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Imidazo[1,2
SLAMF7 and TREM1 Mediate Immunogenic Cell Death in Colorectal Cancer Cells Focus on Microsatellite Stability PMID 34732412
Avutometinib
Synergistic effect of programmed death
Endogenous Metabolite
O
Verapamil inhibits ureteral scar formation by regulating CaMK II
Optimal lymphocytic choriomeningitis virus sequences restricted by H
ABHD11 Human Pre
Carteolol hydrochloride 51781
Astragaloside IV Reduces OxLDL
DMT
NMR
Highly Efficient Bifunctional Peptides for Tumor Immunotherapy by Simultaneously Activating T Cells and Blocking PD
Ex Vivo Phenotypic Screening of Two Small Repurposing Drug Collections Identifies Nifuratel as a Potential New Treatment against Visceral and Cutaneous Leishmaniasis PMID 34114790
SKUT1B
CRACC/SLAMF7 蛋白, Mouse (HEK293, His)
potassium current
Oridonin regulates the polarized state of Kupffer cells to alleviate nonalcoholic fatty liver disease through ROS
Essential fatty acid deficiency a new look at an old problem PMID 3020581
3,5,7
EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c
Eticlopride hydrochloride
Isoliquiritigenin Ameliorates Acute Pancreatitis in Mice via Inhibition of Oxidative Stress and Modulation of the Nrf2/HO
Unraveling the neuroimmune mechanisms in cancer
FITC
Avadomide
splice
Balancing reactivity and antitumor activity heteroarylthioacetamide derivatives as potent and time
Dermaseptin
Genetically Engineered Nanovesicles Mobilize Synergistic Antitumor Immunity by ADAR1 Silence and PDL1 Blockade PMID 37087570
Human Immunoglobulin G, Fc Fragment (IgG, Fc Fragment)
Echovirus 11 infection induces pyroptotic cell death by facilitating NLRP3 inflammasome activation PMID 36026486
O
Irisin ameliorates doxorubicin
Cd40lg
Duck plague virus ICP27 protein suppresses IFN
Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells PMID 35485606
cockroach
PP4C facilitates lung cancer proliferation and inhibits apoptosis via activating MAPK/ERK pathway PMID 32139257
1
Design, synthesis and evaluation of sulfonylurea
NrCAM activates the NF
Pyrintegrin 1228445
Validated LC
DMP
Proteomic analysis identifies mechanism(s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13 PMID 32424294
尿石素B (Standard)
Choline Protects the Heart from Doxorubicin
3
Brown adipose tissue
Targeting the JAK2
PpSQ1_00405 蛋白, Pseudomonas putida (His, StrepⅡ)
D
Monomethyl auristatin E (MMAE), a payload for multiple antibody drug conjugates (ADCs), demonstrates differential red blood cell partitioning across human and animal species PMID 38647387
EphB4 signaling maintains the contractile phenotype of adult venous smooth muscle cells PMID 32913525
CSF2 upregulates CXCL3 expression in adipocytes to promote metastasis of breast cancer via the FAK signaling pathway PMID 37073091
Aberrant expression of MRAS and HEG1 as the biomarkers for osimertinib resistance in LUAD PMID 39560891
Butyrate Inhibits the HDAC8/NF
Substrate stiffness regulates the proliferation and inflammation of chondrocytes and macrophages through exosomes PMID 39662715
MAM
(±)
The OsFBX388
Azide
Study on effect of pancreatic kininogenase on diabetic nephropathy
CD164 Human Pre
The Amino Acid
Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection PMID 27174919
Delamanid (Standard) (OPC
氯磺丙脲
肉碱棕榈酰转移酶 1A（CPT1A）基因
Oxysterol
Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel PMID 34364968
Polycarbophil 9003
BI 1230
Fmoc
达卡他韦 (Standard)
Human endothelial colony
Setoperone
Tert
LINC complex protein nesprin
Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis PMID 36319062
ML318
ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress PMID 22351695
聚乙二醇甲醚甲苯磺酸酯 (MW 900)
RP
Histone methyltransferase SETDB1 inhibits TGF
Curculigoside Protects against Titanium Particle
Xenbucin 959
(Chlorocarbonyl)cyclohexane
Endothelial cell Orai1 is essential for endothelium
The Efficacy of Recombinant Platelet
Progress in using chemical biology as a tool to uncover novel regulators of plant endomembrane trafficking PMID 31546132
Design, docking, and synthesis of novel indeno[1,2
Thrombin
HSD17B13
瑞卡帕布
Upregulation of IL
KLF15 suppresses cell growth and predicts prognosis in lung adenocarcinoma PMID 29990857
DACN(Tos)
PP2AC Level Determines Differential Programming of p38
Mestranol
PER1 suppresses glycolysis and cell proliferation in oral squamous cell carcinoma via the PER1/RACK1/PI3K signaling complex PMID 33723221
Gallic acid suppresses esophageal squamous cell carcinoma progression and enhances cisplatin chemosensitivity through IL
Epitope mapping of mouse monoclonal antibody EP
Relatlimab 1673516
TWIK
V
(Rac)
Histone Deacetylase Inhibitor Panobinostat Benefits the Therapeutic Efficacy of Oncolytic Herpes Simplex Virus Combined with PD
CTX
N
RT
氨磺必利 d<sub>5</sub>（N 氧化物）
Bivittoside A
VHR
SAF
Leflunomide Inhibits Proliferation and Induces Apoptosis via Suppressing Autophagy and PI3K/Akt Signaling Pathway in Human Bladder Cancer Cells PMID 32546957
二十碳五烯酸
Protein sorting in the synaptic vesicle life cycle PMID 17074429
Netupitant (Standard)
naRNA
PD
GW642444
MST1/2 in PDGFRα+ cells negatively regulates TGF
AT
N
CLK3 Recombinant Human Active Protein Kinase
EX 1314
miR
Cholic acid 3
MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo PMID 20197380
Antimalarial agent13
MK3281
MBX
Increased expression of PD
PRL 295
Platycodin D ameliorates polycystic ovary syndrome
cAIMP 1507367
eudesmane
Azido
Ercalciol
Dual function of VGLL4 in muscle regeneration PMID 31328806
巴利卡替
c
Decynium 22
N
Chga Rat Pre
卡瑞利珠单抗
1,4
Doxycycline alleviates paraquat
MK 793
Lipopeptide CPK 4
The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model PMID 24069069
Mavacamten 1642288
A novel high
Shen Zhi Ling oral liquid improve neuroinflammation against Alzheimer's disease via the PI3K/Akt pathway PMID 39760003
伊戈伏单抗
2
烯醇化酶
ATP
Carteolol
Caspase
Palmitoyl serinol
Inhibitory activity of kinetin on free radical formation of activated platelets in vitro and on thrombus formation in vivo PMID 12681440
RhoNox
SiR700
Doxorubicin inhibits human DNA topoisomerase I PMID 1318169
Acidic microenvironment enhances MT1
DYSF Human Pre
Complete Freund's adjuvant (CFA, 1 mg/ml)
黑素瘤细胞黏附分子 (MCAM/CD146)
EXP3174
Elaidic acid
2,2',6
Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer PMID 19476376
Absolute Configuration of Periplosides C and F and Isolation of Minor Spiro
Development of novel G
Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors PMID 38088921
Nitric Oxide Scavenging Alleviates Scar Pruritus by Inhibiting S
Effects and mechanisms of frehmaglutin D and rehmaionoside C improve LPS
GYY4137
Investigating the therapeutic effects of Shenzhiling oral liquid on Alzheimer's disease a network pharmacology and experimental approach PMID 39703418
ZmPP2C45 and ZmBELL4 suppress maize biochemical defense against insect herbivores PMID 40855607
Synthesis and biological evaluation of 6
Rutin
A continuous fluorometric assay for gamma
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors PMID 34654817
iTRAQ
Cyanazine
3,7,16
MLL4 Regulates the Progression of Non
Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation PMID 26499517
MCE
Levovirin valinate
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys PMID 32632286
SHR 1210
Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice PMID 24086674
HGFR 蛋白, Human (495a.a, HEK293, His)
Identification of Chemical Scaffolds Targeting Drug
FOLR1 蛋白, Mouse (Biotinylated, HEK293, His
Bis(2
Nicotine induces senescence in spermatogonia stem cells by disrupting homeostasis between circadian oscillation and rhythmic mitochondrial dynamics via the SIRT6/Bmal1 pathway PMID 38936603
Celecoxib prevents tumor necrosis factor
USP7/USP47 inhibitor
Methyl D
Pacritinib 937272
Astragaloside IV Ameliorates Colonic Adenomatous Polyps Development by Orchestrating Gut Bifidobacterium and Serum Metabolome PMID 39164214
丝裂原活化蛋白激酶激酶激酶 5（MAP3K5）基因
Discovery of Small Molecule CHI3L1 Inhibitors by SPR
CP320626 186430
Dapk2 dysfunction leads to Mic60 lactylation and mitochondrial metabolic reprogramming, promoting lung cancer EGFR
Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non
1H
Histone deacetylase 3 in hippocampus contributes to memory impairment after chronic constriction injury of sciatic nerve in mice PMID 32868749
TRIM31 facilitates K27
Colchicine prevents atrial fibrillation promotion by inhibiting IL
A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics PMID 32589666
Antibody
The discovery of quinoline derivatives, as NF
Diosgenin exerts anti
MCE
Galectin
Depletion of STAT5 blocks TEL
Complement component 3 protects human bronchial epithelial cells from cigarette smoke
Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts PMID 31678002
3
Decitabine potentiates efficacy of doxorubicin in a preclinical trastuzumab
Age mosaic of gut epithelial cells prevents aging PMID 40695820
DRD4 promotes chemo
Cardiac SIRT1 ameliorates doxorubicin
ABCC10
NGR
2,5
BMS
HDAC6/HSP90
Gpc2
NSC380470
PD
ATP6V1B1 Human Pre
Tcf21 Alleviates Pancreatic Fibrosis by Regulating the Epithelial
APV
Blapstin, a Diapause
HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma PMID 40050614
Salmonella typhimurium targeting with monoclonal antibodies prevents infection in mice PMID 38048368
Gene Sequencing and Synthesis
粘蛋白 15，细胞表面相关（MUC15）基因
Picoberin
LEAP2 ameliorates high fat diet
AIF1 Human Pre
Spastin is required for human immunodeficiency virus
AIF1 蛋白, Human (N
The endoplasmic reticulum
CVT
KIF17 Modulates Epileptic Seizures and Membrane Expression of the NMDA Receptor Subunit NR2B PMID 35678994
JPC0323 5972
Mitophagy induction improves salivary gland stem/progenitor cell function by reducing senescence after irradiation PMID 38007043
Piezo1 activates nitric oxide synthase in red blood cells via protein kinase C with increased activity in diabetes PMID 40809083
The Cullin3
Dual MNK/VEGFR2 Inhibitor JDB153 Enhances Immunotherapeutic Efficiency and Chemosensitivity in Lung Cancer PMID 40308810
瑞巴派特 d&lt;sub&gt;4&lt;/sub&gt;
ERK
氯贝胆碱 d&lt;sub&gt;6&lt;/sub&gt; (氯化物)
NOP agonist2
Substance P modulates BMSCs migration for tissue repair through NK
IL
Mesothelioma cell proliferation through autocrine activation of PDGF
RD 0392
1
Amprolium
UCB 0599
Clinical Value and Potential Molecular Mechanism of miR
C24 1 Ganglioside GM2 (d18 1/24 1)
UMP
Bombesin Receptor
RNA
SLM6031434
Nampt activator 2
CUHK242 2408055
PD
NSC 703786
DMT
Ramiprilat
A new water
IGFBP5 is released by senescent cells and is internalized by healthy cells, promoting their senescence through interaction with retinoic receptors PMID 38351010
Carboxymethyl cellulose/quaternized chitosan hydrogel loaded with polydopamine nanoparticles promotes spinal cord injury recovery by anti
CAPN1 Human Pre
Delamanid
Chrysophanol alleviates acute lung injury caused by Klebsiella pneumoniae infection by inhibiting pro
The function and immune role of cuproptosis associated hub gene in Barrett's esophagus and esophageal adenocarcinoma PMID 37866883
CircRPPH1 serves as a sponge for miR
Neuropathic
Fosthiazate exposure induces oxidative stress, nerve damage, and reproductive disorders in nontarget nematodes PMID 36112285
Discovery of a potent and isoform
Inhibition of Fibroblast Growth Factor Receptor by AZD4547 Protects Against Inflammation in Septic Mice PMID 31321583
Psoralen alleviates ulcerative colitis by suppressing inflammation, modulating oxidative stress, and regulating ferroptosis PMID 40848885
Curzerene suppresses epithelial
MIA SH3 域 ER 导出因子 2（MIA2）基因
(Rac)
cytarabine
Marine derived xyloketal derivatives exhibit anti
NQO1
Bedaquiline susceptibility test for totally drug
Nogo
(
Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit PMID 39019613
Centipeda minima active components and mechanisms in lung cancer PMID 36959600
PLA2G4C Human Pre
Itaconate attenuates osteoarthritis by inhibiting STING/NF
1H
PD
Coptisin
Pectinesterase (果胶酯酶)
CD276/B7
Human lung microvascular endothelial cell protein modification by 2
DC371739 2135765
BACH2 promotes seeding and establishment of long
Carvacrol/cyclodextrin/ceria nanoparticle/hyaluronate hybrid microneedle for promoted diabetic wound healing through the modulation of microenvironment PMID 39725110
Epigenetic drug screening defines a PRMT5 inhibitor
RSK
(R)
Uridine 5'
Galectin
HMBPP analog 1
Deguelin inhibits IL
SPB
Cropropamide 633
Oncolytic reovirus induces ovarian cancer cell apoptosis in a TLR3
Hexylene glycol
Desmethyl Erlotinib hydrochloride (Standard) (OSI
Anti
Role of APE1 redox function in chronic rhinosinusitis pathogenesis Implications for targeted therapy PMID 40683569
Prostaglandin Receptor
n
Micheliolide ameliorates lipopolysaccharide
Mechanistic insights into SIRT7 and EZH2 regulation of cisplatin resistance in bladder cancer cells PMID 39719443
Azacytidine and decitabine induce gene
aminocarnitine derivative
PTPN23[Thr] variant reduces susceptibility and tumorigenesis in esophageal squamous cell carcinoma through dephosphorylation of EGFR PMID 38704135
SMER3 67200
HIV
Vitamin CK3 1085703
AR
Synthesis of novel analogs of cabergoline improving cardiovascular safety by removing 5
NS
Eno2 Rat Pre
mutation
PROTAC Linker 14
Eldecalcitol inhibits the progression of oral cancer by suppressing the expression of GPx
Highly effective combination of LSD1 (KDM1A) antagonist and pan
VEGF Receptor 1 抗体 (YA015)（VEGF Receptor 1 Antibody (YA015)）
Inhibition of IL1R1 or CASP4 attenuates spinal cord injury through ameliorating NLRP3 inflammasome
Pyridine nucleotide
JD
MiR
2
Metformin inhibits EV
Molecular mechanism of miR
Quercetin
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets PMID 33571445
Ribes diacanthum Pall modulates bile acid homeostasis and oxidative stress in cholestatic mice by activating the SIRT1/FXR and Keap1/Nrf2 signaling pathways PMID 39864603
Epidermal growth factor receptor signaling in precancerous keratinocytes promotes neighboring head and neck cancer squamous cell carcinoma cancer stem cell
Store
Emodin disrupts the Notch1/Nrf2/GPX4 antioxidant system and promotes renal cell ferroptosis PMID 37393915
donor
Design, synthesis and biological evaluation of novel benzimidazole
FGFR
non
灵芝酸C1
Tumor microenvironment
Sodium glycocholate hydrate, 98% 338950
DZ
The effect of hyaluronic acid on nucleus pulposus extracellular matrix production through hypoxia
Detection of viral components in exosomes derived from NDV
NLRP3
癌胚抗原相关细胞粘附分子 3 (CD66d/CEACAM3)
Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple
MicroRNA
Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN
ANKFN1 plays both protumorigenic and metastatic roles in hepatocellular carcinoma PMID 35725908
TTX
AM
General principles of antimicrobial therapy PMID 21282489
Theranostic targeting of CUB domain containing protein 1 (CDCP1) in multiple subtypes of bladder cancer PMID 36648492
6
Raf 家族
Elucidating the molecular mechanisms behind the therapeutic impact of median nerve stimulation on cognitive dysfunction post
IGFBP
Putting the BRK on breast cancer From molecular target to therapeutics PMID 33391524
SBT
Butyrolactone
Urinary sampling for 5HIAA and metanephrines determination revisiting the recommendations PMID 28566493
3'
The effect of a novel, small non
An overview of quinazolines Pharmacological significance and recent developments PMID 29656203
Nimbolide inhibits IGF
BRD 2492
Ethyl p
double
VHR
Aminometradine
MSC778 3098173
Cdh17 Rat Pre
Modulation of aryl hydrocarbon receptor inhibits esophageal squamous cell carcinoma progression by repressing COX2/PGE2/STAT3 axis PMID 31925646
irampanel
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation PMID 33450198
HTF
Engineered B7
Gyg1 Mouse Pre
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO
Biosafe cerium oxide nanozymes protect human pluripotent stem cells and cardiomyocytes from oxidative stress PMID 38532378
Comparative efficacy of novobiocin and amoxicillin in experimental sepsis caused by beta
Metformin facilitates mesenchymal stem cell
Role of Rab35 in modulating lipid metabolism and viral entry during pseudorabies virus infection PMID 39528177
KF
recombinant
CDH17 Human Pre
Layered
Inhibitors of endosomal acidification suppress SARS
LncRNA TUG1 compromised neuronal mitophagy in cerebral ischemia/reperfusion injury by targeting sirtuin 1 PMID 35348966
HATs
Decoupling HIV
Long
Effect of antipyrine on the gastric emptying of liquid in rats PMID 17146564
3
Pneumocandin A 3
Periostin increased by mechanical stress upregulates interleukin
Fragment
PF
The Role of the cGAS/STING Pathway in Arsenic
Cancer cell membrane
On
Nicotinamide mononucleotide attenuates isoproterenol
Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII PMID 30849520
Organotypic culture of human brain explants as a preclinical model for AI
MCE
The chloride intracellular channel 1 (CLIC1) is essential for microglial morphodynamics and neuroinflammation PMID 41124273
JNJ
MiR
A culture method with berbamine, a plant alkaloid, enhances CAR
EPS8 样 1（EPS8L1）基因
The molecular chronology of mammary epithelial cell fate switching PMID 39415993
YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling PMID 34415667
Penfluridol regulates p62 / Keap1 / Nrf2 signaling pathway to induce ferroptosis in osteosarcoma cells PMID 38996707
Uniform and controllable surface nano
CLI 86815
VP
Effects of NLRP6 in Cerebral Ischemia/Reperfusion (I/R) Injury in Rats PMID 31267316
Lupane triterpenoids from Maytenus species PMID 16038541
MiR
Muscovy duck reovirus enters susceptible cells via a caveolae
TLR7 agonist 14
Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF
CCT241533 hydrochloride
N
Functional characterization of Vip3Aa from Bacillus thuringiensis reveals the contributions of specific domains to its insecticidal activity PMID 36764522
GZ11608
Vps34 sustains Treg cell survival and function via regulating intracellular redox homeostasis PMID 39117783
NSC
REX
PKC
NF340
Tyrphostin A1 (Tyrphostin 1)
Ti3 C2 Tx MXene Composite 3D Hydrogel Potentiates mTOR Signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids PMID 36117048
Proinflammatory S100A9 Stimulates TLR4/NF
Didemnins and tunichlorin novel natural products from the marine tunicate Trididemnum solidum PMID 3373220
vasodilator
Identification of O
7,8
Ibuprofen inhibits survival of bladder cancer cells by induced expression of the p75NTR tumor suppressor protein PMID 15342406
Mild iron overload induces TRIP12
Synthesis and biological evaluation of novel tricyclic oxazine and oxazepine fused quinazolines. Part 1 erlotinib analogs PMID 24411123
Ethyl 2
N
VHR
8
AIF1L Human Pre
MCE
DNAJC5 facilitates the proliferation and migration of lung adenocarcinoma cells by augmenting EGFR trafficking PMID 40374748
Flutrimazole 119006
envelope
BAG3 regulates cilia homeostasis of glioblastoma via its WW domain PMID 38655699
2
MCE
Reelin
HSD17B13
Arginase
Cy3
KRAS
Dl
Methylophiopogonanone A Inhibits Ferroptosis in H9c2 Cells An Experimental and Molecular Simulation Study PMID 39683922
SDF2 promotes glioma progression via GRP78‑mediated ERAD and copper homeostasis disruption PMID 40709395
BBB
s
Ring finger protein 216 loss
Identification of SARS
Pirquinozol 65950
Interferon
Tobramycin (Standard)
Glycine
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