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DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes PMID 35660116
Silica
Paniculidine A 97399
Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma PMID 32104684
Pleconaril
AS1069562, the (+)
The viral fitness and intrinsic pathogenicity of dominant SARS
Avrainvillamide 269741
5
ANO1
S1P1 agonist 5 2760666
Immunization with an immunodominant self
BIM
Amelioration of bone fragility by pulsed electromagnetic fields in type 2 diabetic KK
TGR5 agonist INT
Increased Kcnq2 in the hippocampal contributes to esketamine
Iodophenpropit dihydrobromide
VEGFR
20(R)
Drugs in development for herpes simplex and varicella zoster virus PMID 28160282
ALKBH5 mediates silica particles
COH29 1190932
HSD17B13
Benzophenone
First
Hydroxylysylpyridinoline
Inhibiting Rho kinase 2 reduces memory dysfunction in adult rats exposed to sevoflurane at postnatal days 7
Apoptotic and antiproliferative effects of Stigmast
Structure
1
AChE
A forward chemical genetic screen reveals an inhibitor of the Mre11
Structural characterization and in vitro hypoglycemic activity of a glucan from Euryale ferox Salisb. seeds PMID 30732819
VDR agonist 2 3052323
Protein cage nanoparticles bearing the LyP
HIV
An Antenna
MRT
Production of d
Amubarvimab/Romlusevimab First Approval PMID 35997943
Ruxolitinib 941678
Synthesis and biological evaluation of 2,4
Octahydroaminoacridine 13415
Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer PMID 30374743
Phase IIb multicentred randomised trial of besifovir (LB80380) versus entecavir in Asian patients with chronic hepatitis B PMID 23979965
Combining the NanaPPI Toolbox and AI
DR3/TNFRSF25 蛋白, Human (HEK293, Fc)
Orbifloxacin 113617
Mycobacterium tuberculosis Utilizes Host Histamine Receptor H1 to Modulate Reactive Oxygen Species Production and Phagosome Maturation via the p38MAPK
Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator PMID 38470246
Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease PMID 29227285
YM
Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus PMID 8799579
Nitric oxide donating anilinopyrimidines synthesis and biological evaluation as EGFR inhibitors PMID 23792318
U
Preclinical Targeting of the PGRMC1
CCN1 is an opsonin for bacterial clearance and a direct activator of Toll
Phytoalexin sakuranetin attenuates endocytosis and enhances resistance to rice blast PMID 38653755
Activation of the MEK/ERK Pathway Mediates the Inhibitory Effects of Silvestrol on Nasopharyngeal Carcinoma Cells via RAP1A, HK2, and GADD45A PMID 38682208
Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells PMID 25993097
CerS1
IP
核因子 kappa B 激酶调节亚基 γ 抑制因子（IKBKG）基因
Growth, molecular structure, NBO analysis and vibrational spectral analysis of l
Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature PMID 37999975
Antitumor agent
Metabolism
Boc
糖尿病
Glaucocalyxin D
Emerimicin III 52931
The MASTL/YBX1/PAK4 axis regulated by stress
Caspase
Assessment of sublethal effects of clofentezine on life
miRNA
Small
Fmoc
Inhibition of classical pathway of complement activation with negative charged derivatives of bisphenol A and bisphenol disulphates PMID 15670912
Stearyl arachidonate 2416860
Alaproclate effects on voltage
TROP2 expression and therapeutic targeting in uterine carcinosarcoma PMID 40344963
HDAC/BET
hsa
SaCas9
Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition PMID 35840557
Acequinocyl
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1
Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti
Diethyl succinate
Tetramethylpyrazine Alleviates Behavioral and Psychological Symptoms of Dementia Through Facilitating Hippocampal Synaptic Plasticity in Rats With Chronic Cerebral Hypoperfusion PMID 34025340
microtubule acetylation inhibitor
NSC697923 343351
PLA2G16 蛋白, Human (His)
pan
miRNA
(Rac)
Pyrroformyl
Aagab acts as a novel regulator of NEDD4
TNF
Anti
Mcl1
Metolachlor
Cefotaxime
动态 1 样（DNM1L）基因
Antifungal agent 22 2640054
Identification of Isovitexin as a novel CYP17A1 inhibitor through virtual screening and evaluation of its anti
Fmoc
Silicon
Transcription Factor yin
Selamectin 220119
Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor PMID 38518755
Extraction and preparative purification of tanshinones from Salvia miltiorrhiza Bunge by high
Cadherin
Substrate binding and inhibition mechanism of norepinephrine transporter PMID 39143211
微染色体维护复杂组件 2（MCM2）基因
N
Serotonin reuptake inhibition by citalopram in rat strains differing for their emotionality PMID 10633492
A mitochondria
The protective mechanisms of glycyrrhizic acid for deoxynivalenol
p
SMU
(R)
Ginsenoside Rh1, a novel casein kinase II subunit alpha (CK2α) inhibitor, retards metastasis via disrupting HHEX/CCL20 signaling cascade involved in tumor cell extravasation across endothelial barrier PMID 37944834
CXCL1 contributes to IL
Erythromycylamine 26116
Schisantherin A attenuates sepsis
Dendrobium officinale polysaccharides attenuate uropathogenic Escherichia coli (UPEC)
Sodium 2
Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor
Picrasidine I 100234
Kaempferol attenuates cyclosporine
Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema PMID 11104784
Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure PMID 38847080
High glucose inhibits myogenesis and induces insulin resistance by down
BAY 80
(R)
Discovery of First Branched
MAO
The Role of Epidermal Growth Factor Receptor Signaling Pathway during Bovine Herpesvirus 1 Productive Infection in Cell Culture PMID 32846937
Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin
Rationally Repurposing Ruxolitinib (Jakafi (®)) as a Solid Tumor Therapeutic PMID 27379204
CSF1R
Discovery of a potent dual EGFR/HER
PROTAC PTK6 ligand
KGF impedes TRIM21
Anticancer activity of bergenin against cervical cancer cells involves apoptosis, cell cycle arrest, inhibition of cell migration and the STAT3 signalling pathway PMID 30988733
Hck
ZINC20906412
Nomifensine 24526
MoSec13 combined with MoGcn5b modulates MoAtg8 acetylation and regulates autophagy in Magnaporthe oryzae PMID 40320672
Selective and competitive functions of the AAR and UPR pathways in stress
VEGF164 蛋白, Canine (HEK293)
Fmoc
Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non
7
PF 4693627
DAPK
Self
N
Design, synthesis, and biological evaluation of novel pyrimidine/pyridine derivatives for Vesicular Stomatitis Virus (VSV) infection PMID 40803166
Induction of rat hepatic and intestinal UDP
Chaperone
Evaluation of the developmental toxicity of methacrylamide and N,N'
Electrophysiologic and antiarrhythmic effects of AZD1305 in canine pulmonary vein sleeves PMID 20360353
Hippocampal LASP1 ameliorates chronic stress
Quantification of lactate dehydrogenase
PROTAC BTK Degrader
Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine
Glimepiride
Benzo[a]pyrene evokes epithelial
Aloe Emodin Alleviates Radiation
Bacterial cellulose membrane integrating phase
l,8
Hybrid pyrimidine alkynyls inhibit the clinically resistance related Bcr
Programmable embedded bioprinting for one
HCC
4
Design, synthesis and biological evaluation of saccharin
New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum PMID 18484537
Ethyl Caffeate 102
2
MCE
H
Circulating extracellular vesicle
Novel 3'
Protective effects and molecular mechanisms of baicalein on thioacetamide
A
Anti
Targeted degradation of aberrant tau in frontotemporal dementia patient
LCL161 1005342
Ephrin
Autocamtide
Specificity of the ecto
1
含 Sad1 和 UNC84 域 1（SUN1）基因
Defective CFTR modulates mechanosensitive channels TRPV4 and PIEZO1 and drives endothelial barrier failure PMID 39252977
泛素结合酶 E2 T（UBE2T）基因
Induction of the antimicrobial peptide CRAMP in the blood
Tolerability, Safety, Pharmacokinetics, and Immunogenicity of a Novel SARS
Opposing USP19 splice variants in TGF
CMPF 86879
(((9H
Diclofenac Sodium 15307
PROTAC K
Irsogladine 57381
NH2
Analgesic Effect of Intrathecal Administration of Chemokine Receptor CCR2 Antagonist is Related to Change in Spinal NR2B, nNOS, and SIGIRR Expression in Rat with Bone Cancer Pain PMID 25653100
SIRP alpha/CD172a 蛋白, Human (G75A, HEK293, His)
Cyclooctyne
Vasculoprotective Effects of 3
Tirabrutinib First Approval PMID 32382949
14
TLR4 agonist
缝隙连接蛋白γ1（GJC1）基因
Z
EZM 2302 1628830
Functional coupling between MC4R and Kir7.1 contributes to clozapine
Notch 3 蛋白, Human (HEK293, C
Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety PMID 19285389
The interplay between HIF
Highly purified Type II collagen, from human sternal cartilage (Human Type II collagen, immunization grade)
Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382 PMID 12323381
A role for calcium/calmodulin
Etilefrine 709
6,4'
THP
The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING PMID 30566866
DHICA 4790
11
Comparative anti
Cellular stress induces non
Aqp2 Mouse Pre
Doxorubicinol 54193
Imiglitazar 250601
PD173074 219580
Dopamine acrylamide 201610
Cystatin M/CST6 蛋白, Human (HEK293, His)
The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy
Fluazinam impairs oxidative phosphorylation and induces hyper/hypo
Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma PMID 10850439
SU5408 (VEGFR2 Kinase Inhibitor I)
Gap 26 197250
Interleukin
Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma Design, Synthesis, and Biological Evaluation PMID 34473510
HAVCR1
Tetrac as an anti
L
Synthesis and structure
Synthesis, characterization, solubilization, cytotoxicity and antioxidant activity of aminomethylated dihydroquercetin PMID 30108751
Sabcomeline hydrochloride 159912
AGL 2043
CD1D 蛋白, Mouse (HEK293, His
Sodium 2
Synthesis, antileishmanial and antitrypanosomal activities of N
PHF6 329897
Oxolamine 959
Diiodohydroxyquinoline 83
TgAKS3
Fc gamma RIIB/CD32b 蛋白, Human (HEK293, His
(Rac)
Ki 23057
CYP51
Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity PMID 38356061
Tspan9 Exacerbates Cardiac Hypertrophy by Impairing Cardiac Autophagy PMID 40406987
BM
Dihydroartemisinin inhibits the migration of esophageal cancer cells by inducing autophagy PMID 32831913
cephalosporin
Ald
Falcarinolone 18089
PPI
BIIB021 (Standard) (CNF2024 (Standard))
Antiproliferative activity and mode of action analysis of novel amino and amido substituted phenantrene and naphtho[2,1
In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms PMID 34915848
(
ATG16L1 restrains macrophage NLRP3 activation and alveolar epithelial cell injury during septic lung injury PMID 40211890
Uncovering the mechanistic basis of Rheum palmatum L. (rhubarb) in the treatment of chronic kidney disease an integrative approach using network pharmacology, molecular docking, and experimental validation PMID 40783939
Fluoxetine 54910
Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood
AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5 PMID 32929041
5
TOP1 蛋白, Human (575a.a, sf9, His)
Loureirin B ameliorates cholestatic liver fibrosis via AKT/mTOR/ATG7
呼吸系统疾病模型 (Respiratory System Disease Models)
Ornipressin (Por 8) An efficient alternative to counteract hypotension during combined general/epidural anesthesia PMID 10825311
Obeticholic acid
Polyglycerol
N1
The antiarrhythmic actions of bisaramil and penticainide result from mixed cardiac ion channel blockade PMID 30594781
Glycocyamine
Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development PMID 40521668
The PTPN2/PTPN1 inhibitor ABBV
Nitrilotriacetic acid trisodium salt 5064
The role of CXCR3/LRP1 cross
Conserved 5
DHA/AA alleviates LPS
Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice PMID 26998906
Comparison of the effect of TAK
Galectin抑制剂、基因
KYA1797K down
Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin
Imatinib
Discovery of epigenetic regulator I
rhophilin Rho GTPase 结合蛋白 1（RHPN1）基因
Dualism in the effect of cholinolytics upon the human parotid gland deprived of parasympathetic control PMID 3781706
nonesterified
Rivaroxaban 366789
Potent μ
Zoosporicidal metabolites from an endophytic fungus Cryptosporiopsis sp. of Zanthoxylum leprieurii PMID 22883958
5
(1R,3R)
The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain PMID 12110614
Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease PMID 23048024
Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers PMID 17455217
The histidine
PhosTAC7 3016307
Synthesis, antitumor activity and structure
Bifenthrin Caused Parkinson's
Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer PMID 27773735
A pharmacological map of the PI3
Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse
MPXV infection activates cGAS
Polyvinylpyrrolidone
Phenibut hydrochloride 3060
Effects of some pyrrolic and dihydropyrrolizine esters on mouse skin a preliminary study PMID 462580
Troubleshooting Arterial
A Novel Hybrid Peptide VLP
Rheum palmatum extract exerts anti
CD137/4
Ap4A induces apoptosis in human cultured cells PMID 10452553
DREADD agonist 21 dihydrochloride 2250025
The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma PMID 26909611
Leoidin
Methylclonazepam
Ferroheme 14875
The effects of idazoxan and other alpha 2
SU9518
Co
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d
Antiviral effect of mangiferin and isomangiferin on herpes simplex virus PMID 2167819
HSD17B13
Yeast peptone dextrose (YPD，酵母浸出粉胨葡萄糖培养基)
Sel1
ARMCX5
Myristoyl coenzyme A lithium 187100
CLM3 1312024
Design, synthesis and anticancer activity of 1
Tosufloxacin hydrate 107097
Mogroside V protects against acetaminophen
trans
Notch signaling regulates a metabolic switch through inhibiting PGC
Fucosterol ameliorates depressive
MMP
The metabolite alpha
Neuroinflammatory
Oleic acid
细胞侵袭
Inhibition of Bcl
T4 endonuclease V review and application to dermatology PMID 18476794
FBXO45 restricts HIV
Characterization of the genotoxicity of nitrilotriacetic acid PMID 18449932
The Hidden Conformation of Lewis x, a Human Histo
The newly developed CRF1
Discovery of 2
Pulp stem cells with hepatocyte growth factor overexpression exhibit dual effects in rheumatoid arthritis PMID 32522231
capping
Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKα
Autophagy induces mTOR
Three new cassane diterpenes from the seeds of Caesalpinia minax Hance PMID 20839126
Downregulation of miR
Targeting invadopodia
HIV protease inhibitor ritonavir a more potent inhibitor of P
Paw oedema
Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α
PI3K
Autophagy
PK095 380314
Alcohol promotes CPT1A
Hydroxy
Generation of Anti
The traditional herb Sargentodoxa cuneata alleviates DSS
79175
1
Ammonium trichloro(dioxoethylene
Asalin 13425
ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2 PMID 33107021
inactive ingredients
Rhubarb granule promotes diethylnitrosamine
PTGDS 蛋白, Human (HEK293, His, solution)
Additive immunosuppressive effect of leflunomide and hydroxychloroquine supports rationale for combination therapy for Sjögren's syndrome PMID 31192747
5 S,15 S
Mechanism of action of the SWI/SNF family complexes PMID 36633435
GTPase，IMAP 家族成员 5（GIMAP5）基因
Turonicin A, an Antifungal Linear Polyene Polyketide from an Australian Streptomyces sp PMID 37526586
Ion Trap LC/MS reveals the generation of reactive intermediates in acalabrutinib metabolism phase I metabolic profiling and bioactivation pathways elucidation PMID 38769961
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin PMID 17206729
Kinesin
Massoniresinol 96087
Oral administration of asparagine and 3
Exploring the impact of mitochondrial
Histone lysine demethylase 1A inhibitors, seclidemstat and tranylcypromine, induce astrocytogenesis in rat neural stem cells PMID 39899938
Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase PMID 11080540
Protocol for neurogenin
Roscovitine
FINDY
A PKA/cdc42 Signaling Axis Restricts Angiogenic Sprouting by Regulating Podosome Rosette Biogenesis and Matrix Remodeling PMID 30787359
Capillary
Pomalidomide
Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient
Estradiol 17
Isradipine
A new class of highly potent and selective endomorphin
Cbz
Adenosine dialdehyde 34240
Protective mucosal immunity mediated by epithelial CD1d and IL
2E
Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47 PMID 36112140
Engineering of Orally Available, Ultralong
CCK
Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells PMID 23765509
Immunoreceptor tyrosine
Bis(N
(7S,8S)
Magnolol 528
Exogenous L
Methyl 11(S),12(S)
IRF2BPL inhibits proliferation, migration and invasion of osteosarcoma cells by inhibiting FOSL2
LSD1
Discovery of thiapyran
Discovery of tetrasubstituted thiophenes as Cisd2 activators A potential novel therapeutic option in nonalcoholic fatty liver disease PMID 37393792
Omectatug 2867393
原病毒整合位点 1（Pim1）基因
A8 peptide 1140483
TNF
Environmental impact of mosquito pesticides influence of temefos on the brain acetylcholinesterase of killifish PMID 1213034
A Cdk5 inhibitor restores cognitive function and alleviates type 2 diabetes in mice PMID 40224020
Diethyl phosphate 598
Epigenetic silencing by the SMC5/6 complex mediates HIV
Targeting hypoxia in combination with paclitaxel to enhance therapeutic efficacy in breast and ovarian cancer PMID 39476764
Tunaxanthin 12738
Maximakinin reversed H2O2 induced oxidative damage in rat cardiac H9c2 cells through AMPK/Akt and AMPK/ERK1/2 signaling pathways PMID 38513595
伸长素 A（ELOA）基因
N6
C
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5
HY
CB839
Lamalbid 52212
The amount of membrane cholesterol required for robust cell adhesion and proliferation in serum
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation
Evaluation of DNA repair inhibition by antitumor or antibiotic drugs using a chemiluminescence microplate assay PMID 9450493
桃提取物 (Amygdalus persica L., Peach)
1
GSK 2256294
PGF
Neferine promotes the apoptosis of HNSCC through the accumulation of p62/SQSTM1 caused by autophagic flux inhibition PMID 33982791
Thalidomide
DSPE
6
SU
Effects of amino acid substitutions in and around the arginine
Cyp1a2
蝙蝠葛碱
CFTR acts as a potential therapeutic target for attention deficit
AIM
Rocaglates as dual
Efficient feeder
Microbial hemicellulases PMID 12831897
Nabumetone 42924
circPTPN12/miR
Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII
DSPE
The pharmacology study of a new recombinant human VEGF receptor
DMTr
Polystyrene microplastics arrest skeletal growth in puberty through accelerating osteoblast senescence PMID 36746288
Bilastine 202189
Lycopene Ameliorates Polycystic Ovary Syndrome in Rats by Inhibiting Ovarian Ferroptosis Through Activation of the AMPK/Nrf2 Pathway PMID 39871526
Molecular mechanism underlying modulation of TRPV1 heat activation by polyols PMID 34022223
RIFM fragrance ingredient safety assessment, 3
127665
Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat PMID 30448421
沙格列汀
Zidebactam sodium salt 1706777
RGD
Aluminon 569
Linoleic acid PMID 23674797
Edoxaban impurity 6 480452
TD
Arbutin alleviates Mycoplasma gallinarum
KRAS inhibition activates an actionable CD24 'don't eat me' signal in pancreas cancer PMID 37790498
2
Targeting ASK1 by CS17919 alleviates kidney
MK
Plasticity in binding confers selectivity in ligand
Penicillin V Potassium 132
Creatine monohydrate 6020
DL
Major vault protein (MVP) suppresses aging
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