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Inhibition of ferroptosis rescues BMP osteogenic differentiation impaired by iron overload in the osteoporotic microenvironment PMID 40930476
endothelial cannabinoid receptor
IONIS
R 7050
The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation PMID 39865175
1
Diflomotecan, a promising homocamptothecin for cancer therapy PMID 19053883
Cefdinir (CI
4
Evaluation of the antinociceptive effects of lidocaine and bupivacaine on the tail nerves of healthy rats PMID 23506425
Rotating magnetic field improved cognitive and memory impairments in a sporadic ad model of mice by regulating microglial polarization PMID 38904930
Angiotensin II increases angiogenesis by NF
Lipoprotein
Tepoxalin 103475
Beta
β
PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice PMID 31239244
4
Vebicorvir (ABI
Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism PMID 36369291
3′
Epigenetic inhibitors eliminate senescent melanoma BRAFV600E cells that survive long‑term BRAF inhibition PMID 32236593
Modified Sijunzi Decoction Inhibits Epithelial
avoidance
Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro PMID 22040433
GSK591
Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer's disease PMID 40055645
The role of the PIK3CA gene in the development and aging of the brain PMID 33431926
2
Cotadutide 1686108
Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition PMID 36520461
Arprinocid
Leptin
Lumichrome inhibits osteoclastogenesis and bone resorption through suppressing RANKL
Methantheline
Rotating magnetic field improves cognitive and memory impairments in APP/PS1 mice by activating autophagy and inhibiting the PI3K/AKT/mTOR signaling pathway PMID 39461710
SDNUM04
N
Bioactive triterpene glycosides from the sea cucumber Holothuria fuscocinerea PMID 17067169
VB124
ACAT1 Human Pre
The validity of scopolamine as a pharmacological model for cognitive impairment a review of animal behavioral studies PMID 20398692
TNFSF14
2
Wnt5a Regulates Junctional Function of Sertoli cells Through PCP
TM
CSL362
The gut microbiome in patients with Cushing's disease affects depression
(S,R,S)
N
Peroxiredoxin II exerts neuroprotective effects by inhibiting endoplasmic reticulum stress and oxidative stress
(±)11(12)
Design and synthesis of tetrahydropyridothieno[2,3
hsa
Etbicyphat
Etidronic acid
Deletion of SH2D5 alleviates epileptic seizures and NMDAR expression via autophagic degradation of STAT1 PMID 40857409
First Bispecific Inhibitors of the Epidermal Growth Factor Receptor Kinase and the NF
18 1 PI(3)P
LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2
Antifungal and cytotoxic activity of withanolides from Acnistus arborescens PMID 20590148
Targeting lectin
Curcumin suppresses the stemness of non
Recombinant Klotho alleviates vancomycin
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile PMID 29424542
SC
Bioenergetic Heterogeneity in Mycobacterium tuberculosis Residing in Different Subcellular Niches PMID 34060333
A novel orally administered trimebutine compound (GIC
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T
PCLAF induces bone marrow adipocyte senescence and contributes to skeletal aging PMID 38961077
Onjixanthone I 136083
Ibrutinib disrupts blood
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator
Solid stress
ASK1
lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression PMID 34239555
CD3D
Telocyte
HEYL
Dihydrexidine (DAR
FGFR1 抗体 (YA4859)（FGFR1 Antibody (YA4859)）
HY
Yangonin
N6
From inflammation to healing the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recovery PMID 40702577
Roles of the pyroptosis signaling pathway in a sepsis
Cytotoxic flavonoids from the leaves of Cryptocarya chinensis PMID 20704331
Prothracarcin
SNIPER(BRD)
N6
ARHGEF4 Human Pre
RNA disruption is a widespread phenomenon associated with stress
Ex vivo AKT
Chenodeoxycholic acid stimulates Cl(
Glutaminase 1 inhibition reduces thymidine synthesis in NSCLC PMID 27338638
TYM
Effects of 101BHG
RECTAS
Targeting CIRP and IL
Regdanvimab
Prostaglandin B2
PROTAC CDK9 degrader
Sustained store
Procyanidin B2 improves developmental capacity of bovine oocytes via promoting PPARγ/UCP1
2
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis PMID 38438346
U92016A hydrochloride
Isorhynchophylline alleviates cartilage degeneration in osteoarthritis by activating autophagy of chondrocytes PMID 36864518
Global analysis of HLA
Ribosomal protein L22
A CRISPR
仅 LIM 域 1（LMO1）基因
c
Enhanced Eradication of Bacterial/Fungi Biofilms by Glucose Oxidase
Connectivity
丙氨酰氨基肽酶，膜（ANPEP）基因
Almotriptan
Mixed Lineage Kinase
Hexamethylbenzene
TGR5
NKTT120
ROCK inhibition enhanced hepatocyte liver engraftment by retaining membrane CD59 and attenuating complement activation PMID 36860134
Chlorthiamid (氯硫酰草胺)
A small
The NR3C2
氯吡格雷(Standard)
Penicillin G
Discovery and structure
Lycorine hydrochloride inhibits cell proliferation and induces apoptosis through promoting FBXW7
Exosomes Derived from Hypoxic Colorectal Cancer Cells Transfer miR
A 1335
中心体蛋白 76（CEP76）基因
Albumin
Hypothermic machine perfusion reduces donation after circulatory death liver ischemia
Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid
Fendiline hydrochloride 13636
A novel natural PPARγ agonist, Gypenoside LXXV, ameliorates cognitive deficits by enhancing brain glucose uptake via the activation of Akt/GLUT4 signaling in db/db mice PMID 35192202
miR
Smad5 Mouse Pre
Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A PMID 25024194
TrkB activator
Octylbenzene
miR
Regulatory T cells inhibit FoxP3 to increase the population of tumor initiating cells in hepatocellular carcinoma PMID 39073490
FOXO3a
ABCC5 蛋白, Human (E1355Q, HEK293)
N
ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes PMID 40991281
A genome
discovery
Effects of Nervilia fordii Extract on Pulmonary Fibrosis Through TGF
Andrographolide 5508
Safety and immunogenicity of CPG 7909 injection as an adjuvant to Fluarix influenza vaccine PMID 15297066
BET inhibition blocks inflammation
Barcoded viral tracing identifies immunosuppressive astrocyte
PROTAC MTP3 degrader
Smad5 Rat Pre
Tau accumulation triggers STAT1
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development PMID 33314701
Synthesis of non
Triblock PolyA
Smurf1
METTL3
Clinically relevant clot resolution via a thromboinflammation
Low
Cyclo(
Smad1 Rat Pre
Evidence for an imipramine
Ubiquitin C
N
Bis
Buloxibutid 477775
New insights into the olfactory development disrupted by 4
Efficient Delivery of siRNA via Tetrahedral Framework Nucleic Acids Inflammation Attenuation and Matrix Regeneration in Temporomandibular Joint Osteoarthritis PMID 39330704
ZINC194100678
An infection
PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C
LpxC
Pentacycle derivatives as cannabinoid CB1 receptor ligands PMID 19850473
FOSL1 transcriptionally dictates the Warburg effect and enhances chemoresistance in triple
microRNA
Burfiralimab
Near
Jian
LVGN 6051
骨形态发生蛋白 5（BMP5）基因
AMPK
FNDC3B promotes gastric cancer metastasis via interacting with FAM83H and preventing its proteasomal degradation PMID 40450207
Domain
A structure
PfDHODH
Cytotoxic and antibacterial beilschmiedic acids from a Gabonese species of Beilschmiedia PMID 22758788
Macrophage peroxisomes guide alveolar regeneration and limit SARS
JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules PMID 28626520
Oxytetracycline biosynthesis PMID 20522541
cFos
3
PARP
Nontoxic combretafuranone analogues with high in vitro antibacterial activity PMID 29223099
EP300/YAP1
Mycobacterium tuberculosis produces D
HDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer PMID 38705532
BI
FZD1/2/5/7/8
Bergamottin Inhibits Bovine Viral Diarrhea Virus Replication by Suppressing ROS
Checkpoint regulator B7x is epigenetically regulated by HDAC3 and mediates resistance to HDAC inhibitors by reprogramming the tumor immune environment in colorectal cancer PMID 32934224
Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis PMID 32702447
TEAD1
Mxene
Mechanism of RhoA regulating benign prostatic hyperplasia RhoA
Winrevair
Enramycin
Porcine Circovirus Type 2 ORF5 Protein Induces Autophagy to Promote Viral Replication via the PERK
Shield
TRIB3 regulates Cx43 expression in human granulosa cells via the Wnt/β
AMG910
Melatonin suppresses atherosclerosis by ferroptosis inhibition via activating NRF2 pathway PMID 38780199
BMS
Design, synthesis, and in vitro hMAO
Highly potent non
KANK2 Human Pre
Dextran sulfate
Efficient Hydrolysis of Earthworm Protein and the Lipid
Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid
Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles PMID 34623756
Efficacy and safety of voretigene neparvovec (AAV2
Eugenol
Three types of cytotoxic natural caged
Chlorocyclohexane
N
阿利奈肽
Recent contribution of medicinally active 2
Current and emerging biologics for the treatment of hereditary angioedema PMID 30912460
A hMTR4
MGD 010
SK
ACHM
Donetidine (SK&F 93574)
Zolantidine (SK&F 95282)
SAR107375
Ak7
硫利达嗪EP杂质B
Site
TachypleginA
RNA 结合蛋白、mRNA 加工因子（RBPMS）基因
Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment PMID 31354292
Cystatin SA attenuates gastric cancer cells growth and increases sensitivity to oxaliplatin via PI3K/AKT signaling pathway PMID 38717526
Mussel inspired sequential protein delivery based on self
Urolithin a alleviates oxidative stress
Systematic protein
10
肾素（REN）基因
Hydroxy
HSD17B13
Modulation of proliferation and differentiation of human bone marrow stromal cells by fibroblast growth factor 2 potential implications for tissue engineering of tendons and ligaments PMID 15738660
Esculin Alleviates Osteoarthritis Progression Through the Sirt1/NF
DYRK2
Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action PMID 40108208
APD791, 3
84970
Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2
ADSL
SET7 methylates the deubiquitinase OTUB1 at Lys 122 to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis PMID 36822329
配体门控离子通道
Desdiacetyl
BAY
Possible pharmacological targets and mechanisms of sivelestat in protecting acute lung injury PMID 38306776
Envelope domain III E324, E351, and E380 mutations lever adaptive evolution of DENV
CD5 蛋白, Human (Biotinylated, HEK293, Fc
Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer PMID 33139838
HSF cell
Structure
LncRNA LHFPL3
Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β
Guanosine 5& 039;
Isoliquiritigenin alleviates neuropathic pain by reducing microglia inflammation through inhibition of the ERK signaling pathway and decreasing CEBPB transcription expression PMID 39488922
channels isoforms
Design, synthesis and bioactivity study on 5
Codon readthrough inducer 1
Stac Mouse Pre
MAT2A
Biology of GDNF and its receptors
Activation of NLRP2 in Triple
The human testis
Allosteric site in M2 acetylcholine receptors evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist PMID 16362429
MCE
Myomodulin (肌调蛋白)
The cloning of CD70 and its identification as the ligand for CD27 PMID 8120384
PROTAC SMARCA2/4
Single
PROTAC SMARCA2 degrader
Sofituzumab (MMUC 1206A，索非妥珠单抗)
Three
FNDC5 induces M2 macrophage polarization and promotes hepatocellular carcinoma cell growth by affecting the PPARγ/NF
B
Synthesis and initial in vitro biological evaluation of two new zinc
1
Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein PMID 22112540
Dihydroorotate Dehydrogenase
PMEDAP
(S,S)
Co
Penflufen 494793
Metitepine
AP5
Amelioration of myocarditis by HVEM
A pathological role of O
血小板衍生生长因子受体 β（Pdgfrb）基因
1
Lactobacillus extracellular vesicle
B7
Duocarmycin analog2
Amd1 Mouse Pre
密蛋白 2（CLDN2）基因
Mechanism of arsenic regulation of mitochondrial damage and autophagy induced synaptic damage through SIRT1 and protective effect of melatonin in HT22 cell PMID 40081728
Novel quinazoline derivatives bearing various 6
Identification of methyl (5
c(GRGDSP)
Oxycodegol
Control compound
(
PROTAC ALK degrader
RvD 4
L
Phillygenin prevents osteoclast differentiation and bone loss by targeting RhoA PMID 38358766
Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the Early Detection of Chronic Kidney Disease in Dogs PMID 26079532
Bromperidol 10457
PROTAC SGK3 degrader
Indirubin
Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs PMID 21402146
Iloperidone metabolite P88
Trk Receptor
PROTAC α
Both LmDicer
Alcohol in Baijiu Contributes to the Increased Probability of Host Infection by Clostridioides difficile Spores PMID 39049788
miR
(−)
neural cell
AMG 900 945595
PF
LncRNA Taurine Up
4,5
Lercanidipine hydrochloride (Standard)
DBCO
Paeoniflorin
O
Protein
brain function
Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells PMID 22533316
Identification of a Novel Substrate for eEF2K and the AURKA
Calcium carbonate,99.8%,PT
Artemisia capillaris Thunb. water extract attenuates adriamycin
Paclitaxel‑resistant gastric cancer MGC‑803 cells promote epithelial‑to‑mesenchymal transition and chemoresistance in paclitaxel‑sensitive cells via exosomal delivery of miR‑155‑5p PMID 30365045
STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma PMID 38941297
Peripheral Cannabinoid
Myc inhibition tips the immune balance to promote antitumor immunity PMID 35962189
CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure PMID 37106446
Ide Mouse Pre
LLGL2 Inhibits Ovarian Cancer Metastasis by Regulating Cytoskeleton Remodeling via ACTN1 PMID 38136424
Cancer
hNET
BTK degrader
Conservation of structure, function and inhibitor binding in UNC
KMG
Nur77 is involved in the regulation of obesity
TNBC
ARE
U
Cholecystokinin 9011
The combinatorial activities of oseltamivir and molnupiravir against influenza virus infections in vitro and in vivo PMID 40730007
A novel PDGFR inhibitor WQ
Ca 2 oscillations
AP1867
(
MB
microsatellite instability
C9ORF72 transcript
B
IONIS
CD28 蛋白, Mouse (Biotinylated , HEK293, His
Eritadenine (Lentinacin)
Dihydroquercetin attenuates lipopolysaccharide
3β
Cp Mouse Pre
DMP
Dimethyl phthalate
PDPK1 蛋白, Human (sf9)
PTPRC/CD45R0 蛋白, Human (HEK293, His
Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice PMID 34541001
Caveolae
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS
Decreased MFN2 activates the cGAS
5α
Discovery of a Novel and Selective Indoleamine 2,3
miR
A facile nanopattern modification of silk fibroin electrospun scaffold and the corresponding impact on cell proliferation and osteogenesis PMID 39575301
Targeted inhibition of the serotonin 5HT2A receptor improves coronary patency in an in vivo model of recurrent thrombosis PMID 19922435
Melatonin Nuclear Receptors Mediate Green
hPMSCs inhibit the expression of PD
PI3K/mTOR inhibitor VS
Diterpenoids from the feces of Trogopterus xanthipes PMID 20402524
Targeting HSP90 by the novel inhibitor NVP
Structural basis for sterol sensing by Scap and Insig PMID 34192549
RNF4 controls the extent of replication fork reversal to preserve genome stability PMID 35640614
Autophagy impairment as a key feature for acetaminophen
Antagonists for the orphan G
BCL
Rationally designed febuxostat
AQP4 (205
YAP1 regulates PPARG and RXR alpha expression to affect the proliferation and differentiation of ovine preadipocyte PMID 31297878
ACY
KRAB
驱动蛋白家族成员 5B（KIF5B）基因
Selective promotion of sensory innervation
Levacetylleucine 1188
D(
Lentinan inhibits oxidative stress and alleviates LPS
Vif
DAOS
Nano
LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer PMID 34716410
Poly(l
The pharmacology of halogenated salicylanilides and their anthelmintic use in animals PMID 10855824
Mitoquinone ameliorates cigarette smoke
Effect of ST2825 on the proliferation and apoptosis of human hepatocellular carcinoma cells PMID 26985932
LCS
FLT3
Inhibition of the deubiquitinase USP10 induces degradation of SYK PMID 32015510
Saikosaponin A and Its Epimers Alleviate LPS
Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models PMID 25341110
Nucleoprotein (396
Novel vandetanib derivative inhibited proliferation and promoted apoptosis of cancer cells under normoxia and hypoxia PMID 35331723
ADAM12 is A Potential Therapeutic Target Regulated by Hypomethylation in Triple
TLR9 activation cooperates with T cell checkpoint blockade to regress poorly immunogenic melanoma PMID 31771649
Ferritinophagy
PSNCBAM
LncRNA NEAT1 ameliorate ischemic stroke via promoting Mfn2 expression through binding to Nova and activates Sirt3 PMID 35067795
Pla1a Mouse Pre
Pyroxasulfone
依库珠单抗
Design, synthesis, and structure
Tolfenamic acid negatively regulates YAP and TAZ expression in human cancer cells PMID 37544381
ASA
Establishment of a trastuzumab
Bystander effect of SARS
Noncanonical role of Golgi
RNA methyltransferase METTL3 induces intrinsic resistance to gefitinib by combining with MET to regulate PI3K/AKT pathway in lung adenocarcinoma PMID 33491264
Effect of an aldose reductase inhibitor, SNK
ATPase
Chemo
盐酸地尔硫卓 d<sub>3</sub> (盐酸盐)
SCR
Mechanisms and targeted prevention of chronic pancreatitis
Lysine succinylome analysis of MRSA reveals critical roles in energy metabolism and virulence PMID 39825643
Ethacridine inhibits SARS
Brain nuclear receptors and cardiovascular function PMID 36670468
纺锤体和着丝粒相关复合亚基 1（SKA1）基因
dGEM
具有免疫球蛋白样和 EGF 样结构域的酪氨酸激酶 1（TIE1）基因
Differential impact of the kinase inhibitors ruxolitinib and ceritinib on porcine sperm in vitro PMID 40318512
Copper exposure elicits pyroptosis and inflammation in bursa of Fabricius and omega
Sesamin attenuates intestinal injury in sepsis via the HMGB1/TLR4/IL
Role of Na+/H+ exchanger in the pathogenesis of ischemic acute renal failure in mice PMID 17414227
Endoproteinase Asp
beta
Obrixtamig (BI 764532)
Development of immunoprecipitation
In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase PMID 22760227
Perampanel ameliorates nitroglycerin
Di
1
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 PMID 26771665
Lower androgen levels promote abnormal cartilage development in female patients with adolescent idiopathic scoliosis PMID 34268397
PROTAC PTPN2 degrader
GNF2133 2561414
FLI1 induces erythroleukemia through opposing effects on UBASH3A and UBASH3B expression PMID 38461240
Top Publications Citing MCE Products
Antitumoral activity of quinoxaline derivatives A systematic review PMID 30503938
有丝分裂原活化蛋白激酶激酶 1（MAP3K1）基因
Data Resources for the Computer
Cxcl9
NerveGreen C3
Metabolism
Three
The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential PMID 36744297
Interleukin
hsa
The interaction between E3 ubiquitin ligase Parkin and mitophagy receptor PHB2 links inner mitochondrial membrane ubiquitination to efficient mitophagy PMID 36379251
(Rac)
Bone deterioration in response to chronic high
Almotriptan hydrochloride
Genome
4(Z),7(Z),10(Z)
肌球蛋白结合蛋白 C2（MYBPC2）基因
Expression of ribosomal protection protein RppA is regulated by a ribosome
驱动蛋白家族成员 C3（KIFC3）基因
The lipogenic LXR
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