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Synthesis and Agonistic Activity at the GPR35 of 5,6
Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR
Histone acetylation by HBO1 (KAT7) activates Wnt/β
Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose
Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis PMID 20004647
Xerophenone H, a naturally
Macrophage migration inhibitory factor (MIF) inhibitor 4
Cardioprotective effect of sonic hedgehog ligand in pig models of ischemia reperfusion PMID 32226535
TRPA1 mediates formalin
Heat
A genome
A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion PMID 37898620
4
The effects of a new aldose reductase inhibitor (tolrestat) in galactosemic and diabetic rats PMID 3930915
Peptide inhibitor of complement c1, a novel suppressor of classical pathway activation mechanistic studies and clinical potential PMID 25202312
TRPA1 mediates mechanical sensitization in nociceptors during inflammation PMID 22927999
Integrated multi
Wnt
Identification of Balanol as a potential inhibitor of PAK1 that induces apoptosis and cytoprotective autophagy in colorectal cancer cells PMID 37323074
Peroxisome proliferator
Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis PMID 37963874
Anthragallol
MicroRNA miR
Effect of riboflavin supplementation on zinc and iron absorption and growth performance in mice PMID 9881515
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist PMID 15537354
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age
Amoebicidal action of isoliquiritigenin and glabridin from Glycyrrhiza species Mechanisms and effects against Acanthamoeba castellanii PMID 40701128
Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy PMID 40671262
Hydrogel
GABAergic neurons of anterior thalamic reticular nucleus regulate states of consciousness in propofol
Protocatechuic aldehyde promotes the functional recovery of spinal cord injury by activating the Wnt/β
Structure
cardiac
Stromal nicotinamide N
5
Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptor mechanisms PMID 1325800
Molecular Insights into the Insensitivity of Lepidopteran Pests to Cycloxaprid PMID 31909997
tau Protein/α
Identification of VISTA regulators in macrophages mediating cancer cell survival PMID 39602545
The Neuroprotective Effects of Muscle
Transmissible Gastroenteritis Virus Infection Promotes the Self
Montelukast in hospitalized patients diagnosed with COVID
Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation PMID 12573694
Anteroposterior polarity and elongation in the absence of extra
TGN
Optimising conditions for radiolabelling of DOTA
Enamel matrix derivative expedites osteogenic differentiation of BMSCs via Wnt/β
Isovitexin
The Kennedy pathway
Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity PMID 24116873
DOT1L is a barrier to histone acetylation during reprogramming to pluripotency PMID 37976354
PI
Spatiotemporal Dynamic Immunomodulation by Infection
NOTCH Signaling via WNT Regulates the Proliferation of Alternative, CCR2
cardiac
Azido
KT
4
Evaluation of the analgesic properties of zomepirac PMID 6247371
T0070907 inhibits repair of radiation
GSD
JNJ 10329670
Paeoniflorin Inhibits the Activation of Microglia and Alleviates Depressive Behavior by Regulating SIRT1
IL
Synthesis and Biological Evaluation of Paclitaxel and Camptothecin Prodrugs on the Basis of 2
BAFF/TNFSF13B 蛋白, Human (HEK293, His)
BMS
MAP4K5/KHS1抑制剂、基因
Purification and characterization of multiple components of human lymphoblastoid interferon
Emvistegrast (GS
Glycerol Monoleate (Standard)
15
AMPPD 122341
The Discovery of a Dual TTK Protein Kinase/CDC2
Discovery of podofilox as a potent cGAMP
NF
Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen
DSPE
Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950 PMID 27994733
Design, synthesis, and biological evaluation of novel 4
DSPE
Prednisolone disodium phosphate (Prednisolone 21
Transforming growth factor
Blontuvetmab 1608112
Ferrous
Bile acid toxicity structure
ADORA1 蛋白, Human (Cell
AQP9 weakens the cytotoxicity of CD8+ T cells in colon adenocarcinoma by boosting M2 polarization of macrophages under hypoxia conditions PMID 40329438
DSPE
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease PMID 29533874
TWEAK regulates the functions of hair follicle stem cells via the Fn14
透明质酸合酶 2（HAS2）基因
Synthesis and Activity of a New Series of Antileishmanial Agents PMID 28835791
USP39 抗体 (YA6827)（USP39 Antibody (YA6827)）
Discovery of orally available tetrahydroquinoline
Trigonelline reverses high glucose
Humanized Anti
Synthesis and discovery of asiatic acid based 1,2,3
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23
α
Phospho
Tetrahydroquinoline glucocorticoid receptor agonists discovery of a 3
Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG PMID 26804230
WZ66, a novel acetyl
α
Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma PMID 27207779
L
DSPE
DSPE
WNT16 from decidual stromal cells regulates HTR8/SVneo trophoblastic cell function via AKT/beta
(E/Z)
DSPE
DMG
DSPE
Leptin
1
DL
Exosomes derived from NGF
Lp(a)
Angiotensin II type I receptor and miR
calcium channel
Qin
KAC
Detection and clinical significance of circulating tumor cells in patients with nasopharyngeal carcinoma PMID 31452741
Yohimbine
intestinal pathogen
Microsomal antiestrogen
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial
Sperabillin A dihydrochloride 111337
CCR9 initiates epithelial
CD300a/LMIR1 蛋白, Human (HEK293, Fc
Activation of Ca2+/calmodulin
PW0787
Methyl 2
FITC
β
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding PMID 29033244
RAR 相关孤儿受体 γ（Rorc）基因
Decanoic acid sodium 1002
PARP1
Blocking ATP
ARD
Cathepsin B 蛋白, Rat (HEK293, His)
MEK Inhibition Induces Canonical WNT Signaling through YAP in KRAS Mutated HCT
3
Mst1r
PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR
rno
FLT3
High
Conoidin A 18080
Structure
Isoliquiritigenin attenuates pathological cardiac hypertrophy via regulating AMPKα in vivo and in vitro PMID 35834120
Camphene 79
TERT activator
NOP2 facilitates EZH2
fatty
Tranilast 53902
Top Publications Citing MCE Products
Azacyclonol hydrochloride 1798
Nutlin 1 548472
Zanthoxylum rigidum Humb. & Bonpl. ex Willd.提取物 (Zanthoxylum rigidum Humb. & Bonpl. ex Willd.)
ISG20 serves as a potential biomarker and drives tumor progression in clear cell renal cell carcinoma PMID 32003757
全球办事处
Soluble (pro)renin receptor via β
DSPE
A biosensing system using a multiparameter nonlinear dynamic analysis of cardiomyocyte beating for drug
(R)
Alfuzosin
DSPE
Arachidonic acid
DSPE
Aars1 Rat Pre
(S)
DSPE
dTTP
Single
Cathepsin抑制剂、基因
Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents PMID 40766615
Pancreatic ductal adenocarcinoma cell secreted extracellular vesicles containing ceramide
DSPE
Signal amplification of microarray
Polymeric nano
cerebral
Huanglian decoction prevents and treats radiation
IGF‑1 inhibits palmitic acid‑induced mitochondrial apoptosis in macrophages PMID 37921069
Targeting PARP and autophagy evoked synergistic lethality in hepatocellular carcinoma PMID 31175354
The hepatoprotective effects of Herbt Tea Essences on phenanthrene
Bavituximab (Anti
ddCTP 66004
上皮膜蛋白 1（EMP1）基因
Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti
Cochliomycin B 1278520
Lidocaine attenuates hypoxia/reoxygenation‑induced inflammation, apoptosis and ferroptosis in lung epithelial cells by regulating the p38 MAPK pathway PMID 35244190
DSPE
DSPE
Protein kinase inhibitor 14
GP47779
Potent and Selective Human Constitutive Androstane Receptor Activator DL5055 Facilitates Cyclophosphamide
Terephthalic acid 100
Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists
Assessment of anxiolytic and panicolytic effects of dichloromethane fraction from stems of Kielmeyera coriacea PMID 21975171
7
Mesuol 16981
去甲基酶活性测定
N
Kdn
GSK3 regulation Wnt/β
Lidocaine inhibits influenza a virus replication by up
Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells structure
H
DSPE
The GAL/GALR2 axis promotes the perineural invasion of salivary adenoid cystic carcinoma via epithelial
DSPE
Isoatriplicolide tiglate
Targeting senescent hepatocytes for treatment of metabolic dysfunction
HDAC6
New constituent from Podocarpus macrophyllus var. macrophyllus shows anti
Protective role of 17β
Inhibitory effects of choleretic hydroxyacetophenones on ileal bile acid transport in rats PMID 16253286
Kv3 modulator 2
Bisoprolol
CE(20 2(6Z,9Z)) (Cholesteryl 11,14
Sulodexide decreases albuminuria and regulates matrix protein accumulation in C57BL/6 mice with streptozotocin
Mosaic composition of RIP1
Cilostamide 68550
ABSK
Activation of TREM
齿冠紫堇提取物 (Corydalis bulleyana Diels)
MCE
Design and synthesis of 7
DSPE
A Natural Plant Ingredient, Menthone, Regulates T Cell Subtypes and Lowers Pro
12
DREADDs
chronic eosinophilic leukemia
DSPE
Tropomyosin related kinase receptor
DSPE
3,4
MK
RAF
Neomycin 1404
烯丙酰草胺
S
DSPE
VOPP1, a determinant of the sensitivity of non
Angenomalin
鞘甘氨酸
AT
Addressing cytotoxicity of 1,4
(R)
MAGE 家族成员 H1（MAGEH1）基因
DSPE
Batoprotafib 1801765
DSPE
CLIC3 interacts with NAT10 to inhibit N4
ferroptosis
Design, synthesis and SAR studies of NAD analogues as potent inhibitors towards CD38 NADase PMID 25268725
HDAC
Amisulpride
cytoplasmic tail of RAGE
DSPE
Bebtelovimab 2578319
Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro PMID 18389485
H
Huoxin Pill inhibits isoproterenol
Lilial 80
PF
DSPE
3
PET
CD39 蛋白, Human (HEK293, His)
MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin PMID 27004400
Anti
鲁沙香茅提取物 (Cymbopogon martini)
DSPE
ribosomal
Hemagglutinin
13
Angiotensin
hu
1,3
Phenazine oxide 304
Lithocholic acid 3
Endogenous Metabolite
Oleic acid
Polyphyllin I promotes cell death via suppressing UPR
Gastrodin 62499
Lucanthone 479
Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis PMID 29227619
AKT constitutes a signal
Cetirizine Impurity C dihydrochloride 2702511
α
LPAR6 Participates in Neuropathic Pain by Mediating Astrocyte Cells via ROCK2/NF
alpha
OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression PMID 40338740
Penetratin
USP33 facilitates the ovarian cancer progression via deubiquitinating and stabilizing CBX2 PMID 39256572
transdifferentiation
Immunoglobulin Fc Region
Inhibition of the ATR
PET imaging assist investigation of HDAC6 expression change in MDD and evaluating antidepressant efficacy of a newly developed HDAC6 inhibitor PMID 39366254
Critical amino acid residues of AIP, a highly specific inhibitory peptide of calmodulin
Cathepsin激活剂、基因
Lalistat 2 1234569
DSPE
SSD114
A dual CCR2/CCR5 chemokine antagonist, BMS
Z
Sensory Glia Detect Repulsive Odorants and Drive Olfactory Adaptation PMID 32970991
Synthesis and structure
Elk3 Rat Pre
(2
5
Identification of effective CCR2 inhibitors for cancer therapy using humanized mice PMID 37947138
Pimprinine 13640
Pneumocandin B2 138530
L
Metabolism of KO143, an ABCG2 inhibitor PMID 28619281
NTPDase2抑制剂、基因
Discovery and Characterization of a Novel Cereblon
shikimate pathway
Inhibition of 20
Antiflammin
L
Cryptochrome抑制剂、基因
DSPE
嘧啶能受体P2 Y4（P2ry4）基因
5
MK
Hydrangetin 485
Psychosine
DSPE
Reactions of 2
DSPE
Tri(TLR4
PRKAB1 Human Pre
6H05 TFA 2061344
TMEM11 Human Pre
DSPE
DSPE
Adamtsl1 Rat Pre
黑色素瘤中缺失 2（AIM2）基因
Aptamer to ErbB
Thiazolides Elicit Anti
Hydrochlorothiazide modulates ischemic heart failure
C
CDK8/19 inhibition plays an important role in pancreatic β
Glutathione S
Erythromycin
Identification of competitive antagonists of the P2Y1 receptor PMID 8913364
Immune response caused by M1 macrophages elicits atrial fibrillation
Structure and mechanism of receptor sharing by the IL
鹅掌草提取物 (Anemone flaccida Fr. Schmidt)
Glycine
Theophylline inhibits NF
Brg1
ZCZ011
Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule PMID 28716944
血清/糖皮质激素调节激酶家族成员 3（SGK3）基因
MCE
RALA peptide
Sulfometuron
DSPE
DSPE
Naphthyl ketones a new class of Janus kinase 3 inhibitors PMID 10741557
Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice PMID 19457128
GCA
Diphlorethohydroxycarmalol
Adhesive Ergothioneine Hyaluronate Gel Protects against Radiation Gastroenteritis by Alleviating Apoptosis, Inflammation, and Gut Microbiota Dysbiosis PMID 37052616
NYAD
Propanoic
ZM39923 273727
粘附 G 蛋白偶联受体 G3（ADGRG3）基因
SMTIN
Romidepsin induces caspase
(R)
DSPE
MCE
Tokinolide B
GW549390X
DSPE
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization PMID 37797618
Organoid
Acetazolamide potentiates the anti
Procyanidin B3 alleviates intervertebral disc degeneration via interaction with the TLR4/MD
Oxalic Acid
Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin PMID 18606222
26098
Metabolism of Isoflavones Found in the Pueraria thomsonii Flower by Human Intestinal Microbiota PMID 25045319
Molecular Mechanisms of KDELC2 on Glioblastoma Tumorigenesis and Temozolomide Resistance PMID 32927743
NB
Midostaurin (PKC412，米哚妥林)
Blumeatin 118024
Caspase
Lipopolysaccharides
Argatroban
Synthesis, SAR and biological evaluation of 1,6
Rho
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway PMID 36852868
LCMV gp33
N1,N5
Chloridazon
MCE
Acetyl
Imidazole
Dimethyl fumarate inhibits necroptosis and alleviates systemic inflammatory response syndrome by blocking the RIPK1
DMT 003096
VHL
[Nle8,18,Tyr34]
Porous PLGA microspheres loaded with PTH1
An overview of potential inhibitors targeting non
Vericiguat as a novel PPARα ligand alleviates pressure
HDAC
Phthalimidinoglutarimide
Hepatocyte
Reactive Oxygen Species (ROS)
3
LXR
CSF2
The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist
Rifampicin
Anti
7
Usaramine N
Aspa Mouse Pre
LY2048978
[Protective effect of anhydroicaritin against peritonitis in mice] PMID 24103264
chromogenic glucosaminide substrate
SPSB2
Aromatic hydrazides A potential solution for Acinetobacter baumannii infections PMID 36739749
ZD 7155(hydrochloride)
(S,R,S)
Polyphemusin II
Biotin 58
白细胞介素 12 b（Il12b）基因
ICAM
VU0361747 1309976
AX102 sodium
D
琥珀酸多西拉敏
m6A RNA methylation
AGN
Didox 69839
Discovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti
Metformin inhibits IL
Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7
Microglial CD2AP deficiency exerts protection in an Alzheimer's disease model of amyloidosis PMID 39695808
Fulvine
Efficacy of photodynamic therapy using 5
STT3A/B
Evaluation of hexadecyloxypropyl
鼠李亭
Trilinolein 537
Pimonidazole 70132
Cystamine 51
Epithelial MST1 deficiency promotes pyroptosis and aggravates inflammatory bowel disease via the YAP/p73 signaling pathway PMID 41006633
Halicin 40045
A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo PMID 20971185
MET Y1230A Recombinant Human Active Protein Kinase
2
Top Publications Citing MCE Products
TL13
broad
ATPase Na+/K+ 转运亚基 β 3（ATP1B3）基因
7
二球悬铃木提取物 (Platanus acerifolia Aiton) Willd.)
[Arg8]vasopressin
Nilgirine (尼勒吉扔碱)
L
Citrullinated amyloid
加利司韦
4
Ceramide kinase confers tamoxifen resistance in estrogen receptor
Thifluzamide 130000
Dehydrocyclopeptine
Biotin
Anpirtoline, a novel, highly potent 5
Functionally selective dopamine D₂, D₃ receptor partial agonists PMID 24831693
Turmeric yellow
CD16/PD
(R)
Anti
AMG
Tmem19 Mouse Pre
CD44 蛋白, Human (Biotinylated, HEK293, mFc
Panitumumab safety for treating colorectal cancer PMID 24766434
髓磷脂相关糖蛋白（MAG）基因
AKT inhibitor IV (AKTIV)
Monocrotaline N
IONIS
Gene Therapy for Inflammatory Cascade in Intrauterine Injury with Engineered Extracellular Vesicles Hybrid Snail Mucus
Autoantibodies Targeting Vinculin Reveal Novel Insight into the Mechanisms of Autoimmune Podocytopathies PMID 40463498
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