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Major vault protein (MVP) suppresses aging
MicroRNA modulator
MFN2 agonist
Tetramethylpyrazine protects against scopolamine
DC
Stimulation of Fas (CD95) induces production of pro
TMP195 1314891
Epha1
Differential effects of ceramide species on exocytosis in rat PC12 cells PMID 17624518
Dose Effects of Histone Deacetylase Inhibitor Tacedinaline (CI
Elucidation of the key therapeutic targets and potential mechanisms of Andrographolide multi
(7S,8R,17S)
Anipamil 83200
CD40L/CD154/TRAP 蛋白, Human (Biotinylated, HEK293, Fc
Oxacillin sodium monohydrate (Standard) (苯唑青霉素钠一水合物 (Standard))
Cathepsin激动剂、基因
Aqueous extract of Saposhnikovia divaricata root alleviates rheumatoid arthritis by acting on TNF
Discovery of 4
17β
11
整合素亚基α5（ITGA5）基因
Fraxin 524
Cytotoxic halogenated metabolites from the Brazilian red alga Laurencia catarinensis PMID 20039643
AK
Kyotorphin 70904
Phosmidosine C
Effect of Sch 55700, a humanized monoclonal antibody to human interleukin
Lead Optimization of 2
Fabrication of a dual
Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats PMID 2451639
Hybrid furoxanyl N
A canine model to evaluate efficacy and safety of γ
Hypoxia Regulates the Proliferation and Apoptosis of Coronary Artery Smooth Muscle Cells Through HIF
Mal
Tff2
(R)
Type 2 diabetic mice enter a state of spontaneous hibernation
Multi
Analysis of multiple programmed cell death
丝氨酸羟甲基转移酶 1（SHMT1）基因
ER
Bisindolylmaleimides New Ligands of CaM Protein PMID 36363988
High expression of HVEM is associated with improved prognosis in intrahepatic cholangiocarcinoma PMID 33365080
Inhibition of CDK9 activity compromises global splicing in prostate cancer cells PMID 34592899
L
Discovery of 2
Cancer
Celastrol ameliorates Aspergillus fumigatus keratitis via inhibiting LOX
Stearoyl
Clodinafop
Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure
突触相关蛋白 1（SYAP1）基因
Combining RNA
Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model eukaryotic elongation factor 1A2 as a potential target PMID 19738051
CaMKII alpha/CAMK2A 蛋白, Human (sf9, GST)
CD85a/ILT
Nonclinical safety evaluation of pabinafusp alfa, an anti
CSF1
2'
Cxcl13
CDK12
Propagation of senescent phenotypes by extracellular HMGB1 is dependent on its redox state PMID 40189139
ChREBPα/14
One
PTEN
Centmitor
Discovery of thiazole salt AChE inhibitors and development of thiamine disulfide prodrugs targeting the central nervous system PMID 37390634
II399
NVP
MRS8454
Lipid Droplet Fusion in Mammary Epithelial Cells is Regulated by Phosphatidylethanolamine Metabolism PMID 29188493
Nevirapine
4,4'
Discovery and structure
DSPE
PROTAC K
含 V
Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4'
DSPE
Investigating NanoLuc
CD161 蛋白, Cynomolgus (HEK293, His)
Nafamostat formate salt
Discovery and binding studies on a series of novel Pin1 ligands PMID 19291099
4
Covalent binding of the 13C
Targeting the C481S Ibrutinib
3
CDK2
Ofloxacin
Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo PMID 3057387
MicroRNA
DSPE
MicroRNA
CXC 基序趋化因子配体 9（CXCL9）基因
Manual GO annotation of predictive protein signatures the InterPro approach to GO curation PMID 22301074
(Rac)
Antimalarial compounds from Grewia bilamellata PMID 16562832
JNK
Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity PMID 1415445
1
Iron
Modulation of NR1 receptor by CaMKIIα plays an important role in chronic itch development in mice PMID 32112850
STING activation in TET2
Efficient magnesium lactate production with in situ product removal by crystallization PMID 26433791
Molecular modeling study and synthesis of novel dicationic flexible triaryl guanidines and imidamides as antiprotozoal agents PMID 22005186
Palmitoyl tetrapeptide
TATA
L
Synthesis and biological evaluation of halogenated phenoxychalcones and their corresponding pyrazolines as cytotoxic agents in human breast cancer PMID 34894967
GFRAL Human Pre
Pramlintide acetate 187887
Estrogenic potency of endocrine disrupting chemicals and their mixtures detected in environmental waters and wastewaters PMID 37068617
Proconvulsant effects of neurosteroids pregnenolone sulfate and dehydroepiandrosterone sulfate in mice PMID 9593594
GlcNAcstatin a picomolar, selective O
HLA
Phenolics, acyl galactopyranosyl glycerol, and lignan amides from Tetragonia tetragonioides (Pall.) Kuntze PMID 30263405
Amifostine induces anaerobic metabolism and hypoxia
Scutebata F 1207181
Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis PMID 2591299
Galantamine a review of its use in Alzheimer's disease PMID 11129124
Carboxypeptidase M/CPM 蛋白, Human (HEK293, His)
HER2
(R)
Minoxidil 38304
Regorafénib N
Olaparib hydroxamic acid derivatives as dual PARP and HDAC inhibitors for cancer therapy PMID 28601509
Glycoprotein PTGDS promotes tumorigenesis of diffuse large B
Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors PMID 38894918
MAP4K
Design and synthesis of a vialinin A analog with a potent inhibitory activity of TNF
DSPE
acetyl
CEP
Cytochrome P450
DSPE
Secoisolariciresinol Monoglucoside 63320
TRPV3
Tesevatinib tosylate 1000599
Isotype Switching Converts Anti
A novel alkaloid, aristopyridinone A and anti
81850
IL
Top Publications Citing MCE Products
Cremophor EL
mGluR3
Endothelial β
N
Pivekimab 2234335
Combined OLA1 and CLEC3B Gene Is a Prognostic Signature for Hepatocellular Carcinoma and Impact Tumor Progression PMID 38564315
CCNA2 Human Pre
MAK683
Danshensu attenuates cisplatin
Natamycin 7681
PM102 1234564
2,8
Discovery of (S)
PHA
Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling PMID 27283020
Salicylates enhance CRM1 inhibitor antitumor activity by induction of S
CD73/5'
蔗糖酶
New phenolic compounds from Coreopsis tinctoria Nutt. and their antioxidant and angiotensin i
Engineered Endometrial Clear Cell Cancer
HSF1 as a mitotic regulator phosphorylation of HSF1 by Plk1 is essential for mitotic progression PMID 18794143
Naphthalimide Scaffold Provides Versatile Platform for Selective Thiol Sensing and Protein Labeling PMID 26813105
mNLS
The egg ribonuclease SjCP1412 accelerates liver fibrosis caused by Schistosoma japonicum infection involving damage associated molecular patterns (DAMPs) PMID 38105713
A patient
Cinnzeylanol 62394
DMABA NHS ester 58068
IFN
UCHL3 inhibits ferroptosis by stabilizing β
Piezo1 initiates platelet hyperreactivity and accelerates thrombosis in hypertension PMID 34411418
Maytansine and cellular metabolites of antibody
T2AA 1380782
(S,S)
Mechanical stretch promotes sustained proliferation and inflammation in developing human airway smooth muscle PMID 40668642
盘基蛋白结构域受体酪氨酸激酶 1（DDR1）基因
PACAP Receptor抑制剂、基因
The bile acid
23
CYP3A4
Overcoming venetoclax resistance through heme
Donitriptan mesylate 200615
YY2
R
NLS (PKKKRKV) hydrochloride
Second
CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress PMID 31155494
Selective inhibition by apocynin of the proliferation and adhesion to fibronectin of v
Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates PMID 39166702
TNF switches homeostatic efferocytosis to lytic caspase
MicroRNA
ANGPTL5/Angiopoietin
The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits PMID 3423267
Pepsinogen C Interacts with IQGAP1 to Inhibit the Metastasis of Gastric Cancer Cells by Suppressing Rho
Quantitation of sorafenib and its active metabolite sorafenib N
Antibiotic
MK
1,5
Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells PMID 8101561
Polypectate sodium 9049
多囊蛋白 1，瞬时受体电位通道相互作用（PKD1）基因
Eicosapentaenoic acid methyl ester 2734
Zexieyin formula alleviates Alzheimer's disease via post
Noninvasive bioluminescence imaging of the dynamics of sanguinarine induced apoptosis via activation of reactive oxygen species PMID 26968950
1,3
PI3K
Discovery of Multitarget
STK40 蛋白, Human (sf9, His
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties PMID 34713696
去唾液酸糖蛋白受体 1（ASGR1）基因
Crucial role of TRPC6 in maintaining the stability of HIF
Apolipoprotein C
Comparative evaluation of the 2
Discovery of a potential bladder cancer inhibitor CHNQD
Methylenedihydrotanshinquinone 126979
Nuciferine Restores Autophagy via the PI3K
Esterase, pig liver 9016
脑多巴胺神经营养因子（CDNF）基因
DMOG (Dimethyloxallyl Glycine)
Proteomic and lipidomic landscape of the infrapatellar fat pad and its clinical significance in knee osteoarthritis PMID 38788831
Potent inhibitions of monoamine oxidase A and B by acacetin and its 7
Non
Hesperidin methylchalcone 24292
Phase I dose
Protective effect of adipose
Hydrogen peroxide modulates clock gene expression via PRX2
Effects of Jatrorrhizine on inflammatory response induced by H2O2 in microglia by regulating the MAPK/NF
MCE
IQDMA
Occurrence and spatio
LLT1 overexpression renders allogeneic
DMUP 2364350
AD57 1093380
Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild
Glucosinolate profile variation of growth stages of wild radish (Raphanus raphanistrum) PMID 20163113
Dietary
Involvement of oxidative stress
Identification of KW
Undecaprenyl
An integrin beta4
TWIST1 Human Pre
Helicobacter pylori alpha
Autophagy
L
Purification and characterization of native spliceosomes suitable for three
Tara up
A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia PMID 28536367
Effect of degree of quaternization of N
Novel molecular discovery of promising amidine
Ionizable lipid
PSMA
Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site
Chondroitinase AC II 9047
含 ITPR 相互作用域 2（ITPRID2）基因
Buxus macowanii Oliv.提取物 (Buxus macowanii Oliv.)
Tnfrsf4
Oseltamivir carboxylate, the active metabolite of oseltamivir phosphate (Tamiflu), detected in sewage discharge and river water in Japan PMID 20056566
Kanglexin 2228847
Propyl hexanoate 626
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway PMID 35302840
BODIPY 576/589
Single
Boc
Pterostilbene
Artepillin C overcomes apalutamide resistance through blocking androgen signaling in prostate cancer cells PMID 36642262
Sulazepam 2898
Studies on anti
Anhydrous sodium dihydrogen phosphate 7558
多囊蛋白 1 like 2 (基因/假基因)（PKD1L2）基因
Dietary hispidulin ameliorated chemically
Benzimidazole 51
5
ESR1 F404 mutations and acquired resistance to fulvestrant in ESR1 mutant breast cancer PMID 37982575
Ro 20
High
Phospholipase C gamma 1 抗体 (YA3850)（Phospholipase C gamma 1 Antibody (YA3850)）
D
PD
Pharmacotherapy of retinal disease with visual cycle modulators PMID 29542350
Autoradiography techniques and quantification of drug distribution PMID 25604842
L
BIRC3 deficiency blocks the ubiquitination and degradation of GOT2 to impede antitumor immune responses in lung squamous cell carcinoma PMID 40690196
Ephb6
FGF
6,7
C
Myricanol triacetate 34509
Pimicotinib 2253123
Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue
Ethyl 8
An update of teriflunomide for treatment of multiple sclerosis PMID 23761970
KLF 转录因子 15（KLF15）基因
Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3
Mitochondrial
(Rac)
cyclo(RLsKDK) 1975145
Niranthin 50656
Isotheaflavin 31701
Discovery of a Meisoindigo
细胞间粘附分子 1（ICAM1）基因
Estimating Efflux Transporter
4
Comparison of gene expression and activation of transcription factors in organoid
Novel nonsecosteroidal VDR agonists with phenyl
3’
GADGVGKSAL
Glyphosate 1071
2',3'
Oncometabolite 2
Dactolisib Tosylate 1028385
MCE
Inhibition of ileal Na+/bile acid cotransporter by S
DSPE
Protease inhibitors targeting coronavirus and filovirus entry PMID 25666761
Flubendazole suppresses VEGF
DSPE
The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents PMID 31792284
Collismycin A 158792
糖原磷酸化酶，肌肉相关（PYGM）基因
脯氨酰 3
Dihydrolinalool 18479
TAK
Effect of BI
Antiviral activity of diallyl trisulfide against H9N2 avian influenza virus infection in vitro and in vivo PMID 34412671
Ether phospholipid
Agonistic anti
The use of 1
Squalamine as a broad
Anti
CLTRN
Bestatin attenuates breast cancer stemness by targeting puromycin
含溴结构域 9（Brd9）基因
Mechanochemical feedback mediates tissue bending required for seedling emergence PMID 33417884
DSPE
Randomized Phase II Trial of Parsatuzumab (Anti
NSC 641396 605685
TNG908 is a brain
3,4
(+)
The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism PMID 27629523
Midkine mediates dysfunction of liver sinusoidal endothelial cells through integrin α4 and α6 PMID 36184060
Evaluation of different PNGase F enzymes in immunoglobulin G and total plasma N
Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease PMID 23702831
CD226 分子（CD226）基因
Platycodin D regulates high glucose
DSPE
Control of thiol
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma PMID 18829493
Antioxidant compounds from propolis collected in Anhui, China PMID 21512452
The selective antagonist EPPTB reveals TAAR1
Mtb ATP synthase
Stepronin
Role of Acorus calamus extract in reducing exosome secretion by targeting Rab27a and nSMase2 a therapeutic approach for breast cancer PMID 39812915
Tanshinone I 568
The 17,18
GEBR
MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation PMID 38424044
Dabigatran acyl
Talatisamine 20501
Selective degradation
Pam3
Fasudil mesylate 1001206
Deficiency of KIF15 contributes to oxaliplatin
MASP
TLN232
泛联蛋白 1（PANX1）基因
Acetoacetate and D
Raloxifene Prevents Chemically
Identification and mechanism of action of the acylguanidine MRT
A
Impaired clearance of sunitinib leads to metabolic disorders and hepatotoxicity PMID 30875096
Tumor
Nortropine hydrochloride 14383
Pinocembrin reduces pyroptosis to improve flap survival by modulating the TLR4/NF
Glimepiride
Pdzk1ip1 Mouse Pre
Effects of beta
Monocyte/macrophage
Inhibition of SMYD2 suppresses tumor progression by down
Selective inhibition of CDK9 in triple negative breast cancer PMID 38001268
Targeting BET proteins inhibited the growth of non
Tos
The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt
A novel pyridine
Palmitic acid
LY2955303 1433497
4
Role of creatine kinase in cardiac excitation
Didemnin C 77327
Tiopronin
Scrambled TRAP Fragment 1348418
Isoagarotetrol 104060
Lap3
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer PMID 37210549
Screening for 18 diuretics and probenecid in doping analysis by liquid chromatography
Ethanolamine modulates the rate of rat hepatocyte proliferation in vitro and in vivo PMID 9207089
The histone demethylase inhibitor GSK
Ketorolac 74103
Denifanstat 1399177
An Effective NADPH Oxidase 2 Inhibitor Provides Neuroprotection and Improves Functional Outcomes in Animal Model of Traumatic Brain Injury PMID 32072445
DSPE
N
Thematic review series brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal PMID 15254070
Potassium Channel
KP136 76239
Multifunctional lactobionic acid
Cyperin 33716
TRIP12 promotes small
Disrupted target binding with acryloyl group as potential Bcr
Mertk+ Liver Sinusoidal Endothelial Cells Negatively Regulate PINK1 Related Mitophagy and Accelerate MASH PMID 40964873
Piperine targets SOAT1 to inhibit the progression of esophageal squamous cell carcinoma via ferroptosis PMID 41061292
Virginiamycin M1 21411
Boc
Mdm4
Cholinesterase activities of various nematode parasites and their inhibition by the organophosphate anthelmintic haloxon PMID 5938096
CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF
N
GC
Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure PMID 28557445
Design, cytotoxic and fluorescent properties of novel N
Anti
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP PMID 24102134
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin
Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma PMID 23784627
Structure
淀粉样蛋白前体蛋白结合蛋白 2（APPBP2）基因
SGK3 Rat Pre
PI
Curcumin glucuronides assessing the proliferative activity against human cell lines PMID 24280069
vc
HA1/Hemagglutinin 蛋白, Influenza B (ABF21280, HEK293, His)
Periodontal CGRP contributes to orofacial pain following experimental tooth movement in rats PMID 26164378
N6
Design, Synthesis, Antifungal Activity, and Molecular Docking Studies of Novel Chiral Isoxazoline
Drug Discovery in Low Data Regimes Leveraging a Computational Pipeline for the Discovery of Novel SARS
Dexpramipexole 104632
Pyridinium bisretinoid A2E 173449
Tsugafolin
RO 23
Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice PMID 19528469
SB
A novel mechanism of FTO modulating the progression of endometriosis through mediating the m6A methylation of GEF
Structure of the human ATP synthase PMID 37244256
PDSS1 Human Pre
PWT
FAP
Pharmacokinetic interactions in mice between irinotecan and MBL
Generation 2.5 antisense oligonucleotides targeting the androgen receptor and its splice variants suppress enzalutamide
AkaLumine 1176235
Synthesis of a novel fluorescent berberine derivative convenient for its subcellular localization study PMID 32629278
CTB probe
Enasidenib 1446502
p
DSPE
9
Analysis on benzothiazole necroptosis inhibitors with chiral substitutions in the solvent
Monoterpene indole alkaloid hydrazone derivatives with apoptosis inducing activity in human HCT116 colon and HepG2 liver carcinoma cells PMID 26169128
lin
Z
FXa
Acquisition of Extended
Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria Implications for the pathogenesis of mevalonic aciduria PMID 28284974
Protosappanin A inhibits oxidative and nitrative stress via interfering the interaction of transmembrane protein CD14 with Toll
Estimation of impurity profiles of drugs and related materials Part 18. Impurities and degradation products of mazipredone PMID 9884192
Fructose 5
Discovery of a novel potent EGFR inhibitor against EGFR activating mutations and on
Lauric acid
N
RIPK2
Genetic tracing uncovers the importance of epithelial
CGP 28014 111757
C3
Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia PMID 33129109
Ro 09
Pinitol targets nuclear factor
Ziprasidone 146939
Synthesis and structure
FrzA
Kaolin alleviates the toxicity of graphene oxide for mammalian cells PMID 31534660
Haloperidol
PSMA precursor
Propionylcarnitine 17298
A first
Edoxudine 15176
Synthesis and biological evaluation of CHX
GSK9311
Identification of novel fluorescent probes preventing PrPSc replication in prion diseases PMID 27842893
B2M/Beta
Driving axon regeneration by orchestrating neuronal and non
PACAP Receptor Ligand、基因
BET bromodomain is a novel regulator of TAZ and its activity PMID 27717711
p
USP24
Bradykinin
GSK983
Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning a comparison of ethanol and fomepizole PMID 18639955
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