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Transcriptome Analysis Reveals the Effect of PdhR in Plesiomonas shigelloides PMID 37833920
Locating chemical modifications in RNA sequences through ribonucleases and LC
Resveratrol induces PD
Novel application of cyclo(
RAGE ligation affects T cell activation and controls T cell differentiation PMID 18768885
beta
6
h
Massive centriole production can occur in the absence of deuterosomes in multiciliated cells PMID 31792378
Diacylglycerol acyltransferase 1/2 inhibition induces dysregulation of fatty acid metabolism and leads to intestinal barrier failure and diarrhea in mice PMID 32786057
Solvothermal Synthesis of Functionalized UiO
Aflatrem 70553
MET mutation causes muscular dysplasia and arthrogryposis PMID 30777867
白介素
Bioenergetic programs of cancellous and cortical bone are distinct and differ with age and mechanical loading PMID 40450018
A subpopulation of projections from the parabrachial nucleus to the central amygdala mediates itch PMID 40691451
ETP
Discovery and characterization of olokizumab a humanized antibody targeting interleukin
Para
N
KRAS Mutant Combination Therapy for the Effective Treatment of Cancer PMID 34676026
Coacervate
Synthesis and antimicrobial evaluation of dirithromycin (AS
NSC689857, an inhibitor of Skp2, produces antidepressant
c
Discontinued drugs for pulmonary, allergy, gastrointestinal, arthritis (2012) PMID 24024675
1,3
Cymiazole (Standard) (CGA 50439 (Standard))
Desmosterol
Ledipasvir (diacetone) 1502655
Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice PMID 30134985
Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models PMID 39448865
Macrocarpal B 142698
Bimatoprost isopropyl ester 130273
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes PMID 10358093
Efficacy and immunomodulatory actions of ONO
Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy PMID 27896299
Bulaquine 79781
组织蛋白酶 L（Ctsl）基因
NRG1
Benzbromarone 3562
TIE
PF
Holo
Effect of S
Lupeol inhibits the proliferation and migration of MDA
Metofenazate (diethanesulfonate) 1674
ALKBH5 reverses romidepsin
Potentiation of cognitive enhancer effects of Alzheimer's disease medication memantine by alpha7 nicotinic acetylcholine receptor agonist PHA
The niacin receptor HCAR2 prevents sleep deprivation
ADAM17/TACE 蛋白, Mouse (HEK293, His)
Whole
Design and SAR of Withangulatin A Analogues that Act as Covalent TrxR Inhibitors through the Michael Addition Reaction Showing Potential in Cancer Treatment PMID 32886510
Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src
25
Mast cell expression of the serotonin1A receptor in guinea pig and human intestine PMID 23518679
A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice PMID 11696672
Rapid Recognition and Targeted Isolation of Anti
Amyloid
DAT
Preclinical Investigation of 212Pb
Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer PMID 38991141
Latrunculin B 76343
Bradykinin attenuates NiSO4
Isolation of Glu
Theaflavin
3,4
The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK
PARPi
Red Blood Cell
Polyprotein synthesis a journey from the traditional pre
Exploring the Anti
5
Prolyl Hydroxylase inhibitor 1
Studies on lankacidin
P
ON 01500
A novel anti
Isovalerylspiramycin I Reprograms the Immunosuppressive and Temozolomide
Selective activity of bamifylline on adenosine A1
Emerging Oligonucleotide Therapeutics for Rare Neuromuscular Diseases PMID 34092651
AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet
Ogerin analogue 1
ω
A citrus flavonoid, 6
New 3
Gapdh
Decreased mRNA and protein stability of W1282X limits response to modulator therapy PMID 30803905
HLA
Ergosterol 57
BuChE
The catalytic effect of L
PH
Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth PMID 33782401
Difluoromethyl
Propionyl
Triptophenolide 74285
Esterase, pig liver (CESs)
Novel phenanthrene and isocoumarin from the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting (Dioscoreaceae) PMID 28606759
ISAM
A Huntingtin
Prevention of delayed cerebral vasospasm by continuous intrathecal infusion of glyceroltrinitrate and nimodipine in the rabbit model in vivo PMID 18214428
Probucol 23288
The PRC2 molecule EED is a target of epigenetic therapy for neuroblastoma PMID 35636260
A new method of quantifying glutathione levels in freshly isolated single superfused rat cardiomyocytes PMID 15519908
Antihepatitis activity (anti
Amezalpat (TPST
In
HDP 30.1699
Synergistic effects of polydatin and vitamin C in inhibiting cardiotoxicity induced by doxorubicin in rats PMID 27891661
Hypoxia
CGS 21680
Olaptesed pegol 1390628
HY
MCE
A tyrosine
Boc
Biophysical and docking study on the interaction of anticancer drugs encorafenib and binimetinib with human serum albumin PMID 37527692
Revospirone 95847
mTOR inhibitor
Selective inhibition of intestinal guanosine 3',5'
Chalcones are potent inhibitors of aromatase and 17beta
AMPD2 inhibitor 2
NTP Toxicology and Carcinogenesis Studies of o
MALT1
Bacterial degradation of benzalphthalide PMID 24425489
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives Discovery of potent and selective JNK3 kinase inhibitors PMID 35764033
AMG
SRPKIN
Tanshinol alleviates ischemia
Secoisolariciresinol diglucoside induces pyroptosis by activating caspase
Pyrazolo[3,4
Downregulation of miR
Insulin
Cortistatin
Sulfasalazine 599
The lung microbiome regulates brain autoimmunity PMID 35197636
Fmoc
4
C6 Biotin ceramide (d18 1/6 0) 192070
Interferon sensitivity
(9Z,12Z)
SOS1
Solar Light Induced Photon
CDH1
Updated peer review of the pesticide risk assessment of the active substance asulam (variant evaluated asulam
ZT
肌动蛋白α1（ACTN1）基因
Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase
Regulation of cardiolipin biosynthesis in H9c2 cardiac myoblasts by cytidine 5'
Procarbazine Hydrochloride 366
Mre11
Melanin
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three
Bay 41
Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase PMID 24070012
The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance PMID 17618300
Cetoniacytone B 496775
Organic ultraviolet filters regulate hyaluronan metabolism in human epidermal keratinocytes through the phosphatidylinositol 3
Tefinostat (CHR
Fludarabine
Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice distinct roles of resolvin D1, D2, and E1 PMID 22171045
Bilobalide 33570
Amlodipine metabolite
Hematological and Neurological Expressed 1 Promotes Tumor Progression Through mTOR Signaling in Ovarian Cancer PMID 38263477
Investigation on the mechanism of 2,3,4',5
Doripenem monohydrate (Standard) (S 4661 monohydrate (Standard)，多利培南一水合物 (Standard))
Prenatal diagnostic approaches diagnosed craniosynostosis and identified a novel nonsense variant in SMAD6 in a Chinese fetus PMID 37977316
Pelvic vasectomy and its protective effects on rat testis function PMID 40055615
Alantolactone induces platelet apoptosis by activating the Akt pathway PMID 36813739
Encapsulation of oleanolic acid into cyclodextrin metal
Hyperactivated Wnt
微管相关蛋白 tau（Mapt）基因
Sp1 Controls the Basal Level of Interleukin
Threo
CD72 蛋白, Human (HEK293, His)
αMSH inhibits adipose inflammation via reducing FoxOs transcription and blocking Akt/JNK pathway in mice PMID 28514752
Disitamab vedotin in preclinical models of HER2
Top Publications Citing MCE Products
DSPE
AFP deletion leads to anti
USP7 Stabilizes USF1 to Aggravate ox
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor PMID 9089668
DSPE
Ginsenoside Rb1 inhibits porcine epidemic diarrhea virus replication through suppressing S1 protein mediated the MAPK/ERK pathway and reducing apoptosis PMID 39947549
钩藤提取物 (Uncaria rhynchophylla (Miq.) Miq. ex Havil.)
Alisol E 23
SARS
Glucagon regulates hepatic kisspeptin to impair insulin secretion PMID 24703698
Caspase 8诱导剂、基因
PRKAB2 Human Pre
Dodecylethyldimethylammonium bromide (EDDAB), 98%(T) 68207
Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance PMID 26259791
WCK 5222 (cefepime/zidebactam) antimicrobial activity tested against Gram
MK
IL
PARP1
Synthesis and biological evaluation of novel 5
(R)
Design, synthesis and biological evaluation of novel arylpropionic esters for the treatment of acute kidney injury PMID 33197847
LH846 639052
Neuropeptide substance P and the immune response PMID 27314883
Hesperetin protects hippocampal neurons from the neurotoxicity of Aflatoxin B1 in mice PMID 38056121
Trandolapril. An update of its pharmacology and therapeutic use in cardiovascular disorders PMID 9829159
Loss of ERα induces amoeboid
Anti
Endoplasmic reticulum stress regulates autophagic response that is involved in Saikosaponin a
Alloxazine 490
Development of bivalent triarylalkene
Application of an ultra
Cytotoxic constituents from Brazilian red propolis and their structure
Evaluation of anticancer agents using patient
Imiquimod dihydrochloride 2995277
Rigid helical
Lofexidine, an {alpha}2
Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse PMID 4379909
EC
Ethyl 2
Determining the quantitative relationship between glycolysis and GAPDH in cancer cells exhibiting the Warburg effect PMID 33545174
Emtricitabine an antiretroviral agent for HIV infection PMID 14609348
Discovery of 5
Synthesis and biological activity of novel N6
Sodium 2
Sutimlimab for the Treatment of Cold Agglutinin Disease PMID 37153870
Transcription
Aluminum stearate (Octadecanoate aluminum，硬脂酸铝)
Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues PMID 9046333
Anti
Mitochondria
MI
1
A network toxicology and machine learning approach to investigate the mechanism of kidney injury from melamine and cyanuric acid co
ISX
Targeting glioblastoma signaling and metabolism with a re
EphA1 蛋白, Human (sf9, His, GST)
Microglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model PMID 39285282
SM
BRD4 degrader
Pterulinic acid and pterulone, two novel inhibitors of NADH ubiquinone oxidoreductase (complex I) produced by a Pterula species. II. Physico
Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease PMID 37870434
LPA5 antagonist 1
1,1,3,3
m
Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding PMID 23181972
Necrocide 1 mediates necrotic cell death and immunogenic response in human cancer cells PMID 37015922
HER3 upregulation reduces DS
剪接因子 3b 亚基 2（SF3B2）基因
DSPE
Design and synthesis of 1
β
Psychomotor stimulation by dopamine D₁
氟比洛芬酯
[In vitro combined effects of pirarubicin (THP) and various antitumor drugs on human tumor cell lines] PMID 2108612
Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On
Simple di
CA IX/VEGFR
Proapoptotic Bcl
Isosorbide mononitrate 16051
DprE1
UP202
Rapamycin Alleviates Hypertriglyceridemia
AZD3988 892489
Design and synthesis of quinazolin
Meteneprost 61263
Intranasal delivery of influenza rNP adjuvanted with c
Effective combination of liposome
Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT
The inhibitory effects of ginsenosides on protein tyrosine kinase activated by hypoxia/reoxygenation in cultured human umbilical vein endothelial cells PMID 11270715
Boc
Agathadiol diacetate 24022
DIMBOA 15893
BIM
The Discovery and Characterization of ML218 A Novel, Centrally Active T
CPT
Identification of novel angiogenesis inhibitors PMID 15993586
LY334370 182563
Reactions of Escherichia coli TEM beta
Raloxifene nanomicelles reduce the growth of castrate
Chaperonin
DSPE
Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation PMID 17268086
Circulating follistatin in relation to energy metabolism PMID 27264073
Possibilities and prospects of obtaining energy by methane fermentation PMID 232991
CAT
Cannabidiol Ameliorates Monocrotaline
A comprehensive review on biological properties of citrinin PMID 28993214
Pharmacological and Genetic Approaches to Downregulate FIS1 Mitigate Neuropathic Pain PMID 40769725
C6 Ceramide 124753
Molecular structure of VEGFA polysaccharide protein and its regulation of monocyte infiltration and oxidative stress after myocardial infarction PMID 40258548
Design and synthesis of m1
PD 128042 114289
Cell level
Synthesis and cytotoxic activity of nitric oxide
Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine PMID 23263813
RSU 1164
VEGFR
Suppression of human T cell proliferation by the caspase inhibitors, z
Tranylcypromine
Isolation, synthesis and anti
Extracellular Signal
Anti
9605
Bmp8b
Cysteamine hydrochloride 156
Deferasirox acyl
MONIRO
Nitrophenolic
Bovine Endothelial cell growth supplement,suitable for cell culture
I
Preparation and Evaluation of Liposomes Co
Directed differentiation of pancreatic δ cells from human pluripotent stem cells PMID 39068220
Garenoxacin Mesylate hydrate (BMS284756 Mesylate hydrate，加雷沙星甲磺酸盐)
Zemocimig 2955620
MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target PMID 36185598
BDNF 蛋白, Human (R125A, R127A, R128A, solution)
Zonisamide reduces cell death in SH
NETs activate the GAS6
Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein PMID 29396292
Leucettinib
Cefamandole sodium (Standard) (Cephamandole sodium (Standard)，头孢孟多酯钠(Standard))
NPS ALX Compound 4a dihydrochloride 1781934
Forelimb motor recovery by modulating extrinsic and intrinsic signaling as well as neuronal activity after the cervical spinal cord injury PMID 38979293
TRIM44 aggravates cardiac fibrosis after myocardial infarction via TAK1 stabilization PMID 37271349
Efficacy of ER
Toxicity of substituted p
MCE
The novel cereblon modulator CC
A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction PMID 38963839
Identification of pyrazolopyrimidine arylsulfonamides as CC
MCE
Design, synthesis and biological evaluation of biaryl amide derivatives as modulators of multi
Xanthohumol inhibits non
Synthesis, cytotoxicity and structure
Unveiling the potential of MSC extracellular vesicles MiR
Cytosolic escape of mitochondrial DNA triggers cGAS
The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms PMID 11108011
Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress
Synthesis of amide derivatives containing the imidazole moiety and evaluation of their anti
S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy PMID 37217945
Alkaloids from Sri Lankan curry
Gnetifolin E 140671
Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS
Gastrin I (human) (sulfated)
Bioactive flavonoids from Kaempferia parviflora PMID 14693228
Interleukin 17 Family Cytokines Signaling Mechanisms, Biological Activities, and Therapeutic Implications PMID 28620097
Preclinical characterization of amubarvimab and romlusevimab, a pair of non
Activin and Hepatocyte Growth Factor Promotes Colorectal Cancer Stemness and Metastasis through FOXM1/SOX2/CXCR4 Signaling PMID 37458065
Effect of D
Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth PMID 22785205
Antitumor activity of shikonin and its derivatives PMID 589729
BT173
Lazuvapagon 2379889
Effects of formoterol (BD 40A), a beta
PGP Human Pre
Radiotherapy
Sodium 3
Anhydrodihydro artemisinin (无水二氢青蒿素)
Development of Sulfamoylated 4
Sparsentan 254740
Monohydroxy melphalan hydrochloride 2707535
Single
(2S,3S)
13
Serine endopeptidases
Lactate
Structure
Abz
Soft substrates promote direct chemical reprogramming of fibroblasts into neurons PMID 36041647
Bepirovirsen 1403787
The involvement of lipid raft pathway in suppression of TGFβ
E
Novel antimicrobial lipopeptides with long in vivo half
Votoplam 2407849
The innate defense regulator peptides IDR
[Acute lymphoblastic leukemia
PRO 132365
fatty acid
SGX
4β
Antifungal agent28
m
Medetomidine hydrochloride 86347
Identification of risk for ovarian disease enhanced by BPB or BPAF exposure PMID 36587784
Huzhangoside C 96315
Teleocidin A2 inhibits human proteinase
Anti
AMPK α1β2γ1激活剂、基因
Biphenomycin A 100296
Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines PMID 31294975
(3R,19Z,22Z,25Z,28Z)
Antiproliferative effects of [D
LGK974 (WNT974)
Efficient synthesis of anacardic acid analogues and their antibacterial activities PMID 23416004
Adenosine
Antileishmanial compounds from Moringa oleifera Lam PMID 24873031
IL
A Nanopore Based Molnupiravir Sensor PMID 35427117
Intestinal activating transcription factor 4 regulates stress
phospho
LRRC56
Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4 PMID 27090571
Differential CCR1
Invention of novel 3
Cardiomyocyte
Salicylidene salicylhydrazide, a selective inhibitor of beta 1
Verdiperstat attenuates acute lung injury by modulating MPO/μ
Therapy
NOTCH2 蛋白, Human (sf9, His)
Neuronal expression of herpes simplex virus
Noggin 蛋白, Mouse (CHO)
Piperaquine a resurgent antimalarial drug PMID 15610051
The Reduction Division in Haploid, Diploid, Triploid and Tetraploid Daturas PMID 16576677
Animal
Activation of lipophagy is required for RAB7 to regulate ferroptosis in sepsis
Mumefural 222973
PKC Substrate、基因
Virtual screening identified natural Keap1
Cathepsin诱导剂、基因
Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells PMID 23818609
2
1
信号转导和转录激活因子 1（STAT1）基因
tert
Seeded aggregation of TDP
Targeting carbonic anhydrase IX/XII prevents the anti
Henriol A 1000995
Prefrontal Cortex
CD59 分子 (CD59 血型)（CD59）基因
VNPP433
2
Ingenol 20
Recombinant protein purification using complementary peptides as affinity tags PMID 21664994
Drug
6
Mechanisms of inhibition of T
Exploring the Molecular Mechanisms of Autophagy
Label
α
Ketohakonanol 18004
KDOAM
KIT Recombinant Human Active Protein Kinase
Taurodeoxycholate
Regulation of gene expression in rats with heart failure treated with the thyroid hormone analog 3,5
MGCD
Urolithin E 1453297
Palonosetron hydrochloride is an effective and safe option to prevent chemotherapy
Miconazole
55093
Dihydroartemisinin overcomes the resistance to osimertinib in EGFR
(
Ecopipam 112108
Daminozide 1596
NA/Neuraminidase 蛋白, H1N1 (AKM14549, HEK293, His)
Flavidulols B
Design, synthesis and biological evaluation of quinoline derivatives as HDAC class I inhibitors PMID 28371677
Isolation, purification, and characterization of xylanase produced by a new species of bacillus in solid state fermentation PMID 22315613
PSMA
Multifunctional nanoparticles from albumin for stimuli
Maximin Hv
Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation PMID 16756958
mTOR inhibitor
Repeated Social Defeat Enhances CaCl2
Inhibition of Interleukin
CRANAD
Ufenamate 67330
Galanin regulates M1/M2 polarization of microglia after spinal cord injury through TRPV1/Ca2+/CaMKII/NRF2 signaling pathway PMID 40811950
A Brain
极光激酶 B（AURKB）基因
Anti
Nociceptin(1
α
3
BChE
Lipoic acid and dihydrolipoic acid. A comprehensive theoretical study of their antioxidant activity supported by available experimental kinetic data PMID 24881907
hsa
Tuning of G
H
Liproxstatin
Combined Mcl
β
DC
BCL6B 转录抑制因子（BCL6B）基因
细胞因子信号抑制因子 1（SOCS1）基因
TIMP1 Human Pre
Gingipains promote RANKL
Concerting magnesium implant degradation facilitates local chemotherapy in tumor
Tetramethylammonium
Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro PMID 31279006
Omzotirome 1092551
DC
Synergistic neurotoxicity of polystyrene nanoparticles and MEHP in zebrafish (Danio rerio) PMID 40609886
ER
Bromosporine 1619994
Cannabisin H (大麻酰胺H)
Leukemia inhibitory factor is an anti
Acetamide
Dopaminergic unique affinity of tetrahydroberberine and l
蛋白 C，凝血因子 Va 和 VIIIa 的灭活因子（PROC）基因
Cytochalasin J (细胞松弛素J)
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