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Novel piperidinylpyrimidine derivatives as inhibitors of HIV
Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor PMID 15476670
New designer drug 1
TP0597850 2642181
Fucoxanthin Inhibits the NMDA and AMPA Receptors Through Regulating the Calcium Response on Substantia Gelatinosa Neurons of the Trigeminal Subnucleus Caudalis in Juvenile Mice PMID 39949835
A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies PMID 34375582
Vitamin E regulates bovine granulosa cell apoptosis via NRF2
The Toll
JNJ
BODIPY
Pegsebrenatide 2243292
12
High
5’
Analysis of GCRV Pathogenesis and Therapeutic Measures Through Proteomic and Metabolomic Investigations in GCRV
Significance of glioma
Amiodarone
Lipid 50 2440135
Arecaidine
Aberrant methylation of WD
FSL
SaeR Inhibitor
Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid
An experimental study of the anti
组织蛋白酶 S（Ctss）基因
Curcumin attenuates arsenic
Therapeutic Effects of Lifei Decoction in a Murine Model of COPD Induced by LPS and Cigarette Smoke PMID 38650680
转录因子 7 样 2（TCF7L2）基因
CP
1
The inhibitory effect of an ergoline derivative (lergotrile, compound 83636) on prolactin secretion in man PMID 4416328
RhoA/Rock activation represents a new mechanism for inactivating Wnt/β
N4
HO
RIFM fragrance ingredient safety assessment, 4,5
The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma PMID 33754016
Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for alpha 1
UCHL3
RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth PMID 38769389
Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells PMID 22959527
Daidzein
Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG
L
MUC
Gibberellic acid targeting ZBTB16 reduces NF
Osteocalcin and matrix Gla protein vitamin K
Vicenin
酮体
M5N36 2832887
STEAP3 promotes cancer cell proliferation by facilitating nuclear trafficking of EGFR to enhance RAC1
Tildrakizumab (MK
TBS
Development of a metabolically stable topoisomerase I poison as anticancer agent PMID 32682183
Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis PMID 30592285
AZ
Mexiletine 31828
mGluR8拮抗剂、基因
Full
Role of ferroptosis in mitochondrial damage in diabetic retinopathy PMID 39433112
Grin2a
Activation of methotrexate
Ciclopirox drives growth arrest and autophagic cell death through STAT3 in gastric cancer cells PMID 36443287
DNA glycosylases in DNA repair and beyond PMID 22048164
Pericancerous cross
1,3
The discovery of Polo
Sulfo
CS2164, a novel multi
d
Nodal promotes colorectal cancer survival and metastasis through regulating SCD1
VPA Enhances Pulp Regeneration by Regulating LPS
Acarbose 56180
Lauroyl coenzyme A 6244
β, β
Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode PMID 23259038
表皮生长因子受体
Overexpression of NDNF Improves the Cytoprotective Effects of Aged Human Bone Marrow Mesenchymal Stem Cells by Modulating Oxidative Stress and Apoptosis PMID 38801165
EGF
Antitumor agent
Kuwanon W
DSPE
BTMPS 52829
Anti
Preclinical characterization of dostarlimab, a therapeutic anti
N
Interspecies comparison and role of human cytochrome P450 and flavin
In vitro reconstitution of a minimal human centrosome scaffold capable of forming and clustering microtubule asters PMID 40454523
Desacetylripariochromene B 69790
Affinity
Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor PMID 27694321
Interlukin
Obrindatamab 2069959
The role of GABA in the in the dorsal striatum
Loss of ten
MASP2
Besides fibrillization putative role of the peptide fragment 71
The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents PMID 30837875
Long noncoding RNA Linc01612 represses hepatocellular carcinoma progression by regulating miR
Actarit 18699
Carpinontriol B 473451
bc1 Complex
LNA
Cleavage of Mcd1 by caspase
WEHI
LILRB2/CD85d/ILT
Losartan
A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity PMID 33446260
L
L82
Matrine alleviates the immune imbalance of atopic dermatitis by up
Thiosemicarbazone
Cell
Goniopypyrone 129578
FC9402
Discovery of 2,4
d
Synthesis and anticancer activity of 5
DMT003096
CCT68127 660822
AnnH31
Transcriptional Repression and Protein Degradation of the Ca2+
Neuroprotectin A 354986
A sub
(S)
Labeling nuclear DNA with hoechst 33342 PMID 21205857
The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU
Setomimycin as a potential molecule for COVID‑19 target in silico approach and in vitro validation PMID 35622309
3
Synthesis, antiviral activity and molecular modeling of oxoquinoline derivatives PMID 19581097
VU 0360223
Papain
Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats PMID 28784762
Effects of moroxydine hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation PMID 29175011
Trans
JTS
Ndc80
3'
Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH PMID 19722284
ALKBH5
Some aspects of the pharmacology of butibufen, a non
Genome
Anxiolytic effect of a novel 9,10
Down
Mild hypothermia pretreatment extenuates liver ischemia
Targeting two
Tilorone, a Broad
Mycobactin
Effects of CGS 10746B on hyperactivity and place preference induced by morphine PMID 11704248
白细胞介素 6（IL6）基因
Effect of attachment site on stability of cleavable antibody drug conjugates PMID 25643134
SIRT6 Protects Against Myocardial Ischemia
Aminopeptidase
Hepatic covalent adduct formation with zomepirac in the CD26
DSPE
5
Diphenyl Phosphate
Anti
PD
Carprofen 53716
Sildenafil
Design, synthesis and evaluation of novel monoamine oxidase B (MAO
Chenodeoxycholic acid activates the TGR5/TRPA1
P4pal10 1021346
TP
Copy number amplification of FLAD1 promotes the progression of triple
The anti
HyT36
Antimicrobial resistance among imipenem
Synthesis and aminoacylation of 3'
Epigenetic modification regulates the ligamentum flavum hypertrophy through miR
Macrophages promote pre
CC 基序趋化因子配体 24（CCL24）基因
Okadaic acid more than a diarrheic toxin PMID 24184795
Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene
Prostaglandin E2
Metformin reverses chemoresistance in non
Enantioselective analysis of citalopram and escitalopram in postmortem blood together with genotyping for CYP2D6 and CYP2C19 PMID 19239731
Targeting the transcriptional activity of STAT3 by a novel fusion protein PMID 35810312
Boc
Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2
UK
白介素 1 受体相关激酶 1（IRAK1）基因
Tubuloside A 112516
Design, synthesis, and biological evaluation of thieno[2,3
单胺氧化酶 A（MAOA）基因
Angiopoietin
Recombinant Kex2 protease 99676
Small
谷氨酸离子型受体 NMDA 型亚基 2A（GRIN2A）基因
MYG1 核酸外切酶（MYG1）基因
Allergic Reactions and Anaphylaxis to LNP
Inhibition of 12/15
LncRNA FIRRE functions as a tumor promoter by interaction with PTBP1 to stabilize BECN1 mRNA and facilitate autophagy PMID 35110535
ES9
Top Publications Citing MCE Products
Discovery of 1
Sanguinarine 2447
MSHFBA 53296
TNFRSF13C
Upacicalcet 1333218
Knockdown of fatty acid binding protein 4 exacerbates Bacillus Calmette
Attenuation of paraquat
Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts PMID 31071512
ARL13B Human Pre
Oncohistone Mutations Occur at Functional Sites of Regulatory ADP
Identification of Macrolepiota procera extract as a novel G6PD inhibitor for the treatment of lung cancer PMID 35865797
Pyocyanin induces systemic oxidative stress, inflammation and behavioral changes in vivo PMID 29338525
Non
Notch 4 蛋白, Human (sf9, His)
In vitro and in vivo antiangiogenic activity of caged polyprenylated xanthones isolated from Garcinia hanburyi Hook. f PMID 24335612
MDL
MUC1 attenuates neutrophilic airway inflammation in asthma by reducing NLRP3 inflammasome
溶质载体家族 2 成员 4（Slc2a4）基因
Absolute configuration of acremoxanthone C, a potent calmodulin inhibitor from Purpureocillium lilacinum PMID 23876004
Alginate Methacryloyl (MW 300000)
Amikacin 37517
Orexin A (human, rat, mouse) 205640
DSPE
AR antagonist 12 2902679
Synthesis of robalzotan, ebalzotan, and rotigotine precursors via the stereoselective multienzymatic cascade reduction of α,β
BS2G Crosslinker disodium 881415
The metabotropic glutamate receptor antagonist L
Fat mass and obesity
Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole
BMPR
Hypoxia
EGFR blockade confers sensitivity to pan
N
13
Monosaccharide and Disaccharide Saponins of Shade
Carvedilol phosphate hemihydrate 610309
Tracing Immunological Interaction in Trimethylamine N
Crocin prevents platelet‑derived growth factor BB‑induced vascular smooth muscle cells proliferation and phenotypic switch PMID 29620234
Cytotoxic Yohimbine
Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene PMID 30373917
7
11
Alemtuzumab 216503
Retinyl acetate inhibits mammary carcinogenesis induced by N
CHK1
High ability of zileuton ((±)
Comparative effects of 1,25
B
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3
Pharmacokinetics of the R
COP9 信号体亚基 3（COPS3）基因
Biosynthesis and function of chondroitin sulfate PMID 23774590
Casein agar a useful medium for differentiating Candida dubliniensis from Candida albicans PMID 12624062
Discovery of Brigatinib (AP26113), a Phosphine Oxide
[Contact dermatitis to topical antiviral drugs] PMID 10739980
Exploring the focal role of LRRK2 kinase in Parkinson's disease PMID 35147886
Ethacrynic acid sodium (Etacrynic acid sodium，依他尼酸钠)
8
AS602801, an Anticancer Stem Cell Candidate Drug, Reduces Survivin Expression and Sensitizes A2780 Ovarian Cancer Stem Cells to Carboplatin and Paclitaxel PMID 30504379
A molecular dynamics investigation on the crizotinib resistance mechanism of C1156Y mutation in ALK PMID 22659414
Highly selective salicylketoxime
Synthesis, in vitro cytotoxicity evaluation and mechanism of 5' monosubstituted chalcone derivatives as antitumor agents PMID 36924947
Paneth cell
Isoglobotriaose 41744
Structure
ACE2
Genistein protects against acetaminophen
FMNL1 down
Synthesis and evaluation of vitamin D receptor
M1 macrophages enhance breast cancer chemoresistance via JAK
Trim27
Harmine acts as a quorum sensing inhibitor decreasing the virulence and antibiotic resistance of Pseudomonas aeruginosa PMID 39085766
TYK2 ligand 1 2770471
Alterlactone 1030376
Promotional effects of HIF1α and KDM3A interaction on vascular smooth muscle cells in thoracic aortic dissection PMID 35172598
The natural product avrainvillamide binds to the oncoprotein nucleophosmin PMID 17958425
Therapeutic potential of NGF
Casp14 Rat Pre
Ruminal microbe of biohydrogenation of trans
Salidroside directly activates HSC70, revealing a new role for HSC70 in BDNF signalling and neurogenesis after cerebral ischemia PMID 38488455
Direct in
Catalysis
AGT serves as a potential biomarker and drives tumor progression in colorectal carcinoma PMID 34655849
Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells PMID 10677365
Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer's disease PMID 40450296
SSR
17β
Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia
Targeted Delivery of AR
整合素亚基β6（ITGB6）基因
Deacetylase Inhibitor Trichostatin A Promotes the Proliferation of Epithelial Cells and Suppresses Glycolytic Activity of Fibroblasts in the Kidney PMID 40685571
[Chemical constituents of Dysosma aurantiocaulis (H.
聚 (ADP
JNJ
5α
Yoda2 3081450
Ethylenethiourea
Arginine vasopressin and angiotensin II coregulate Aquaporin 2 expression in M
Angiotensin AT2
ICAM
Cefpodoxime 80210
DSPE
Erastin Reverses ABCB1
Integrin antagonist 27
HE
5
TNFSF15/TL1A
Discovery of ( S)
EpCAM/TROP1 蛋白, Rat (HEK293, His)
DSPE
Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy PMID 36478399
Segigratinib hydrochloride 2847066
Benzimidazole (Standard) (苯并咪唑 (Standard))
Dopamine and serotonin receptor binding and antipsychotic efficacy PMID 17251913
Sildenafil
Ultrasound
Synergistic Inhibition of Breast Cancer Cell Growth by an Epigenome
Application of excitation and emission matrix fluorescence (EEM) and UV
CELF1 Promotes Post
PEGylation of lysine residues improves the proteolytic stability of fibronectin while retaining biological activity PMID 24803071
Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol
GGsTop 926281
SMPDL3A 蛋白, Human (HEK293, His)
Agmatine an endogenous clonidine
Tebuconazole 107534
The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats PMID 16751799
2
噻吗洛尔
Structure
IL
BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis PMID 33022573
Cathepsin B Modulates Alzheimer's Disease Pathology Through SAPK/JNK Signals Following Administration of Porphyromonas gingivalis
BMP4 uses several different effector pathways to regulate proliferation and differentiation in the epithelial and mesenchymal tissue compartments of the developing mouse ureter PMID 28655168
Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane PMID 8605892
Amide Bond Bioisosteres Strategies, Synthesis, and Successes PMID 32686940
Mitophagy
Potentiation of TRAP
A membrane transporter determines the spectrum of activity of a potent platinum
VU6004909 1860797
Sulfuretin exerts diversified functions in the processing of amyloid precursor protein PMID 34522714
Cy3
Mitochondrial Autophagy
Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1
Essential role of endogenous prolactin and CDK7 in estrogen
Combretastatin dinitrogen
胆碱磷酸转移酶 1（CHPT1）基因
Image
Amplifying STING activation by cyclic dinucleotide
Sphingosine 1
Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity PMID 35973629
Sildenafil Attenuates Persistent Pulmonary Hypertension of the Newborn via Inhibiting the Growth and Migration of Pulmonary Artery Smooth Muscle Cells PMID 39809035
Aripiprazole 129722
Rnd3
1
Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo PMID 15781876
Pigment Red 49 1 (Barium lithol red)
ICOS agonism by JTX
IL
4,5
蛋白质精氨酸 N
Anti
(2S,3R,E)
Self
Characterisation of multiple substrate
Second
AML cell
Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis
Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E
Uridine triphosphate increases proliferation of human cancerous pancreatic duct epithelial cells by activating P2Y2 receptor PMID 23462325
(±)
Nocarimidazoles A and B from a Marine
circE2F1
Identification of a novel Src inhibitor K882 derived from quinazoline
Notch 4 蛋白, Mouse (HEK293, His)
Fmoc
DSPE
Glesatinib, a c
DSPE
CircADAMTS12 Inhibits the Anti
Cilgavimab 2420563
Suppression of JNK/ERK dependent autophagy enhances Jaspine B derivative
ENAH transcriptionally activated by YY1 promotes growth and invasion of laryngocarcinoma cells through PI3K/AKT signaling PMID 39265883
Lactam based 7
In vitro anti
MK
GC
C.I. Vat Yellow 2
DSPE
PW0729 2767348
Angelicone (Glabralactone)
Digitoxigenin
Anti
Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species PMID 10213516
Comparative review of imipenem/cilastatin versus meropenem PMID 32035719
Design and optimization of highly
DEPRESSION OF PHAGOCYTIC ACTIVITY AND IMMUNE RESPONSE BY METHYL PALMITATE PMID 14208965
Elevated KCa3.1 expression by angiotensin II via the ERK/NF
6
PDE4
XP
Structure
17β
Epipterosin L 52611
Regulating NCOA4
Development and validation of analytical methodology by GC
(E)
EGFR
lipids
Fluzoparib disrupts Golgi apparatus to inhibit O
Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice PMID 27152363
DSPE
Wnt 家族成员 5B（WNT5B）基因
alpha
Interleukin
Fmoc
Tumor Diagnosis and Treatment Based on Stimuli
BrdU(Proliferation Marker) 抗体 (YA6399)（BrdU(Proliferation Marker) Antibody (YA6399)）
EGFmRC797S mutation
Wnt signaling preserves progenitor cell multipotency during adipose tissue development PMID 37337125
KAT6A/B inhibition synergizes with retinoic acid and enhances the efficacy of GD2
Nafamostat hydrochloride 80251
ATR/PARP1
Dissecting the effect of ileal faecal diversion on the intestine using single
DSPE PEG2k
Milrinone
Interleukin
Mechanical stress reduces secreted frizzled
A Reactivity
Morusinol (桑树醇)
DSPE
Efficacy of a series of alpha
T
DSPE
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling PMID 23416332
Attenuation of amyloid
Z
Metabolomics of Methylphenidate and Ethylphenidate Implications in Pharmacological and Toxicological Effects PMID 27438788
Lipid droplets restrict phagosome formation in antifungal immunity PMID 40195475
(8S,13S,14S)
Cefodizime sodium 86329
p
Neuraminidase
Nobiletin 478
MAP4K4/HGK抑制剂、基因
EGFmRC797S mutation
Anti
1
Panitumumab 339177
ATR/PARP1
T
5,15
α
Sodium benzoate 532
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening PMID 27106709
Stearic acid
LAH5
Asterric Acid (Dimethylosoic acid)
Adenosine receptor inhibitor 2
Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus
Melatonin protects against focal cerebral ischemia
Epstein
Saponarin activates AMPK in a calcium
Design, Synthesis, and Biological Evaluation of a Novel Series of Teriflunomide Derivatives as Potent Human Dihydroorotate Dehydrogenase Inhibitors for Malignancy Treatment PMID 34905371
SRT 1720 hydrochloride
DC
Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting PMID 39868226
JTE
Azido
1,25(OH)2D3 inhibits osteogenic differentiation through activating β‑catenin signaling via downregulating bone morphogenetic protein 2 PMID 33173996
EMD
parasympathomimetic
Design of Potent Menin
Niraparib Maintenance Therapy in Platinum
Conformational Constrained 4
Sodium Selenite 10102
VEGF164 蛋白, Rat (P.pastoris)
EMD
全球办事处
Vascular endothelial growth factor receptor
tau Protein/α
XJB
Moxetumomab Pasudotox First Global Approval PMID 30357593
Telmisartan inhibits microglia
hu
Quercetin dihydrate 6151
Vascular endothelial growth factor receptor
tetrahydrobenzo
BRD 4354 ditrifluoroacetate
Andrias davidianus Ranavirus (ADRV) Genome Replicate Efficiently by Engaging Cellular Mismatch Repair Protein MSH2 PMID 35632694
FASN contributes to ADM resistance of diffuse large B
KIT
(E)
细胞粘附分子 1（CADM1）基因
Reactive astrocyte
Activity reconstitution of Kre33 and Tan1 reveals a molecular ruler mechanism in eukaryotic tRNA acetylation PMID 38613394
Lumichrome Inhibits Human Lung Cancer Cell Growth and Induces Apoptosis via a p53
KLF5
A novel polypeptide from stony coral Goniopora columna inhibits thrombosis by interfering with the contact
Bloch
Dual
Activated Natural Killer Cells in Combination with Anti
Zebrafish embryos as a teratogenicity screening tool to reduce potential birth defects PMID 40097051
Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy PMID 25362207
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