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Knockdown of IGF
EV71 3C protease cleaves host anti
Roflupram alleviates autophagy defects and reduces mutant hSOD1
Design, synthesis and biological evaluation of 3
LncRNA BlncAD1 Modulates Bovine Adipogenesis by Binding to MYH10, PI3K/Akt Signaling Pathway, and miR
Tissue Factor Pathway Inhibitor 2 Enhances Hepatocellular Carcinoma Chemosensitivity by Activating CCAR2
1
delta
DMT
Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme PMID 33024813
Antidepressant
TRC4186
Lactylation of METTL16 promotes cuproptosis via m6A
4
CCN2/CTGF 蛋白, Human (HEK293)
Mitochondrial
Octreotide attenuates experimental severe acute pancreatitis through inhibiting pyroptosis and modulating intestinal homeostasis PMID 39922420
The transcriptional landscape of lncRNAs reveals the oncogenic function of LINC00511 in ER
ENPP
PIEZO1 mediates periostin+ myofibroblast activation and pulmonary fibrosis in mice PMID 40454481
Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti
Eltrombopag, an FDA
Tenifatecan
3
SRI
Bcl
Urolithin A 1143
Mcm8 Mouse Pre
Molecular Dissection of the AHR
Basal IFN
Pozdeutinurad
METTL3 and STAT3 form a positive feedback loop to promote cell metastasis in hepatocellular carcinoma PMID 37231451
1,2,3,4,5,6,8
Discovery of dipiperidines as new antitubercular agents PMID 19917527
Nepetoidin B
LCE1
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma
Cldn9 Rat Pre
Propyl bromide
Permeation Enhancer
Chick CB10 of type II collagen (Chick cyanogen bromide digested peptide 10)
Thiocarbanilide
Isoimperatorin Inhibits Angiogenesis by Suppressing VEGFR2 Signaling Pathway PMID 38363479
Ferlins regulators of vesicle fusion for auditory neurotransmission, receptor trafficking and membrane repair PMID 21838746
Sequence
H
MGAT5 蛋白, Human (HEK293, His)
Glutaredoxin
NCGC00138783
Cardiomyopeptide
Safety, pharmacokinetics, and pharmacodynamics of oral apoA
IDO1/TDO
DSS
Guanidine
Multiparametric and accurate functional analysis of genetic sequence variants using CRISPR
Taprostene
楝叶吴萸提取物 (Tetradium glabrifolium (Champion ex Bentham) T. G. Hartley)
Ceftolozane
GSK2800528
Unlocking the Anti
Methyl Violet 10B
Di
SW044248 522650
Ezrin T567 phosphorylation regulates migration and invasion of ectopic endometrial stromal cells by changing actin cytoskeleton PMID 32380081
岷江百合苷A
G277
乙胺嘧啶 d<sub>3</sub>
The Dual Roles of Lamin A/C in Macrophage Mechanotransduction PMID 39710429
GB1107
Taar1 Rat Pre
FGFR
BMS
Spatial Metabolism of Primary Limited Cutaneous Amyloidosis Based on Mass Spectrometry Imaging PMID 40955599
2
Optunal
3,5
Ethacizine
Cooperating JAK1 and JAK3 mutants increase resistance to JAK inhibitors PMID 25352124
Intermittent hypoxia therapy ameliorates beta
NSC 146109 hydrochloride
Comparison of Ferroptosis
ErbB3 is required for hyperaminoacidemia
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D
ThrRS
MBP (146
PUMA BH3
钙蛋白酶小亚基 1（CAPNS1）基因
N6AMT1 Human Pre
GCPII
CD2 Human Pre
Macrophages Promote Growth of Squamous Cancer Independent of T cells PMID 31189369
Fucosylation of hemocyanin is critical for antibacterial immunity in Penaeus vannamei PMID 40350103
tBPC 1942
奈妥吡坦 d<sub>6</sub>
WP1193
Salvianolic acid C 115841
S. lycopersicum
Stoml3
Elemene mitigates oxidative stress and neuronal apoptosis induced by cerebral ischemia
Discovery of MK
SETD7 蛋白, Human (sf9, GST)
Agatolimod sodium 541547
Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3‑dependent pyroptosis in non‑small cell lung cancer cells PMID 39950328
异欧前胡素 (Standard)
7
Kindlin
USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin PMID 33390801
ZFP2 Human Pre
Connexin mimetic peptide 40GAP27
DHRS9 promotes malignant progression of ovarian cancer through SQSTM1 PMID 40864320
N3
TL1A primed dendritic cells activation exacerbated chronic murine colitis PMID 32781075
加巴喷丁杂质E
ORG 33628 155768
Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma PMID 35350587
Molecular View on the i RGD Peptide Binding Mechanism Implications for Integrin Activity and Selectivity Profiles PMID 37788340
Calcitonin inhibits intervertebral disc degeneration by regulating protein kinase C PMID 32564456
Further validation of in vivo and in vitro pharmacological procedures for assessing the alpha 2/alpha 1
The inhibitor of autophagy SBI
起源识别复合亚基 2（ORC2）基因
Early growth response 1 exacerbates thoracic aortic aneurysm and dissection of mice by inducing the phenotypic switching of vascular smooth muscle cell through the activation of Krüppel
1H
Inflammasome activation
Trehalose alleviates apoptosis by protecting the autophagy
Benzo[c]phenanthrene
BAF155
Anti
Intranasal insulin ameliorates cognitive impairment in a rat model of Parkinson's disease through Akt/GSK3β signaling pathway PMID 32763288
RNA transcription
L 45
Sitagliptin inhibits the survival, stemness and autophagy of glioma cells, and enhances temozolomide cytotoxicity PMID 36966667
TAS114
An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression PMID 34916221
核孔蛋白 133（NUP133）基因
cardiac
ZFP57 suppress proliferation of breast cancer cells through down
Fmoc
Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy PMID 29344310
Production of interleukin
Microbiota
Hmox1
Development of chalcone
Clustered Cobalt Nanodots Initiate Ferroptosis by Upregulating Heme Oxygenase 1 for Radiotherapy Sensitization PMID 36627264
5
Denosumab stimulates spermatogenesis in infertile men with preserved Sertoli cell capacity PMID 39383870
Straightforward synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents of hybrid Chromeno[4,3
Sprouty2 Regulates Endocytosis and Degradation of Fibroblast Growth Factor Receptor 1 in Glioblastoma Cells PMID 39682716
Hexaenoic acid
Cystatin SN/CST1 蛋白, Human (HEK293, His)
Brucella rough RB51 infection activates P53
Anti
A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice PMID 20870946
Aberrant MEK5 signalling promotes clear cell renal cell carcinoma development via mTOR activation PMID 35713705
Targeting JAK/STAT3 in glioblastoma cells using an alginate
YAP is required for prostate development, regeneration, and prostate stem cell function PMID 37689711
Structure of human glycosylphosphatidylinositol transamidase PMID 35165458
ZINC00640089
Drug Intermediate
Z
4
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C PMID 35404998
GMP SCF 蛋白, Human (HEK293, His)
2
Crocin
Brucella abortus transcriptional regulator ArsR6 inhibits host pyroptosis via BAB_RS28760 by triggering the endoplasmic reticulum stress pathway PMID 39787758
3
Effects and Mechanisms of the Xianhecao
CD63 蛋白, Rat (HEK293, Fc)
Talc (滑石粉)
SJ
Silencing long non
IMCgp100
Gilteritinib reverses ABCB1
Flupyrsulfuron
Decylplastoquinone
Pentadecylbenzene
A positive feedback loop between LINC01605 and NF
S
Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons PMID 22158868
Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF
CDK7
CDK2
KDM1A epigenetically enhances RAD51 expression to suppress the STING
Equilin
Synthesis and pharmacological characterization of 1
含 pleckstrin 同源性和 FYVE 结构域 2（PLEKHF2）基因
Rare sugar L
Knockdown of membrane
蛋白激酶 cAMP 激活的催化亚基 alpha（PRKACA）基因
BTLA dysregulation correlates with poor outcome and diminished T cell
Ilexgenin A inhibits mitochondrial fission and promote Drp1 degradation by Nrf2
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity PMID 39039181
Mitotane
cIAP1 Ligand
丙酮酸氧化酶
NFATC2 Human Pre
NSC
Bromhexine elevates REP2 expression to stimulate secretion from human primary conjunctiva fornix epithelial cells PMID 31365127
胆甾烷酸
Discovery of N
McN5691 99254
Carcinoma
Discovery of Limonoids from Xylocarpus granatum as Potential Leads against Neuroinflammation PMID 40228158
In
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors PMID 22004374
Transport and cytotoxicity of the anticancer drug 3
ELQ
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways PMID 31275971
Acetyl
PLD
Binding of carbamyl
Phospho
Suv3 样 RNA 解旋酶（SUPV3L1）基因
CircSMYD4 regulates proliferation, migration and apoptosis of hepatocellular carcinoma cells by sponging miR
Nutrient transporter
Comparative activities of amoxycillin, amoxycillin/clavulanic acid and tetracycline against Chlamydia trachomatis in cell culture and in an experimental mouse pneumonitis PMID 1885420
Bromperidol
Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62
CD24 蛋白, Human (HEK293, mFc)
DA
FH Human Pre
CTSC Human Pre
1,2,3
MCE
DOPE
Glyceryl triacetate promotes blood
Bioprinted Multi
Arnt Rat Pre
ASN
Glucosylceramide Synthase (GCS)
氢溴酸后马托品
N
半胱天冬酶 8（CASP8）基因
A new strategy for the rapid identification and validation of direct toxicity targets of psoralen
UBTD1 Human Pre
UBC9 deficiency enhances immunostimulatory macrophage activation and subsequent antitumor T cell response in prostate cancer PMID 36626227
3
2
Cyclohexanecarboxylic acid
4
Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E
Cldn9 Mouse Pre
Immunosuppressive gentianellane
Design, synthesis and anti
Ibuprofen 15687
3,5
Putting the STING back into BH3
Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia PMID 14975696
5
Parallel gut
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424 therapeutic implications for the treatment of myeloproliferative neoplasms PMID 20130243
TA
Cdh6 Mouse Pre
Tetramethyluric acid (1,3,7,9
Chloroacetic acid
Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer PMID 39406919
Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine PMID 37667199
Isoquercitrin 482
Inactivation of SERCA2 Cys674 accelerates aortic aneurysms by suppressing PPARγ PMID 33591571
Antiferroptotic Activities of Oxindole GIF
Hydroquinone impurity 1 (Standard)
Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin
Protease Nexin I is a feedback regulator of EGF/PKC/MAPK/EGR1 signaling in breast cancer cells metastasis and stemness PMID 31501409
Downregulation of Protein Tyrosine Phosphatase Receptor Type R Accounts for the Progression of Hirschsprung Disease PMID 31024255
Biotinylated leptomycin B
Safety, Tolerability, and Pharmacokinetics of Single Ascending Doses of ELX
Lonazolac
A salicylate
Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Improve the Inflammatory Microenvironment through Mitophagy Activation PMID 40370272
Identification of MK
COX
Systemic cytokines inhibition with Imp7 siRNA nanoparticle ameliorates gut injury in a mouse model of ventilator
A multifunctional hydrogel with hemostatic and photothermal properties for burn repair PMID 40661193
利匹韦林
R278474
Endoxifen
VHR
Advancing vaccine development Evaluation of a mannose
氯化血根碱 (Standard)
N6
Discovery of novel pyrrolo
chemometrics
PSPH Human Pre
Terminolic acid 564
NOP agonist
Mycobacterium tuberculosis Suppresses Inflammatory Responses in Host through Its Cholesterol Metabolites PMID 39360613
NGF
SB 252218
3
Synthesis and Structure
Mcm8 Mouse Pre
Betulinaldehyde regulates VSMC phenotypic transition to alleviate vascular hyperplasia through PPARγ/mitochondria/ROS axis PMID 41033650
Taurocholic acid
CMT2D neuropathy is linked to the neomorphic binding activity of glycyl
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2
Anti
HMPL012
The HER2
PDGFRA Human Pre
Identification of novel O
PROTAC Linkers
6
VU0080241 393845
MCM3AP Human Pre
利吡韦林
practice
HF
Dual roles of HK3 in regulating the network between tumor cells and tumor
PD
Pdgfra Mouse Pre
Long
(rac)
Simple, streamlined, cost
Pyruvic
FKBP
BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis PMID 33510838
二氯吡啶酸(2
Ferrocene
Cy3
Bcl
High
CDP
Design, synthesis and biological evaluation of novel β
Azide
Arnt Mouse Pre
Autophagy
Sigma
Cryptotanshinone attenuates lactate
Anakinra PMID 12196041
Ethylene
ERIS
ERK/Drp1
TLR2/4 promotes PGE2 production to increase tissue damage in Escherichia coli
B16F10 cells
NAMPT
Azido
DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma PMID 31176743
SPDI
DDR2
MCM2 抗体 (YA302)（MCM2 Antibody (YA302)）
alcohol
SPP 86
L
Distinct Ring1b complexes defined by DEAD
N
Exosome
IL
Cy5
SLM
Design, synthesis, and evaluation of pyrrolo[2,1
含 B9 域 2（B9D2）基因
Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo PMID 26167903
AT
A novel regulatory network of linc00174/miR
Synthesis, molecular docking and biological evaluation of 1,3,4
细胞周期蛋白 B1（CCNB1）基因
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half
Anti
EpCAM/TROP1 蛋白, Mouse (HEK293, His)
GNE
Multidrug resistance associated proteins in multidrug resistance PMID 22098952
N1, N10
Self
Coexpression of TP53, BIM, and PTEN Enhances the Therapeutic Efficacy of Non
Cezanne promoted autophagy through PIK3C3 stabilization and PIK3C2A transcription in lung adenocarcinoma PMID 37596251
Sibrotuzumab 216669
DHODH
Enhanced Therapeutic Effects of Mesenchymal Stem Cell
Neuroprotective effects of ononin against the aluminium chloride
Expression of Mafb is down
PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1
PPP6R3
Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export PMID 36825757
USP1
细胞周期蛋白 C（CCNC）基因
Src
Design, synthesis and biological evaluation of novel hydrogen sulfide releasing capsaicin derivatives PMID 29685681
In vitro and in vivo pharmacokinetic characterizations of AMG 900, an orally bioavailable small molecule inhibitor of aurora kinases PMID 21294625
SlMPK1
Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS
Iodobenzene
DEP
Knockdown of C3aR alleviates age
LncRNA PPP1R14B
Matrixyl
Enpep Rat Pre
Regulation of the integrin αVβ3
myofibroblas
Pharmacologic targeting of the P
Il22ra1 Rat Pre
Apelin
N3
ICAM5 Human Pre
A long
Nek3 Rat Pre
Hepatic
Design, semisynthesis and potent cytotoxic activity of novel 10
Poly(I C) preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt
KPNA6 is a Cofactor of ANP32A/B in Supporting Influenza Virus Polymerase Activity PMID 35044222
Dimethyl fumarate promotes the degradation of HNF1B and suppresses the progression of clear cell renal cell carcinoma PMID 39915461
1H
Benzaldehyde
Empagliflozin, a novel selective sodium glucose cotransporter
Proline
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression PMID 23911321
Tumor
Improvement of platelet preservation by inhibition of TRPC6 PMID 36746770
IRX4204 Induces Senescence and Cell Death in HER2
ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8
RWJ
Rosmarinic Acid Ameliorates Type 2 Diabetic Osteoporosis by Reducing NLRP3 Expression and Alleviating Osteoblast Pyroptosis via the FOXO1/TXNIP Signaling Pathway PMID 40552618
Trioctylamine
Ptpn2
Fine
Imnopitant dihydrochloride
Thalidomide
3
modulator
S
IL13RA2 Human Pre
GEFT Inhibits Autophagy and Apoptosis in Rhabdomyosarcoma via Activation of the Rac1/Cdc42
Ac
Preclinical evaluation of AMG 900, a novel potent and highly selective pan
Therapeutic Effects of PEG
2
Therapeutic Effect of C
罗格列酮(Standard)
N
TNPO2 Human Pre
Deficiency of thrombospondin
alsamic resin
Complement C3a and C5a Receptors Are Presented in Mouse Sciatic and Human Sural Nerves and Selectively Modulate the Neuronal Function of Large
FR264205
Cardenolide B 1
N
Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading
Mebendazole 31431
羟吲哚类化合物 (Oxindole Alkaloids)
15(S)
Octyl 4
YTHDF2 protein stabilization by the deubiquitinase OTUB1 promotes prostate cancer cell proliferation via PRSS8 mRNA degradation PMID 38462165
Nexopamil racemate 116759
DBM
Hypoxic preconditioning combined with curcumin promotes cell survival and mitochondrial quality of bone marrow mesenchymal stem cells, and accelerates cutaneous wound healing via PGC
peripheral vasodilator effect
Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy PMID 35777783
Oncogenic Roles of Laminin Subunit Gamma
Sodium deuteroxide (D,99.5%) (40% in D2O) (Sodium hydroxide
Chiisanoside from the Leaves of Acanthopanax sessiliflorus Can Resist Cisplatin
Diphenylmethanol
Gintonin exerts effects via LPAR1/3 and the MEK signaling pathway PMID 40865829
BST2 Human Pre
McN
NS2B/NS3 protease
SIRT5
阿片受体δ1（OPRD1）基因
Deficiency of epidermal protein
坦度螺酮(Standard)
Spautin
Toll
Identification and validation of CDK1 as a promising therapeutic target for Eriocitrin in colorectal cancer a combined bioinformatics and experimental approach PMID 39806333
(R)
决奈达隆杂质25 (标准品)
2
Cell
Mechano
2,2
11
FB
N
BTLA/HVEM Signaling Milestones in Research and Role in Chronic Hepatitis B Virus Infection PMID 30984188
2
BRG1 inhibits glycolysis by promoting SHP1
Succinylsulfathiazole (Succinylsulphathiazole，琥珀酰磺胺噻唑)
Targeting TLR Signaling Cascades in Systemic Lupus Erythematosus and Rheumatoid Arthritis An Update PMID 38255243
Methiocarb
MFDCH016
CGRP Receptor
Terconazole
Sodium 3
vav 鸟嘌呤核苷酸交换因子 3（VAV3）基因
(
The Barrier Disruption and Pyroptosis of Intestinal Epithelial Cells Caused by Perfringolysin O (PFO) from Clostridium perfringens PMID 38994991
Deacetamidine cyano dabigatran
Targeting the ALK
Synthesis of the Oligosaccharides of Burkholderia pseudomallei and B. mallei Capsular Polysaccharide and Preliminary Immunological Studies of Their Protein Conjugates PMID 31912729
MLL1 promotes myogenesis by epigenetically regulating Myf5 PMID 31840352
Boc
Identification of a small
Methionyl
E3 Ligase Ligand
SOCE inhibitor 1 2169316
The activation of Toll
Platelets mediate inflammatory monocyte activation by SARS
Study on the Influence and Mechanism of Resveratrol on Cognitive Impairment in Chronic Kidney Disease Rats Through Regulating Gut Microbiota and the TLR4/NFκB Pathway PMID 40357381
L
A new allosteric site in glycogen phosphorylase b as a target for drug interactions PMID 10873856
GSK429286A
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