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CTX0124143
IMCgp
Signaling Mechanism of Cuproptosis Activating cGAS
GIT1 contributes to autophagy in osteoclast through disruption of the binding of Beclin1 and Bcl2 under starvation condition PMID 30546041
Hexadecanoate
SDF
4
N1
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β
Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade PMID 17404325
MicroRNA
aureus
N
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia PMID 39885312
Avatrombopag for the treatment of thrombocytopenia in patients with chronic liver disease PMID 31352834
Angiotensin receptor blocker attacks armored and cold tumors and boosts immune checkpoint blockade PMID 39244215
BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c
白介素
p38 delta/MAPK13 蛋白, Human (sf9, GST)
Palmatine Attenuated Lipopolysaccharide
Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug
Gene Expression Profiling in Acute Myeloid Leukemia Patient Subgroups With High and Low Sensitivity Toward SYK Inhibitors PMID 40088478
NVP
Resveratrol inhibits bile acid
HG
Dexmedetomidine improve lung inflammation by regulating autophagy and apoptosis of CD4+ T cell via AMPK/mTOR signaling PMID 40311186
醋磺环己脲
Design, synthesis, and evaluation of a novel 4
Phillygenin 487
Aging lens epithelium is susceptible to ferroptosis PMID 33722625
Exploring the potential mechanism of ginsenoside Rg1 to regulate ferroptosis in Alzheimer's disease based on network pharmacology PMID 39067563
PDI
Pyripyropene A 147444
A novel bactericidal small molecule, STK
RP03707
7
Behenic acid
BMS185354
Acephate 30560
CEA
BMS 185354
Altenuisol
BMS
Dihydropyrocurzerenone
HAX1 inhibits apoptosis and promotes maturation of neutrophils PMID 40691563
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport PMID 38816580
Human adipose and synovial
Identification of lysine
(S,R,S)
4
Transferrin Receptor Targeted Cellular Delivery of Doxorubicin Via a Reduction
Apoptosis Inducing 1,3,4
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti PMID 17378609
Monoterpenoid Indole Alkaloids from Kopsia officinalis and the Immunosuppressive Activity of Rhazinilam PMID 28218521
Semisynthetic lectin
Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3) PMID 24904966
CEM/VLB100
1
DHODH
MCE
3
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma PMID 39092767
Fut1 Rat Pre
Alteration in Golgi apparatus fragmentation related genes in human dilated cardiomyopathy PMID 40044985
Technical Support
Autoantibody against angiotensin II type I receptor induces pancreatic β
Dipsacoside B 33289
Four Prognosis
Se
ILT3
Maximin3
Cannabinoids Rescue Cocaine
Dual Template Molecularly Imprinted Polymers Targeting Blockade of CD47 for Enhanced Macrophage Phagocytosis and Synergistic Antimetabolic Therapy PMID 39079025
Oxymatrine alleviates ALD
RARG variant predictive of doxorubicin
Toxic PARP trapping upon cAMP
The X
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation PMID 38906140
Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro PMID 12716029
OCM Human Pre
Design and Development of Microformulations for Rapid Release of Small Molecules and Oligonucleotides PMID 37220816
Arrestin
PRTN3 Human Pre
LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C
Long
3
ABHD11 Human Pre
Single
6
Zuogui Pills alleviate cyclophosphamide
3
ASP2215
3’
Pharmacokinetic/pharmacodynamic modeling for dose selection for the first
(rac)
ST2825, independent of MyD88, induces reactive oxygen species
Agarsenone
HDAC1/6
IL
Antiovarian cancer mechanism of esculetin inducing G0/G1 arrest and apoptosis via JAK2/STAT3 signalling pathway PMID 36332079
2
LJH685
2
Azido
L
Sesquiterpene Lactones from Vernonia tufnelliae Structural Characterization and Biological Evaluation PMID 35704432
Sustained release of a highly specific GSK3β inhibitor SB216763 in the PCL scaffold creates an osteogenic niche for osteogenesis, anti
YF
Caspase
Bivalirudin exerts antiviral activity against respiratory syncytial virus
SIK2 Drives Pulmonary Fibrosis by Enhancing Fibroblast Glycolysis and Activation PMID 40868174
Pax5 Mouse Pre
NEO376
细胞分裂周期 42（CDC42）基因
immunomodulatory
Iretol
recombinant
multiple sclerosis
Orientanol A
JC
WAY
Phosphatidylinositol 3
MIL62
Pravastatin
MK
Mcm2 Mouse Pre
Capn1 Mouse Pre
甲基甲磺酸酯 (Standard)
SCL
chronic
Anti
The role of DRP1
头孢尼西钠
脱氧野尻霉素
Cefonicid
Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP PMID 34038131
ADAR1 Regulates Lipid Remodeling through MDM2 to Dictate Ferroptosis Sensitivity PMID 39896528
tert
Modulation of epithelial
乙氢去甲奎宁
4A3
Development of TPP
盐酸埃罗替尼(Standard)
咪喹莫特 d<sub>6</sub>
Design, synthesis, biological evaluation and molecular modeling of novel 1,3,4
Thujopsene 470
含卷曲螺旋结构域 57（CCDC57）基因
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy PMID 39482491
s
CXCL Gene Clusters Regulated by Enhancer
Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress PMID 35349212
JNK
What did we learn from CTLA
N
histology
Vacuolin
CRLF2 overexpression defines an immature
Discovery of PF
1
S1g
Mitochondrial respiration inhibitor enhances the anti
Four novel tarantula toxins as selective modulators of voltage
O
Nectin
Light
Discovery of novel pyrrolo[2,3
RT3003
Heptane
DBM
6,7
KF392
Capn1 Rat Pre
Antitumor agents. 172. Synthesis and biological evaluation of novel deacetamidothiocolchicin
Prostaglandin H
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4
Ononin 486
ST6GAL1 Human Pre
Card9 Rat Pre
SNpc
Novel inhibitors of bacterial cytokinesis identified by a cell
MCM2 Human Pre
TULP2, a substrate of CCT8, is essential for the intraflagellar transport during spermiogenesis in mice PMID 40613306
LTA4H improves the tumor microenvironment and prevents HCC progression via targeting the HNRNPA1/LTBP1/TGF
Role and mechanism of COL3A1 in regulating the growth, metastasis, and drug sensitivity in cisplatin
CNTO4088
Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells PMID 29382847
Macrophages mediated delivery of chlorin e6 and treatment of lung cancer by photodynamic reprogramming PMID 34562845
Asp
1,2,3
TNF alpha and the TNF receptor superfamily structure
Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway PMID 31892842
5
PTB
(2
N
c
ALOXE3 expression predicts poor prognosis and modulates immune infiltration in colon adenocarcinoma PMID 40696372
Discovery of Aficamten (CK
Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth PMID 40050264
Analysis of verteporfin liposomal formulations for phospholipids and phospholipid degradation products by liquid chromatography
cytarabine
Ceftezole sodium (Standard) (CTZ sodium (Standard)，头孢替唑钠 (Standard))
Role of redox
6
17β
Enhanced efficacy against cervical carcinomas through polymeric micelles physically incorporating the proteasome inhibitor MG132 PMID 26987571
隐丹参醌
CP
GSK805
1
Anti
A novel 4D cell culture mimicking stomach peristalsis altered gastric cancer spheroids growth and malignance PMID 33836517
Pyridoxine
AMG
Discovery and Mechanism of 16
MCE
Itaconate promotes a wound resolving phenotype in pro
Cyprocide
Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin PMID 28671690
Extracellular Vesicles from Adipose
Absorption kinetics
Deacylketoconazole 67914
GMP TPO/Thrombopoietin 蛋白, Human (HEK293, His)
Desethyloxybutynin
PTPRF 相互作用蛋白 alpha 1（PPFIA1）基因
YZ129 1643120
Effect of itopride, a new prokinetic, in patients with mild GERD a pilot study PMID 16015691
Gingerenone A Attenuates Ulcerative Colitis via Targeting IL
A facile and smart strategy to enhance bone regeneration with efficient vitamin D3 delivery through sterosome technology PMID 38653347
Dynamic bidirectional regulation between Stk38 and rabies virus M protein coordinates apoptosis progression during neurotropic infection PMID 40398756
7
Propofol Mitigates Sepsis
CD200R1 Human Pre
(Rac)
蛋白酶体 26S 亚基，ATPase 4（PSMC4）基因
P65
Iron overload facilitates neonatal hypoxic
Carboxypeptidase B2/CPB2 蛋白, Mouse (HEK293, His)
KSC
Inhibition of GRK2 reduced doxorubicin
The pharmacology of cilostazol PMID 12180353
Directional homing of glycosylation
Aif1 Rat Pre
TIM 1 抗体 (YA3545)（TIM 1 Antibody (YA3545)）
1
s
NADPH oxidase NOX4 is a glycolytic regulator through mROS
Sustained
s
Exploring the mechanism of baicalein on breast cancer based on network pharmacology, molecular docking and in vivo experiments PMID 40081541
RIPK1
Scn5a Mouse Pre
Plastoquinone
Delamanid
N
乙酰辅酶 A 羧化酶 α（ACACA）基因
SLC39A8/Zinc Suppresses the Progression of Clear Cell Renal Cell Carcinoma PMID 33869056
ODN 20844 sodium
GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple
COX
CD200 蛋白, Human (HEK293, Fc
Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage PMID 27881652
New synthetic phenylquinazoline derivatives induce apoptosis by targeting the pro
N
Inhibition by the combined Ca2+ and 5
ADAM 金属肽酶结构域 15（ADAM15）基因
Multifunctional natamycin modified chondroitin sulfate eye drops with anti
Phenelfamycins G and H, new elfamycin
cannabinoid，endocannabinoid system
A Ralstonia solanacearum effector regulates plant cell death by disrupting the homeostasis of the BPA1
Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis
Aspinolide B
OPRL1 Human Pre
EBV BZLF1 (190
WWL 70
ML
Noninvasive Optogenetics Realized by iPSC
Chromodomain Y
WWL70
6
来那替尼杂质13
Ananonin B
Linrodostat 1923833
L 838417
Bis
ZP10
Theaflavin 3,3& 039;
NECTIN4 promotes papillary thyroid cancer cell proliferation, migration, and invasion and triggers EMT by activating AKT PMID 31114323
Discovery of highly potent and selective EGFRT790M/L858R TKIs against NSCLC based on molecular dynamic simulation PMID 34794818
(Rac)
DL
钙结合和卷曲螺旋结构域 1（CALCOCO1）基因
Nek7
Long
Doxorubicinol
Protein CoAlation and antioxidant function of coenzyme A in prokaryotic cells PMID 29626155
JAMI1001A 1001019
2
Lupeol 545
双特异性磷酸酶 13（DUSP13）基因
H2
6
Alvimopan metabolite
MK
Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP
Corosolic acid enhances oxidative stress
ASN 04421891
alzheimer disease
screening
HMBPP analog
EHD1 promotes the cancer stem cell (CSC)
Biomodified Extracellular Vesicles Remodel the Intestinal Microenvironment to Overcome Radiation Enteritis PMID 37399352
ELA
MAP2K1 P124L Recombinant Human Active Protein Kinase
CD276/B7
Multi
Di
Peptide YY
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway PMID 40702221
DMT
Cholesterol confers ferroptosis resistance onto myeloid
CD82 蛋白, Human (HEK293, Fc)
Acotiamide
Chronic Exposure to Environmentally Relevant Concentrations of Microcystin
Ginsenoside Rg3 enhances the anticancer effects of 5
Ventricular SK2 upregulation following angiotensin II challenge Modulation by p21
Flonicamid
Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons PMID 26487856
NPC26
The mammalian actin elongation factor ENAH/MENA contributes to autophagosome formation via its actin regulatory function PMID 38705725
淀粉酶
Lithocholenic acid
The METTL3/IGF2BP1 axis
N
Huoxuezhitong capsule ameliorates MIA
VU 0364439 1246086
Title Bioinformatic Identification of Genes Involved in Diabetic Nephropathy Fibrosis and their Clinical Relevance PMID 36715962
Benzothiozinone
CAY10583
8
5
2,2'
Salvinorin A ameliorates pilocarpine
A proteome
KRH
细胞分裂周期相关 8（CDCA8）基因
Competitive
Identification and evaluation of a lipid
Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines PMID 21930909
Cdh17 Mouse Pre
Modified salicylanilide and 3
GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND
Salidroside Ameliorates Mitochondria
Network pharmacology and transcriptomics reveal androgen receptor as a potential protein target for 6PPD
Deciphering meiotic chromatin organization by SYCP3 PMID 40488283
Formoterol Reduces the Pro
Farnesyl
Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro PMID 30142530
Three
Roemerine Improves the Survival Rate of Septicemic BALB/c Mice by Increasing the Cell Membrane Permeability of Staphylococcus aureus PMID 26606133
Low
Butyrate improves abnormal sleep architecture in a Parkinson's disease mouse model via BDNF/TrkB signaling PMID 40537481
Discovery of novel 4
MCE
Pyrogallol protects against influenza A virus
Calnexin mediates the maturation of GPI
Human native soluble CD40L is a biologically active trimer, processed inside microsomes PMID 8626375
Long non
N
CD158z/KIR3DL3
5'
Cyclosporin C is the main antifungal compound produced by Acremonium luzulae PMID 9143111
Activation of the p62
L
AZD
4
ACSM3 suppresses the pathogenesis of high
Mechanism of M2 type macrophage
Lenvatinib promotes hepatocellular carcinoma pyroptosis by regulating GSDME palmitoylation PMID 40653759
Berberine
三角洲样典型 Notch 配体 3（DLL3）基因
Effects of Destruxin A on Silkworm's Immunophilins PMID 31216655
cell
GYY4137 ameliorates blood brain barrier damage by inhibiting autophagy mediated occludin degradation in cardiac arrest and resuscitation PMID 39762518
FGFR
Synthesis and Biological Activity of Peptide α
PtdIns
In Silico Exploration and Biological Evaluation of Bispecific Peptides Derived from Anti
PDE2/PDE10
3
Sodium leak channel contributes to neuronal sensitization in neuropathic pain PMID 33766679
Isotschimgin
Prostaglandin H2
S1g
PF 04979064
NCX
ROS generation attenuates the anti
Pentobarbital
AZ12559322 947184
Shortened Spadin Analogs Display Better TREK
Wiz Rat Pre
Apelin
A Review of Amylin Peptide Receptor Activators for Obesity Pharmacotherapy PMID 40910290
含三方基序 16（TRIM16）基因
Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors PMID 21463944
Cucurbitane glucosides from the root of Machilus yaoshansis PMID 22044245
5
Keoxifene hydrochloride(Standard)
Discovery of potent CSK inhibitors through integrated virtual screening and molecular dynamic simulation PMID 38809025
METTL3
Didesmethylcitalopram
Gal1
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin
Il22ra1 Rat Pre
BMS
IL22RA2 Human Pre
84167
LncRNA ubiquitin
Brain
Carbutamide
Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid
Dihydromyricetin Suppresses Lipopolysaccharide
Epsin3 promotes non
Blocking NS3
Autophagy promotes aortic adventitial fibrosis via the IL
ALDH2 alleviates inflammation and facilitates osteogenic differentiation of periodontal ligament stem cells in periodontitis by blocking ferroptosis via activating Nrf2 PMID 39370484
Verteporfin reverses progestin resistance through YAP/TAZ
Peripherally restricted CB1 receptor blockers PMID 23902803
IMD
TLR3 Knockdown Attenuates Pressure
Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway PMID 30550853
hsa
Effect of alternating nicotinamide phosphoribosyltransferase expression levels on mitophagy in Alzheimer's disease mouse models PMID 38862096
osmolality
CARD9 Human Pre
LTA4H抑制剂、基因
Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti
Pyridoxol
Activity of a new antipseudomonal cephalosporin, CXA
H
Ostenol
Aβ
AG
SiR700
oats
PNU
New antiprotozoal agents Synthesis and biological evaluation of different 4
Nectin
PSMA
PF
(S)
Cysteine‑ and glycine‑rich protein 2 A vital regulator that inhibits necroptosis glioma cell by activating the JAK‑STAT1 pathways PMID 39918019
ALX 0081
Butyrate induces STAT3/HIF
Live tracking
Necrostatin
Assessment of the biological and pharmacological effects of the alpha nu beta3 and alpha nu beta5 integrin receptor antagonist, cilengitide (EMD 121974), in patients with advanced solid tumors PMID 17693653
LBP
Itk
The combination of a PTP1B inhibitor, TNFR2 blocker, and PD‑1 antibody suppresses the progression of non‑small cell lung cancer tumors by enhancing immunocompetence PMID 39301655
Methyl 2
Misoprostol acid
CircBIRC6 facilitates the malignant progression via miR
Targeting heat shock protein 47 alleviated doxorubicin
(S)
FRET
Discovery of potent small molecule ubiquitin
胆汁酸
Cholic acid
Oxidative stress activates YAP/TEAD1/NCOA4 axis to promote ferroptosis of endplate chondrocytes and aggravate intervertebral disc degeneration PMID 40688343
Potassium chloride, for cell culture
AKR
N
Dacarbazine 4342
Interleukin
Environmentally relevant concentrations of perfluorobutane sulfonate impair locomotion behaviors and healthspan by downregulating mitophagy in C. elegans PMID 39326150
MMP
IL
Inhibiting interferon
Vitexin mitigates oxidative stress, mitochondrial damage, pyroptosis and regulates small nucleolar RNA host gene 1/DNA methyltransferase 1/microRNA
Oleamide MEA
TREM
LB
Prostaglandin E2
环(苯丙氨酸
Adgrf4 Rat Pre
crystal
PD254552
Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial
EG01449
PQBP1 regulates the cellular inflammation induced by avian reovirus and interacts with the viral p17 protein PMID 37201645
Activity of panitumumab alone or with chemotherapy in non
Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice PMID 30806715
反式
OPA1 supports mitochondrial dynamics and immune evasion to CD8+ T cell in lung adenocarcinoma PMID 36573240
Clec7a Signaling in Microglia Promotes Synapse Loss Associated with Tauopathy PMID 40243488
6
Long
Targeted AURKA degradation Towards new therapeutic agents for neuroblastoma PMID 36549117
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