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Effects of TCV
PPO
核心 1 合酶，糖蛋白
Standard in vitro co
ZYJ
DAPK
Lupane triterpenoids from the stems of Euonymus carnosus PMID 24467317
Lactate programs PBX1 lactylation and mesangial proliferation in lupus nephritis PMID 40299657
Samioside, a new phenylethanoid glycoside with free
TGFBR2/TGF
Angiopoietin
Doxofylline 69975
Vitamin D deficiency exacerbates alcohol
ROCK2
Phosphatases maintain low catalytic activity of SGK1 DNA damage resets the balance in favor of phosphorylation PMID 37343701
Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/Slug pathway PMID 41014726
ABT
GP
UBE2H 蛋白, Human (GST)
FT709 2413991
High CDK6 Protects Cells from Fulvestrant
Paeciloquinone B 162797
Pirfenidone ameliorates hypertrophic scar through inhibiting proliferation and migration of fibroblasts by regulating the Wnt/GSK
Velnacrine 124027
Cytotoxic Triterpenoids from Roots of Actinidia chinensis PMID 29164821
3,4'
Fmoc
163087
5
Fmoc
SETD2
MET 原癌基因， 受体酪氨酸激酶（MET）基因
JAK2降解剂、基因
Novel osteogenic peptide from bovine bone collagen hydrolysate Targeted screening, molecular mechanism, and stability analysis PMID 38996641
Vitamin K2 ameliorates osteoarthritis by suppressing ferroptosis and extracellular matrix degradation through activation GPX4's dual functions PMID 38759289
Mecillinam, a novel penicillanic acid derivative with unusual activity against gram
Streptococcal Endo
Enocitabine 55726
The Combination Vaccine Adjuvant System Alum/c
Effect of 28 days treatment of baricitinib on mechanical allodynia, osteopenia, and loss of nerve fibers in an experimental model of type
Dimethyl isophthalate 1459
FAPy
Lipid/Polyelectrolyte coatings to control carbon nanotubes intracellular distribution PMID 22905538
Inhibitory effects of JQ1 on listeria monocytogenes
Propofol Protects the Blood
Hanultarin, a cytotoxic lignan as an inhibitor of actin cytoskeleton polymerization from the seeds of Trichosanthes kirilowii PMID 18603435
KRAS G12C inhibitor 27 2648584
Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells PMID 24879147
Lyoniside 34425
BUB1B
12
Paeoniflorin Attenuates APAP
Modulation of c
Ponsegromab for the Treatment of Cancer Cachexia PMID 39282907
Quercetin combined with shTERT induces apoptosis in ovarian cancer via the P53/Bax pathway, and RGD
ML
Mycophenolic acid sodium 37415
PP5
Potassium chloride, AR, 99.5% 7447
New aldo
A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress PMID 30292171
Loss of UBE2S causes meiosis I arrest with normal spindle assembly checkpoint dynamics in mouse oocytes PMID 38546043
Influence of pistachios on performance and exercise
(+)
Hesperetin from Root Extract of Clerodendrum petasites S. Moore Inhibits SARS
PTGDS 蛋白, Human (HEK293, His)
Top Publications Citing MCE Products
Accumulation of Damaging Lipids in the Arf1
LDHA/PDKs
CDK2 heterobifunctional degraders co
Chromatin
白细胞介素 6 受体（IL6R）基因
Impact of purine nucleotide on fatty acid metabolism and expression of lipid metabolism
H
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors PMID 32527535
DSS30
JNJ
Green recipes to quinoline A review PMID 30594028
16 0
HBV抑制剂、基因
A DNA tetrahedron
Ureaplasma urealyticum GrpE protein elicits glycolysis
Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader PMID 40232306
RSM3 TFA
Aflibercept, a VEGF (Vascular Endothelial Growth Factor)
Polyphenol extract ameliorates diabetes
Cyclohexane
CMD178 TFA
2
8
Wu
Phenol Red sodium salt 34487
Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398 PMID 28255027
Discovery of ODM
TMEM176B inhibits ovarian cancer progression by regulating EMT via the Wnt/β
miRNA antagomirs
pSILAC method coupled with two complementary digestion approaches reveals PRPF39 as a new E7070
Pyrimidinone 8 65004
CKIP
Pseudoirroratin A, a new cytotoxic ent
Luciferin derivatives for enhanced in vitro and in vivo bioluminescence assays PMID 16964971
Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells PMID 22049464
NB
NNGH 161314
(R)
1
Pediatric Dosing of Intravenous Sotalol Based on Body Surface Area in Patients with Arrhythmia PMID 28755092
CCK (27
DNMT3A
Electrostimulation suppresses allograft rejection via promoting lymphatic regulatory T cell migration mediated by lymphotoxin
ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10
Synthesis, β
Mussel
Association between NDUFS1 from urinary extracellular vesicles and decreased differential renal function in children with ureteropelvic junction obstruction PMID 38720274
SIRT3
1
USP4 蛋白, Human (Active, sf9, His, Flag)
An ovarian insulin
RTKs 重组蛋白 5 折购
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability PMID 37839786
DL
Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS
Fmoc
Topo I激动剂、基因
HDAC/PSMD14
Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair PMID 37524876
L
OPC
FZD2 蛋白, Mouse (HEK293, Fc)
CDK12
Therapeutic window for cycloheximide treatment after hypoxic
STING agonist 30
Lactobacillus plantarum SMUM211204 Exopolysaccharides Have Tumor
R(+)
Taltobulin intermediate
Inhibitory effect of carboxylic acid group on hERG binding PMID 16931010
Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration PMID 31638236
Phosphorylethanolamine 1071
AChE/BChE
Hypnophilin 80677
Cryptolepine and aromathecin based mimics as potent G
Off
In vitro activity of a new oral triazole, BMS
Serratia symbiotica Enhances Fatty Acid Metabolism of Pea Aphid to Promote Host Development PMID 34073039
Ribonuclease 1 Induces T
FPR2 agonist 2
Sudan III
Fenirofibrate 54419
Theaflavin
PAK抑制剂、 Control、激活剂、降解剂、基因
强力求偶素
Top Publications Citing MCE Products
MEK1抑制剂、基因
Mechanism
Anti
JNK3 inhibitor
Synthesis and biological evaluation of novel synthetic chalcone derivatives as anti
Discovery of potent Pan
Microbially produced imidazole propionate impairs prostate cancer progression through PDZK1 PMID 39819421
The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia PMID 26937215
Nicotine Suppresses the Invasiveness of Human Trophoblasts by Downregulation of CXCL12 Expression through the Alpha
A role for macrophages in hematopoiesis in the embryonic head PMID 31697805
Alpinumisoflavone acetate 86989
PTEN激动剂、基因
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models PMID 18408761
Top Publications Citing MCE Products
HLA
USP14 promotes the cancer stem
Cyclooxygenase
Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model PMID 19410459
11α
FSP1 is a glutathione
CD146 mediates an E
Bikinin
Design, synthesis, and antiviral activity of entry inhibitors that target the CD4
Glutamine availability regulates cDC subsets in tissue PMID 39345449
ZK
Neuropeptide SF (human) acetate 2924824
β
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I
Akkermansia muciniphila inhibits nonalcoholic steatohepatitis by orchestrating TLR2
Detajmium L
Melatonin Prevents against Ethanol
Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts PMID 33965731
Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II PMID 30737134
Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline PMID 38942792
Anti
Cefiderocol 1225208
Caco
LXE408 fumarate 3026790
Rho 鸟嘌呤核苷酸交换因子 4（ARHGEF4）基因
Aspartame
dickkopf WNT 信号通路抑制因子 1（DKK1）基因
Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents PMID 17624792
溶质载体家族 41 成员 1（SLC41A1）基因
TAK
Pre
Low molecular weight dextran sulfate a strong candidate drug to block IBMIR in clinical islet transplantation PMID 16426314
HMGB1 inhibits the IFN
(±)4
(S)
5(S)
Microtubule nucleation from the fibrous corona by LIC1
(2
3
Antifertility action and metabolism of hexamethylphosphoramide PMID 5965579
4
含 Rho 相关卷曲螺旋蛋白激酶 2（Rock2）基因
Citral 5392
O
Sialidases derived from Gardnerella vaginalis remodel the sperm glycocalyx and impair sperm function PMID 39975358
BCTC 393514
Euphol 514
Lodoxamide tromethamine 63610
Daphnetin ameliorates Aβ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double
SDZ
Antimicrobial activity of omiganan pentahydrochloride against contemporary fungal pathogens responsible for catheter
TAPI
DBP Exposure Affects Oocyte Fertilization Via Extracellular Vesicles
RNA helicases, DDX5 and DDX17, facilitate lytic reactivation of gammaherpesviruses PMID 40257982
β
Adulthood bisphenol A exposure induces anxiety in male mice via downregulation of alpha
Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram
ZLWH
ATF7IP inhibits Sorafenib
Anapc1
(1R,4S)
Noncanonical autophagy is a new strategy to inhibit HSV
Allograft inflammatory Factor
Sh2d1a
Apigenin enhancing oxidative resistance and proteostasis to extend lifespan via PTEN
Cosdosiran 1834560
6
Triazole
MCE
L
Eugenyl benzoate
LARP1, an RNA
The Combination of PF
Polyoxyethylene (20) stearyl ether
m
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney PMID 12399320
Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF
Octan
Propynol Ethoxylate (丙炔醇乙氧基化合物)
The Crosstalk Between Sepsis
STAT3
Zoledronic acid
(1S,2R,7S)
Thap11
Chlophedianol 791
Spotlight on histamine dihydrochloride in acute myeloid leukaemia PMID 21428467
N6
JAK2调节剂、基因
Neutrophil
MSX 130
Antagonism of N
Topo II抑制剂、基因
Ropivacaine hydrochloride 98717
Effects of protizinic acid on leukokinin generation and its physiological action PMID 6475667
Discovery of DNA
Development of monoclonal antibodies against pirimiphos
m
Angulasaponin B 1628031
M6a demethylase FTO regulates the oxidative stress, mitochondrial biogenesis of cardiomyocytes and PGC
FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis PMID 30745141
Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants PMID 7664866
Platelet activating factor
Substrate specificity of acetoxy derivatives of coumarins and quinolones towards Calreticulin mediated transacetylation investigations on antiplatelet function PMID 22264757
FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21 PMID 30808376
Okadaic acid sodium 209266
Phosphorylase recognition and phosphorolysis of its oligosaccharide substrate answers to a long outstanding question PMID 10469642
Hsp90ab1
Z
Characterization of the YCjN ABC Transporter in Escherichia coli Role in Maltose and Ethidium Bromide Transport PMID 40721696
Desmethyl
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway PMID 23867477
Quinine hemisulfate hydrate 207671
Leishmanicidal Activity of (+)
MRK
MCE
A selective small molecule inhibitor of c
GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation
4
IL
Beta
Synthesis of a highly active new anti
(9Z,12Z)
Guanine quadruplexes in the RNA genome of the tick
Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing PMID 36647382
The anti
SAR 439774
PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection PMID 34543359
TNF 受体超家族成员 9（TNFRSF9）基因
C
Design, Synthesis, and Characterization of 4
Lactate increases stemness of CD8 + T cells to augment anti
Depsidomycin 131956
Synthesis, biological evaluation, and structure
Reactive orange 13
Ferroptosis induced by DCPS depletion diminishes hepatic metastasis in uveal melanoma PMID 37245534
11
Mutagenicity and antibacterial activity of mycotoxins produced by Penicillium islandicum Sopp and Penicillium rugulosum PMID 368283
Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death PMID 19466982
MSX
Mycophenolic acid glucuronide 31528
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis PMID 18758449
Hedgehog Signaling Pathway Regulates the Proliferation and Differentiation of Rat Meibomian Gland Epithelial Cells PMID 33616621
Batimastat sodium salt 130464
Electrically activated polymetallic nanocrystals for long
Theileria apicoplast as a target for chemotherapy PMID 19075064
(R)
Antiviral activity of C
NCB
Anti
Characterization of the interaction of ingenol 3
Sodium L
Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1 PMID 38594460
DEHP regulates ferritinophagy to promote testicular ferroptosis via suppressing SIRT1/PGC
Astrocyte
Heteroarylisopropylamines as MAO inhibitors PMID 15908219
Tegafur
Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid PMID 10395504
MPT0B392 1346169
Protective role of pretreatment with Anisodamine against sepsis
Cyclamide 664
JPH203 alleviates renal fibrosis via inhibition of serine
TROP2 抗体 (YA2130)（TROP2 Antibody (YA2130)）
Analysis of the antiepileptic, ethosuximide impacts on neurogenesis of rat forebrain stem cells PMID 24354536
Bacoside A3 157408
Ribose
BRD0539 1403838
L
SLC39 (Zinc Transporter)
Epigenomic landscapes define differential Janus kinases inhibitor sensitivity in IFN
Tp47 promoted the phagocytosis of HMC3 cells though autophagy induced by endoplamic reticlum stress PMID 35666816
BFA
A selective high
A new class of HIV
草刺桐提取物 (Erythrina herbacea)
Mast cells interact directly with colorectal cancer cells to promote epithelial
Aminoalkyl derivatives of guanidine diaromatic minor groove binders with antiprotozoal activity PMID 23301592
RAD1901 a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models PMID 26164151
LCC
Regulation of specific abnormal calcium signals in the hippocampal CA1 and primary cortex M1 alleviates the progression of temporal lobe epilepsy PMID 37488907
2
SMURF1 controls the PPP3/calcineurin complex and TFEB at a regulatory node for lysosomal biogenesis PMID 37909662
3
Foliglurax 1883329
Crobenetine hydrochloride 221018
The effects of losartan and captopril on vasopressor actions of cirazoline in the absence and presence of SZL
Dopamine D2 receptor activator quinpirole protects against trypsinogen activation during acute pancreatitis via upregulating HSP70 PMID 32308041
Electroacupuncture prevents the development or establishment of chronic pain via IL
[5
IL
PROTAC SOS1 ligand 1 3027977
T 细胞受体复合物的 CD3 epsilon 亚基（CD3E）基因
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer PMID 35110531
Potential Anticancer Agents Characterized from Selected Tropical Plants PMID 30830783
MB
Notch
Vascular effects of different lipophilic components of Danshen , a traditional Chinese medicine, in the isolated porcine coronary artery PMID 18855446
Pantoprazole sodium 138786
TRIM56 Modulates YBX1 Degradation to Ameliorate ZBP1
The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer PMID 36329124
The sphingomyelin
MMP
CD22
AlgMA (MW 300000)
Comparison of postprandial and ceruletide serum bile acid stimulation in dogs PMID 18537882
Biocompatible 2D Materials via Liquid Phase Exfoliation PMID 38457626
Icariin protects human nucleus pulposus cells from hydrogen peroxide
trans
FMS
TRIB1
Antiviral activity of maribavir in combination with other drugs active against human cytomegalovirus PMID 30040968
TP0427736 hydrochloride 2459963
Fmoc
Elacridar 143664
Potential novel biomarkers of disease activity in rheumatoid arthritis patients CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony
Metabolic studies on metiazinic acid I. Absorption, distribution, excretion and metabolism in rats and rabbits PMID 1173931
5,7,2',6'
EZH2
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells PMID 30769091
NIR
ACC1/2
SLAIN 主题家族成员 1（SLAIN1）基因
Nardosinone 23720
(rac)
amino acid derivative
Bromodomain Protein BRD4
5
Inhibition of nitric oxide production in lipopolysaccharide
PD318088
脯氨酸
Karrikin 2 857054
Mex3a marks drug
Decrease of miR
The regulatory role of COX
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen
170685
Targeting Antigen
BBT594 882405
PSB 603
Biological characterization of 3
Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10
The underlying mechanisms of lorlatinib penetration across the blood
IL
Parallel synthesis, evaluation, and preliminary structure
Histamine increases cytosolic Ca2+ in dibutyryl
Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide
Cytoskeletal disruption induces T cell apoptosis by a caspase
Anti
Evaluation of the pro
Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors PMID 19001433
Kv1.3/Kv1.4 Blocker
A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons PMID 38462574
Teroxirone motivates apoptotic death in tumorspheres of human lung cancer cells PMID 29908167
Demecycline
Surface functionalization of virus
neuron
Inhibition of casein kinase 2 prevents growth of human osteosarcoma PMID 27959425
CDy6, a photostable probe for long
Etamycin A 299
Prostaglandin E2 Inhibitor 3 3054217
The novel GLP
LCB
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth PMID 23153533
(E)
Fluorescein tyramide 210236
Inhibitors of protein kinases CGP 41251, a protein kinase inhibitor with potential as an anticancer agent PMID 10454207
Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using 18F
METTL3
Cordycepin improved neuronal synaptic plasticity through CREB
DNP
EPH 受体 B4（EPHB4）基因
EV20
Ac
Persistent IKKα phosphorylation induced apoptosis in UVB and Poly I C co
DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation
(2S)
Astragaloside IV regulates the ferroptosis signaling pathway via the Nrf2/SLC7A11/GPX4 axis to inhibit PM2.5
Thromboxane B2 54397
Design, synthesis, and biological activity of boronic acid
FER
TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway PMID 38824479
Icopezil 145508
The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats PMID 25704026
[pTyr5] EGFR (988
2
Igfbp1
N
Epidermal growth factor receptor as a potential target of momordin Ic to promote apoptosis of cholangiocarcinoma cells PMID 35640567
LAIR1 蛋白, Human (Biotinylated, HEK293, Fc
Norcantharidin inhibits the METTL16/MAT2A pathway to induce apoptosis and suppress tumor progression in ovarian cancer PMID 40517800
Design, synthesis, and biological evaluation of 4
CDK3
Transthyretin
4
SLMP53
A small
An LC
In Vitro Inhibitory Effects of 8
Il12rb2
MMAD 203849
D
Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK
Thymoquinone Alleviates Paclitaxel
MT
Design, Synthesis, and Biological Evaluation of Chiral
Tryptophan metabolic pathway plays a key role in the stress
Trioxsalen in the presence of UVA is able to induce nuclear factor kappa B binding activity in HaCaT keratinocytes PMID 12239428
Cyclo(
Pore dilation occurs in TRPA1 but not in TRPM8 channels PMID 19159452
FAAH
NIBR189 1599432
Antiangiogenic Pterocarpan and Flavonoid Constituents of Erythrina lysistemon PMID 36938984
Darunavir
Emergence of ceftazidime/avibactam resistance in KPC
Secalonic acid D 35287
Antimicrobial peptide LL
YARA peptide
The Pan
7β
Mutations at site 207 of influenza a virus NS1 protein switch its function in regulating RIG
Telenzepine dihydrochloride 147416
Discovery of (R)
DPQ 129075
S
Survivin
Nogo
Incorporating functionalized polyethylene glycol lipids into reprecipitated conjugated polymer nanoparticles for bioconjugation and targeted labeling of cells PMID 21152603
Vicenin 3 59914
GNF6702
Hypericin
Alaternin 39723
Synthesis and evaluation of anti
(E)
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