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Astragaloside IV Regulates the PI3K/Akt/HO
Bethanidine sulfate 114
DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis a large cohort study PMID 27793038
TREM
Effective therapeutic regimens in two South Asian countries with high resistance to major Helicobacter pylori antibiotics PMID 30815255
Inolitazone (Efatutazone)
PPIC 蛋白, Human (Trx
ALW
A convenient synthesis of 2'
5
IPA
Mulberrin alleviates triclocarban induced hepatic apoptosis and inflammation by regulating the ROS/NF
In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts PMID 2169738
Thienopyridone 1018454
Characterization of the Anti
In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo PMID 25159092
The mechanism of Arhalofenate in alleviating hyperuricemia
Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis PMID 34750273
Pharmacokinetic
Intracellular Dual Fluorescent Lightup Bioprobes for Image
Design, synthesis and biological evaluation of tyrosine
Orphan receptor IL
Talabostat 149682
NR2E1 抗体 (YA2648)（NR2E1 Antibody (YA2648)）
地恶唑可特
pPB Peptide
Retinoic Acid Receptor beta 抗体 (YA1574)（Retinoic Acid Receptor beta Antibody (YA1574)）
Efficacy and safety of aprotinin in cardiac surgery PMID 15239553
mmu
CY3
核因子 kappa B 亚基 1（NFKB1）基因
Sodium 2
AMPA receptor modulator 7
Design and synthesis of a potent macrocyclic 1,6
SB
GRB2 相关衔接蛋白（GRAPL）基因
EG00229
Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma PMID 26035713
Phoenixin
5
(R)
PF
Relative quantitation of glycopeptides based on stable isotope labeling using MALDI
Identification and antitumor activity of a novel inhibitor of the NIMA
Lasiodiplodiapyrones A and B, Pyrone
HSV
Bone marrow mesenchymal stem cells modified with heme oxygenase
Prophylactic and therapeutic benefits of COX
TRAIL/TNFSF10 Trimer 蛋白, Human (HEK293, His
NIC
Silybin B 142797
Myristic acid
Up
arteries
GSK
Lucyoside E 91174
QSAR study
Oncogenic DNA methyltransferase 1 activates the PI3K/AKT/mTOR signalling by blocking the binding of HSPB8 and BAG3 in melanoma PMID 37523636
7
Identification of a degrading enzyme in human serum that hydrolyzes a C
Evaluation of NUC
First
β
Dehydromonocrotaline
JCP 174
3
KCNK2
9
Top Publications Citing MCE Products
Notch激动剂、基因
Azide
Structure
Plasma fractalkine contributes to systemic myeloid diversity and PD
Synthesis and mechanistic evaluation of novel N'
The green tea polyphenol (2)
Scn8α
CXC 基序趋化因子受体 1（CXCR1）基因
3
Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases PMID 20020057
Anti
Trhde
Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5
Taurocholic acid inhibits the response to interferon
Malacidin B
DYRK抑制剂、基因
femoral artery
Inhibition of poly (ADP
OdDHL inhibits T cell subset differentiation and delays diabetes onset in NOD mice PMID 21653742
15
Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR PMID 15272053
Fluo
METTL14 upregulates TCF1 through m6A mRNA methylation to stimulate osteogenic activity in osteoporosis PMID 36401086
Mif
MCE
D
SIRT1调节剂、基因
Branched
Polylactic acid 26100
Effects of sub
Heterogeneous Responses to Mechanical Force of Prostate Cancer Cells Inducing Different Metastasis Patterns PMID 32775149
早老素 2（PSEN2）基因
Mechanisms of type
Qinghaosu
Verlamelin
Ranolazine a review of its use as add
BQ0413
Beneficial Effects of Trillium govanianum Rhizomes in Pain and Inflammation PMID 27556434
Indulging Curiosity Preliminary Evidence of an Anxiolytic
Nesuparib 2055357
Fcgr1
Comparison of biological effects of N
The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino
肌钙素（SRL）基因
Navitoclax (ABT
MRV03
Technical Support
Design, Synthesis, and Biological Evaluation of Peptidomimetic Tetrahydropyrrole Spirodihydroindolones as SARS
Practical silyl protection of ribonucleosides PMID 24000770
iASPP suppression mediates terminal UPR and improves BRAF
Inhibitory effects of apigenin on the growth of gastric carcinoma SGC
Nelociguat (BAY60
PFK
Formosanin C attenuates lipopolysaccharide
Aerosol inhalation of rhIL
Bisphenol A
m
Dihydroeponemycin 126463
A prospective, randomized study comparing cefozopran with piperacillin
Covalent sortase A inhibitor, α, β
A single
cis
Ac
Five new flavone 5
A
PKCγ抑制剂、基因
Clavamycin B 103080
Integration of epigenomic and transcriptomic profiling uncovers EZH2 target genes linked to cysteine metabolism in hepatocellular carcinoma PMID 39516467
Design, synthesis, and antitumor activity of novel compounds based on 1,2,4
Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica PMID 15787451
11
Establishing and characterizing patient
Solvent red 195 72968
Pyrrolizidine alkaloids in honey and bee pollen PMID 21360377
Sulforaphane attenuates irradiation induced testis injury in mice PMID 38052218
Ospemifene 128607
Top Publications Citing MCE Products
Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms PMID 33341872
Selectivity and anti
Pyrazole and Pyrazolate as Ligands in the Synthesis and Stabilization of New Palladium(II) and (III) Compounds PMID 26914982
Photoactivated Protein Degrader for Optical Control of Synaptic Function PMID 37712589
SPDB
Myosin
9α,11
Pifoxime 31224
Synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats PMID 22672299
A Novel Photosensitizer Based 450
CP
Responsiveness of different MET tumour alterations to type I and type II MET inhibitors PMID 40437874
TLR9/NF
USP11 蛋白, Human (sf9)
Antibacterial agent 40 1817768
Cearoin 52811
Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP
Spirulina ameliorates aspirin
Fluvastatin inhibits AGE
Cancer
Synthesis and anti
Schisandrin B Improves Mitochondrial Function and Inhibits HT22 Cell Apoptosis by Regulating Sirt3 Protein PMID 39939534
Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs PMID 29483523
Palmitoylethanolamide
Rational Design of a Boron
(±)
Roseoflavin
Enmenol 28957
Cognitive impairment in Coffin
Prediction and modeling of effects on the QTc interval for clinical safety margin assessment, based on single
Pyranine free acid 27928
C.I. Acid green 27 6408
Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo
Succinate dehydrogenase
A novel peptide
Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β
Poly
6RK73
时钟昼夜节律调节器（CLOCK）基因
Preclinical Development of Novel PSMA
Decanoyl
MF
Rat amylin
Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway PMID 31553577
Discovery of Novel Phosphoinositide
Btnl2
CD223/LAG
Corynecin IV 40958
3
Ro 25
Gambogenic acid induces apoptosis and autophagy through ROS
Microbiota
Exploring the potential mechanism of tofacitinib therapy for ankylosing spondylitis through gut microbiome and plasma metabolomics PMID 40439987
Schisandrin 7432
Excess palmitate induces decidual stromal cell apoptosis via the TLR4/JNK/NF
Mechanisms of aristolochic acid I Hepatotoxicity Central role of PDK4
Arousal and the pupil why diazepam
N
Luzindole 117946
Keap1
Hypocretin
Aβ1–42 aggregation inhibitor 2 3036099
Notch
Studies on wound healing effects of calcium D
Pitavastatin decreases tau levels via the inactivation of Rho/ROCK PMID 22133277
Prl
Safe use of the CXCR4 inhibitor ALX40
Chromatographic methods for characterization of poly(ethylene glycol)
Efficacy of the carbocyclic 2'
The serine protease inhibitors TLCK and TPCK react with the RB
Zinc finger protein 91 positively regulates the production of IL
EMB is essential for enteric nervous system development mediated by PI3K signaling PMID 40999499
Leonurine Protects Bone Mesenchymal Stem Cells from Oxidative Stress by Activating Mitophagy through PI3K/Akt/mTOR Pathway PMID 35681421
Mitochondria
Immunomodulatory Activity of Octenyl Succinic Anhydride Modified Porang (Amorphophallus oncophyllus) Glucomannan on Mouse Macrophage
Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. II. Isolation and structural elucidation PMID 7649857
Evodiamine alleviates lipopolysaccharide
Targeting fatty acid synthase modulates sensitivity of hepatocellular carcinoma to sorafenib via ferroptosis PMID 36604718
Synthesis and preliminary in vitro investigation of bivalent ligands containing homo
Efficacy of NAMPT inhibition in T
Nedisertib 1637542
Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC PMID 36645983
The Core Mechanism of Yiqi Yangjing Decoction Inhibiting Nonsmall
Targeting Xist with compounds that disrupt RNA structure and X inactivation PMID 35355011
CDK7
Evaluation of first pass effect and biliary excretion of diperdipine in the dog PMID 2253647
Anticancer agent 9 592542
Synthesis, radiolabeling, and biological evaluation of methyl 6
Purine nucleoside phosphorylase inhibitor BCX
A heteromeric Texas coral snake toxin targets acid
Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine PMID 17106444
CypHer 5
Small molecule splicing modifiers with systemic HTT
26
Transgelin
PROTAC BCR
Physcion 521
Novel thienoduocarmycin
SARS
Comparative Anticancer Potentials of Taxifolin and Quercetin Methylated Derivatives against HCT
BI
Intrauterine hyperglycaemia during late gestation caused mitochondrial dysfunction in skeletal muscle of male offspring through CREB/PGC1A signaling PMID 39043630
Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication PMID 37852322
Evaluation of Safety of Treatment With Anti
Impact of chelation timing on gadolinium deposition in rats after contrast administration PMID 30321663
Selagibenzophenone B and Its Derivatives SelB
2
The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin PMID 35537456
The RNA
Serum‑derived exosomes from house dust mite‑sensitized guinea pigs contribute to inflammation in BEAS‑2B cells via the TLR4‑NF‑κB pathway PMID 34458929
USP34 regulates PIN1
Apraclonidine hydrochloride (Standard) (ALO 2145 (Standard)，盐酸安普乐定(Standard))
SNIPERs抑制剂、基因
Sulfamethoxazole 723
Glycopyrrolate 596
Induction of interferon
Field effects of simazine at lower trophic levels
无名指和 CCCH 类型域 2（RC3H2）基因
αvβ6抑制剂、基因
PERK调节剂、基因
Acpp
A Dual
Gadolinium chloride 10138
Eosinophil
Alpha
Cancer
Mutations in GDF11 and the extracellular antagonist, Follistatin, as a likely cause of Mendelian forms of orofacial clefting in humans PMID 31215115
DSPE
Mechanism of pyrithione
PTUPB 1287761
First
Lofexidine hydrochloride (Standard) (盐酸洛非西定 (Standard))
Sulfosuccinimidyl oleate (Sulfo
Neuro
Characterization of calcitonin gene
Firategrast
T
Synthesis and structure
Mal
Hepatitis E virus ORF3 protein hijacking thioredoxin domain
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS
Biophysical and pharmacokinetic characterization of a small
Pleckstrin
RYL
Novel PORCN inhibitor WHN
Trilostane 13647
Dialkylamino and nitrogen heterocyclic analogues of hexadecylphosphocholine and cetyltrimetylammonium bromide effect of phosphate group and environment of the ammonium cation on their biological activity PMID 19762125
PRLR
Steroids and related natural products. 90. 15beta
Oxantel is an N
Diarylpropionitrile (DPN) enantiomers synthesis and evaluation of estrogen receptor β
Apoptotic pathways of epothilone BMS 310705 PMID 14529678
A phase 2 study of oral MKC
Neuroprotective effects of new protein kinase C activator TPPB against Aβ₂₅₋₃₅ induced neurotoxicity in PC12 cells PMID 22832950
Phosphoinositide 3
Eosinophils
Electroacupuncture Alleviates Streptozotocin
Loteprednol etabonate a review of ophthalmic clinical studies PMID 10756536
Follicle
Design and synthesis of 4
AMPK
A glycolytic metabolite bypasses two
Isocyclosporin A 59865
Carbamazepine 10,11
MS31 trihydrochloride 2748239
3
Differential gene expression profiling linked to tumor progression of splenic marginal zone lymphoma PMID 28887496
mGluR5 Facilitates Long
Action of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on axonal fibrillar organelles in vitro PMID 558047
Cdk5 Substrate 164669
High Efficacy by GAL
Secalonic Acid
Hoechst 33342 analog 178481
Evalstotug 2460399
Gamma
KD
Targeting TBK1 to overcome resistance to cancer immunotherapy PMID 36634707
AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)
Fkbp10
Discovery of the First Selective M4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy PMID 34423268
Gars1
MAT2A inhibitor 1
Rifamycin
Discovery of N
Notch调节剂、基因
Discovery of vimseltinib (DCC
CSLP37 2244984
Novel all trans
PEDV infection affects the expression of polyamine
Gpt2
Kainic acid 487
鞘磷脂磷酸二酯酶 1（SMPD1）基因
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin α
3
Odanacatib
ACSS2 protects against alcohol
Histone Deacetylation 10 Alleviates Inflammation After Intracerebral Hemorrhage via the PTPN22/NLRP3 Pathway in Rats PMID 32112918
MiR
The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up
Rational design of agonists for bitter taste receptor TAS2R14 from modeling to bench and back PMID 31236627
Anti
Synthesis and evaluation of cytotoxic and Na+/K+
5
Cys
ENMD
CD66b 抗体 (YA4695)（CD66b Antibody (YA4695)）
Valbenazine 1025504
Isoquinoline
Ser/Thr Protease
FPR1 antagonist 2
Highly regioselective hydroxylation of polydatin, a resveratrol glucoside, for one
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts PMID 39814012
Sodium formate
New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae PMID 21169356
Transport Mechanisms of Polymannuronic Acid and Polyguluronic Acid Across Caco
Periplanetasin
Meliponamycins Antimicrobials from Stingless Bee
Apoptolidin
Propagation of conformational instability in FK506
SIRT5
2
3
卵黄羧肽酶 (CPVL)
C
Gap43
Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima PMID 22313254
Exatecan Intermediate 5 143655
Therapeutic targeting nudix hydrolase 1 creates a MYC
BACE1 (beta
eIF4A3
Somatostatin Receptor
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators PMID 31782922
JAK2诱导剂、基因
TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer PMID 36604411
HSD17B13
USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer PMID 34531315
含同源盒 1（HMBOX1）基因
Diarrhoea of famine and malnutrition
Anticancer agent 112 2495321
Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring PMID 20143840
M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland PMID 12122494
CDE
1,5
Rapid flow
XL
LINC00115 promotes chemoresistant breast cancer stem
Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents PMID 22847436
Tubeimosides are pan
Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ) PMID 27471855
Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter implications for the emergence and reversal of cancer drug resistance PMID 22548830
Amylocaine
TIMP
Substituted 2,3
VRK1 蛋白, Human (sf9)
m
Albiflorin 39011
Population Pharmacokinetic Analysis of BMS
Astragaloside VI Promotes Neural Stem Cell Proliferation and Enhances Neurological Function Recovery in Transient Cerebral Ischemic Injury via Activating EGFR/MAPK Signaling Cascades PMID 30088176
免疫共沉淀
Flutamide 13311
Inhibitory effect of mizoribine and ribavirin on the replication of severe acute respiratory syndrome (SARS)
Golgi stress mediates redox imbalance and ferroptosis in human cells PMID 30511023
ACVRL1 drives resistance to multitarget tyrosine kinase inhibitors in colorectal cancer by promoting USP15
Vector
Cathepsin Control、基因
Novel insights in localization and expression levels of C5aR and C5L2 under native and post
An assessment of the validity of adolescent self
The effect and mechanism of erianin on the reversal of oxaliplatin resistance in human colon cancer cells PMID 34351659
Il15ra
Enantioselective syntheses of both enantiomers of 9'
Identification of a diverse indole
L
Dutasteride, the dual 5alpha
Synthesis and evaluation of 2
Photochemical fate of sulfadimethoxine in aquaculture waters PMID 20028056
Tricosanoyl ethanolamide 171022
Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate PMID 25813021
Activation of the CFTR Cl
Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer PMID 34289372
3
Mouse models of breast cancer in preclinical research PMID 30671101
RNA Polymerase II Inhibitor, α
Sulfosuccinimidyl oleate sodium (Sulfo
MFN2
Beneficial Effects of the Direct AMP
TIM 蛋白, Human (His)
Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy PMID 10373220
Blocking WNT7A Enhances MHC
Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves PMID 9879754
Xylose
2
MCE
Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non
KRAS inhibitor
6X His Tag (C
7
[DPro5] Corticotropin Releasing Factor, human, rat 195628
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury PMID 35148842
SGK3 Human Pre
Simultaneous detection of 24 oral antidiabetic drugs and their metabolites in urine by liquid chromatography
HKOCl
FPR2 agonist 4
Positive GLI1/INHBA feedback loop drives tumor progression in gastric cancer PMID 38676428
NETosis promotes chronic inflammation and fibrosis in systemic lupus erythematosus and COVID
A Maleimide
Imaging Leucine
Tesirine 1595275
Synthesis of estrone selenocyanate Compounds, anti
VS
四肽重复结构域 27（TTC27）基因
Electroacupuncture Attenuates Immune
Antifungal agent 113 1373311
SARS
甲硫氨酸腺苷转移酶 2A（MAT2A）基因
Sulfo
双特异性磷酸酶 3（DUSP3）基因
Novel antibody drug conjugates containing exatecan derivative
Phase II study of enlonstobart (SG001), a novel PD
Electroacupuncture
Levomedetomidine hydrochloride
Exosomal annexin A6 induces gemcitabine resistance by inhibiting ubiquitination and degradation of EGFR in triple
AQP1 蛋白, Human (GST)
Direct and two
Laquinimod and 3,3'
Methacrylated Carrageenan/Gelatin Interpenetrating Network Microspheres Loaded with Targeted Drugs and combined with PD
3,7
4
Qinghao
Cimetidine 51481
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3
The MSP
Suppression of inflammation by a synthetic histone mimic PMID 21068722
Synthesis and biological evaluation of arylpiperazine derivatives as potential anti
Aflatoxin Q1 52819
Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity PMID 37121966
NOD1 deficiency promotes inflammation via autophagic degradation of ASK1 PMID 40399666
ALXR
Screening of different species reveals cat hepatocytes support HBV infection PMID 40758741
Docosahexaenoyl glycerol
[d4U]
EphA2 agonist 1
Chromogranin A and derived peptides in health and disease PMID 22388654
1
CBR4
Dantrolene sodium hemiheptahydrate 24868
Antileishmanial agent
Notiretatug 3036556
IL1R2
Bromperidol decanoate (Standard) 75067
Quinacainol 86073
Hemoglobin provides protection against lethal endotoxemia in rats the role of heme oxygenase
Grazoprevir sodium salt 1425038
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