585
Zwitterionic Cross
Peptide MSI
The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma PMID 23857410
Tumor initiating cells escape tumor immunity via CCL8 from tumor
5,6
DSPE
Environmental cadmium impairs blood
3
NNMT is involved in deoxynivalenol
Dapoxetine 119356
S
共659页
首页
上一页
487
486
485
484
483
482
481
480
479
478
477
下一页
尾页
生物活性分子
ICP证:
粤ICP备2021105330号-3
联系人QQ：9145908
返回首页
RSS更新