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Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators PMID 21688779
A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons PMID 40349338
Establishment and characterization of a highly metastatic hepatocellular carcinoma cell line PMID 38184822
Fused Heterocyclic Compounds as Potent Indoleamine
Epigallocatechin‑3‑gallate hinders metabolic coupling to suppress colorectal cancer malignancy through targeting aerobic glycolysis in cancer‑associated fibroblasts PMID 35029285
Spermidine prevents high glucose
Extract of Jasminum grandiflorum L. alleviates CCl4
Targeting SUMO2 reverses aberrant epigenetic rewiring driven by SS18 SSX fusion oncoproteins and impairs sarcomagenesis PMID 40804185
A screening of inhibitors targeting the receptor kinase FERONIA reveals small molecules that enhance plant root immunity PMID 36121304
1
NOTCH3 promotes malignant progression of bladder cancer by directly regulating SPP1 and activating PI3K/AKT pathway PMID 39557868
PLA2G7 蛋白, Mouse (HEK293, His)
Eosinophils promote CD8+ T cell memory generation to potentiate anti
BChE/MAO
N6
SE
Ophiorrhines F and G, Key Biogenetic Intermediates of Ophiorrhine Alkaloids from Ophiorrhiza japonica and Their Immunosuppressant Activities PMID 35104138
Anticancer agent 147 2241283
A potential biomarker of isofenphos
CGAS is a micronucleophagy receptor for the clearance of micronuclei PMID 33752561
Levosimendan protects from sepsis
Carboxypeptidase A1/CPA1 蛋白, Human (HEK293, His)
USP7
progesterone antagonist
A rationally designed fluorescence probe achieves highly specific and long
TRAF4 Maintains Deubiquitination of Caveolin
Targeting NADPH Oxidase and Integrin α5β1 to Inhibit Neutrophil Extracellular Traps
dCBP
The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit PMID 12871647
Vanillylmandelic acid
MW
2
Grape seed
Epiallopregnanolone
Astragaloside IV regulates FOXM1 deubiquitination to ameliorate trophoblast damage caused by high glucose PMID 40514721
Fosrugocrixan 2408145
Capsiate attenuates atherosclerosis by activating Nrf2/GPX4 pathway and reshaping the intestinal microbiota in ApoE
Menoxymycin B
Ketopioglitazone
Toosendanin 58812
Galloylated Toll
HIV
broad
Transcriptome dynamics of the BHK21 cell line in response to human coronavirus OC43 infection PMID 38761489
4
YM
(±)11(12)
The role of blood podoplanin in patients with viral myocarditis PMID 37669599
TGF
Transient Receptor Potential Cation Channel Subfamily V Member 1 Expression Promotes Chemoresistance in Non
叶醇 (Standard)
Targeting CSPG4 enhances the anti
ZFP91 promotes cell proliferation and inhibits cell apoptosis in AML via inhibiting the proteasome
Trimethylammonium chloride
miR
MCE
Circular RNA circLDLR facilitates cancer progression by altering the miR
Therapeutic efficacy of cefadroxil and cephalexin for pneumonia in a rat test model PMID 3752972
Synergistic multi
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest PMID 39022094
Empagliflozin ameliorates cardiac dysfunction in heart failure mice via regulating mitochondrial dynamics PMID 36690056
Sodium dihydrogen phosphate monohydrate, for molecular biology
Oleanonic acid ameliorates mutant Aβ precursor protein
Ozone
N
The differential formation and composition of leukocyte
Mycelial biomass and intracellular polysaccharides production, characterization, and activities in Auricularia auricula
LDH
Identification of AS1842856 as a novel small
ADRB2 is regulated by TRIM22 and facilitates lung adenocarcinoma progression via JAK2/STAT3 signaling pathway PMID 40594822
Targeting notch1 with berbamine alleviates the inflammatory responses of macrophages in sepsis PMID 40489907
hepatic first
Antibiotic
PIF8
MMP
β
Is the complement activation product C3a a proinflammatory molecule? Re
The flavonoid GL
VCP171
Insulin
Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma PMID 26819001
Hsa_circ_0010882 facilitates hepatocellular carcinoma progression by modulating M1/M2 macrophage polarization PMID 38235909
DAB1 Human Pre
Optimization of Fibrin Scaffolds to Study Friction in Cultured Mesothelial Cells PMID 35563371
RGH2981
Identification and analysis of microplastic aggregation in CAR
R1518
HBX 41108 924296
Isobutyric acid
Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders PMID 40334997
Artesunate interacts with the vitamin D receptor to reverse sepsis
Ticlopidine protects hepatic ischemia
Murine double minute 2 aggravates adipose tissue dysfunction through ubiquitin
Cyclopropylamine
Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of the Src
The cyclin
Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing PMID 37226094
EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines PMID 40745342
A silk fibroin based bioadhesive with synergistic photothermal
AAK1
Knockdown of TFB2M induces ferroptosis in lung adenocarcinoma via mitophagy
Apararenone 945966
ISAC
Therapeutic effect of umbilical cord mesenchymal stem cells on renal ischemia
RBM14 蛋白, Human (His
SGMS1 facilitates osteogenic differentiation of MSCs and strengthens osteogenesis
Biological profile of cortexolone 17alpha
(Rac)
Solanum bulbocastanum nucleotide
immunogenicity
N,N’
The Acetylation Modification of SP1 Regulates the Protein Stability in Silkworm PMID 34826090
SERINC5 restricts influenza virus infectivity PMID 36223419
Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH
The mechanism of RGS5 regulating gastric cancer mismatch repair protein PMID 38860604
Checkpoint Kinase (Chk)
Hexadecane
co
Phoenixin
Berberine Rescues D
PCYT1A Human Pre
Characterization of a head and neck cancer
Probiotic domestication and engineering enable one
6
Acyltransferase
PGH
gastric ulcer model in rat
Behavioral pharmacology
ABT494
Clazolam (Isoquinazepon)
吉法酯
NOP agonist
Novel amino acid
Gasdermin D regulates the activation of EGFR in colorectal cancer PMID 39741309
FRMD7 Human Pre
AMG
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling PMID 33318871
GRAF1 integrates PINK1
Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway PMID 36226249
HMGA2
Gls Mouse Pre
SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma PMID 39851260
Role and Mechanism of Rhizopus Nigrum Polysaccharide EPS1
ATP2C2 Human Pre
(4R,5R)
Development and validation of an LC
Guanosine
tert
2
Store
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48
胶质母细胞瘤 (Glioblastoma)
PRX
Antitumor agent
SMN
D
NO Synthase
Chd4 Mouse Pre
Overexpression of SERPINA3 promotes tumor invasion and migration, epithelial
KRN5 1800465
Outer membrane 蛋白 A/OmpA 蛋白, E.coli (His
BMS
Apoptin
Fortuneine 87340
HCP5 prevents ubiquitination
FGFR
ML114
monomeric sarcosine oxidase 蛋白, Bacillus sp.
适配器相关蛋白复合物 2 亚基 beta 1（AP2B1）基因
Mercaptoethylguanidine attenuates caustic esophageal injury in rats a role for scavenging of peroxynitrite PMID 21929984
甲胎蛋白（AFP）基因
Epoxide hydrolase 蛋白, Bacillus gobiensis (His)
L
rtM204I
CAY10583
Alpha
Rab1b Mouse Pre
Proximal Tubular Cannabinoid
N
Octanoic acid
MMP
瑞派替尼
Loxapine hydrochloride 54810
Turmeric yellow
Adenosine N1
Pyrromethene 650 (PM650)
ANGPT2
四溴双酚A
ABT
Activated STAT3 Could Reduce Survival in Patients with Esophageal Squamous Cell Carcinoma by Up
Azide
Optimized zymogram protocol from 3D spheroid cultures to study MMP
N
Pyrromethene 605 (PM605)
Delta
IFNAR1 蛋白, Human (Biotinylated, HEK293, His
From chemical tools to clinical medicines nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds PMID 24831536
Pyrromethene 556 (PM556)
modest
5’
Gilteritinib
Preclinical efficacy of the potent, selective menin
Secretase inhibitors for the treatment of Alzheimer's disease Long road ahead PMID 29477076
Resveratrol and its Nanoparticle suppress Doxorubicin/Docetaxel
2’,3’
IL
SIGLEC9 Human Pre
RRM2 Alleviates Doxorubicin
A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen
GSK729
MCE
CC
烯啶蟲胺
FGFR
Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites PMID 36719201
R
3
Suppression of Cancer Cell Stemness and Drug Resistance via MYC Destabilization by Deubiquitinase USP45 Inhibition with a Natural Small Molecule PMID 36765885
T863
三七淫羊藿素
4
1,8
Coumarin
集落刺激因子 3 受体（CSF3R）基因
mRNA
hypothyroidism
Aminocandin (HMR 3270)
CP
Astragaloside IV Attenuates Angiotensin II
Cbz
Ambra1 in exosomes secreted by HK
Protein disulfide isomerase a promising target for cancer therapy PMID 24184531
Folate receptor
奈韦拉平 (标准品)
Hydroxycerivastatin
7
甲氧基肉桂酸异戊酯 (Standard)
8
USP30 蛋白, Human (sf9)
Mebendazole
Multifunctional Bioactive Nanozyme Systems for Enhanced Diabetic Wound Healing PMID 39077928
Quantifying the inhibitory effect of Bcl
B7
Boc
Targeting TNF
AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration PMID 32896719
Bisphenol A disrupts the neuronal F
DDC Human Pre
帕潘立酮 d<sub>4</sub>
Glycyrrhetinic acid derivatives containing aminophosphonate ester species as multidrug resistance reversers that block the NF
Michael acceptors
Eicosatrienoic acid inhibits estradiol synthesis through the CD36/FOXO1/CYP19A1 signaling pathway to improve PCOS in mice PMID 39236935
Rilpivirine
FOXB1 Human Pre
D
Lamtidine
C3a
Combination of Vismodegib and Paclitaxel Enhances Cytotoxicity via Bak
eltD 蛋白, Mycolicibacterium smegmatis 155
Epirubicin a review of the pharmacology, clinical activity, and adverse effects of an adriamycin analogue PMID 3005521
谷氨酰胺酶
Rosiglitazone
cBu
MAO
(R)
Azide
2
Maternal Electronic Cigarette Exposure Induces Dysregulation of Autophagy via Oxidative Stress/DNA Methylation in Pulmonary Hypertension Offspring PMID 40553255
TNF 受体超家族成员 1A（TNFRSF1A）基因
Inhibition of LCP2 in T cells alleviated apoptosis and oxidative stress via PD
Fluoroalkylation promotes cytosolic peptide delivery PMID 32851155
Ibuproxam (G 277)
Cancer/testis
Autophagic Degradation of GPX4 Mediates Ferroptosis During Sheep Sperm Cryopreservation PMID 40431583
ATP2B2 Human Pre
A cohort of mRNAs undergo high
Azido
16
Discovery of a Furanopyrimidine
MYC
3
A common local anesthetic receptor for benzocaine and etidocaine in voltage
8
Structure
Caspase
Characterization of a fluorescence imaging probe that exploits metabolic dependency of ovarian clear cell carcinoma PMID 37985723
Cholecalciferol pretreatment ameliorates ischemia/reperfusion
The Potential of the Fibronectin Inhibitor Arg
3
TDD
APD791
Autoantibodies to IgE and FcεRI and the natural variability of spleen tyrosine kinase expression in basophils PMID 29859965
Discovery and Early Clinical Development of an Inhibitor of 5
Thieno[2,3
Beta
Targeting DNA topoisomerase II in cancer chemotherapy PMID 19377506
Her2 amplification, Rel
Insights into the GSDMB
caspase
Delta
Tetrahydropalmatine attenuates MSU crystal
cell cycle arrest
Natural phenylethanoid glycosides isolated from Callicarpa kwangtungensis suppressed lipopolysaccharide
Thalidomide
UQCRC1 downregulation impairs cognitive function in mice via AMPK inactivation PMID 40832581
The β
lncRNA SLC7A11
AUY954 820240
Identification of novel influenza polymerase PB2 inhibitors using virtual screening approach and molecular dynamics simulation analysis of active compounds PMID 34839161
rel
Silencing AREG Enhances Sensitivity to Irradiation by Suppressing the PI3K/AKT Signaling Pathway in Colorectal Cancer Cells PMID 39359866
Eltrombopag
Tnc Mouse Pre
Inhibition of RELM
Synstatin (92
Tenascin/Tnc 蛋白, Human (His)
GSK180736A
IL
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells PMID 28965853
SHY
The alkylglycerone phosphate synthase sustains the resistance of gastric cancer cells to ferroptosis induced by Apatinib PMID 40186794
T0070907
ATP disodium salt hydrate 34369
Cyb5r3 Rat Pre
TMEM173
Toxicity mechanism of acrolein on energy metabolism disorder and apoptosis in human ovarian granulosa cells PMID 38866128
EUK
Stimulator of Interferon Genes
JR14a A novel antagonist of C3aR attenuates neuroinflammation in cerebral ischemia
STING
threo
Desisopropylatraton
MPYS
N
MITA
hyperlipidemia
Complement C5a inhibition reduces atherosclerosis in ApoE
DMT
Oct3/4
Attenuating Metabolic Competition of Tumor Cells for Favoring the Nutritional Demand of Immune Cells by a Branched Polymeric Drug Delivery System PMID 36504170
inositol hexakisphosphate kinases
Amelioration of scopolamine
Polystyrene nanoplastics
IL
Octanal
FGFR
Drugs ten years later epirubicin PMID 8353070
MRK
Activation of HIF
SETD8C302R Mutation Revealed from Myofibroblastoma
5
Transcription factor ETV4 plays a critical role in the development of non
2
Maximin 3
vasodilator
TNC Human Pre
The Antiallodynic Effect of Nefopam on Vincristine
Trilobatin
Ganoderic acid B 81907
Nanointegrative Glycoengineering
Discovery of 1
L3MBTL 组蛋白甲基
2
Atp2a2 Mouse Pre
Layer Va neurons, as major presynaptic partners of corticospinal neurons, play critical roles in skilled movements PMID 38979259
6PPD
Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis PMID 38837315
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors PMID 16302818
PINK1/Parkin
肌球蛋白 2（MYOM2）基因
Antagonizing Effects of Chromium Against Iron
Cystatin SA/CST2 蛋白, Human (HEK293, His)
A pan
immune
6a,7
The caspase
Mitigation of non
IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma PMID 38906156
3,4
BEA
4
潜伏膜蛋白 2A
Danicopan 1903768
Blocking triggering receptors expressed on myeloid cell
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules PMID 16959577
D
Gastric cancer derived mesenchymal stem cells promoted DNA repair and cisplatin resistance through up
Neutrophil
histone
GW
Dipeptidyl Peptidase
TGF
Hexadecanoate
乌帕替尼
DAPI dihydrochloride 28718
1
Blue light attenuates TGF
Porphobilinogen
CRTh2 antagonist 4
L741626
Lack of binding of gestodene to estrogen receptor in human breast cancer tissue PMID 2144750
TiSe2
Piperlongumine overcomes osimertinib resistance via governing ubiquitination
Dauricine attenuates Oct4/sonic hedgehog co
Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression PMID 32671444
Activation of the Nrf2 Signaling Pathway by Tetrahydroberberine Suppresses Ferroptosis and Enhances Functional Recovery Following Spinal Cord Injury PMID 40011360
Antimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica PMID 28557449
MCP
Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro
Design, Synthesis, and Evaluation of Pyrazolopyridine Derivatives as Novel Calreticulin (CALR) Ligands That Inhibit Triple
Taraxasterol regulates p53 transcriptional activity to inhibit pancreatic cancer by inducing MDM2 ubiquitination degradation PMID 39671783
Fluoride impairs mitochondrial translation by targeting miR
Irisin 蛋白, Human/Mouse/Rat (HEK293, His)
Roles of lipoxin A4 receptor activation and anti
hCAI/II
N
Cellular assays for dynamic quantification of deubiquitinase activity and inhibition PMID 37858708
Resveratrol mitigated acute sleep deprivation
Synthesis and antiproliferative evaluation of certain indeno[1,2
15(S)
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic
LCK Human Pre
HFD
Pinatuzumab vedotin 1313706
1
PPARγ agonist efatutazone and gefitinib synergistically inhibit the proliferation of EGFR
Ms4a2 Mouse Pre
Morphine
Dephosphorylation by calcineurin regulates translocation of dynamin
Synthesis and antiproliferative activity of quinolone nucleosides against the human myelogenous leukemia k
Cethromycin
N
LCTX
Immune modulation of the liver metastatic colorectal cancer microenvironment via the oral CAPOX
Riociguat
Triclabendazole sulfone
NFAT5 Restricts Bovine Herpesvirus 1 Productive Infection in MDBK Cell Cultures PMID 37227295
N
Discovery and characterization of a positive allosteric modulator of transient receptor potential canonical 6 (TRPC6) channels PMID 30594060
Artesunate Sensitizes Human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2
Methionine Adenosyltransferase (MAT)
BML
Interleukin Related
KCTD11 Human Pre
2
Curcumin reduces paclitaxel resistance in ovarian carcinoma cells by upregulating SNIP1 and inhibiting NFκB activity PMID 37146834
Anti
Docosanoic acid
Antifungal compounds from Melia azedarach leaves for management of Ascochyta rabiei, the cause of chickpea blight PMID 20628965
1,1& 039;
Palmitoylation enhances the stability of porcine epidemic diarrhea virus spike protein by antagonizing its degradation via chaperone
Case report for an adolescent with germline RET mutation and alveolar rhabdomyosarcoma PMID 32532875
1
Anoikis resistance and immune escape mediated by Epstein
Evodiamine induces ferroptosis in prostate cancer cells by inhibiting TRIM26
Immunolocalization of ecto
Behavioral and biochemical investigations of bupropion metabolites PMID 12909199
Anti
Rational discovery of molecular glue degraders via scalable chemical profiling PMID 32747809
DNA Methyltransferase
AI
Polyoxin F
N
5
GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial
Csf2rb Rat Pre
Monoamine oxidase A drives neuroendocrine differentiation in prostate cancer PMID 35349822
Naphthazarin 475
MiR
2,2',5,5'
4
ICAM
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression PMID 36879298
WAY
LPS induces fibroblast
Network pharmacology integrated with experimental validation revealed potential molecular mechanisms of Camellia nitidissima C. W. Chi in the treatment of lung cancer PMID 37142145
N‐(2‐(N‐Palmitoleoyl)aminoethyl)maleimide
LCAT3, a novel m6A
N
6& 039;& 039;
Lactoferrin alleviates doxorubicin
Structural modification aimed for improving solubility of lead compounds in early phase drug discovery PMID 35033884
TCO
Ketohexokinase
芦荟大黄素
1,6,8
Activation of the TLR4/MyD88 signaling pathway contributes to the development of human hepatocellular carcinoma via upregulation of IL
PGC1 alpha+beta 抗体 (YA3458)（PGC1 alpha+beta Antibody (YA3458)）
The Flavagline Compound 1
TRIM27 regulates the expression of PDCD4 by the ubiquitin‑proteasome pathway in ovarian and endometrial cancer cells PMID 35583010
The Protective Role of Brain CYP2J in Parkinson's Disease Models PMID 30046373
The downregulated long noncoding RNA DHRS4
Fmoc
Identification of N
Inhibition of HtrA2 alleviated dextran sulfate sodium (DSS)
Activity
LncRNAs activate longevity regulation pathway due to aging of Leydig cells caused by DEHP exposure A transcriptome
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