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Satisfaction of immediate or delayed switch to paliperidone palmitate in patients unsatisfied with current oral atypical antipsychotics PMID 26196188
The role of nicotinamide riboside in the preservation of retinal ganglion cells using an in vitro glutamate
A sensitive method for the detection of metabolites of dianabol in urine in man PMID 5126886
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis PMID 29113740
MYCBP2
6
Crovalimab 1917321
LDH
Uridine
IL10RA
MTH1
A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis PMID 35077860
Propiverine 60569
NTE
PPA
Albanin A 73343
Wnt/β
Activation of reverse Na+
3
11
非典型趋化因子受体 1 (达菲血型)（ACKR1）基因
Depatuxizumab mafodotin 1585973
Cefepime in vivo activity against carbapenem
mmu
Differential inhibition of human cytochrome P450 enzymes by epsilon
Salicylate downregulates 11β
N6
Development of AO
(S)
Tibolone induces lordosis behavior, but not concurrent or sequential inhibition, in Sprague Dawley rats PMID 33901612
Methyldigoxin 30685
Polygonal 72537
Amplified dosage of the NKX2
Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase PMID 24900769
9
Synthesis, cytostatic, and antiviral activity of novel 6
Empagliflozin ameliorates RSL3
Bermekimab 1401965
Py
Ferulic acid, ligustrazine, and tetrahydropalmatine display the anti
Memoquin
Sulfonamide Inhibition Studies of the β
CAY10566 944808
Nanoparticles retard immune cells recruitment in vivo by inhibiting chemokine expression PMID 32992116
ARS
Zatebradine hydrochloride 91940
NX
BpV(pic) potassium hydrate
Rediocide A
Discovery of TCP
3'
IL
mmu
3
Ac
Anxa2
Bredinin aglycone 56973
Inhibition of cell proliferation by an anti
Pitavastatin
jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl
palmitoleic acid
Controlling Multivalent Binding through Surface Chemistry Model Study on Streptavidin PMID 28234007
Existence of glia mitigated ketamine
HIPK2 Recombinant Human Active Protein Kinase
Hordenine, a single compound produced during barley germination, inhibits melanogenesis in human melanocytes PMID 23768344
In vitro evaluation of the protective effect of crocin on human erythrocytes PMID 34920397
Caspase
iNOs
A comparison of 2
Plxdc1
Allosteric Activation of Protein Phosphatase 5 with Small Molecules PMID 39145509
A primer of deuterium in drug design PMID 31538524
HY
OX40 Ligand/TNFSF4 蛋白, Cynomolgus/Rhesus Macaque (HEK293, Fc)
Glidobactins D, E, F, G and H; minor components of the antitumor antibiotic glidobactin PMID 3145259
Nigericin sodium salt 28643
Igfbp4
Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+
D
THZ1 reveals CDK7
Evaluation of 2,3,5
Enzymatic
Strategic Application of Epigenetic Regulators for Efficient Neuronal Reprogramming of Human Fibroblasts PMID 36823979
Mechanical stretch promotes the migration of mesenchymal stem cells via Piezo1/F
Royal jelly acid inhibits NF
亮氨酸拉链抑癌基因 2（LZTS2）基因
Vin
Expression Differences in BCL2 Family Members between Uveal and Cutaneous Melanomas Account for Varying Sensitivity to BH3 Mimetics PMID 34942200
An antidepressant that extends lifespan in adult Caenorhabditis elegans PMID 18033297
AVE
Aβ
Small molecule kinase inhibitor LRRK2
DuP532
CDK2
Transcriptional pause extension benefits the stand
Lead
5
Polyinosinic polycytidylic acid induces protein kinase D
Serotonin glucuronide 18186
Adenosine receptor antagonist 2 2703054
Inhibition of immunoproteasome subunit low molecular mass polypeptide 7 with ONX
[In vitro and in vivo activities of sulopenem compared with those of imipenem and cephalosporins] PMID 8786623
Advanced oxidation protein products upregulate ABCB1 expression and activity via HDAC2
(R)
TNFRSF3/LTBR 蛋白, Human (HEK293, His
Tetramisole hydrochloride 5086
Promising efficacy of nitrogen
Metal
Xanthopurpurin 518
ZBP1
Genkwanin blocks the interaction between phosphorylated JNK and NFATc1 to promote osteogenic differentiation and collagen Ⅰ α1 production PMID 40311832
The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability PMID 39526890
Interplay between SUMO1
Terminal residue and dietary intake risk assessment of prothioconazole
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK
Inhibition of DNA and RNA synthesis by daunorubicin in sensitive and resistant Ehrlich ascites tumor cells in vitro PMID 5063994
Agomelatine alleviates palmitic acid
BTK ligand 9 1709786
PRMT1 and TDRD3 promote stress granule assembly by rebuilding the protein
Syntheses of 3
Interleukin
α
COX
Tubulin Resists Degradation by Cereblon
The mechanism by which Naru 3 pill protects against intervertebral disc cartilage endplate degeneration based on network pharmacology and experimental verification PMID 37525208
Pharmacokinetics and metabolism of SL
Structurally related mycotoxins ochratoxin A, ochratoxin B, and citrinin differ in their genotoxic activities and in their mode of action in human
Discovery of novel pyrrolo[2,3
Cathelicidins Induce Toll
Akt调节剂、基因
EpCAM/TROP1 蛋白, Rhesus Macaque (HEK293, Fc)
3'
Discovery of Novel Sertraline Derivatives as Potent Anti
Dofequidar fumarate sensitizes cancer stem
P
Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma
SB 02024
First
Cardiomyocyte proliferation promoting agent
IL
Peptide 401
Cefetamet pivoxil hydrochloride 111696
CDK9
Design and synthesis of isoform
Slit proteins molecular guidance cues for cells ranging from neurons to leukocytes PMID 12200164
Isorhamnetin 3
Resection of hepatic metastasis after 5
Nuclear Factor of activated T Cells (NFAT)激活剂、基因
Human MCTS1
Sphingosine 1
Etelcalcetide hydrochloride 1334237
Preparation of the caspase
HDAC3
Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF
泛素 1（UBQLN1）基因
Loureirin D 119425
S100a16 deficiency prevents hepatic stellate cells activation and liver fibrosis via inhibiting CXCR4 expression PMID 35914619
NKG2D blockade facilitates diabetes prevention by antigen
Design, synthesis, and investigation of protein kinase C inhibitors total syntheses of (+)
Identification of known drugs that act as inhibitors of NF
API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs PMID 40641422
Differences in acute toxicity syndromes of 2,3,7,8
hMOF induces cisplatin resistance of ovarian cancer by regulating the stability and expression of MDM2 PMID 37291112
Broad and diverse roles of sphingosine
Palbociclib releases the latent differentiation capacity of neuroblastoma cells PMID 37734383
鼠李素
3,8''
C22 Phytoceramide (t18 0/22 0) 164576
NSUN2
Arteminin
Sotrastaurin
An in vitro cytotoxicities comparison of 16 priority polycyclic aromatic hydrocarbons in human pulmonary alveolar epithelial cells HPAEpiC PMID 29526570
神经营养受体酪氨酸激酶 1（NTRK1）基因
Methyl piperidine
Human organic anion transporting polypeptide 1B3 (OATP1B3) is more heavily N
VEGFR
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy PMID 38806104
Structural modifications modulate stability of glutathione
HDAC as onco target Reviewing the synthetic approaches with SAR study of their inhibitors PMID 30245394
Development of Indoleamine 2,3
WEHI
Brain microglia activation induced by intracranial administration of oligonucleotides and its pharmacological modulation PMID 29869293
N
mmu
In
ODN 1826 202668
LncRNA FAM83H
Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient
Fluoropyrimidin
Oxidative stress
Triggering of endoplasmic reticulum stress via ATF4
Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle PMID 35157953
NT
hsa
P529
Insights into the antimicrobial effects of ceritinib against Staphylococcus aureus in vitro and in vivo by cell membrane disruption PMID 36443539
(S,R,S)
Preservation of ALYREF Phase Separation Mitigates Doxorubicin
Ototoxicity
Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice PMID 38625620
Hexadecanedioyl
Discovery and Optimization of Potent PROTAC Degraders of Phosphoinositide 3
Long
Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer PMID 39657838
Ethylenediaminetetraacetic acid dilithium 14531
Identification of cytoprotective constituents of the flower buds of Tussilago farfara against glucose oxidase
The peroxynitrite donor 3
Juglone promotes spinal cord injury recovery by suppressing pyroptosis and necroptosis through FOS/USP53/ubiquitination PMID 41045624
Efferocytosis Nanoinhibitors to Promote Secondary Necrosis and Potentiate the Immunogenicity of Conventional Cancer Therapies for Improved Therapeutic Benefits PMID 37669546
Combinational Analysis of Metabolomic and O
[Cardiac rupture and tamponade in a pregnant woman with acute myocardial infarction] PMID 1640668
Accumulation of fructosyl
Gastrodin Ameliorates Post
6
Ropinirole
hCA/VEGFR
Discovery of (R)
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis synthesis and biological evaluation PMID 23376997
SM
Discovery of Novel Acethydrazide
Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika PMID 36239304
Identification of a metabolically stable triazolopyrimidine
Androgen receptor mitigates postoperative disease progression of hepatocellular carcinoma by suppressing CD90+ populations and cell migration and by promoting anoikis in circulating tumor cells PMID 27340775
Morolimumab 202833
Fluroxypyr
Estrogen and glucocorticoid promote the lactoferrin synthesis and secretion ability of bovine mammary epithelial cells through ER and GR signaling pathways PMID 39904446
The oncoprotein HBXIP promotes human breast cancer growth through down
Erectile Dysfunction PMID 27929275
The effect on m6A methylation writer complex by the reduced MATR3 in pterygium PMID 37913560
L
Neural Cell Adhesion Molecule L1
Fluridone 59756
Imazalil
ATX inhibitor 18 2402772
Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells PMID 38360085
L
溶质载体家族 16 成员 13（SLC16A13）基因
Discovery of potent and selective c
CC
New use of an old drug inhibition of breast cancer stem cells by benztropine mesylate PMID 27894093
cholestasis
3,5
(S)
Ginger extract (Zingiber officinale) has anti
Scutellarin alleviates tensile stress
p
2′,3′,5′
Temoporfin 122341
2
Fosfomycin calcium 26016
Bragsin1 369631
Malate
Generation and Application of a Luciferase Reporter Virus Based on Yellow Fever Virus 17D PMID 34342842
Planktonic microbial responses to perfluorinated compound (PFC) pollution Integrating PFC distributions with community coalescence and metabolism PMID 34020088
AKAPs
2’
CD200 蛋白, Human (HEK293, His)
Acidosis Licenses the NLRP3 Inflammasome
Morinda officinalis oligosaccharides ameliorate depressive
Ensifentrine 1884461
Molecular cloning and biophysical characterization of CXCL3 chemokine PMID 28928065
MCE
Therapeutic potential of the secreted Kazal
Spantide I 91224
LXRβ agonist
5
Anti
SARS
Targeting Na+ /K+
Ginsenoside Rb2 11021
CDK4 抗体 (YA3763)（CDK4 Antibody (YA3763)）
Allamandicin 51838
Multi
VEGFR
mTOR inhibitor
CB1/2 agonist 1 2986688
Etoricoxib
TLR2/4
Schisandrin B suppresses gastric cancer cell growth and enhances the efficacy of chemotherapy drug 5
Morin Regulates M1/M2 Microglial Polarization via NF
Tetrabenazine treatment for tardive dyskinesia assessment by randomized videotape protocol PMID 10450276
Gabapentin activates presynaptic GABAB heteroreceptors in rat cortical slices PMID 15249162
P. berghei
核糖核蛋白 4（LARP4）基因
ICI 186756
Atacicept 845264
Dtx1
Rankinidine, a new indole alkaloid from Gelsemium rankinii PMID 3819733
TIP48/49
PRN1371 1802929
ATB107 455325
MCE
1
RET
Pharmacologic properties of (
Development of molecular Trojan horses targeting New Delhi metallo
ALDH2 protects against alcoholic cardiomyopathy through a mechanism involving the p38 MAPK/CREB pathway and local renin
Ilomastat 142880
Mechanistic insights into the inhibition of NTCP by myrcludex B PMID 32039379
3,5
Moxifloxacin Hydrochloride 186826
C
cis
TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response PMID 32312989
Diosmin 520
Ablation of Cbl
Neladenoson Bialanate Hydrochloride A Prodrug of a Partial Adenosine A1 Receptor Agonist for the Chronic Treatment of Heart Diseases PMID 28488817
Polystyrene microplastics induces senescence of osteocytes by activating the cyclooxygenase
Tailoring Fibroblast
BV02 292870
Blockade of Tau hyperphosphorylation and Aβ₁₋₄₂ generation by the aminotetrahydrofuran derivative ANAVEX2
Periplocin targets low density lipoprotein receptor
CC 基序趋化因子配体 15（CCL15）基因
Antileishmanial macrolides from ant
Thrombin increases the expression of cholesterol 25
Bromine/Sulfur
半胱氨酰白三烯受体 1（CYSLTR1）基因
Flotillin 2 抗体 (YA1439)（Flotillin 2 Antibody (YA1439)）
Preclinical activity of CPI
unc
chemical synthesis
IGFBP
Alfalone 970
L
MK
Apelin peptides block the entry of human immunodeficiency virus (HIV) PMID 10802050
WRW4 TFA
2
Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection PMID 35973101
Ro 11
rhDNase
MRK 003
Senkyunolide A mitigates lipid deposition in hyperlipidemic hepatocytes through SIRT6
Microcystin
Cytotoxic Effect of Vanicosides A and B from Reynoutria sachalinensis Against Melanotic and Amelanotic Melanoma Cell Lines and in silico Evaluation for Inhibition of BRAFV600E and MEK1 PMID 32610527
O6
Periplocin improves the sensitivity of oxaliplatin
Minaxin C 1418150
ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition PMID 32877678
KB
GW
Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition PMID 36502580
Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors PMID 28505533
YF476 is a new potent and selective gastrin/cholecystokinin
Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors PMID 11901209
Duck Egg White
The BRD4 inhibitor JQ1 suppresses tumor growth by reducing c
Pressure sensing of lysosomes enables control of TFEB responses in macrophages PMID 38997458
Gomisin J inhibits the glioma progression by inducing apoptosis and reducing HKII
In
Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV
Englerin A 1094250
静态光散射
Corticosterone
Impaired degradation of PLCG1 by chaperone
Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis‑induced cardiomyopathy PMID 37859612
Role of the SIRT1/p53 regulatory axis in oxidative stress‑mediated granulosa cell apoptosis PMID 33179088
c
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways PMID 41014201
Shape
Tubulin/VEGFR
GR 82334 129623
The Effect of 4
Structure
Caspase 8激活剂、基因
LSN3213128
Dictysine
Rapid preparation of (3R,4S,5R) polyhydroxylated pyrrolidine
Apidaecins antibacterial peptides from honeybees PMID 2676519
Herceptide (HER2
Pulmonary interleukin 1 beta/serum amyloid A3 axis promotes lung metastasis of hepatocellular carcinoma by facilitating the pre
Synthesis of benzo[3,4]azepino[1,2
核转录因子 Y 亚基 α（NFYA）基因
LILRB2/CD85d/ILT
Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D
Discovery of a 5H
Characterization of C
Tryptophan metabolism regulates inflammatory macrophage polarization as a predictive factor for breast cancer immunotherapy PMID 37972471
Fragment Addition
GCN2
Identification of a novel PAK1 inhibitor to treat pancreatic cancer PMID 32322465
Discovery of a small molecule targeting ULK1
Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart PMID 35594067
Antioxidative glycosides from the leaves of Ligustrum robustum PMID 12828473
HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming PMID 40717222
Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes PMID 18523657
SARS
6
Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells PMID 38773088
Small molecule diketone flavorants diacetyl and 2,3
Safety and efficacy of amiselimod in relapsing multiple sclerosis (MOMENTUM) a randomised, double
Chronic Obstructive Pulmonary Disease PMID 26919673
富亮氨酸重复激酶 1（LRRK1）基因
Carbonic anhydrase 2 facilitates sorafenib resistance by counteracting MCT4
Neurotransmissions of antidepressant
N6
Degradation of the sulfonylurea herbicide LGC
Erythrinin C 63807
(Z)
The mechanism of protriptyline
BW A256C 98410
Up
Levulinic acid
Autophagy
3,4
Synthesis and cytotoxic activity of new acridine
Immunoproteasome subunit PSMB8 promotes skeletal muscle regeneration by regulating macrophage phenotyping switch in mice PMID 40241316
Synthesis and biological evaluation of 4
Myosin XI coordinates ABA
Azurin p28 peptide TFA
Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin PMID 9105397
Dideoxy
A novel application of furazolidone anti
LAH4
ER
L
Vps34 derived phosphatidylinositol 3
Ribostamycin 25546
Pre
Colfosceril miristate
Protective effect of sanguinarine against acetic acid
BX471 (ZK
Psychedelic
Looking for new antileishmanial derivatives in 8
Actionable loss of SLF2 drives B
TRK
Antihypertensive agent losartan promotes tongue squamous cell carcinoma cell proliferation via EGFR/ERK1/2/cyclin D1 signaling axis PMID 39245205
Hyperglycemia induced by the 5
Identification of novel β
[Some problems with testosterone determination] PMID 18058741
A Pyrazolo[3,4
β
Avatrombopag impurity 57 (Standard) 252263
CBL 抗体 (YA2392)（CBL Antibody (YA2392)）
Nanodrug modified with engineered cell membrane targets CDKs to activate aPD
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer PMID 40287115
Inhibitory effects and mode of antifungal action of isobavachalcone on Candida albicans growth and virulence factors PMID 39208670
Mizoribine inhibits hepatitis C virus RNA replication effect of combination with interferon
WB518
VEGFR
Identification of a cell
Aminooxy
Structural basis and functions of abscisic acid receptors PYLs PMID 25745428
Enabling and disabling polo
Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells PMID 10760829
Design, synthesis and biological evaluation of novel 4
Mer 蛋白, Human (HEK293, mFc)
纤溶酶原激活因子，尿激酶受体（PLAUR）基因
Endoproteinase Lys
Capsaicin ameliorates renal fibrosis by inhibiting TGF
Anti
Modeling study of mecamylamine block of muscle type acetylcholine receptors PMID 17938901
Azure B 531
HLCL
(±)
Spirombandakamine A3 and Cyclombandakamines A8 and A9, Polycyclic Naphthylisoquinoline Dimers, with Antiprotozoal Activity, from a Congolese Ancistrocladus Plant PMID 33843232
Sotatercept 1001080
CAII
Ly93 1883528
Disinhibition of PVN
α
(R,S)
L
Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti
Bis
Involvement of Wee1 in the circadian rhythm
Investigation on the ZBG
THIP 64603
Tryprostatin A 171864
Analgesic and anti
Pyriprole 394730
Decylubiquinone 55486
TK4g
Girancitug 3024821
Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor PMID 9928913
A review of compounds exhibiting anti
Altromycins, novel pluramycin
Novel anti
Pseudomonas aeruginosa pyocyanin and 1
Basally distributed actin array drives embryonic hypocotyl elongation during the seed
10
Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365 PMID 8384787
Novel hydroxyamides and amides containing D
Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a pan
Bilirubin oxidase as a single enzymatic oxygen scavenger for the development of reductase
'New/Designer Benzodiazepines' An Analysis of the Literature and Psychonauts' Trip Reports PMID 31933443
Sulfonium
D
Chitoheptaose 68232
MAPI 1260620
Microglial inhibition alleviates alpha
Steroid sulfatase and estrogen sulfotransferase in the atherosclerotic human aorta PMID 14507642
BRCA2 的合作伙伴和本地化者（PALB2）基因
BMS
Bromadoline 67579
VEGFR
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